TDR Targets

Basic information

Technical information

TDR Targets ID: 1481570
Name: N-(3,5-dimethylphenyl)-2-[[5-(4-methylfuro[2, 3-d]pyrrol-5-yl)-4-(2-methylphenyl)-1,2,4-tri azol-3-yl]sulfanyl]acetamide
MW: 471.574 | Formula: C26H25N5O2S
H donors: 1 H acceptors: 3 LogP: 4.86 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cc(C)cc(c1)C)CSc1nnc(n1c1ccccc1C)c1cc2c(n1C)cco2
InChi: 1S/C26H25N5O2S/c1-16-11-17(2)13-19(12-16)27-24(32)15-34-26-29-28-25(31(26)20-8-6-5-7-18(20)3)22-14-23-21(30(22)4)9-10-33-23/h5-14H,15H2,1-4H3,(H,27,32)
InChiKey: SLKIWZUYXRJTPR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3,5-dimethylphenyl)-2-[[5-(4-methyl-5-furo[2,3-d]pyrrolyl)-4-(2-methylphenyl)-1,2,4-triazol-3-yl]thio]acetamide
N-(3,5-dimethylphenyl)-2-[[5-(4-methylfuro[2,3-d]pyrrol-5-yl)-4-(2-methylphenyl)-1,2,4-triazol-3-yl]thio]acetamide
N-(3,5-dimethylphenyl)-2-[[5-(4-methylfuro[2,3-d]pyrrol-5-yl)-4-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]ethanamide
E634-1386
NCGC00123963-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	orphan nuclear receptor NR2E1	0.0179	0.4161	0.4161
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0179	0.4161	0.4161
Schistosoma mansoni	retinoic acid receptor RXR	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Brugia malayi	Cathepsin L-like precursor	0.0084	0.1409	0.1409
Onchocerca volvulus	Cathepsin F homolog	0.0122	0.2502	0.2502
Schistosoma mansoni	thyroid hormone receptor	0.0378	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0122	0.2502	0.3158
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0378	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0304	0.7833	0.7833
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0304	0.7833	0.7833
Leishmania major	cysteine peptidase A (CPA)	0.0122	0.2502	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0179	0.4161	0.4161
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0122	0.2502	0.2502
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0378	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0122	0.2502	0.2504
Loa Loa (eye worm)	hypothetical protein	0.0378	1	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.02	0.4786	0.4786
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Loa Loa (eye worm)	cysteine protease	0.0122	0.2502	0.2502
Brugia malayi	nuclear hormone receptor family member odr-7	0.0179	0.4161	0.4161
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0179	0.4161	0.4161
Brugia malayi	nuclear hormone receptor	0.0179	0.4161	0.4161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Loa Loa (eye worm)	hypothetical protein	0.0378	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Schistosoma mansoni	nuclear receptor nhr-48	0.0179	0.4161	0.4161
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1409	0.1409
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0179	0.4161	0.4161
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0304	0.7833	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0067	0.0899	0.0899
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0705	0.0705
Leishmania major	cathepsin L-like protease	0.0122	0.2502	1
Plasmodium vivax	vivapain-2	0.0122	0.2502	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0122	0.2502	1
Echinococcus granulosus	cathepsin b	0.0304	0.7833	0.7833
Brugia malayi	nuclear receptor NHR-67	0.0179	0.4161	0.4161
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0304	0.7833	0.7833
Onchocerca volvulus		0.0179	0.4161	0.4161
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0179	0.4161	0.4161
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0067	0.0899	0.0899
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0179	0.4161	0.4161
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0122	0.2502	1
Brugia malayi	Papain family cysteine protease containing protein	0.0067	0.0899	0.0899
Plasmodium vivax	vivapain-3	0.0067	0.0899	0.3592
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0037	0.004	0.004
Brugia malayi	Cathepsin L-like precursor	0.0122	0.2502	0.2502
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0122	0.2502	0.2504
Echinococcus granulosus	nuclear receptor nhr 48	0.0179	0.4161	0.4161
Toxoplasma gondii	cathepsin CPL	0.0122	0.2502	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0122	0.2502	1
Echinococcus granulosus	FTZ F1 alpha	0.0378	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0122	0.2502	0.2502
Loa Loa (eye worm)	hypothetical protein	0.02	0.4786	0.4786
Trypanosoma cruzi	cysteine proteinase, putative	0.0067	0.0899	0.1101
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0122	0.2502	0.2504
Brugia malayi	Nuclear hormone receptor-like 1	0.02	0.4786	0.4786
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0179	0.4161	0.4161
Loa Loa (eye worm)	nuclear hormone receptor	0.0179	0.4161	0.4161
Brugia malayi	Nuclear hormone receptor-like 1	0.02	0.4786	0.4786
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0378	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0378	1	1
Echinococcus granulosus	cathepsin l1	0.0084	0.1409	0.1409
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Giardia lamblia	Cathepsin B precursor	0.0114	0.2288	0.5
Entamoeba histolytica	cysteine protease, putative	0.0122	0.2502	1
Brugia malayi	tailless protein	0.0179	0.4161	0.4161
Schistosoma mansoni	cathepsin F (C01 family)	0.0084	0.1409	0.1409
Trypanosoma cruzi	cysteine proteinase, putative	0.0067	0.0899	0.1101
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0378	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0122	0.2502	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0037	0.004	0.004
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0084	0.1409	0.1756
Brugia malayi	hypothetical protein	0.0179	0.4161	0.4161
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0378	1	1
Loa Loa (eye worm)	DR-78	0.0179	0.4161	0.4161
Loa Loa (eye worm)	ctsf protein	0.0122	0.2502	0.2502
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.73	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0378	1	1
Brugia malayi	nuclear receptor RXR	0.02	0.4786	0.4786
Loa Loa (eye worm)	hypothetical protein	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Brugia malayi	hypothetical protein	0.0179	0.4161	0.4161
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0122	0.2502	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0378	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0378	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0378	1	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0179	0.4161	0.4161
Brugia malayi	cathepsin B-like cysteine proteinase	0.0304	0.7833	0.7833
Entamoeba histolytica	cysteine proteinase, putative	0.0122	0.2502	1
Leishmania major	cathepsin L-like protease	0.0122	0.2502	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0122	0.2502	0.3158
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0122	0.2502	0.2504
Leishmania major	cathepsin L-like protease	0.0122	0.2502	1
Echinococcus multilocularis	cysteine protease	0.0122	0.2502	0.2502
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.6286	0.6286
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0378	1	1
Brugia malayi	Pre-SET motif family protein	0.0251	0.6286	0.6286
Onchocerca volvulus	Cathepsin L homolog	0.0122	0.2502	0.2502
Loa Loa (eye worm)	hypothetical protein	0.006	0.0705	0.0705
Plasmodium vivax	vivapain-1	0.0067	0.0899	0.3592
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0084	0.1409	0.0797
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.02	0.4786	0.4786
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Brugia malayi	hypothetical protein	0.02	0.4786	0.4786
Brugia malayi	Nuclear hormone receptor-like 1	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0378	1	1
Brugia malayi	Cathepsin L-like precursor	0.0122	0.2502	0.2502
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0378	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0122	0.2502	0.2504
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0179	0.4161	0.4161
Brugia malayi	Cathepsin L-like precursor	0.0084	0.1409	0.1409
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0122	0.2502	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0378	1	1
Brugia malayi	nuclear receptor NHR-88	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0378	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0122	0.2502	1
Brugia malayi	Papain family cysteine protease containing protein	0.0122	0.2502	0.2502
Schistosoma mansoni	nuclear receptor	0.0179	0.4161	0.4161
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0122	0.2502	0.2502
Schistosoma mansoni	nuclear hormone receptor	0.0179	0.4161	0.4161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Echinococcus granulosus	cathepsin l1	0.0122	0.2502	0.2502
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0378	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0114	0.2288	0.2288
Brugia malayi	nuclear hormone receptor	0.0378	1	1
Schistosoma mansoni	zinc finger protein	0.0179	0.4161	0.4161
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Leishmania major	cathepsin L-like protease	0.0122	0.2502	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0179	0.4161	0.4161
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0122	0.2502	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0378	1	1
Brugia malayi	cathepsin L-like precursor	0.0084	0.1409	0.1409
Trypanosoma cruzi	cruzipain precursor, putative	0.0122	0.2502	0.3158
Brugia malayi	Nuclear hormone receptor E75	0.0179	0.4161	0.4161
Echinococcus multilocularis	cathepsin L cysteine protease	0.0122	0.2502	0.2502
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0122	0.2502	0.2504
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0378	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0378	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Onchocerca volvulus		0.0084	0.1409	0.1409
Loa Loa (eye worm)	cathepsin B	0.0114	0.2288	0.2288
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0122	0.2502	1
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0378	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0122	0.2502	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0378	1	1
Echinococcus granulosus	cathepsin b	0.0304	0.7833	0.7833
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0179	0.4161	0.4161
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0179	0.4161	0.4161
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0304	0.7833	0.7833
Onchocerca volvulus		0.0286	0.73	0.73
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0122	0.2502	1
Loa Loa (eye worm)	hypothetical protein	0.02	0.4786	0.4786
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.02	0.4786	0.4786
Leishmania major	cathepsin L-like protease	0.0122	0.2502	1
Brugia malayi	Papain family cysteine protease containing protein	0.0067	0.0899	0.0899
Echinococcus multilocularis	ecdysone induced protein 78C	0.0378	1	1
Echinococcus multilocularis	cathepsin L	0.0067	0.0899	0.0899
Brugia malayi	Nuclear hormone receptor E75	0.0179	0.4161	0.4161
Schistosoma mansoni	coup transcription factor	0.0378	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0179	0.4161	0.4161
Onchocerca volvulus		0.0179	0.4161	0.4161
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0378	1	1
Brugia malayi	Cathepsin L-like precursor	0.0122	0.2502	0.2502
Schistosoma mansoni	cathepsin F (C01 family)	0.0122	0.2502	0.2502
Echinococcus multilocularis	cysteine protease	0.0122	0.2502	0.2502
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0179	0.4161	0.4161
Schistosoma mansoni	nuclear hormone receptor	0.0378	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0122	0.2502	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0067	0.0899	0.0899
Plasmodium vivax	unspecified product	0.0067	0.0899	0.3592
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Onchocerca volvulus		0.0122	0.2502	0.2502
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0149	0.0149
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0378	1	1
Brugia malayi	steroid hormone receptor	0.0378	1	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.02	0.4786	0.4786
Plasmodium vivax	vivapain-2	0.0122	0.2502	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0122	0.2502	0.2504
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.02	0.4786	0.4786
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0378	1	1
Brugia malayi	Cathepsin L-like precursor	0.0037	0.004	0.004
Onchocerca volvulus		0.0122	0.2502	0.2502
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Toxoplasma gondii	cathepsin B	0.0114	0.2288	0.9148
Onchocerca volvulus	Cathepsin L homolog	0.0122	0.2502	0.2502
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0122	0.2502	0.2504
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2502	0.2502
Schistosoma mansoni	cathepsin s	0.0037	0.004	0.004
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0705	0.0705
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.3157	0.3157
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0067	0.0899	0.1101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Schistosoma mansoni	hypothetical protein	0.0041	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0179	0.4161	0.4161
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1409	0.1409
Brugia malayi	conserved hypotetical protein	0.0179	0.4161	0.4161
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0378	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0122	0.2502	0.2504
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Brugia malayi	nuclear receptor RXR	0.0179	0.4161	0.4161
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0378	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0304	0.7833	0.7833
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0378	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0378	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0122	0.2502	0.2504
Loa Loa (eye worm)	hypothetical protein	0.0378	1	1
Brugia malayi	Cathepsin L-like precursor	0.0122	0.2502	0.2502
Brugia malayi	hypothetical protein	0.02	0.4786	0.4786
Onchocerca volvulus		0.0122	0.2502	0.2502
Loa Loa (eye worm)	fibroinase	0.0122	0.2502	0.2502
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0122	0.2502	0.2502
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Onchocerca volvulus		0.0122	0.2502	0.2502
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0378	1	1
Brugia malayi	Cathepsin L-like precursor	0.0122	0.2502	0.2502
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0114	0.2288	0.2171
Onchocerca volvulus		0.0122	0.2502	0.2502
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0114	0.2288	0.867
Echinococcus granulosus	cysteine protease	0.0067	0.0899	0.0899
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0122	0.2502	0.2502
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0378	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0122	0.2502	0.2502
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0122	0.2502	0.2504
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0179	0.4161	0.4161
Brugia malayi	MH2 domain containing protein	0.0144	0.3157	0.3157
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0084	0.1409	0.1409
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0378	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0378	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0067	0.0899	0.0899
Brugia malayi	nuclear receptor NHR-88	0.0179	0.4161	0.4161
Loa Loa (eye worm)	hypothetical protein	0.02	0.4786	0.4786
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0179	0.4161	0.4161
Echinococcus multilocularis	cathepsin b	0.0304	0.7833	0.7833
Echinococcus multilocularis	FTZ F1 alpha	0.0378	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.0378	1	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0378	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4161	0.4161
Trypanosoma cruzi	cysteine peptidase, putative	0.0122	0.2502	0.3158
Entamoeba histolytica	cysteine proteinase, putative	0.0084	0.1409	0.3182
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0378	1	1
Echinococcus granulosus	cathepsin L	0.0067	0.0899	0.0899
Trypanosoma cruzi	cysteine peptidase, putative	0.0122	0.2502	0.3158
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0378	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0378	1	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0378	1	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0179	0.4161	0.4161
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0705	0.0705
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.3157	0.3157
Giardia lamblia	Cathepsin B precursor	0.0114	0.2288	0.5
Brugia malayi	ecdysone receptor	0.0179	0.4161	0.4161
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0122	0.2502	0.2502
Leishmania major	cathepsin L-like protease	0.0122	0.2502	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0378	1	1
Leishmania major	cathepsin L-like protease	0.0122	0.2502	1
Onchocerca volvulus		0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.02	0.4786	0.4786
Giardia lamblia	Cathepsin B precursor	0.0114	0.2288	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0378	1	1
Onchocerca volvulus		0.0122	0.2502	0.2502
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0114	0.2288	0.2885
Trypanosoma cruzi	cysteine protease, putative	0.0067	0.0899	0.1101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0084	0.1409	0.0797
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0122	0.2502	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0122	0.2502	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0122	0.2502	0.2502
Leishmania major	cathepsin L-like protease	0.0122	0.2502	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1409	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0378	1	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0179	0.4161	0.4161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.2502	0.2504
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0179	0.4161	0.4161
Echinococcus multilocularis	cathepsin b	0.0304	0.7833	0.7833
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0149	0.0149
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0378	1	1
Brugia malayi	Cathepsin L-like precursor	0.0122	0.2502	0.2502
Onchocerca volvulus	Bile acid receptor homolog	0.0378	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0378	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.004	0.004
Echinococcus granulosus	ecdysone induced protein 78C	0.0378	1	1
Onchocerca volvulus		0.0122	0.2502	0.2502
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0122	0.2502	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.02	0.4786	0.4786
Plasmodium vivax	unspecified product	0.0037	0.004	0.0161
Schistosoma mansoni	nuclear receptor	0.0179	0.4161	0.4161
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0899	0.1101
Brugia malayi	cathepsin F-like cysteine proteinase	0.0037	0.004	0.004

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.7783 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1714281

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1481570