TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 387.43 | Formula: C20H25N3O5
H donors: 1 H acceptors: 4 LogP: 1.19 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)NC(=O)CN(C(=O)CN1C(=O)C2C(C1=O)CCCC2)C
InChi: 1S/C20H25N3O5/c1-22(11-17(24)21-13-7-9-14(28-2)10-8-13)18(25)12-23-19(26)15-5-3-4-6-16(15)20(23)27/h7-10,15-16H,3-6,11-12H2,1-2H3,(H,21,24)
InChiKey: CRCRIQIFLGVTJZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0376	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0068	0.0642	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Echinococcus granulosus	cathepsin b	0.0143	0.2921	0.2921
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0178	0.3967	0.3553
Onchocerca volvulus		0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0642	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0642	0.2198
Echinococcus multilocularis	ecdysone induced protein 78C	0.0376	1	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0376	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Onchocerca volvulus		0.0068	0.0642	0.0642
Schistosoma mansoni	cathepsin F (C01 family)	0.0068	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0376	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0178	0.3967	0.3967
Brugia malayi	hypothetical protein	0.0199	0.4613	0.4613
Echinococcus multilocularis	cathepsin b	0.0143	0.2921	0.2436
Loa Loa (eye worm)	hypothetical protein	0.0376	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.2921	0.2921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Leishmania major	cysteine peptidase A (CPA)	0.0068	0.0642	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0376	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0642	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0178	0.3967	0.3553
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0178	0.3967	0.3967
Onchocerca volvulus	Protein ultraspiracle homolog	0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Loa Loa (eye worm)	cysteine protease	0.0068	0.0642	0.0642
Leishmania major	cathepsin L-like protease	0.0068	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0376	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0068	0.0642	0.0642
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0642	1
Leishmania major	cathepsin L-like protease	0.0068	0.0642	1
Plasmodium vivax	vivapain-2	0.0068	0.0642	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0376	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0376	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0376	1	1
Schistosoma mansoni	coup transcription factor	0.0376	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0068	0.0642	0.0642
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0376	1	1
Leishmania major	cathepsin L-like protease	0.0068	0.0642	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0376	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0199	0.4613	0.4613
Loa Loa (eye worm)	hypothetical protein	0.0199	0.4613	0.4613
Brugia malayi	hypothetical protein	0.0178	0.3967	0.3967
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0376	1	1
Giardia lamblia	Cathepsin B precursor	0.0055	0.0253	0.5
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967
Schistosoma mansoni	zinc finger protein	0.0178	0.3967	0.3967
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0642	1
Echinococcus multilocularis	FTZ F1 alpha	0.0376	1	1
Loa Loa (eye worm)	hypothetical protein	0.0376	1	1
Brugia malayi	nuclear receptor NHR-88	0.0376	1	1
Entamoeba histolytica	cysteine protease, putative	0.0068	0.0642	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0178	0.3967	0.3967
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0199	0.4613	0.4613
Loa Loa (eye worm)	hypothetical protein	0.0199	0.4613	0.4613
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0178	0.3967	0.3553
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0376	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0068	0.0642	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0055	0.0253	0.394
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0178	0.3967	0.3553
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0376	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0068	0.0642	0.0642
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0376	1	1
Leishmania major	cathepsin L-like protease	0.0068	0.0642	1
Leishmania major	cathepsin L-like protease	0.0068	0.0642	1
Echinococcus multilocularis	cathepsin b	0.0143	0.2921	0.2436
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0376	1	1
Onchocerca volvulus		0.0178	0.3967	0.3967
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0376	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0068	0.0642	0.2198
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0178	0.3967	0.3967
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.2921	0.2921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0068	0.0642	1
Echinococcus granulosus	FTZ F1 alpha	0.0376	1	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0642	0.2198
Onchocerca volvulus	Bile acid receptor homolog	0.0376	1	1
Onchocerca volvulus		0.0068	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967
Brugia malayi	conserved hypotetical protein	0.0178	0.3967	0.3967
Onchocerca volvulus		0.0068	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0068	0.0642	0.0642
Brugia malayi	nuclear receptor NHR-88	0.0178	0.3967	0.3967
Brugia malayi	cathepsin B-like cysteine proteinase	0.0143	0.2921	0.2921
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Brugia malayi	hypothetical protein	0.0199	0.4613	0.4613
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0143	0.2921	0.2921
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967
Brugia malayi	Nuclear hormone receptor-like 1	0.0199	0.4613	0.4613
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0068	0.0642	0.5
Loa Loa (eye worm)	hypothetical protein	0.0376	1	1
Brugia malayi	hypothetical protein	0.0178	0.3967	0.3967
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0376	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0178	0.3967	0.3553
Brugia malayi	nuclear receptor RXR	0.0199	0.4613	0.4613
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0178	0.3967	0.3967
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0642	0.0642
Schistosoma mansoni	thyroid hormone receptor	0.0376	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0376	1	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.2921	0.2921
Leishmania major	cathepsin L-like protease	0.0068	0.0642	1
Brugia malayi	Nuclear hormone receptor E75	0.0178	0.3967	0.3967
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0642	1
Loa Loa (eye worm)	DR-78	0.0178	0.3967	0.3967
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0642	0.0642
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0199	0.4613	0.4613
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0376	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0376	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0068	0.0642	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0642	0.2198
Echinococcus granulosus	cathepsin l1	0.0068	0.0642	0.0642
Brugia malayi	Nuclear hormone receptor-like 1	0.0376	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0642	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0199	0.4613	0.4613
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0068	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Brugia malayi	nuclear hormone receptor	0.0376	1	1
Loa Loa (eye worm)	hypothetical protein	0.0376	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0642	1
Echinococcus granulosus	cathepsin b	0.0143	0.2921	0.2921
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0642	0.0642
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0376	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0178	0.3967	0.3967
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0178	0.3967	0.3553
Onchocerca volvulus		0.0068	0.0642	0.0642
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0376	1	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0178	0.3967	0.3967
Loa Loa (eye worm)	hypothetical protein	0.0199	0.4613	0.4613
Schistosoma mansoni	retinoic acid receptor RXR	0.0376	1	1
Loa Loa (eye worm)	hypothetical protein	0.0199	0.4613	0.4613
Brugia malayi	steroid hormone receptor	0.0376	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0143	0.2921	1
Brugia malayi	ecdysone receptor	0.0178	0.3967	0.3967
Brugia malayi	Nuclear hormone receptor E75	0.0178	0.3967	0.3967
Brugia malayi	orphan nuclear receptor NR2E1	0.0178	0.3967	0.3967
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0376	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0376	1	1
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0642	0.0642
Brugia malayi	tailless protein	0.0178	0.3967	0.3967
Schistosoma mansoni	nuclear hormone receptor	0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0642	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0376	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0376	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0642	0.0642
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0199	0.4613	0.4244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0376	1	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0178	0.3967	0.3967
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0178	0.3967	0.3967
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0642	1
Loa Loa (eye worm)	cathepsin B	0.0055	0.0253	0.0253
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0376	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0068	0.0642	0.0642
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0642	0.2198
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0376	1	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0178	0.3967	0.3967
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0068	0.0642	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0376	1	1
Leishmania major	cathepsin L-like protease	0.0068	0.0642	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0376	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0068	0.0642	0.0642
Loa Loa (eye worm)	fibroinase	0.0068	0.0642	0.0642
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0642	1
Onchocerca volvulus		0.0068	0.0642	0.0642
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0376	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0178	0.3967	0.3967
Onchocerca volvulus	Cathepsin L homolog	0.0068	0.0642	0.0642
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0376	1	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0178	0.3967	0.3967
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0199	0.4613	0.4613
Brugia malayi	Papain family cysteine protease containing protein	0.0068	0.0642	0.0642
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0642	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0376	1	1
Leishmania major	cathepsin L-like protease	0.0068	0.0642	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0253	0.0253
Schistosoma mansoni	nuclear receptor	0.0178	0.3967	0.3967
Brugia malayi	nuclear receptor NHR-67	0.0178	0.3967	0.3967
Schistosoma mansoni	nuclear receptor nhr-48	0.0178	0.3967	0.3967
Loa Loa (eye worm)	hypothetical protein	0.0376	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0642	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0199	0.4613	0.4613
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0376	1	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0642	1
Onchocerca volvulus		0.0068	0.0642	0.0642
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.2921	0.2921
Echinococcus granulosus	thyroid hormone receptor alpha	0.0178	0.3967	0.3967
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0642	1
Entamoeba histolytica	cysteine proteinase, putative	0.0068	0.0642	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0642	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0178	0.3967	0.3967
Schistosoma mansoni	nuclear hormone receptor	0.0178	0.3967	0.3967
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0642	0.0642
Onchocerca volvulus		0.0068	0.0642	0.0642
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0376	1	1
Loa Loa (eye worm)	ctsf protein	0.0068	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0376	1	1
Schistosoma mansoni	nuclear receptor	0.0178	0.3967	0.3967
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0642	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0376	1	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0178	0.3967	0.3967
Brugia malayi	nuclear receptor RXR	0.0178	0.3967	0.3967
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0642	1
Brugia malayi	Steroid receptor seven-up type 2	0.0376	1	1
Giardia lamblia	Cathepsin B precursor	0.0055	0.0253	0.5
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0376	1	1
Plasmodium vivax	vivapain-2	0.0068	0.0642	0.5
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0055	0.0253	0.0866
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0376	1	1
Toxoplasma gondii	cathepsin CPL	0.0068	0.0642	1
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0642	0.0642
Onchocerca volvulus		0.0178	0.3967	0.3967
Echinococcus granulosus	ecdysone induced protein 78C	0.0376	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0178	0.3967	0.3967
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0178	0.3967	0.3967
Brugia malayi	nuclear hormone receptor	0.0178	0.3967	0.3967
Giardia lamblia	Cathepsin B precursor	0.0055	0.0253	0.5
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3967	0.3967

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1714165

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1481567