Detailed information for compound 1481282

Basic information

Technical information
  • TDR Targets ID: 1481282
  • Name: 3-hydroxy-1-(3-imidazol-1-ylpropyl)-4-(5-meth ylfuran-2-carbonyl)-5-(3-prop-2-enoxyphenyl)- 5H-pyrrol-2-one
  • MW: 447.483 | Formula: C25H25N3O5
  • H donors: 1 H acceptors: 4 LogP: 3.48 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1cccc(c1)C1N(CCCn2cncc2)C(=O)C(=C1C(=O)c1ccc(o1)C)O
  • InChi: 1S/C25H25N3O5/c1-3-14-32-19-7-4-6-18(15-19)22-21(23(29)20-9-8-17(2)33-20)24(30)25(31)28(22)12-5-11-27-13-10-26-16-27/h3-4,6-10,13,15-16,22,30H,1,5,11-12,14H2,2H3
  • InChiKey: FBTKIGVYWIEJFA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(3-allyloxyphenyl)-3-hydroxy-1-(3-imidazol-1-ylpropyl)-4-(5-methylfuran-2-carbonyl)-5H-pyrrol-2-one
  • 5-(3-allyloxyphenyl)-3-hydroxy-1-[3-(1-imidazolyl)propyl]-4-[(5-methyl-2-furyl)-oxomethyl]-5H-pyrrol-2-one
  • 5-(3-allyloxyphenyl)-3-hydroxy-1-(3-imidazol-1-ylpropyl)-4-(5-methylfuran-2-carbonyl)-3-pyrrolin-2-one
  • 3-hydroxy-1-(3-imidazol-1-ylpropyl)-4-(5-methylfuran-2-yl)carbonyl-5-(3-prop-2-enoxyphenyl)-5H-pyrrol-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0039 0.0056
Echinococcus granulosus cathepsin l1 0.009 0.0309 0.0309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0098 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0039 0.0056
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0078 0.022 0.032
Echinococcus granulosus mitogen activated protein kinase 0.0322 0.195 0.195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.009 0.0309 0.0998
Toxoplasma gondii cathepsin CPL 0.009 0.0309 0.0134
Schistosoma mansoni tyrosine kinase 0.0198 0.1071 0.1071
Loa Loa (eye worm) cysteine protease 0.009 0.0309 0.0272
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0048 0.0011 0.0011
Onchocerca volvulus 0.009 0.0309 0.0395
Brugia malayi MAP kinase sur-1 0.0322 0.195 0.2835
Loa Loa (eye worm) hypothetical protein 0.006 0.0098 0.006
Onchocerca volvulus 0.0078 0.022 0.0265
Loa Loa (eye worm) hypothetical protein 0.009 0.0309 0.0272
Leishmania major cathepsin L-like protease 0.009 0.0309 0.0134
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0198 0.1071 0.1071
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0179 0.0938 0.0938
Entamoeba histolytica aminopeptidase, putative 0.0078 0.022 0.2747
Echinococcus multilocularis cathepsin L cysteine protease 0.009 0.0309 0.0309
Onchocerca volvulus 0.009 0.0309 0.0395
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Echinococcus multilocularis tyrosine protein kinase Abl 0.0048 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.0309 0.045
Onchocerca volvulus Cathepsin L homolog 0.009 0.0309 0.0395
Loa Loa (eye worm) thymidylate synthase 0.1018 0.688 0.6868
Echinococcus granulosus epidermal growth factor receptor 0.0417 0.2624 0.2624
Echinococcus granulosus thymidylate synthase 0.1018 0.688 0.688
Entamoeba histolytica cysteine proteinase, putative 0.006 0.0098 0.1229
Brugia malayi ecdysteroid receptor 0.0052 0.0039 0.0056
Loa Loa (eye worm) TK/EGFR protein kinase 0.0772 0.5134 0.5115
Echinococcus granulosus c src tyrosine kinase 0.0048 0.0011 0.0011
Brugia malayi hypothetical protein 0.0484 0.3101 0.4507
Echinococcus granulosus mitogen activated protein kinase 3 0.0322 0.195 0.195
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0039 0.0039
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.009 0.0309 0.0272
Brugia malayi nuclear receptor NHR-88 0.0052 0.0039 0.0056
Echinococcus multilocularis thymidylate synthase 0.1018 0.688 0.688
Onchocerca volvulus Cathepsin L homolog 0.009 0.0309 0.0395
Onchocerca volvulus 0.009 0.0309 0.0395
Echinococcus multilocularis tyrosine protein kinase Srms 0.0179 0.0938 0.0938
Trichomonas vaginalis CMGC family protein kinase 0.0322 0.195 0.629
Echinococcus multilocularis mitogen activated protein kinase 3 0.0322 0.195 0.195
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0078 0.022 0.022
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0039 0.0039
Echinococcus multilocularis epidermal growth factor receptor 0.0772 0.5134 0.5134
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0078 0.022 0.032
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0078 0.022 0.032
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0039 0.0056
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0198 0.1071 0.1071
Plasmodium vivax vivapain-2 0.009 0.0309 0.045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.0309 0.045
Loa Loa (eye worm) aminopeptidase N 0.0078 0.022 0.0182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Trypanosoma brucei Aminopeptidase M1, putative 0.0078 0.022 0.032
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0078 0.022 0.022
Echinococcus granulosus tyrosine protein kinase Fyn 0.0198 0.1071 0.1071
Trypanosoma brucei protein kinase, putative 0.0322 0.195 0.2835
Loa Loa (eye worm) fibroinase 0.009 0.0309 0.0272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.0309 0.0998
Brugia malayi Protein kinase domain containing protein 0.025 0.1443 0.2097
Leishmania major cathepsin L-like protease 0.009 0.0309 0.0134
Brugia malayi Peptidase family M1 containing protein 0.0078 0.022 0.032
Schistosoma mansoni tyrosine kinase 0.025 0.1443 0.1443
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0039 0.0039
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0322 0.195 0.2835
Onchocerca volvulus 0.0078 0.022 0.0265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.0309 0.0998
Echinococcus granulosus insulin receptor 0.025 0.1443 0.1443
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0322 0.195 0.2835
Entamoeba histolytica cysteine protease, putative 0.009 0.0309 0.3863
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.0309 0.0998
Echinococcus multilocularis cysteine protease 0.009 0.0309 0.0309
Schistosoma mansoni tyrosine kinase 0.025 0.1443 0.1443
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0039 0.0056
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0078 0.022 0.032
Mycobacterium ulcerans thymidylate synthase 0.1018 0.688 1
Leishmania major cathepsin L-like protease 0.009 0.0309 0.0134
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0078 0.022 0.022
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0048 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.0309 0.0998
Trichomonas vaginalis conserved hypothetical protein 0.0484 0.3101 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.006 0.0098 0.0143
Loa Loa (eye worm) SRC-1 0.0198 0.1071 0.1036
Trypanosoma cruzi aminopeptidase, putative 0.0078 0.022 0.032
Brugia malayi steroid hormone receptor 0.0052 0.0039 0.0056
Echinococcus multilocularis insulin receptor 0.025 0.1443 0.1443
Loa Loa (eye worm) hypothetical protein 0.006 0.0098 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.0309 0.045
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0198 0.1071 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Trichomonas vaginalis CMGC family protein kinase 0.0322 0.195 0.629
Echinococcus granulosus aminopeptidase N 0.0078 0.022 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0098 0.0317
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0198 0.1071 0.1071
Schistosoma mansoni tyrosine kinase 0.0417 0.2624 0.2624
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0078 0.022 0.071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.0309 0.045
Entamoeba histolytica protein kinase, putative 0.016 0.0801 1
Brugia malayi Cathepsin L-like precursor 0.006 0.0098 0.0143
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1459 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.0309 0.0998
Giardia lamblia Kinase, CMGC MAPK 0.0322 0.195 0.5
Brugia malayi Cathepsin L-like precursor 0.009 0.0309 0.045
Echinococcus multilocularis tyrosine protein kinase HCK 0.016 0.0801 0.0801
Entamoeba histolytica cysteine proteinase, putative 0.009 0.0309 0.3863
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0039 0.0039
Trypanosoma cruzi cysteine peptidase, putative 0.009 0.0309 0.045
Loa Loa (eye worm) TK protein kinase 0.0179 0.0938 0.0902
Trichomonas vaginalis CMGC family protein kinase 0.0322 0.195 0.629
Echinococcus granulosus tyrosine protein kinase Src42A 0.0198 0.1071 0.1071
Echinococcus granulosus cathepsin l1 0.006 0.0098 0.0098
Brugia malayi Papain family cysteine protease containing protein 0.009 0.0309 0.045
Entamoeba histolytica cysteine proteinase, putative 0.009 0.0309 0.3863
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1459 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.0309 0.0998
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0039 0.0039
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0322 0.195 0.2835
Leishmania major cathepsin L-like protease 0.009 0.0309 0.0134
Trichomonas vaginalis CMGC family protein kinase 0.0322 0.195 0.629
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0039 0.0056
Onchocerca volvulus 0.009 0.0309 0.0395
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0039 0.0039
Plasmodium falciparum cysteine proteinase falcipain 2a 0.009 0.0309 0.045
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.025 0.1443 0.1443
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0039 0.0039
Onchocerca volvulus Cathepsin F homolog 0.009 0.0309 0.0395
Loa Loa (eye worm) TK/INSR protein kinase 0.025 0.1443 0.141
Loa Loa (eye worm) hypothetical protein 0.0078 0.022 0.0182
Leishmania major cathepsin L-like protease 0.009 0.0309 0.0134
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0322 0.195 0.2835
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0039 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0039 0.0039
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0078 0.022 0.022
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0179 0.0938 0.0938
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Brugia malayi cathepsin L-like precursor 0.006 0.0098 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Loa Loa (eye worm) peptidase family M1 containing protein 0.0078 0.022 0.0182
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0078 0.022 0.022
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1018 0.688 0.5
Brugia malayi Cathepsin L-like precursor 0.009 0.0309 0.045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Echinococcus granulosus tyrosine protein kinase Src42A 0.0169 0.0869 0.0869
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.0309 0.0998
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0039 0.0056
Echinococcus granulosus tyrosine protein kinase Fyn 0.0198 0.1071 0.1071
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0039 0.0039
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0078 0.022 0.022
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0078 0.022 0.032
Echinococcus granulosus cathepsin l cysteine peptidase 0.009 0.0309 0.0309
Echinococcus granulosus tyrosine protein kinase Src64B 0.0198 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0078 0.022 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.009 0.0309 0.0998
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0078 0.022 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.0309 0.045
Trypanosoma cruzi Aminopeptidase M1, putative 0.0078 0.022 0.032
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0039 0.0056
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1018 0.688 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0198 0.1071 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.0048 0.0011 0.0011
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0078 0.022 0.022
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0078 0.022 0.032
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0198 0.1071 0.1071
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0198 0.1071 0.1071
Echinococcus granulosus tyrosine protein kinase HCK 0.016 0.0801 0.0801
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.0309 0.0998
Plasmodium falciparum cysteine proteinase falcipain 3 0.009 0.0309 0.045
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0039 0.0039
Loa Loa (eye worm) papain family cysteine protease containing protein 0.009 0.0309 0.0272
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0198 0.1071 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Echinococcus granulosus tyrosine kinase 0.0179 0.0938 0.0938
Echinococcus multilocularis c src tyrosine kinase 0.0048 0.0011 0.0011
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0078 0.022 0.032
Brugia malayi hypothetical protein 0.0078 0.022 0.032
Schistosoma mansoni cathepsin F (C01 family) 0.006 0.0098 0.0098
Brugia malayi Cathepsin L-like precursor 0.009 0.0309 0.045
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0039 0.0039
Brugia malayi Cathepsin L-like precursor 0.009 0.0309 0.045
Brugia malayi Cathepsin L-like precursor 0.006 0.0098 0.0143
Plasmodium falciparum cysteine proteinase falcipain 2b 0.009 0.0309 0.045
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0039 0.0056
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0078 0.022 0.022
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0039 0.0039
Echinococcus multilocularis 0.0237 0.135 0.135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Leishmania major cathepsin L-like protease 0.009 0.0309 0.0134
Onchocerca volvulus 0.006 0.0098 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0039 0.0056
Brugia malayi Peptidase family M1 containing protein 0.0078 0.022 0.032
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0322 0.195 0.2835
Loa Loa (eye worm) ctsf protein 0.009 0.0309 0.0272
Onchocerca volvulus 0.0078 0.022 0.0265
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0078 0.022 0.022
Echinococcus multilocularis epidermal growth factor receptor 0.0417 0.2624 0.2624
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.0309 0.045
Echinococcus granulosus epidermal growth factor receptor 0.0772 0.5134 0.5134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.0309 0.045
Echinococcus multilocularis cathepsin L cysteine protease 0.009 0.0309 0.0309
Echinococcus multilocularis mitogen activated protein kinase 0.0322 0.195 0.195
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1018 0.688 1
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.195 0.195
Leishmania major cathepsin L-like protease 0.009 0.0309 0.0134
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0039 0.0039
Schistosoma mansoni aminopeptidase A (M01 family) 0.0078 0.022 0.022
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0198 0.1071 0.1071
Echinococcus multilocularis cysteine protease 0.009 0.0309 0.0309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.0309 0.045
Schistosoma mansoni tyrosine kinase 0.0407 0.2555 0.2555
Trypanosoma brucei aminopeptidase, putative 0.0078 0.022 0.032
Trypanosoma cruzi cysteine peptidase, putative 0.009 0.0309 0.045
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0322 0.195 0.2598
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0078 0.022 0.022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0039 0.0056
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0039 0.0039
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1018 0.688 0.688
Loa Loa (eye worm) hypothetical protein 0.006 0.0098 0.006
Echinococcus multilocularis tyrosine protein kinase Blk 0.0179 0.0938 0.0938
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0039 0.0056
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0322 0.195 0.2598
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0078 0.022 0.022
Trypanosoma cruzi cysteine peptidase, putative 0.009 0.0309 0.045
Leishmania major cysteine peptidase A (CPA) 0.009 0.0309 0.0134
Echinococcus granulosus tyrosine protein kinase Blk 0.0179 0.0938 0.0938
Trypanosoma brucei Aminopeptidase M1, putative 0.0078 0.022 0.032
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0039 0.0039
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0417 0.2624 0.2624
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1018 0.688 1
Schistosoma mansoni cathepsin F (C01 family) 0.009 0.0309 0.0309
Leishmania major cathepsin L-like protease 0.009 0.0309 0.0134
Echinococcus granulosus insulin growth factor 1 receptor beta 0.025 0.1443 0.1443
Schistosoma mansoni tyrosine kinase 0.0407 0.2555 0.2555
Trypanosoma cruzi cysteine peptidase, putative 0.009 0.0309 0.045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0039 0.0039
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0039 0.0039
Brugia malayi Furin-like cysteine rich region family protein 0.0772 0.5134 0.7461
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0078 0.022 0.071
Trypanosoma cruzi cruzipain precursor, putative 0.009 0.0309 0.045
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0322 0.195 0.1919
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0048 0.0011 0.0011
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0078 0.022 0.071
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0078 0.022 0.032
Brugia malayi hypothetical protein 0.0671 0.442 0.6424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.0309 0.045
Brugia malayi hypothetical protein 0.0078 0.022 0.032
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0078 0.022 0.022
Onchocerca volvulus 0.009 0.0309 0.0395
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.0309 0.0998
Echinococcus multilocularis cathepsin l cysteine peptidase 0.009 0.0309 0.0309
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0039 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0039 0.0039
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0169 0.0869 0.0869
Brugia malayi protein-tyrosine kinase 0.0179 0.0938 0.1363
Schistosoma mansoni tyrosine kinase 0.0417 0.2624 0.2624
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0098 0.0143
Loa Loa (eye worm) TATA binding protein associated factor 0.0078 0.022 0.0182
Schistosoma mansoni tyrosine kinase 0.0772 0.5134 0.5134
Schistosoma mansoni coup transcription factor 0.0052 0.0039 0.0039
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0039 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.0309 0.045
Onchocerca volvulus 0.009 0.0309 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0039 0.0056
Brugia malayi Cathepsin L-like precursor 0.009 0.0309 0.045
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0039 0.0056
Echinococcus multilocularis cathepsin l cysteine peptidase 0.009 0.0309 0.0309
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1018 0.688 1
Schistosoma mansoni tyrosine kinase 0.0198 0.1071 0.1071
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0078 0.022 0.022
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0198 0.1071 0.1071
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0078 0.022 0.022
Loa Loa (eye worm) TK protein kinase 0.016 0.0801 0.0765
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0039 0.0039
Brugia malayi Peptidase family M1 containing protein 0.0078 0.022 0.032
Brugia malayi Cathepsin L-like precursor 0.009 0.0309 0.045
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1018 0.688 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0322 0.195 0.2598
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0039 0.0039
Brugia malayi Tyrosine-protein kinase abl-1 0.0048 0.0011 0.0016
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1018 0.688 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0078 0.022 0.022
Echinococcus granulosus tyrosine protein kinase Lyn 0.0201 0.1092 0.1092
Schistosoma mansoni cathepsin F (C01 family) 0.009 0.0309 0.0309
Echinococcus granulosus tyrosine protein kinase Fyn 0.0198 0.1071 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Onchocerca volvulus 0.009 0.0309 0.0395
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0039 0.0039
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0484 0.3101 0.4507
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0039 0.0039
Brugia malayi SRC-1 0.0198 0.1071 0.1557
Trypanosoma cruzi aminopeptidase, putative 0.0078 0.022 0.032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0309 0.0998
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0039 0.0056
Brugia malayi TATA binding protein associated factor 0.0078 0.022 0.032
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0198 0.1071 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.009 0.0309 0.045
Loa Loa (eye worm) hypothetical protein 0.0078 0.022 0.0182
Brugia malayi thymidylate synthase 0.1018 0.688 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.009 0.0309 0.0309
Onchocerca volvulus 0.1018 0.688 1
Schistosoma mansoni tyrosine kinase 0.0048 0.0011 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.0407 0.2555 0.2555
Echinococcus multilocularis aminopeptidase N 0.0078 0.022 0.022
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1459 1 1
Brugia malayi nuclear hormone receptor 0.0052 0.0039 0.0056
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0078 0.022 0.032
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1018 0.688 1
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0039 0.0039
Plasmodium vivax vivapain-2 0.009 0.0309 0.045

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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