Detailed information for compound 1481165

Basic information

Technical information
  • TDR Targets ID: 1481165
  • Name: 5-(2,4-dioxo-1H-thieno[3,2-d]pyrimidin-3-yl)- N-[(4-methylphenyl)methyl]pentanamide
  • MW: 371.453 | Formula: C19H21N3O3S
  • H donors: 2 H acceptors: 3 LogP: 2.46 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccc(cc1)C)CCCCn1c(=O)[nH]c2c(c1=O)scc2
  • InChi: 1S/C19H21N3O3S/c1-13-5-7-14(8-6-13)12-20-16(23)4-2-3-10-22-18(24)17-15(9-11-26-17)21-19(22)25/h5-9,11H,2-4,10,12H2,1H3,(H,20,23)(H,21,25)
  • InChiKey: JHTZQBULGUQJKZ-UHFFFAOYSA-N  

Network

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Synonyms

  • 5-(2,4-diketo-1H-thieno[3,2-d]pyrimidin-3-yl)-N-(4-methylbenzyl)valeramide
  • ZINC02688211
  • 5-(2,4-dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)-N-(4-methylbenzyl)pentanamide
  • MLS000730041
  • SMR000308318

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni carbonyl reductase 0.0009 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0009 0.5 0.5
Trichomonas vaginalis steroid dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Plasmodium falciparum steroid dehydrogenase, putative 0.0009 0.5 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0009 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0009 0.5 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0009 0.5 0.5
Brugia malayi Retinol dehydrogenase 12 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0009 0.5 0.5
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0009 0.5 0.5
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0009 0.5 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0009 0.5 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0009 0.5 0.5
Leishmania major oxidoreductase-like protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Schistosoma mansoni retinal dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans oxidoreductase 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0009 0.5 0.5
Brugia malayi Dehydrogenases, short chain protein 30 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0009 0.5 0.5
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Leishmania major dehydrogenase-like protein 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans carveol-like dehydrogenase 0.0009 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.5 0.5
Brugia malayi oxidoreductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Leishmania major pteridine reductase 1 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0009 0.5 0.5
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Mycobacterium ulcerans dehydrogenase/reductase 0.0009 0.5 0.5
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans oxidoreductase 0.0009 0.5 0.5
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, putative 0.0009 0.5 0.5
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase, putative 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0009 0.5 0.5
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 13 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0009 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0009 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Brugia malayi hypothetical protein 0.0009 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0009 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.5 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Loa Loa (eye worm) dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0009 0.5 0.5
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0009 0.5 0.5
Echinococcus granulosus steroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Toxoplasma gondii carbonyl reductase 1, putative 0.0009 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0009 0.5 0.5
Loa Loa (eye worm) dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.5 0.5
Mycobacterium leprae Probable oxidoreductase 0.0009 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0009 0.5 0.5
Brugia malayi dehydrogenases, short chain protein 2 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Brugia malayi hypothetical protein 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0009 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0009 0.5 0.5
Giardia lamblia Hypothetical protein 0.0009 0.5 0.5
Echinococcus granulosus oxidoreductase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Echinococcus granulosus hypothetical protein 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type oxidoreductase 0.0009 0.5 0.5
Giardia lamblia Reductase, putative 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0009 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.5 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0009 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0009 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0009 0.5 0.5
Echinococcus granulosus WW domain containing oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase, putative 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Brugia malayi Dehydrogenases, short chain protein 2 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0009 0.5 0.5
Plasmodium vivax hypothetical protein, conserved 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis oxidoreductase 0.0009 0.5 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0009 0.5 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0009 0.5 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0009 0.5 0.5
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0009 0.5 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0009 0.5 0.5
Leishmania major 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0009 0.5 0.5
Brugia malayi dehydrogenases, short chain protein 9 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0009 0.5 0.5
Onchocerca volvulus Sepiapterin reductase homolog 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0009 0.5 0.5
Echinococcus multilocularis conserved hypothetical protein 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus granulosus hypothetical protein 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, putative 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0009 0.5 0.5
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0009 0.5 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase-like protein 0.0009 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Trypanosoma brucei oxidoreductase-like protein 0.0009 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0009 0.5 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0009 0.5 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0009 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 10.7 uM PUBCHEM_BIOASSAY: Dose response for HTS for Beta-2AR agonists via FAP method from CP1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID492947, AID504448] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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