TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.482 | Formula: C20H33NO2
H donors: 1 H acceptors: 1 LogP: 5.68 Rotable bonds: 14
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC/C=C\C/C=C\C=C\C=C\C(CCC/C=N/O)OC
InChi: 1S/C20H33NO2/c1-3-4-5-6-7-8-9-10-11-12-13-14-17-20(23-2)18-15-16-19-21-22/h7-8,10-14,17,19-20,22H,3-6,9,15-16,18H2,1-2H3/b8-7-,11-10-,13-12+,17-14+,21-19+
InChiKey: YQRMQDXFOKIJKA-BQKWCRQLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0471	0.2162	0.4418
Brugia malayi	mothers against decapentaplegic homolog 3	0.0063	0.0181	0.0181
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0049	0.0108	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0099	0.0351	0.0711
Loa Loa (eye worm)	MH2 domain-containing protein	0.0142	0.0562	0.0562
Echinococcus granulosus	replication factor c subunit 1	0.0049	0.0108	0.0214
Brugia malayi	MH1 domain containing protein	0.0079	0.0254	0.0254
Echinococcus multilocularis	nibrin	0.0049	0.0108	0.0214
Schistosoma mansoni	hypothetical protein	0.0188	0.0785	0.1601
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0027	0.0004	0.0004
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0142	0.0562	0.1144
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0099	0.0351	1
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0108	1
Schistosoma mansoni	smad1 5 8 and	0.0142	0.0562	0.1144
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0075	0.0075
Echinococcus granulosus	Smad4	0.0142	0.0562	0.1144
Echinococcus granulosus	mothers against decapentaplegic 6	0.0063	0.0181	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0549	0.2542	0.2542
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0075	0.6879
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0063	0.0181	0.0711
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0075	0.064
Entamoeba histolytica	hypothetical protein	0.0038	0.0055	0.5094
Trypanosoma cruzi	hypothetical protein, conserved	0.0049	0.0108	0.1224
Trypanosoma cruzi	hypothetical protein, conserved	0.0049	0.0108	0.1224
Toxoplasma gondii	LsmAD domain-containing protein	0.0057	0.0148	0.416
Schistosoma mansoni	Smad4	0.0142	0.0562	0.1144
Brugia malayi	RNA binding protein	0.1032	0.4888	0.4888
Schistosoma mansoni	chromosome transmission fidelity factor	0.0049	0.0108	0.0214
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0027	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0049	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0075	0.0075
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0075	0.6879
Schistosoma mansoni	tar DNA-binding protein	0.1032	0.4888	1
Brugia malayi	isocitrate dehydrogenase	0.0099	0.0351	0.0351
Toxoplasma gondii	isocitrate dehydrogenase	0.0099	0.0351	1
Treponema pallidum	DNA ligase (lig)	0.0049	0.0108	0.5
Loa Loa (eye worm)	hypothetical protein	0.1489	0.7108	0.7108
Brugia malayi	N-terminal motif family protein	0.0549	0.2542	0.2542
Onchocerca volvulus		0.0049	0.0108	0.0426
Toxoplasma gondii	isocitrate dehydrogenase	0.0099	0.0351	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.0079	0.0155
Schistosoma mansoni	hypothetical protein	0.0471	0.2162	0.4418
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0099	0.0351	0.0711
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0075	0.0075
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0471	0.2162	0.2162
Brugia malayi	MH2 domain containing protein	0.0142	0.0562	0.0562
Brugia malayi	MH2 domain containing protein	0.0142	0.0562	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0004	0.0004
Brugia malayi	topoisomerase	0.0049	0.0108	0.0108
Schistosoma mansoni	hypothetical protein	0.0471	0.2162	0.4418
Plasmodium vivax	replication factor C subunit 1, putative	0.0049	0.0108	0.1224
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0075	0.064
Schistosoma mansoni	tar DNA-binding protein	0.1032	0.4888	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0181	0.0181
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0043	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0605	0.0605
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0075	0.064
Brugia malayi	MH1 domain containing protein	0.0142	0.0562	0.0562
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0049	0.0108	0.1224
Schistosoma mansoni	smad1 5 8 and	0.0142	0.0562	0.1144
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0075	0.6879
Echinococcus granulosus	mothers against decapentaplegic 5	0.0142	0.0562	0.1144
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0099	0.0351	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.0079	0.0155
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0099	0.0351	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0049	0.0108	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0063	0.0181	0.0181
Schistosoma mansoni	tar DNA-binding protein	0.1032	0.4888	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0043	0.0079	0.0079
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0471	0.2162	0.2162
Brugia malayi	DKFZp564C0469 protein	0.0049	0.0108	0.0108
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0049	0.0108	1
Schistosoma mansoni	tar DNA-binding protein	0.1032	0.4888	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0075	0.064
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0142	0.0562	0.1144
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0108	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0266	0.1165	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0099	0.0351	1
Brugia malayi	RNA recognition motif domain containing protein	0.1032	0.4888	0.4888
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0108	0.0108
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0055	0.0106
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.0079	0.0155
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0099	0.0351	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0471	0.2162	0.4418
Echinococcus granulosus	GPCR family 2	0.0471	0.2162	0.4418
Schistosoma mansoni	smad	0.0142	0.0562	0.1144
Schistosoma mansoni	Smad4	0.0063	0.0181	0.0362
Schistosoma mansoni	hypothetical protein	0.0471	0.2162	0.4418
Onchocerca volvulus		0.0027	0.0004	0.0014
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0049	0.0108	0.0108
Onchocerca volvulus		0.0042	0.0075	0.0293
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.1489	0.7108	0.7108
Brugia malayi	hypothetical protein	0.0038	0.0055	0.0055
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0099	0.0351	0.3014
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0049	0.0108	0.5
Leishmania major	hypothetical protein, conserved	0.0057	0.0148	0.422
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0108	0.0108
Trypanosoma cruzi	PAB1-binding protein , putative	0.0057	0.0148	0.2662
Echinococcus granulosus	geminin	0.0188	0.0785	0.1601
Brugia malayi	MH1 domain containing protein	0.0079	0.0254	0.0254
Schistosoma mansoni	DNA ligase IV	0.0049	0.0108	0.0214
Schistosoma mansoni	hypothetical protein	0.0038	0.0055	0.0106
Entamoeba histolytica	hypothetical protein	0.0038	0.0055	0.5094
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0075	0.0075
Trichomonas vaginalis	replication factor C large subunit, putative	0.0049	0.0108	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.0079	0.0155
Echinococcus multilocularis	GPCR, family 2	0.0471	0.2162	0.4418
Echinococcus multilocularis	geminin	0.0188	0.0785	0.1601
Brugia malayi	beta-lactamase	0.0042	0.0075	0.0075
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0057	0.0148	0.0148
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.0079	0.0155
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0027	0.0004	0.0014
Brugia malayi	Calcitonin receptor-like protein seb-1	0.1489	0.7108	0.7108
Leishmania major	hypothetical protein, conserved	0.0042	0.0075	0.2124
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0108	1
Brugia malayi	hypothetical protein	0.0027	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0151	0.0605	0.0605
Trypanosoma cruzi	PAB1-binding protein , putative	0.0057	0.0148	0.2662
Brugia malayi	TAR-binding protein	0.1032	0.4888	0.4888
Brugia malayi	DIX domain containing protein	0.0027	0.0004	0.0004
Echinococcus multilocularis	Smad4	0.0142	0.0562	0.1144
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0099	0.0351	0.0711
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0027	0.0004	0.0004
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0049	0.0108	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.0079	0.0155
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0099	0.0351	0.0711
Schistosoma mansoni	hypothetical protein	0.0471	0.2162	0.4418
Schistosoma mansoni	smad1 5 8 and	0.0142	0.0562	0.1144
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0075	0.6879
Entamoeba histolytica	hypothetical protein	0.0049	0.0108	1
Brugia malayi	hypothetical protein	0.0027	0.0004	0.0004
Brugia malayi	beta-lactamase family protein	0.0042	0.0075	0.0075
Mycobacterium ulcerans	lipase LipD	0.0042	0.0075	0.6879
Brugia malayi	MH2 domain containing protein	0.0063	0.0181	0.0181
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0049	0.0108	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0471	0.2162	0.4418
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0075	0.064
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0049	0.0108	0.3015
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0108	0.0108
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0099	0.0351	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0142	0.0562	0.0562
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0075	0.064
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0049	0.0108	1
Echinococcus granulosus	tar DNA binding protein	0.1032	0.4888	1
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0099	0.0351	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0057	0.0148	0.1639
Trypanosoma brucei	PAB1-binding protein , putative	0.0057	0.0148	0.2662
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0099	0.0351	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0108	0.0108
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0075	0.064
Echinococcus granulosus	nibrin	0.0049	0.0108	0.0214
Loa Loa (eye worm)	Smad1	0.0142	0.0562	0.0562
Onchocerca volvulus		0.0151	0.0605	0.2379
Schistosoma mansoni	Smad4	0.0063	0.0181	0.0362
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0142	0.0562	0.1144
Plasmodium vivax	ataxin-2 like protein, putative	0.0057	0.0148	0.2662
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0471	0.2162	0.4418
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.1032	0.4888	0.4888
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0075	0.0075
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0099	0.0351	0.0711
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0055	0.0106
Brugia malayi	hypothetical protein	0.0037	0.005	0.005
Schistosoma mansoni	tar DNA-binding protein	0.1032	0.4888	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0055	0.5094
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0075	0.6879
Toxoplasma gondii	ABC1 family protein	0.0042	0.0075	0.2041
Brugia malayi	regulator of G-protein signaling egl-10	0.0027	0.0004	0.0004
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0049	0.0108	0.1224
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.0079	0.0155
Echinococcus granulosus	smad	0.0142	0.0562	0.1144
Entamoeba histolytica	hypothetical protein	0.0038	0.0055	0.5094
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0549	0.2542	1
Brugia malayi	Latrophilin receptor protein 2	0.0471	0.2162	0.2162
Schistosoma mansoni	hypothetical protein	0.0188	0.0785	0.1601
Schistosoma mansoni	topbp1	0.0049	0.0108	0.0214
Onchocerca volvulus		0.0042	0.0075	0.0293
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0075	0.064
Loa Loa (eye worm)	TAR-binding protein	0.1032	0.4888	0.4888
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0148	0.0148
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0075	0.6879
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0099	0.0351	0.0711
Trypanosoma cruzi	FHA domain containing protein, putative	0.0049	0.0108	0.1224
Brugia malayi	latrophilin 2 splice variant baaae	0.1018	0.4818	0.4818
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0075	0.064
Brugia malayi	Smad1	0.0142	0.0562	0.0562
Loa Loa (eye worm)	transcription factor SMAD2	0.2084	1	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0075	0.0145
Schistosoma mansoni	smad	0.0063	0.0181	0.0362
Loa Loa (eye worm)	nuclear factor I	0.0079	0.0254	0.0254
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0063	0.0181	0.0362
Brugia malayi	beta-lactamase family protein	0.0042	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0049	0.0108	0.0108
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0075	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.1018	0.4818	0.4818
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0055	0.0106
Echinococcus granulosus	mothers against decapentaplegic 2	0.0063	0.0181	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0004	0.0004
Brugia malayi	Pax transcription activation domain interacting protein	0.0049	0.0108	0.0108
Loa Loa (eye worm)	MH2 domain-containing protein	0.2084	1	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0075	0.0145
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0063	0.0181	0.0362
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0049	0.0108	1
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0108	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.1489	0.7108	0.7108
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0142	0.0562	0.1144
Loa Loa (eye worm)	MH1 domain-containing protein	0.0063	0.0181	0.0181
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0075	0.064
Echinococcus multilocularis	replication factor c subunit 1	0.0049	0.0108	0.0214
Loa Loa (eye worm)	DIX domain-containing protein	0.0027	0.0004	0.0004
Giardia lamblia	Replication factor C, subunit 1	0.0049	0.0108	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0108	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0004	0.0004
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0075	0.0075
Toxoplasma gondii	ATPase, AAA family protein	0.0049	0.0108	0.3015
Echinococcus multilocularis	smad	0.0142	0.0562	0.1144
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0099	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0471	0.2162	0.2162
Brugia malayi	Isocitrate dehydrogenase	0.0099	0.0351	0.0351
Echinococcus multilocularis	tar DNA binding protein	0.1032	0.4888	1
Loa Loa (eye worm)	RNA binding protein	0.1032	0.4888	0.4888
Plasmodium falciparum	ataxin-2 like protein, putative	0.0057	0.0148	0.1639
Schistosoma mansoni	hypothetical protein	0.1018	0.4818	0.9858
Chlamydia trachomatis	DNA ligase	0.0049	0.0108	0.5
Onchocerca volvulus		0.0042	0.0075	0.0293
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0075	0.0145
Brugia malayi	MH1 domain containing protein	0.0142	0.0562	0.0562
Schistosoma mansoni	topbp1	0.0049	0.0108	0.0214

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Inhibition of cyclooxygenase was evaluated in rat platelets stimulated by thrombin up to a concentration of 10 uM; NE means No effect	ChEMBL.	No reference
Activity (binding)		Inhibition of 12-lipoxygenase was evaluated in rat platelets stimulated by thrombin up to a concentration of 10 uM; NE means No effect	ChEMBL.	No reference
Activity (binding)	0	Inhibition of cyclooxygenase was evaluated in rat platelets stimulated by thrombin up to a concentration of 10 uM; NE means No effect	ChEMBL.	No reference
Activity (binding)	0	Inhibition of 12-lipoxygenase was evaluated in rat platelets stimulated by thrombin up to a concentration of 10 uM; NE means No effect	ChEMBL.	No reference
IC50 (binding)	uM	Inhibition of 5-lipoxygenase was evaluated in human polymorphonuclear leukocytes stimulated by calcium ionophore A-23,187 for formation of 5-HETE; NA means Not active	ChEMBL.	No reference
IC50 (binding)	uM	Inhibition of 5-lipoxygenase was evaluated in human polymorphonuclear leukocytes stimulated by calcium ionophore A-23,187 for formation of LTB4; NA means Not active	ChEMBL.	No reference
IC50 (binding)	0 uM	Inhibition of 5-lipoxygenase was evaluated in human polymorphonuclear leukocytes stimulated by calcium ionophore A-23,187 for formation of 5-HETE; NA means Not active	ChEMBL.	No reference
IC50 (binding)	0 uM	Inhibition of 5-lipoxygenase was evaluated in human polymorphonuclear leukocytes stimulated by calcium ionophore A-23,187 for formation of LTB4; NA means Not active	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL88814

Bibliographic References

No literature references available for this target.

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Detailed information for compound 148141