TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 371.453 | Formula: C27H19N2+
H donors: 0 H acceptors: 1 LogP: 7.25 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc2c(c1)ccc1[n+]2nc(c2ccccc2)c2c1ccc1c2cccc1
InChi: 1S/C27H19N2/c1-18-11-15-24-21(17-18)13-16-25-23-14-12-19-7-5-6-10-22(19)26(23)27(28-29(24)25)20-8-3-2-4-9-20/h2-17H,1H3/q+1
InChiKey: HOJNSUQBJKEPNU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0021	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0314	1	1
Brugia malayi	nuclear hormone receptor	0.0314	1	1
Echinococcus multilocularis	DNA directed RNA polymerase II subunit	0.0038	0.0601	0.0601
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0148	0.4343	0.4343
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0314	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0021	0	0.5
Plasmodium vivax	DNA-directed RNA polymerase I 190 kDa polypeptide, putative	0.0076	0.1891	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0314	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0314	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0314	1	1
Trypanosoma cruzi	DNA-directed RNA polymerase III subunit C1, putative	0.0038	0.0601	0.3766
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0021	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0314	1	1
Loa Loa (eye worm)	hypothetical protein	0.0166	0.4949	0.4949
Echinococcus granulosus	thyroid hormone receptor alpha	0.0148	0.4343	0.4343
Loa Loa (eye worm)	DNA-directed RNA polymerase II largest subunit	0.0038	0.0601	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1891	0.1891
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0021	0	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0314	1	1
Entamoeba histolytica	DNA-directed RNA polymerase I largest subunit, putative	0.0076	0.1891	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0314	1	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0148	0.4343	0.4343
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Toxoplasma gondii	DNA-directed RNA polymerase III RPC1	0.0038	0.0601	0.3179
Loa Loa (eye worm)	hypothetical protein	0.0314	1	1
Trichomonas vaginalis	RNA polymerase A, putative	0.0068	0.1596	1
Loa Loa (eye worm)	hypothetical protein	0.0314	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0021	0	0.5
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0021	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0314	1	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0148	0.4343	0.4343
Trypanosoma cruzi	RNA polymerase IIA largest subunit, putative	0.0038	0.0601	0.3766
Schistosoma mansoni	thyroid hormone receptor	0.0314	1	1
Schistosoma mansoni	coup transcription factor	0.0314	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0314	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0021	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0314	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0314	1	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0166	0.4949	0.4949
Loa Loa (eye worm)	hypothetical protein	0.0314	1	1
Mycobacterium leprae	DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT).	0.0038	0.0601	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0148	0.4343	0.4343
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0314	1	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0166	0.4949	0.4949
Schistosoma mansoni	nuclear receptor	0.0148	0.4343	0.4343
Trypanosoma brucei	DNA-directed RNA polymerase I largest subunit	0.0068	0.1596	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0314	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0021	0	0.5
Brugia malayi	nuclear receptor NHR-88	0.0148	0.4343	0.4343
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0148	0.4343	0.4343
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0314	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0314	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0314	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0314	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0314	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0148	0.4343	0.4343
Brugia malayi	hypothetical protein	0.0166	0.4949	0.4949
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0166	0.4949	0.4949
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0314	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0314	1	1
Onchocerca volvulus		0.0148	0.4343	0.3987
Toxoplasma gondii	DNA-directed RNA polymerase II RPB1	0.0038	0.0601	0.3179
Toxoplasma gondii	DNA-directed RNA polymerase I RPA1	0.0076	0.1891	1
Schistosoma mansoni	plexin	0.0022	0.005	0.005
Brugia malayi	hypothetical protein	0.0148	0.4343	0.4343
Echinococcus granulosus	DNA directed RNA polymerase I subunit RPA1	0.0068	0.1596	0.1596
Leishmania major	DNA-directed rna polymerase I largest subunit, putative	0.0068	0.1596	1
Echinococcus granulosus	FTZ F1 alpha	0.0314	1	1
Loa Loa (eye worm)	DR-78	0.0148	0.4343	0.4343
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0314	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0314	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0021	0	0.5
Echinococcus multilocularis	DNA directed RNA polymerase III subunit RPC1	0.0038	0.0601	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0148	0.4343	0.3987
Brugia malayi	Plexin repeat family protein	0.0038	0.0593	0.0593
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0314	1	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Brugia malayi	nuclear receptor NHR-67	0.0148	0.4343	0.4343
Schistosoma mansoni	RNA polymerase Rpb1	0.0038	0.0601	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0166	0.4949	0.4949
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Plasmodium falciparum	RNA polymerase I	0.0076	0.1891	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0148	0.4343	0.4343
Brugia malayi	Nuclear hormone receptor-like 1	0.0166	0.4949	0.4949
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Echinococcus multilocularis	DNA directed RNA polymerase I subunit RPA1	0.0068	0.1596	0.1596
Loa Loa (eye worm)	hypothetical protein	0.0314	1	1
Chlamydia trachomatis	DNA-directed RNA polymerase subunit beta'	0.0038	0.0601	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0021	0	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0314	1	1
Loa Loa (eye worm)	hypothetical protein	0.0166	0.4949	0.4949
Brugia malayi	tailless protein	0.0148	0.4343	0.4343
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0148	0.4343	0.4343
Loa Loa (eye worm)	hypothetical protein	0.0314	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0314	1	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Trypanosoma brucei	DNA-directed RNA polymerase III largest subunit, putative	0.0024	0.0097	0.0611
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0314	1	1
Trypanosoma brucei	DNA-directed rna polymerase I largest subunit, putative	0.0068	0.1596	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0314	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0314	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0021	0	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0314	1	1
Loa Loa (eye worm)	hypothetical protein	0.0166	0.4949	0.4949
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0148	0.4343	0.4343
Schistosoma mansoni	zinc finger protein	0.0148	0.4343	0.4343
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0021	0	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0314	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0021	0	0.5
Echinococcus granulosus	plexin a4	0.0045	0.0831	0.0831
Schistosoma mansoni	RAR-like nuclear receptor	0.0314	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0314	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0314	1	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0148	0.4343	0.4343
Echinococcus multilocularis	plexin a4	0.0045	0.0831	0.0831
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0021	0	0.5
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0166	0.4949	0.4949
Schistosoma mansoni	hypothetical protein	0.0022	0.005	0.005
Trypanosoma brucei	DNA-directed RNA polymerase III subunit C1	0.0038	0.0601	0.3766
Brugia malayi	RNA polymerase Rpb1, domain 2 family protein	0.0076	0.1891	0.1891
Loa Loa (eye worm)	hypothetical protein	0.0022	0.005	0.005
Echinococcus granulosus	ecdysone induced protein 78C	0.0314	1	1
Onchocerca volvulus		0.0148	0.4343	0.3987
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0148	0.4343	0.4343
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Trypanosoma brucei	RNA polymerase IIA largest subunit	0.0038	0.0601	0.3766
Brugia malayi	hypothetical protein	0.0166	0.4949	0.4949
Onchocerca volvulus	Protein ultraspiracle homolog	0.0314	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0166	0.4949	0.4949
Brugia malayi	nuclear hormone receptor family member odr-7	0.0148	0.4343	0.4343
Brugia malayi	nuclear receptor NHR-88	0.0314	1	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0148	0.4343	0.4343
Schistosoma mansoni	nuclear receptor nhr-48	0.0148	0.4343	0.4343
Brugia malayi	hypothetical protein	0.0148	0.4343	0.4343
Giardia lamblia	RNA polymerase AI large subunit	0.0076	0.1891	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0314	1	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0021	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0314	1	1
Brugia malayi	steroid hormone receptor	0.0314	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0314	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0314	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0314	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0021	0	0.5
Brugia malayi	plexin A	0.0045	0.0831	0.0831
Brugia malayi	Nuclear hormone receptor E75	0.0148	0.4343	0.4343
Schistosoma mansoni	retinoic acid receptor RXR	0.0314	1	1
Brugia malayi	nuclear receptor RXR	0.0166	0.4949	0.4949
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0148	0.4343	0.4343
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0314	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.0314	1	1
Brugia malayi	RNA polymerase Rpb1, domain 1 family protein	0.0038	0.0601	0.0601
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0148	0.4343	0.4343
Brugia malayi	Steroid receptor seven-up type 2	0.0314	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0314	1	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0593	0.0593
Trypanosoma cruzi	DNA-directed rna polymerase I largest subunit, putative	0.0068	0.1596	1
Leishmania major	DNA-directed RNA polymerase III largest subunit , putative	0.0038	0.0601	0.3766
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0314	1	1
Wolbachia endosymbiont of Brugia malayi	DNA-directed RNA polymerase subunit beta/beta'	0.0038	0.0601	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0314	1	1
Echinococcus granulosus	DNA directed RNA polymerase II subunit	0.0038	0.0601	0.0601
Trypanosoma brucei	DNA-directed RNA polymerase II subunit RPB1	0.0038	0.0601	0.3766
Loa Loa (eye worm)	RNA polymerase Rpb1	0.0038	0.0601	0.0601
Mycobacterium ulcerans	DNA-directed RNA polymerase subunit beta'	0.0038	0.0601	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0148	0.4343	0.4343
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0314	1	1
Treponema pallidum	DNA-directed RNA polymerase subunit beta'	0.0038	0.0601	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0166	0.4949	0.4949
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Echinococcus granulosus	DNA directed RNA polymerase III subunit RPC1	0.0038	0.0601	0.0601
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0314	1	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Schistosoma mansoni	plexin	0.0038	0.0593	0.0593
Brugia malayi	conserved hypotetical protein	0.0148	0.4343	0.4343
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0148	0.4343	0.4343
Brugia malayi	nuclear receptor RXR	0.0148	0.4343	0.4343
Onchocerca volvulus	Bile acid receptor homolog	0.0314	1	1
Loa Loa (eye worm)	hypothetical protein	0.0166	0.4949	0.4949
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0021	0	0.5
Onchocerca volvulus		0.0314	1	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0148	0.4343	0.4343
Leishmania major	RNA polymerase ii largest subunit	0.0038	0.0601	0.3766
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0148	0.4343	0.4343
Schistosoma mansoni	DNA-directed RNA polymerase I	0.0076	0.1891	0.1891
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0021	0	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0148	0.4343	0.4343
Loa Loa (eye worm)	plexin A	0.0045	0.0831	0.0831
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0314	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0314	1	1
Schistosoma mansoni	DNA-directed RNA polymerase II largest subunit	0.0038	0.0601	0.0601
Schistosoma mansoni	nuclear receptor	0.0148	0.4343	0.4343
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0148	0.4343	0.4343
Brugia malayi	Nuclear hormone receptor-like 1	0.0314	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0021	0	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0021	0	0.5
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0148	0.4343	0.3987
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0314	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0148	0.4343	0.4343
Loa Loa (eye worm)	hypothetical protein	0.0314	1	1
Loa Loa (eye worm)	hypothetical protein	0.0314	1	1
Brugia malayi	ecdysone receptor	0.0148	0.4343	0.4343
Brugia malayi	nuclear hormone receptor	0.0148	0.4343	0.4343
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0314	1	1
Brugia malayi	DNA-directed RNA polymerase II largest subunit, putative	0.0038	0.0601	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4343	0.4343
Schistosoma mansoni	nuclear hormone receptor	0.0148	0.4343	0.4343

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Compound was tested for the inhibition of human DNA topoisomerase I at a compound concentration of 10 occurred	ChEMBL.	14971893
Activity (binding)	0	Compound was tested for the inhibition of human DNA topoisomerase I at a compound concentration of 10 occurred	ChEMBL.	14971893
GI50 (functional)	0 uM	In vitro antiproliferative activity of the compound against human HeLa-APL cervix cell line; NS = Not significant	ChEMBL.	14971893
GI50 (functional)	= 0.2 uM	In vitro antiproliferative activity of the compound against human LN-caP prostrate cell line	ChEMBL.	14971893
GI50 (functional)	= 0.2 uM	In vitro antiproliferative activity of the compound against human K-562 cell line	ChEMBL.	14971893
GI50 (functional)	= 0.2 uM	In vitro antiproliferative activity of the compound against human LN-caP prostrate cell line	ChEMBL.	14971893
GI50 (functional)	= 0.2 uM	In vitro antiproliferative activity of the compound against human K-562 cell line	ChEMBL.	14971893
GI50 (functional)	= 0.4 uM	In vitro antiproliferative activity of the compound against human HT-29 colon cell line	ChEMBL.	14971893
GI50 (functional)	= 0.4 uM	In vitro antiproliferative activity of the compound against human LOVO colon cell line	ChEMBL.	14971893
GI50 (functional)	= 0.4 uM	In vitro antiproliferative activity of the compound against human HT-29 colon cell line	ChEMBL.	14971893
GI50 (functional)	= 0.4 uM	In vitro antiproliferative activity of the compound against human LOVO colon cell line	ChEMBL.	14971893
GI50 (functional)	= 0.5 uM	In vitro antiproliferative activity of the compound against human DU-145 prostrate cell line	ChEMBL.	14971893
GI50 (functional)	= 0.5 uM	In vitro antiproliferative activity of the compound against human IGROV ovarian cell line	ChEMBL.	14971893
GI50 (functional)	= 0.5 uM	In vitro antiproliferative activity of the compound against human SK-BR-3 breast cell line	ChEMBL.	14971893
GI50 (functional)	= 0.5 uM	In vitro antiproliferative activity of the compound against human MEL-28 melanoma cell line	ChEMBL.	14971893
GI50 (functional)	= 0.5 uM	In vitro antiproliferative activity of the compound against human HeLa cervix cell line	ChEMBL.	14971893
GI50 (functional)	= 0.5 uM	In vitro antiproliferative activity of the compound against human DU-145 prostrate cell line	ChEMBL.	14971893
GI50 (functional)	= 0.5 uM	In vitro antiproliferative activity of the compound against human IGROV ovarian cell line	ChEMBL.	14971893
GI50 (functional)	= 0.5 uM	In vitro antiproliferative activity of the compound against human SK-BR-3 breast cell line	ChEMBL.	14971893
GI50 (functional)	= 0.5 uM	In vitro antiproliferative activity of the compound against human MEL-28 melanoma cell line	ChEMBL.	14971893
GI50 (functional)	= 0.5 uM	In vitro antiproliferative activity of the compound against human HeLa cervix cell line	ChEMBL.	14971893
GI50 (functional)	= 0.6 uM	In vitro antiproliferative activity of the compound against human A-549 NSCL cell line	ChEMBL.	14971893
GI50 (functional)	= 0.6 uM	In vitro antiproliferative activity of the compound against human A-549 NSCL cell line	ChEMBL.	14971893
GI50 (functional)	= 0.7 uM	In vitro antiproliferative activity of the compound against human PANC-1 pancreas cell line	ChEMBL.	14971893
GI50 (functional)	= 0.7 uM	In vitro antiproliferative activity of the compound against human PANC-1 pancreas cell line	ChEMBL.	14971893
GI50 (functional)	= 1.8 uM	In vitro antiproliferative activity of the compound against human IGROV-ET ovarian cell line	ChEMBL.	14971893
GI50 (functional)	= 1.8 uM	In vitro antiproliferative activity of the compound against human IGROV-ET ovarian cell line	ChEMBL.	14971893
GI50 (functional)	= 3.6 uM	In vitro antiproliferative activity of the compound against human LOVO-DOX colon cell line	ChEMBL.	14971893
GI50 (functional)	= 3.6 uM	In vitro antiproliferative activity of the compound against human LOVO-DOX colon cell line	ChEMBL.	14971893

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL14895

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 14814