TDR Targets

Basic information

Technical information

TDR Targets ID: 1481586
Name: (2S)-N-(2-chlorophenyl)-1-(4-methylphenyl)sul fonylpyrrolidine-2-carboxamide
MW: 378.873 | Formula: C18H19ClN2O3S
H donors: 1 H acceptors: 3 LogP: 3.49 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@@H]1CCCN1S(=O)(=O)c1ccc(cc1)C)Nc1ccccc1Cl
InChi: 1S/C18H19ClN2O3S/c1-13-8-10-14(11-9-13)25(23,24)21-12-4-7-17(21)18(22)20-16-6-3-2-5-15(16)19/h2-3,5-6,8-11,17H,4,7,12H2,1H3,(H,20,22)/t17-/m0/s1
InChiKey: YKVOZXOGCIHQSK-KRWDZBQOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2S)-N-(2-chlorophenyl)-1-(4-methylphenyl)sulfonyl-pyrrolidine-2-carboxamide
(2S)-N-(2-chlorophenyl)-1-(4-methylphenyl)sulfonyl-2-pyrrolidinecarboxamide
T5285986
ZINC01510713

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0279	0.0893
Brugia malayi	Tyrosine-protein kinase abl-1	0.0038	0.0023	0.0034
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0058	0.0058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0279	0.0405
Loa Loa (eye worm)	TK protein kinase	0.0128	0.0785	0.0737
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0158	0.1046	0.1046
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0149	0.0968	0.0968
Brugia malayi	hypothetical protein	0.0065	0.0251	0.0364
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0065	0.0251	0.0251
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0058	0.0085
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0042	0.0058	0.0085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0279	0.0893
Schistosoma mansoni	tyrosine kinase	0.0149	0.0968	0.0968
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0848	0.689	1
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0058	0.0058
Echinococcus granulosus	aminopeptidase N	0.0065	0.0251	0.0251
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0279	0.0405
Loa Loa (eye worm)	TATA binding protein associated factor	0.0065	0.0251	0.0199
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0065	0.0251	0.0364
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0158	0.1046	0.1046
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0042	0.0058	0.0058
Leishmania major	cathepsin L-like protease	0.0068	0.0279	0.0042
Brugia malayi	Cathepsin L-like precursor	0.0045	0.0089	0.0129
Schistosoma mansoni	coup transcription factor	0.0042	0.0058	0.0058
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0279	0.0405
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0279	0.0405
Loa Loa (eye worm)	hypothetical protein	0.006	0.0214	0.0162
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0065	0.0251	0.0251
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0065	0.0251	0.0364
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0058	0.0085
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0143	0.0917	0.0917
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0058	0.0085
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0042	0.0058	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0158	0.1046	0.1046
Schistosoma mansoni	tyrosine kinase	0.0149	0.0968	0.0968
Trypanosoma cruzi	aminopeptidase, putative	0.0065	0.0251	0.0364
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0042	0.0058	0.0058
Leishmania major	cathepsin L-like protease	0.0068	0.0279	0.0042
Echinococcus multilocularis	mitogen activated protein kinase	0.0268	0.1976	0.1976
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0848	0.689	1
Schistosoma mansoni	tyrosine kinase	0.0241	0.1746	0.1746
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0068	0.0279	0.0405
Onchocerca volvulus		0.0068	0.0279	0.0323
Echinococcus granulosus	epidermal growth factor receptor	0.0458	0.3582	0.3582
Leishmania major	cathepsin L-like protease	0.0068	0.0279	0.0042
Brugia malayi	MAP kinase sur-1	0.0268	0.1976	0.2868
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0065	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0251	0.0199
Onchocerca volvulus		0.0068	0.0279	0.0323
Echinococcus granulosus	mitogen activated protein kinase	0.0268	0.1976	0.1976
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0065	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0089	0.0036
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0042	0.0058	0.0058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0279	0.0405
Onchocerca volvulus	Cathepsin L homolog	0.0068	0.0279	0.0323
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0158	0.1046	0.1046
Brugia malayi	Cathepsin L-like precursor	0.0045	0.0089	0.0129
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0065	0.0251	0.0251
Schistosoma mansoni	tyrosine kinase	0.0458	0.3582	0.3582
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0058	0.0006
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0065	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0058	0.0006
Trypanosoma cruzi	cruzipain precursor, putative	0.0068	0.0279	0.0405
Trichomonas vaginalis	CMGC family protein kinase	0.0268	0.1976	0.6327
Toxoplasma gondii	cathepsin CPL	0.0068	0.0279	0.0042
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0158	0.1046	0.1046
Leishmania major	cathepsin L-like protease	0.0068	0.0279	0.0042
Brugia malayi	thymidylate synthase	0.0848	0.689	1
Trichomonas vaginalis	CMGC family protein kinase	0.0268	0.1976	0.6327
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0058	0.0058
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0065	0.0251	0.0364
Echinococcus granulosus	tyrosine protein kinase Blk	0.0143	0.0917	0.0917
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0279	0.0405
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0279	0.0405
Entamoeba histolytica	aminopeptidase, putative	0.0065	0.0251	0.3194
Schistosoma mansoni	tyrosine kinase	0.0248	0.1804	0.1804
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0058	0.0006
Loa Loa (eye worm)	TK protein kinase	0.0143	0.0917	0.0869
Echinococcus multilocularis	thymidylate synthase	0.0848	0.689	0.689
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0214	0.0162
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0045	0.0089	0.0129
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0042	0.0058	0.0058
Brugia malayi	Peptidase family M1 containing protein	0.0065	0.0251	0.0364
Onchocerca volvulus		0.0068	0.0279	0.0323
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0268	0.1976	0.2598
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0251	0.0199
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0279	0.0405
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0268	0.1976	0.2868
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0279	0.0405
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0065	0.0251	0.0364
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0268	0.1976	0.2598
Entamoeba histolytica	cysteine proteinase, putative	0.0045	0.0089	0.1129
Brugia malayi	protein-tyrosine kinase	0.0143	0.0917	0.1331
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0136	0.0858	0.0858
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0042	0.0058	0.0058
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0042	0.0058	0.0058
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0038	0.0023	0.0023
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0068	0.0279	0.0893
Entamoeba histolytica	cysteine proteinase, putative	0.0068	0.0279	0.355
Entamoeba histolytica	cysteine protease, putative	0.0068	0.0279	0.355
Brugia malayi	steroid hormone receptor	0.0042	0.0058	0.0085
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0065	0.0251	0.0364
Onchocerca volvulus		0.0065	0.0251	0.0282
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0068	0.0279	0.0405
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0458	0.3582	0.3548
Echinococcus multilocularis	aminopeptidase N	0.0065	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0251	0.0199
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0268	0.1976	0.1976
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0042	0.0058	0.0006
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0279	0.0405
Trypanosoma brucei	Aminopeptidase M1, putative	0.0065	0.0251	0.0364
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0158	0.1046	0.1046
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0065	0.0251	0.0251
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0158	0.1046	0.1046
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0848	0.689	1
Onchocerca volvulus		0.0068	0.0279	0.0323
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0042	0.0058	0.0058
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0279	0.0405
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0042	0.0058	0.0058
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0068	0.0279	0.0279
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0279	0.0405
Schistosoma mansoni	RAR-like nuclear receptor	0.0042	0.0058	0.0058
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0058	0.0085
Brugia malayi	hypothetical protein	0.0559	0.4438	0.644
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0158	0.1046	0.1046
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0065	0.0251	0.0251
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0058	0.0058
Brugia malayi	hypothetical protein	0.0404	0.3123	0.4532
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0279	0.0893
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0058	0.0006
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0158	0.1046	0.1046
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0068	0.0279	0.0227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0279	0.0405
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0158	0.1046	0.1046
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0065	0.0251	0.0364
Echinococcus granulosus	c src tyrosine kinase	0.0038	0.0023	0.0023
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0042	0.0058	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0042	0.0058	0.0085
Schistosoma mansoni	tyrosine kinase	0.0038	0.0023	0.0023
Echinococcus granulosus	thymidylate synthase	0.0848	0.689	0.689
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0042	0.0058	0.0006
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0042	0.0058	0.0006
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0268	0.1976	0.2598
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0848	0.689	0.5
Leishmania major	cathepsin L-like protease	0.0068	0.0279	0.0042
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0065	0.0251	0.0364
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0042	0.0058	0.0058
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0128	0.0785	0.0785
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0279	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0058	0.0006
Mycobacterium ulcerans	thymidylate synthase	0.0848	0.689	1
Brugia malayi	hypothetical protein	0.0065	0.0251	0.0364
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0042	0.0058	0.0006
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.1215	1	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0065	0.0251	0.0803
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0268	0.1976	0.2868
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0058	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0058	0.0085
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0848	0.689	0.689
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0038	0.0023	0.0023
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0848	0.689	1
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0065	0.0251	0.0199
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0065	0.0251	0.0364
Brugia malayi	Papain family cysteine protease containing protein	0.0068	0.0279	0.0405
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0158	0.1046	0.1046
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0042	0.0058	0.0058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Brugia malayi	nuclear hormone receptor	0.0042	0.0058	0.0085
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0214	0.031
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0065	0.0251	0.0364
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0279	0.0893
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0268	0.1976	0.2868
Brugia malayi	photoreceptor-specific nuclear receptor	0.0042	0.0058	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0068	0.0279	0.0893
Echinococcus granulosus	insulin receptor	0.0149	0.0968	0.0968
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0279	0.0405
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0279	0.0893
Brugia malayi	cathepsin L-like precursor	0.0045	0.0089	0.0129
Entamoeba histolytica	cysteine proteinase, putative	0.0068	0.0279	0.355
Schistosoma mansoni	tyrosine kinase	0.0241	0.1746	0.1746
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0065	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0058	0.0006
Echinococcus granulosus	cathepsin l1	0.0045	0.0089	0.0089
Onchocerca volvulus	Cathepsin F homolog	0.0068	0.0279	0.0323
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0058	0.0058
Giardia lamblia	Kinase, CMGC MAPK	0.0268	0.1976	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0404	0.3123	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0042	0.0058	0.0058
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0042	0.0058	0.0006
Echinococcus multilocularis	epidermal growth factor receptor	0.0458	0.3582	0.3582
Schistosoma mansoni	cathepsin F (C01 family)	0.0045	0.0089	0.0089
Schistosoma mansoni	serine/threonine protein kinase	0.0268	0.1976	0.1976
Schistosoma mansoni	hypothetical protein	0.0041	0.0052	0.0052
Onchocerca volvulus		0.0848	0.689	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0068	0.0279	0.0279
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0848	0.689	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0042	0.0058	0.0058
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0279	0.0405
Onchocerca volvulus	Cathepsin L homolog	0.0068	0.0279	0.0323
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0038	0.0023	0.0023
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0068	0.0279	0.0227
Echinococcus multilocularis	cysteine protease	0.0068	0.0279	0.0279
Onchocerca volvulus		0.0065	0.0251	0.0282
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0143	0.0917	0.0917
Echinococcus multilocularis	insulin receptor	0.0149	0.0968	0.0968
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0279	0.0405
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0068	0.0279	0.0279
Onchocerca volvulus		0.0065	0.0251	0.0282
Loa Loa (eye worm)	aminopeptidase N	0.0065	0.0251	0.0199
Onchocerca volvulus		0.0068	0.0279	0.0323
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0042	0.0058	0.0006
Trypanosoma cruzi	aminopeptidase, putative	0.0065	0.0251	0.0364
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0068	0.0279	0.0405
Brugia malayi	Protein kinase domain containing protein	0.0149	0.0968	0.1405
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0042	0.0058	0.0058
Leishmania major	cysteine peptidase A (CPA)	0.0068	0.0279	0.0042
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0065	0.0251	0.0251
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0065	0.0251	0.0251
Brugia malayi	Furin-like cysteine rich region family protein	0.0458	0.3582	0.5198
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0042	0.0058	0.0006
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0065	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0058	0.0006
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0052	0.0076
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0268	0.1976	0.2868
Echinococcus granulosus	epidermal growth factor receptor	0.0248	0.1804	0.1804
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0143	0.0917	0.0917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Loa Loa (eye worm)	cysteine protease	0.0068	0.0279	0.0227
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0848	0.689	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0058	0.0085
Onchocerca volvulus		0.0068	0.0279	0.0323
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0042	0.0058	0.0085
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0042	0.0058	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0404	0.3123	0.4532
Brugia malayi	Peptidase family M1 containing protein	0.0065	0.0251	0.0364
Leishmania major	cathepsin L-like protease	0.0068	0.0279	0.0042
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0848	0.689	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0065	0.0251	0.0251
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0042	0.0058	0.0058
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0158	0.1046	0.1046
Echinococcus multilocularis	ecdysone induced protein 78C	0.0042	0.0058	0.0058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Loa Loa (eye worm)	ctsf protein	0.0068	0.0279	0.0227
Loa Loa (eye worm)	fibroinase	0.0068	0.0279	0.0227
Echinococcus granulosus	mitogen activated protein kinase 3	0.0268	0.1976	0.1976
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0158	0.1046	0.1046
Echinococcus multilocularis	cathepsin L cysteine protease	0.0068	0.0279	0.0279
Brugia malayi	TATA binding protein associated factor	0.0065	0.0251	0.0364
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0268	0.1976	0.1933
Plasmodium vivax	vivapain-2	0.0068	0.0279	0.0405
Schistosoma mansoni	tyrosine kinase	0.0158	0.1046	0.1046
Brugia malayi	Peptidase family M1 containing protein	0.0065	0.0251	0.0364
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0042	0.0058	0.0058
Schistosoma mansoni	tyrosine kinase	0.0158	0.1046	0.1046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Onchocerca volvulus		0.0068	0.0279	0.0323
Trypanosoma brucei	protein kinase, putative	0.0268	0.1976	0.2868
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0149	0.0968	0.0968
Schistosoma mansoni	cathepsin F (C01 family)	0.0068	0.0279	0.0279
Trypanosoma brucei	aminopeptidase, putative	0.0065	0.0251	0.0364
Trichomonas vaginalis	CMGC family protein kinase	0.0268	0.1976	0.6327
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0158	0.1046	0.1046
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0089	0.0036
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0065	0.0251	0.0364
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0248	0.1804	0.1804
Loa Loa (eye worm)	TK/INSR protein kinase	0.0149	0.0968	0.0921
Schistosoma mansoni	cathepsin F (C01 family)	0.0068	0.0279	0.0279
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Onchocerca volvulus		0.0045	0.0089	0.0045
Schistosoma mansoni	retinoic acid receptor RXR	0.0042	0.0058	0.0058
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0161	0.1067	0.1067
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0065	0.0251	0.0251
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0143	0.0917	0.0917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0045	0.0089	0.0284
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0042	0.0058	0.0085
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0279	0.0405
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0214	0.031
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0158	0.1046	0.1046
Trichomonas vaginalis	CMGC family protein kinase	0.0268	0.1976	0.6327
Echinococcus multilocularis		0.014	0.0893	0.0893
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0042	0.0058	0.0085
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0279	0.0405
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0068	0.0279	0.0279
Entamoeba histolytica	protein kinase, putative	0.0128	0.0785	1
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0279	0.0405
Echinococcus multilocularis	epidermal growth factor receptor	0.0248	0.1804	0.1804
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.1215	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0045	0.0089	0.0129
Echinococcus granulosus	tyrosine protein kinase HCK	0.0128	0.0785	0.0785
Brugia malayi	Steroid receptor seven-up type 2	0.0042	0.0058	0.0085
Echinococcus granulosus	FTZ F1 alpha	0.0042	0.0058	0.0058
Echinococcus multilocularis	c src tyrosine kinase	0.0038	0.0023	0.0023
Schistosoma mansoni	tyrosine kinase	0.0241	0.1746	0.1746
Plasmodium vivax	vivapain-2	0.0068	0.0279	0.0405
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0065	0.0251	0.0364
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0158	0.1046	0.1046
Echinococcus granulosus	cathepsin l1	0.0068	0.0279	0.0279
Brugia malayi	nuclear receptor NHR-88	0.0042	0.0058	0.0085
Echinococcus multilocularis	FTZ F1 alpha	0.0042	0.0058	0.0058
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0058	0.0058
Brugia malayi	SRC-1	0.0158	0.1046	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0279	0.0227
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0058	0.0058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0279	0.0405
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.0058	0.0058
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0279	0.0893
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0042	0.0058	0.0058
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0268	0.1976	0.2868
Schistosoma mansoni	tyrosine kinase	0.0038	0.0023	0.0023
Leishmania major	cathepsin L-like protease	0.0068	0.0279	0.0042
Schistosoma mansoni	tyrosine kinase	0.0248	0.1804	0.1804
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0089	0.0036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.1215	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0068	0.0279	0.0279
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0279	0.0893
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0065	0.0251	0.0251
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0065	0.0251	0.0803
Brugia malayi	ecdysteroid receptor	0.0042	0.0058	0.0085
Loa Loa (eye worm)	SRC-1	0.0158	0.1046	0.0999
Loa Loa (eye worm)	steroid hormone receptor	0.0042	0.0058	0.0006
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0038	0.0023	0.0023
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0279	0.0893
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0136	0.0858	0.0858
Echinococcus multilocularis	cysteine protease	0.0068	0.0279	0.0279
Leishmania major	cathepsin L-like protease	0.0068	0.0279	0.0042
Loa Loa (eye worm)	thymidylate synthase	0.0848	0.689	0.6874
Trypanosoma brucei	Aminopeptidase M1, putative	0.0065	0.0251	0.0364
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0279	0.0893
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0065	0.0251	0.0803
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0045	0.0089	0.0284
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0279	0.0893
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0058	0.0085
Echinococcus granulosus	tyrosine kinase	0.0143	0.0917	0.0917
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0065	0.0251	0.0251

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1719821

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1481586