Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | chromobox protein | 0.0084 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.838 | 0.8223 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.838 | 0.8223 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.216 | 0.216 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.4925 | 0.4432 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.838 | 0.838 |
Brugia malayi | RNA binding protein | 0.0076 | 0.838 | 0.8223 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.4925 | 0.4925 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.292 | 0.0969 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.216 | 0.1398 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.838 | 0.8223 |
Schistosoma mansoni | chromobox protein | 0.0084 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.292 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.838 | 0.838 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.838 | 0.8223 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.216 | 0.7399 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.4925 | 0.4925 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.4925 | 0.4432 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0886 | 0.0886 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.838 | 0.838 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.292 | 0.0969 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.838 | 0.8223 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.838 | 0.8223 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.838 | 0.8223 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.