Detailed information for compound 1481219

Basic information

Technical information
  • TDR Targets ID: 1481219
  • Name: phenyl-[4-[(4-propan-2-ylphenyl)amino]-[1,2,4 ]triazolo[3,4-c]quinoxalin-8-yl]methanone
  • MW: 407.467 | Formula: C25H21N5O
  • H donors: 1 H acceptors: 4 LogP: 5.87 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)n1cnnc1c(n2)Nc1ccc(cc1)C(C)C)c1ccccc1
  • InChi: 1S/C25H21N5O/c1-16(2)17-8-11-20(12-9-17)27-24-25-29-26-15-30(25)22-14-19(10-13-21(22)28-24)23(31)18-6-4-3-5-7-18/h3-16H,1-2H3,(H,27,28)
  • InChiKey: MZPBNONMGAUSAD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • [4-[(4-isopropylphenyl)amino]-[1,2,4]triazolo[3,4-c]quinoxalin-8-yl]-phenyl-methanone
  • [4-[(4-isopropylphenyl)amino]-[1,2,4]triazolo[3,4-c]quinoxalin-8-yl]-phenylmethanone
  • NCGC00126225-01
  • E869-0099

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi SH2 domain containing protein 0.0087 0.2149 0.2149
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Schistosoma mansoni tyrosine kinase 0.0149 0.7208 1
Loa Loa (eye worm) STAT protein 0.0087 0.2149 0.2149
Onchocerca volvulus 0.0087 0.2149 0.2149
Onchocerca volvulus 0.0182 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Echinococcus granulosus SH2 motif 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0061 0 0.5
Schistosoma mansoni shc transforming protein 0.0087 0.2149 0.2981
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0061 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0087 0.2149 0.2981
Loa Loa (eye worm) TK/FER protein kinase 0.0149 0.7208 0.7208
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0149 0.7208 1
Echinococcus multilocularis SH2 motif 0.0087 0.2149 0.2981
Loa Loa (eye worm) TK/FER protein kinase 0.0149 0.7208 0.7208
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Giardia lamblia Kinase, NEK 0.0061 0 0.5
Echinococcus multilocularis c src tyrosine kinase 0.0149 0.7208 1
Loa Loa (eye worm) TK/FER protein kinase 0.0149 0.7208 0.7208
Onchocerca volvulus 0.0087 0.2149 0.2149
Trichomonas vaginalis conserved hypothetical protein 0.0061 0 0.5
Onchocerca volvulus 0.0149 0.7208 0.7208
Brugia malayi tRNA modification GTPase TrmE family protein 0.0087 0.2149 0.2149
Echinococcus multilocularis growth factor receptor bound protein 2 0.0087 0.2149 0.2981
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Schistosoma mansoni tyrosine kinase 0.0149 0.7208 1
Echinococcus multilocularis tensin 0.0087 0.2149 0.2981
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0061 0 0.5
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0087 0.2149 0.2981
Trypanosoma cruzi protein kinase, putative 0.0061 0 0.5
Brugia malayi STAT protein, DNA binding domain containing protein 0.0087 0.2149 0.2149
Trichomonas vaginalis AGC family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Echinococcus granulosus suppressor of cytokine signaling 6 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0061 0 0.5
Echinococcus multilocularis SH2 domain containing protein 7 0.0087 0.2149 0.2981
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0087 0.2149 0.2981
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0149 0.7208 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Brugia malayi SH2 domain containing protein 0.0087 0.2149 0.2149
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Brugia malayi Sex muscle abnormal protein 5 0.0087 0.2149 0.2149
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0149 0.7208 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0149 0.7208 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0061 0 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0087 0.2149 0.2149
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0061 0 0.5
Trypanosoma brucei protein kinase, putative 0.0061 0 0.5
Echinococcus granulosus hypothetical protein 0.0087 0.2149 0.2981
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0087 0.2149 0.2981
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0087 0.2149 0.2981
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0087 0.2149 0.2981
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0149 0.7208 1
Brugia malayi SRC-1 0.0149 0.7208 0.7208
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Schistosoma mansoni tensin 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0149 0.7208 1
Plasmodium falciparum protein kinase, putative 0.0061 0 0.5
Trichomonas vaginalis TK family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0087 0.2149 0.2981
Echinococcus granulosus growth factor receptor bound protein 2 0.0087 0.2149 0.2981
Onchocerca volvulus 0.0149 0.7208 0.7208
Loa Loa (eye worm) SH2 domain-containing protein 0.0087 0.2149 0.2149
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0087 0.2149 0.2149
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0149 0.7208 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0149 0.7208 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0149 0.7208 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0149 0.7208 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0087 0.2149 0.2149
Brugia malayi hypothetical protein 0.0087 0.2149 0.2149
Loa Loa (eye worm) TK/FER protein kinase 0.0149 0.7208 0.7208
Trypanosoma cruzi protein kinase, putative 0.0061 0 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0061 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Echinococcus granulosus suppressor of cytokine signaling 7 0.0087 0.2149 0.2981
Onchocerca volvulus 0.0087 0.2149 0.2149
Echinococcus granulosus tyrosine protein kinase Blk 0.0149 0.7208 1
Trichomonas vaginalis conserved hypothetical protein 0.0061 0 0.5
Schistosoma mansoni tensin-related 0.0087 0.2149 0.2981
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0087 0.2149 0.2981
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Schistosoma mansoni growth factor receptor-bound protein 0.0087 0.2149 0.2981
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0087 0.2149 0.2981
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0087 0.2149 0.2149
Echinococcus multilocularis 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Giardia lamblia Protein 21.1 0.0061 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Loa Loa (eye worm) TK/FER protein kinase 0.0149 0.7208 0.7208
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Brugia malayi cytokine inducible SH2-containing protein 5 0.0087 0.2149 0.2149
Schistosoma mansoni tensin-related 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0087 0.2149 0.2149
Brugia malayi SH2 domain containing protein 0.0087 0.2149 0.2149
Echinococcus granulosus SH2 motif 0.0087 0.2149 0.2981
Trichomonas vaginalis protein kinase atn1, putative 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Onchocerca volvulus 0.0087 0.2149 0.2149
Echinococcus multilocularis SH2 motif 0.0087 0.2149 0.2981
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0149 0.7208 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0149 0.7208 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0087 0.2149 0.2149
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Onchocerca volvulus 0.0149 0.7208 0.7208
Loa Loa (eye worm) hypothetical protein 0.0149 0.7208 0.7208
Echinococcus granulosus tyrosine protein kinase ABL1 0.0149 0.7208 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0087 0.2149 0.2981
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0087 0.2149 0.2981
Schistosoma mansoni suppressor of cytokine signaling 0.0087 0.2149 0.2981
Brugia malayi Protein kinase domain containing protein 0.0149 0.7208 0.7208
Loa Loa (eye worm) TK/FER protein kinase 0.0149 0.7208 0.7208
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0087 0.2149 0.2149
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0149 0.7208 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Brugia malayi Protein kinase domain containing protein 0.0149 0.7208 0.7208
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0087 0.2149 0.2981
Leishmania major hypothetical protein, conserved 0.0061 0 0.5
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0087 0.2149 0.2981
Schistosoma mansoni hypothetical protein 0.0087 0.2149 0.2981
Echinococcus granulosus tensin 0.0087 0.2149 0.2981
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0149 0.7208 1
Echinococcus granulosus tyrosine kinase 0.0149 0.7208 1
Echinococcus multilocularis SHC transforming protein 3 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Schistosoma mansoni tyrosine kinase 0.0149 0.7208 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0087 0.2149 0.2149
Schistosoma mansoni adapter molecule crk 0.0087 0.2149 0.2981
Schistosoma mansoni SH2A 0.0087 0.2149 0.2981
Onchocerca volvulus 0.0149 0.7208 0.7208
Trichomonas vaginalis conserved hypothetical protein 0.0061 0 0.5
Brugia malayi Variant SH3 domain containing protein 0.0087 0.2149 0.2149
Plasmodium falciparum tyrosine kinase-like protein 0.0061 0 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0087 0.2149 0.2981
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0149 0.7208 1
Echinococcus multilocularis tensin 0.0087 0.2149 0.2981
Leishmania major protein kinase, putative 0.0061 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0149 0.7208 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Brugia malayi SH2 domain containing protein 0.0087 0.2149 0.2149
Loa Loa (eye worm) TK/FER protein kinase 0.0149 0.7208 0.7208
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Schistosoma mansoni hypothetical protein 0.0087 0.2149 0.2981
Loa Loa (eye worm) TK/FER protein kinase 0.0149 0.7208 0.7208
Entamoeba histolytica SH2 domain containing protein 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Onchocerca volvulus 0.0087 0.2149 0.2149
Toxoplasma gondii protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Schistosoma mansoni tensin 0.0087 0.2149 0.2981
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Echinococcus granulosus signal transduction protein lnk realted 0.0087 0.2149 0.2981
Schistosoma mansoni tyrosine kinase 0.0149 0.7208 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0149 0.7208 1
Toxoplasma gondii STE kinase 0.0061 0 0.5
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0087 0.2149 0.2981
Brugia malayi Variant SH3 domain containing protein 0.0087 0.2149 0.2149
Trichomonas vaginalis protein tyrosine kinase, putative 0.0061 0 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0061 0 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0061 0 0.5
Echinococcus multilocularis signal transduction protein lnk realted 0.0087 0.2149 0.2981
Echinococcus multilocularis tyrosine protein kinase Blk 0.0149 0.7208 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Leishmania major protein kinase, putative 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0087 0.2149 0.2981
Brugia malayi Tyrosine-protein kinase abl-1 0.0149 0.7208 0.7208
Brugia malayi Variant SH3 domain containing protein 0.0087 0.2149 0.2149
Echinococcus granulosus SH2 domain containing protein 7 0.0087 0.2149 0.2981
Onchocerca volvulus 0.0149 0.7208 0.7208
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0149 0.7208 0.7208
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0061 0 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0061 0 0.5
Brugia malayi SH2 domain containing protein 0.0087 0.2149 0.2149
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trypanosoma brucei Pseudokinase, putative 0.0061 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0061 0 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0061 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Trichomonas vaginalis conserved hypothetical protein 0.0061 0 0.5
Echinococcus multilocularis tyrosine protein kinase shark 0.0149 0.7208 1
Brugia malayi Protein kinase domain containing protein 0.0149 0.7208 0.7208
Brugia malayi protein-tyrosine kinase 0.0149 0.7208 0.7208
Echinococcus granulosus tyrosine protein kinase Fyn 0.0149 0.7208 1
Echinococcus granulosus tyrosine kinase 0.0149 0.7208 1
Echinococcus multilocularis N chimaerin 0.0087 0.2149 0.2981
Echinococcus granulosus tyrosine protein kinase Src42A 0.0149 0.7208 1
Plasmodium falciparum protein kinase, putative 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Echinococcus granulosus N chimaerin 0.0087 0.2149 0.2981
Loa Loa (eye worm) SRC-1 0.0149 0.7208 0.7208
Brugia malayi Variant SH3 domain containing protein 0.0087 0.2149 0.2149
Brugia malayi SH2 domain containing protein 0.0149 0.7208 0.7208
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Brugia malayi Protein kinase domain containing protein 0.0149 0.7208 0.7208
Plasmodium falciparum tyrosine kinase-like protein 0.0061 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0149 0.7208 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Plasmodium vivax protein kinase, putative 0.0061 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0149 0.7208 0.7208
Onchocerca volvulus 0.0087 0.2149 0.2149
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0149 0.7208 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Brugia malayi RhoGAP domain containing protein 0.0087 0.2149 0.2149
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0149 0.7208 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0087 0.2149 0.2149
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Plasmodium falciparum protein kinase, putative 0.0061 0 0.5
Loa Loa (eye worm) TK protein kinase 0.0149 0.7208 0.7208
Echinococcus multilocularis tyrosine kinase 0.0149 0.7208 1
Brugia malayi SH2 domain containing protein 0.0149 0.7208 0.7208
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0087 0.2149 0.2149
Echinococcus granulosus expressed conserved protein 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0087 0.2149 0.2149
Echinococcus granulosus tyrosine protein kinase Src64B 0.0149 0.7208 1
Trichomonas vaginalis CAMK family protein kinase 0.0061 0 0.5
Toxoplasma gondii protein kinase domain-containing protein 0.0061 0 0.5
Echinococcus granulosus SHC transforming protein 3 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0149 0.7208 1
Echinococcus granulosus NCK adaptor protein 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis STE family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Giardia lamblia Kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.0087 0.2149 0.2981
Brugia malayi Protein kinase domain containing protein 0.0149 0.7208 0.7208
Giardia lamblia Kinase, NEK 0.0061 0 0.5
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0087 0.2149 0.2981
Echinococcus granulosus tyrosine protein kinase shark 0.0149 0.7208 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Brugia malayi SH2 domain containing protein 0.0087 0.2149 0.2149
Echinococcus granulosus c src tyrosine kinase 0.0149 0.7208 1
Echinococcus multilocularis SH2 motif 0.0087 0.2149 0.2981
Echinococcus granulosus tyrosine protein kinase Fyn 0.0149 0.7208 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0087 0.2149 0.2149
Schistosoma mansoni GTPase activating protein 0.0087 0.2149 0.2981
Echinococcus multilocularis heat shock protein 70 0.0061 0.0003 0.0004
Brugia malayi hypothetical protein 0.0149 0.7208 0.7208
Echinococcus multilocularis NCK adaptor protein 0.0087 0.2149 0.2981
Brugia malayi Tensin 0.0087 0.2149 0.2149
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Schistosoma mansoni nck2/grb4 0.0087 0.2149 0.2981
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Onchocerca volvulus 0.0149 0.7208 0.7208
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Schistosoma mansoni vav2 0.0087 0.2149 0.2981
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0087 0.2149 0.2981
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0061 0 0.5
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0149 0.7208 1
Trichomonas vaginalis TKL family protein kinase 0.0061 0 0.5
Entamoeba histolytica protein kinase, putative 0.0087 0.2149 0.2981
Schistosoma mansoni tyrosine kinase 0.0149 0.7208 1
Schistosoma mansoni tensin 0.0087 0.2149 0.2981
Echinococcus granulosus tyrosine protein kinase Fyn 0.0149 0.7208 1
Schistosoma mansoni tyrosine kinase 0.0149 0.7208 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0149 0.7208 0.7208
Brugia malayi SH2 domain containing protein 0.0087 0.2149 0.2149
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0149 0.7208 1
Schistosoma mansoni suppressor of cytokine signaling 0.0087 0.2149 0.2981
Echinococcus granulosus tyrosine protein kinase Lyn 0.0149 0.7208 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 2.3109 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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