Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Werner syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0012 | 0.0296 | 0.011 |
Schistosoma mansoni | DNA helicase recq5 | 0.0012 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2725 | 0.3702 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0652 | 0.0474 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.002 | 0.068 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2725 | 0.375 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.7043 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6955 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6955 | 0.9871 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2725 | 0.3702 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0012 | 0.0296 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0652 | 0.0678 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1881 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0188 | 0.0188 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0029 | 0.1153 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0025 | 0.0976 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0652 | 0.0474 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1766 | 0.2332 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0652 | 0.0678 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0652 | 0.0687 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1881 | 0.2503 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1766 | 0.2302 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.001 | 0.0188 | 0.0188 |
Schistosoma mansoni | DNA helicase recq1 | 0.0012 | 0.0296 | 0.0296 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1881 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0188 | 0.0188 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0029 | 0.1153 | 0.0984 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2725 | 0.375 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0652 | 0.0474 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0652 | 0.0652 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0012 | 0.0296 | 0.011 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0652 | 0.0652 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1881 | 0.1881 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | RecQ helicase | 0.0029 | 0.1153 | 0.1408 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1881 | 0.1881 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1881 | 0.1726 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0012 | 0.0296 | 0.011 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0652 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0296 | 0.0158 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0652 | 0.0687 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0296 | 0.016 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6955 | 0.9871 |
Schistosoma mansoni | smad | 0.001 | 0.0188 | 0.0188 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0668 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0296 | 0.016 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1766 | 0.1766 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0652 | 0.0652 |
Entamoeba histolytica | recQ family helicase, putative | 0.0015 | 0.0473 | 0.2514 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0652 | 0.0474 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1881 | 0.1726 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0023 | 0.0846 | 0.0846 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0012 | 0.0296 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1881 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0029 | 0.1153 | 0.0984 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0652 | 0.0652 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0296 | 0.4422 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0652 | 0.0474 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0296 | 0.4422 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1881 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0012 | 0.0296 | 0.0158 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0029 | 0.1153 | 0.1427 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0029 | 0.1153 | 1 |
Schistosoma mansoni | Smad4 | 0.001 | 0.0188 | 0.0188 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0006 | 0 | 0.5 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1636 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.3264 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.6858 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.