Detailed information for compound 148117

Basic information

Technical information
  • TDR Targets ID: 148117
  • Name: [2-(1,3-thiazol-2-ylcarbamoyl)pyridin-3-yl] c yclohexanecarboxylate
  • MW: 331.389 | Formula: C16H17N3O3S
  • H donors: 1 H acceptors: 4 LogP: 3.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCCC1)Oc1cccnc1C(=O)Nc1nccs1
  • InChi: 1S/C16H17N3O3S/c20-14(19-16-18-9-10-23-16)13-12(7-4-8-17-13)22-15(21)11-5-2-1-3-6-11/h4,7-11H,1-3,5-6H2,(H,18,19,20)
  • InChiKey: MLHUZNTWTGOAHV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(thiazol-2-ylcarbamoyl)-3-pyridyl] cyclohexanecarboxylate
  • cyclohexanecarboxylic acid [2-[oxo-(2-thiazolylamino)methyl]-3-pyridyl] ester
  • cyclohexanecarboxylic acid [2-(thiazol-2-ylcarbamoyl)-3-pyridyl] ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli methionine aminopeptidase Starlite/ChEMBL References
Saccharomyces cerevisiae Map1p Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma brucei methionine aminopeptidase, putative Get druggable targets OG5_126721 All targets in OG5_126721
Cryptosporidium parvum methionine aminopeptidase with MYND finger at N-terminus Get druggable targets OG5_126721 All targets in OG5_126721
Treponema pallidum methionine aminopeptidase (map) Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium falciparum methionine aminopeptidase 1a, putative Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium knowlesi methionine aminopeptidase 1b, putative Get druggable targets OG5_126721 All targets in OG5_126721
Loa Loa (eye worm) methionine aminopeptidase type I Get druggable targets OG5_126721 All targets in OG5_126721
Cryptosporidium hominis methionine aminopeptidase 1 (MetAP 1) (MAP 1) (Peptidase M 1) Get druggable targets OG5_126721 All targets in OG5_126721
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium berghei methionine aminopeptidase 1a, putative Get druggable targets OG5_126721 All targets in OG5_126721
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium berghei methionine aminopeptidase 1b, putative Get druggable targets OG5_126721 All targets in OG5_126721
Theileria parva methionine aminopeptidase, type I, putative Get druggable targets OG5_126721 All targets in OG5_126721
Mycobacterium ulcerans methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Toxoplasma gondii methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Neospora caninum methionine aminopeptidase, putative Get druggable targets OG5_126721 All targets in OG5_126721
Candida albicans methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Toxoplasma gondii methionine aminopeptidase, type i, putative Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) Get druggable targets OG5_126721 All targets in OG5_126721
Chlamydia trachomatis methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma brucei gambiense methionine aminopeptidase, putative,metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium vivax methionine aminopeptidase 1a, putative Get druggable targets OG5_126721 All targets in OG5_126721
Babesia bovis methionine aminopeptidase, putative Get druggable targets OG5_126721 All targets in OG5_126721
Leishmania infantum methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Leishmania donovani metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium yoelii methionine aminopeptidase, type I, putative Get druggable targets OG5_126721 All targets in OG5_126721
Leishmania mexicana methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma brucei methionine aminopeptidase, type I, putative Get druggable targets OG5_126721 All targets in OG5_126721
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) Get druggable targets OG5_126721 All targets in OG5_126721
Mycobacterium ulcerans methionine aminopeptidase MapB Get druggable targets OG5_126721 All targets in OG5_126721
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) Get druggable targets OG5_126721 All targets in OG5_126721
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Brugia malayi Methionine aminopeptidase protein type I Get druggable targets OG5_126721 All targets in OG5_126721
Echinococcus granulosus methionyl aminopeptidase 1 M24 family Get druggable targets OG5_126721 All targets in OG5_126721
Schistosoma japonicum ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative Get druggable targets OG5_126721 All targets in OG5_126721
Babesia bovis methionine aminopeptidase, putative Get druggable targets OG5_126721 All targets in OG5_126721
Schistosoma japonicum Methionine aminopeptidase 1, putative Get druggable targets OG5_126721 All targets in OG5_126721
Neospora caninum methionine aminopeptidase, putative Get druggable targets OG5_126721 All targets in OG5_126721
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) Get druggable targets OG5_126721 All targets in OG5_126721
Neospora caninum methionine aminopeptidase, putative Get druggable targets OG5_126721 All targets in OG5_126721
Leishmania braziliensis methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Theileria parva methionine aminopeptidase, type I, putative Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium vivax methionine aminopeptidase 1b, putative Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium yoelii methionine aminopeptidase, type I Get druggable targets OG5_126721 All targets in OG5_126721
Candida albicans methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) Get druggable targets OG5_126721 All targets in OG5_126721
Schistosoma japonicum ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium knowlesi methionine aminopeptidase 1a, putative Get druggable targets OG5_126721 All targets in OG5_126721
Toxoplasma gondii methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium falciparum methionine aminopeptidase 1b, putative Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma congolense metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis 0.0077 0.036 0.036
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0086 0.0428 0.0102
Echinococcus multilocularis mothers against decapentaplegic 5 0.0052 0.0187 0.0187
Plasmodium vivax hypothetical protein, conserved 0.0077 0.036 0.2692
Loa Loa (eye worm) RNA binding protein 0.0552 0.3748 0.3748
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.0187 0.0187
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0337 0.0337
Brugia malayi MH1 domain containing protein 0.0052 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0214 0.1338 0.1338
Brugia malayi amine oxidase, flavin-containing family protein 0.0077 0.036 0.036
Echinococcus multilocularis GPCR, family 2 0.0034 0.0056 0.0056
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0061 0.0252 0.0252
Schistosoma mansoni GTP-binding protein alpha subunit 0.0061 0.0252 0.0252
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0061 0.0252 0.0252
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0061 0.0252 1
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0061 0.0252 0.0252
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0061 0.0252 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0096 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0034 0.0056 0.0056
Toxoplasma gondii methionine aminopeptidase 0.0086 0.0428 0.3201
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0106 0.057 0.4261
Plasmodium falciparum protoporphyrinogen oxidase 0.0077 0.036 0.2692
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0061 0.0252 0.0252
Trypanosoma cruzi PAB1-binding protein , putative 0.0214 0.1338 1
Schistosoma mansoni Smad4 0.0052 0.0187 0.0187
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0061 0.0252 1
Brugia malayi Pax transcription factor protein 2 0.0253 0.1621 0.1621
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0061 0.0252 0.0252
Echinococcus granulosus mothers against decapentaplegic 5 0.0052 0.0187 0.0187
Schistosoma mansoni tar DNA-binding protein 0.0552 0.3748 0.3748
Giardia lamblia DUB-1 0.0026 0 0.5
Echinococcus multilocularis smad 0.0052 0.0187 0.0187
Leishmania major UDP-galactopyranose mutase 0.0077 0.036 0.2692
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0579 0.0579
Loa Loa (eye worm) hypothetical protein 0.0061 0.0252 0.0252
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0061 0.0252 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0061 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0073 0.0337 0.0337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1429 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0252 0.0252
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0061 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0034 0.0056 0.0056
Echinococcus multilocularis tar DNA binding protein 0.0552 0.3748 0.3748
Toxoplasma gondii LsmAD domain-containing protein 0.0214 0.1338 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0061 0.0252 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0552 0.3748 0.3748
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0056 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0552 0.3748 0.3748
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0086 0.0428 0.3201
Brugia malayi MH2 domain containing protein 0.0052 0.0187 0.0187
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0061 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0077 0.036 0.036
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1011 0.7021 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.04 0.2666 1
Brugia malayi MH2 domain containing protein 0.0767 0.5282 0.5282
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0061 0.0252 0.0252
Echinococcus multilocularis Smad4 0.0052 0.0187 0.0187
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0061 0.0252 0.0252
Echinococcus granulosus Smad4 0.0052 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0077 0.036 0.036
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0086 0.0428 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1429 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.0056 0.0056
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0106 0.057 0.4261
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0026 0 0.5
Toxoplasma gondii methionine aminopeptidase 0.0106 0.057 0.4261
Schistosoma mansoni amine oxidase 0.0077 0.036 0.036
Toxoplasma gondii histone lysine-specific demethylase 0.0077 0.036 0.2692
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0077 0.036 0.036
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0061 0.0252 0.0252
Echinococcus granulosus TGF beta signal transducer SmadC 0.0052 0.0187 0.0187
Echinococcus granulosus expressed protein 0.0061 0.0252 0.0252
Brugia malayi hypothetical protein 0.0061 0.0252 0.0252
Schistosoma mansoni smad1 5 8 and 0.0052 0.0187 0.0187
Loa Loa (eye worm) pax transcription factor protein 2 0.0253 0.1621 0.1621
Loa Loa (eye worm) hypothetical protein 0.0061 0.0252 0.0252
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0061 0.0252 0.0252
Onchocerca volvulus 0.0253 0.1621 0.6079
Brugia malayi hypothetical protein 0.0214 0.1338 0.1338
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0056 0.0056
Loa Loa (eye worm) MH2 domain-containing protein 0.0767 0.5282 0.5282
Brugia malayi TAR-binding protein 0.0552 0.3748 0.3748
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1429 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0214 0.1338 1
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0056 0.0056
Brugia malayi hypothetical protein 0.0077 0.036 0.036
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0086 0.0428 0.0094
Giardia lamblia Hypothetical protein 0.0026 0 0.5
Onchocerca volvulus 0.0061 0.0252 0.0945
Trypanosoma brucei methionine aminopeptidase, putative 0.0106 0.057 0.4261
Loa Loa (eye worm) hypothetical protein 0.0077 0.036 0.036
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0077 0.036 0.2692
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0096 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.04 0.2666 0.2666
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0061 0.0252 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0061 0.0252 0.0252
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0061 0.0252 0.0252
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0061 0.0252 0.0252
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0052 0.0187 0.0187
Leishmania major hypothetical protein, conserved 0.0214 0.1338 1
Echinococcus multilocularis expressed protein 0.0061 0.0252 0.0252
Brugia malayi Smad1 0.0052 0.0187 0.0187
Brugia malayi G-protein alpha subunit 0.0061 0.0252 0.0252
Brugia malayi MH1 domain containing protein 0.0052 0.0187 0.0187
Brugia malayi RNA binding protein 0.0552 0.3748 0.3748
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0106 0.057 0.4261
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0077 0.036 0.036
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0077 0.036 0.2692
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0061 0.0252 0.0252
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0061 0.0252 0.0252
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0086 0.0428 0.0428
Schistosoma mansoni smad1 5 8 and 0.0052 0.0187 0.0187
Loa Loa (eye worm) G protein alpha subunit 3 0.0061 0.0252 0.0252
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0061 0.0252 0.0252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1429 1 1
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0086 0.0428 0.3201
Mycobacterium ulcerans methionine aminopeptidase 0.0086 0.0428 0.0094
Brugia malayi SWIRM domain containing protein 0.0077 0.036 0.036
Schistosoma mansoni amine oxidase 0.0077 0.036 0.036
Brugia malayi hypothetical protein 0.0138 0.0798 0.0798
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0086 0.0428 0.5
Echinococcus granulosus lysine specific histone demethylase 1A 0.0077 0.036 0.036
Chlamydia trachomatis methionine aminopeptidase 0.0086 0.0428 1
Trypanosoma brucei PAB1-binding protein , putative 0.0214 0.1338 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0579 0.0579
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1429 1 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0026 0 0.5
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1088 0.7567 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.036 0.036
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.1429 1 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0077 0.036 0.036
Brugia malayi N-terminal motif family protein 0.04 0.2666 0.2666
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0061 0.0252 0.0252
Onchocerca volvulus 0.0061 0.0252 0.0945
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0061 0.0252 1
Schistosoma mansoni hypothetical protein 0.0034 0.0056 0.0056
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0106 0.057 0.4261
Schistosoma mansoni smad 0.0052 0.0187 0.0187
Schistosoma mansoni smad1 5 8 and 0.0052 0.0187 0.0187
Schistosoma mansoni GTP-binding protein alpha subunit 0.0061 0.0252 0.0252
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0052 0.0187 0.0187
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0061 0.0252 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0077 0.036 0.2692
Loa Loa (eye worm) nuclear factor I 0.0029 0.002 0.002
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0061 0.0252 0.0252
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0061 0.0252 0.0252
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0077 0.036 0.2692
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0026 0 0.5
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0086 0.0428 0.3201
Loa Loa (eye worm) hypothetical protein 0.0073 0.0337 0.0337
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0061 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0096 0.0498 0.0498
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0061 0.0252 0.0252
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0077 0.036 0.2692
Trypanosoma cruzi PAB1-binding protein , putative 0.0214 0.1338 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0252 0.0252
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0061 0.0252 0.0252
Treponema pallidum methionine aminopeptidase (map) 0.0086 0.0428 0.5
Plasmodium vivax hypothetical protein, conserved 0.0077 0.036 0.2692
Plasmodium falciparum ataxin-2 like protein, putative 0.0214 0.1338 1
Onchocerca volvulus 0.0061 0.0252 0.0945
Onchocerca volvulus 0.0077 0.036 0.1352
Loa Loa (eye worm) hypothetical protein 0.0077 0.036 0.036
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0106 0.057 0.4261
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0056 0.0056
Brugia malayi MH2 domain containing protein 0.0052 0.0187 0.0187
Loa Loa (eye worm) methionine aminopeptidase type I 0.0106 0.057 0.057
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0106 0.057 0.057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1429 1 1
Schistosoma mansoni tar DNA-binding protein 0.0552 0.3748 0.3748
Brugia malayi Methionine aminopeptidase protein type I 0.0106 0.057 0.057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1429 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0056 0.0056
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0061 0.0252 0.0252
Echinococcus multilocularis protoporphyrinogen oxidase 0.0077 0.036 0.036
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0106 0.057 0.4261
Echinococcus granulosus GPCR family 2 0.0034 0.0056 0.0056
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0061 0.0252 0.0252
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0061 0.0252 0.0252
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0086 0.0428 0.0428
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0579 0.0579
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0056 0.0056
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0061 0.0252 0.0252
Loa Loa (eye worm) MH1 domain-containing protein 0.0052 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0077 0.036 0.036
Echinococcus granulosus tar DNA binding protein 0.0552 0.3748 0.3748
Echinococcus granulosus smad 0.0052 0.0187 0.0187
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0061 0.0252 0.0252
Brugia malayi RNA recognition motif domain containing protein 0.0552 0.3748 0.3748
Entamoeba histolytica G protein alpha subunit, putative 0.0061 0.0252 1
Brugia malayi MH1 domain containing protein 0.0029 0.002 0.002
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0077 0.036 0.2692
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0086 0.0428 0.0428
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0061 0.0252 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0552 0.3748 0.3748
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0552 0.3748 0.3748
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0106 0.057 0.4261
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0026 0 0.5
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0061 0.0252 0.0252
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0061 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0107 0.0579 0.0579
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0056 0.0056
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0061 0.0252 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0077 0.036 0.036
Loa Loa (eye worm) TAR-binding protein 0.0552 0.3748 0.3748
Trypanosoma cruzi UDP-galactopyranose mutase 0.0077 0.036 0.2692
Loa Loa (eye worm) hypothetical protein 0.0061 0.0252 0.0252
Loa Loa (eye worm) transcription factor SMAD2 0.0767 0.5282 0.5282
Schistosoma mansoni hypothetical protein 0.0034 0.0056 0.0056
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0061 0.0252 0.0252
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0106 0.057 0.057
Plasmodium falciparum ataxin-2 like protein, putative 0.0214 0.1338 1
Brugia malayi MH1 domain containing protein 0.0029 0.002 0.002
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0086 0.0428 0.0102
Loa Loa (eye worm) Smad1 0.0052 0.0187 0.0187
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1088 0.7567 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0086 0.0428 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.32 uM Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae ChEMBL. 12801227
IC50 (binding) = 0.32 uM Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae ChEMBL. 12801227
IC50 (binding) = 2.39 uM Inhibitory activity against Methionine aminopeptidase 1 from Escherichia coli ChEMBL. 12801227
IC50 (binding) = 2.39 uM Inhibitory activity against Methionine aminopeptidase 1 from Escherichia coli ChEMBL. 12801227
Ratio (binding) = 7.5 Selectivity of inhibitory activity of Methionine aminopeptidase 1 from Escherichia coli to Methionine aminopeptidase 1 from Saccharomyces cerevisiae ChEMBL. 12801227

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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