Detailed information for compound 1481586

Basic information

Technical information
  • TDR Targets ID: 1481586
  • Name: (2S)-N-(2-chlorophenyl)-1-(4-methylphenyl)sul fonylpyrrolidine-2-carboxamide
  • MW: 378.873 | Formula: C18H19ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.49 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H]1CCCN1S(=O)(=O)c1ccc(cc1)C)Nc1ccccc1Cl
  • InChi: 1S/C18H19ClN2O3S/c1-13-8-10-14(11-9-13)25(23,24)21-12-4-7-17(21)18(22)20-16-6-3-2-5-15(16)19/h2-3,5-6,8-11,17H,4,7,12H2,1H3,(H,20,22)/t17-/m0/s1
  • InChiKey: YKVOZXOGCIHQSK-KRWDZBQOSA-N  

Network

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Synonyms

  • (2S)-N-(2-chlorophenyl)-1-(4-methylphenyl)sulfonyl-pyrrolidine-2-carboxamide
  • (2S)-N-(2-chlorophenyl)-1-(4-methylphenyl)sulfonyl-2-pyrrolidinecarboxamide
  • T5285986
  • ZINC01510713

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0068 0.0279 0.0893
Brugia malayi Tyrosine-protein kinase abl-1 0.0038 0.0023 0.0034
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0279 0.0405
Loa Loa (eye worm) TK protein kinase 0.0128 0.0785 0.0737
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0158 0.1046 0.1046
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0149 0.0968 0.0968
Brugia malayi hypothetical protein 0.0065 0.0251 0.0364
Schistosoma mansoni aminopeptidase A (M01 family) 0.0065 0.0251 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0058 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0058 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0068 0.0279 0.0893
Schistosoma mansoni tyrosine kinase 0.0149 0.0968 0.0968
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0848 0.689 1
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0058 0.0058
Echinococcus granulosus aminopeptidase N 0.0065 0.0251 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0279 0.0405
Loa Loa (eye worm) TATA binding protein associated factor 0.0065 0.0251 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0065 0.0251 0.0364
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0158 0.1046 0.1046
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0058 0.0058
Leishmania major cathepsin L-like protease 0.0068 0.0279 0.0042
Brugia malayi Cathepsin L-like precursor 0.0045 0.0089 0.0129
Schistosoma mansoni coup transcription factor 0.0042 0.0058 0.0058
Brugia malayi Cathepsin L-like precursor 0.0068 0.0279 0.0405
Brugia malayi Cathepsin L-like precursor 0.0068 0.0279 0.0405
Loa Loa (eye worm) hypothetical protein 0.006 0.0214 0.0162
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0065 0.0251 0.0251
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0065 0.0251 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0058 0.0085
Echinococcus multilocularis tyrosine protein kinase Blk 0.0143 0.0917 0.0917
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0058 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0058 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0158 0.1046 0.1046
Schistosoma mansoni tyrosine kinase 0.0149 0.0968 0.0968
Trypanosoma cruzi aminopeptidase, putative 0.0065 0.0251 0.0364
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0058 0.0058
Leishmania major cathepsin L-like protease 0.0068 0.0279 0.0042
Echinococcus multilocularis mitogen activated protein kinase 0.0268 0.1976 0.1976
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0848 0.689 1
Schistosoma mansoni tyrosine kinase 0.0241 0.1746 0.1746
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0068 0.0279 0.0405
Onchocerca volvulus 0.0068 0.0279 0.0323
Echinococcus granulosus epidermal growth factor receptor 0.0458 0.3582 0.3582
Leishmania major cathepsin L-like protease 0.0068 0.0279 0.0042
Brugia malayi MAP kinase sur-1 0.0268 0.1976 0.2868
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0065 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0065 0.0251 0.0199
Onchocerca volvulus 0.0068 0.0279 0.0323
Echinococcus granulosus mitogen activated protein kinase 0.0268 0.1976 0.1976
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0065 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0045 0.0089 0.0036
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0058 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0279 0.0405
Onchocerca volvulus Cathepsin L homolog 0.0068 0.0279 0.0323
Echinococcus granulosus tyrosine protein kinase Src42A 0.0158 0.1046 0.1046
Brugia malayi Cathepsin L-like precursor 0.0045 0.0089 0.0129
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0065 0.0251 0.0251
Schistosoma mansoni tyrosine kinase 0.0458 0.3582 0.3582
Loa Loa (eye worm) hypothetical protein 0.0042 0.0058 0.0006
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0065 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0042 0.0058 0.0006
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0279 0.0405
Trichomonas vaginalis CMGC family protein kinase 0.0268 0.1976 0.6327
Toxoplasma gondii cathepsin CPL 0.0068 0.0279 0.0042
Echinococcus granulosus tyrosine protein kinase Src64B 0.0158 0.1046 0.1046
Leishmania major cathepsin L-like protease 0.0068 0.0279 0.0042
Brugia malayi thymidylate synthase 0.0848 0.689 1
Trichomonas vaginalis CMGC family protein kinase 0.0268 0.1976 0.6327
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0058 0.0058
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0065 0.0251 0.0364
Echinococcus granulosus tyrosine protein kinase Blk 0.0143 0.0917 0.0917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0279 0.0405
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0279 0.0405
Entamoeba histolytica aminopeptidase, putative 0.0065 0.0251 0.3194
Schistosoma mansoni tyrosine kinase 0.0248 0.1804 0.1804
Loa Loa (eye worm) hypothetical protein 0.0042 0.0058 0.0006
Loa Loa (eye worm) TK protein kinase 0.0143 0.0917 0.0869
Echinococcus multilocularis thymidylate synthase 0.0848 0.689 0.689
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0214 0.0162
Brugia malayi Cathepsin L-like cysteine proteinase 0.0045 0.0089 0.0129
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0058 0.0058
Brugia malayi Peptidase family M1 containing protein 0.0065 0.0251 0.0364
Onchocerca volvulus 0.0068 0.0279 0.0323
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0268 0.1976 0.2598
Loa Loa (eye worm) hypothetical protein 0.0065 0.0251 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0279 0.0405
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0268 0.1976 0.2868
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0279 0.0405
Trypanosoma cruzi Aminopeptidase M1, putative 0.0065 0.0251 0.0364
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0268 0.1976 0.2598
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0089 0.1129
Brugia malayi protein-tyrosine kinase 0.0143 0.0917 0.1331
Echinococcus granulosus tyrosine protein kinase Src42A 0.0136 0.0858 0.0858
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0058 0.0058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0058 0.0058
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0038 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0068 0.0279 0.0893
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0279 0.355
Entamoeba histolytica cysteine protease, putative 0.0068 0.0279 0.355
Brugia malayi steroid hormone receptor 0.0042 0.0058 0.0085
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0065 0.0251 0.0364
Onchocerca volvulus 0.0065 0.0251 0.0282
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0068 0.0279 0.0405
Loa Loa (eye worm) TK/EGFR protein kinase 0.0458 0.3582 0.3548
Echinococcus multilocularis aminopeptidase N 0.0065 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0065 0.0251 0.0199
Echinococcus multilocularis mitogen activated protein kinase 3 0.0268 0.1976 0.1976
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0058 0.0006
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0279 0.0405
Trypanosoma brucei Aminopeptidase M1, putative 0.0065 0.0251 0.0364
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0158 0.1046 0.1046
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0065 0.0251 0.0251
Echinococcus granulosus tyrosine protein kinase Fyn 0.0158 0.1046 0.1046
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0848 0.689 1
Onchocerca volvulus 0.0068 0.0279 0.0323
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0058 0.0058
Brugia malayi Cathepsin L-like precursor 0.0068 0.0279 0.0405
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0058 0.0058
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0068 0.0279 0.0279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0279 0.0405
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0058 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0058 0.0085
Brugia malayi hypothetical protein 0.0559 0.4438 0.644
Echinococcus granulosus tyrosine protein kinase Fyn 0.0158 0.1046 0.1046
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0065 0.0251 0.0251
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0058 0.0058
Brugia malayi hypothetical protein 0.0404 0.3123 0.4532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0068 0.0279 0.0893
Loa Loa (eye worm) hypothetical protein 0.0042 0.0058 0.0006
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0158 0.1046 0.1046
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0068 0.0279 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0279 0.0405
Echinococcus granulosus tyrosine protein kinase Fyn 0.0158 0.1046 0.1046
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0065 0.0251 0.0364
Echinococcus granulosus c src tyrosine kinase 0.0038 0.0023 0.0023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0058 0.0085
Schistosoma mansoni tyrosine kinase 0.0038 0.0023 0.0023
Echinococcus granulosus thymidylate synthase 0.0848 0.689 0.689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0058 0.0006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0058 0.0006
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0268 0.1976 0.2598
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0848 0.689 0.5
Leishmania major cathepsin L-like protease 0.0068 0.0279 0.0042
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0065 0.0251 0.0364
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0058 0.0058
Echinococcus multilocularis tyrosine protein kinase HCK 0.0128 0.0785 0.0785
Brugia malayi Cathepsin L-like precursor 0.0068 0.0279 0.0405
Loa Loa (eye worm) hypothetical protein 0.0042 0.0058 0.0006
Mycobacterium ulcerans thymidylate synthase 0.0848 0.689 1
Brugia malayi hypothetical protein 0.0065 0.0251 0.0364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0058 0.0006
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1215 1 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0065 0.0251 0.0803
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0268 0.1976 0.2868
Loa Loa (eye worm) hypothetical protein 0.0042 0.0058 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0058 0.0085
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0848 0.689 0.689
Echinococcus multilocularis tyrosine protein kinase Abl 0.0038 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0848 0.689 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0065 0.0251 0.0199
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0065 0.0251 0.0364
Brugia malayi Papain family cysteine protease containing protein 0.0068 0.0279 0.0405
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0158 0.1046 0.1046
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Brugia malayi nuclear hormone receptor 0.0042 0.0058 0.0085
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0214 0.031
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0065 0.0251 0.0364
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0068 0.0279 0.0893
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0268 0.1976 0.2868
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0058 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0068 0.0279 0.0893
Echinococcus granulosus insulin receptor 0.0149 0.0968 0.0968
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0279 0.0405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0068 0.0279 0.0893
Brugia malayi cathepsin L-like precursor 0.0045 0.0089 0.0129
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0279 0.355
Schistosoma mansoni tyrosine kinase 0.0241 0.1746 0.1746
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0065 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0042 0.0058 0.0006
Echinococcus granulosus cathepsin l1 0.0045 0.0089 0.0089
Onchocerca volvulus Cathepsin F homolog 0.0068 0.0279 0.0323
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0058 0.0058
Giardia lamblia Kinase, CMGC MAPK 0.0268 0.1976 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0404 0.3123 1
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0058 0.0006
Echinococcus multilocularis epidermal growth factor receptor 0.0458 0.3582 0.3582
Schistosoma mansoni cathepsin F (C01 family) 0.0045 0.0089 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0268 0.1976 0.1976
Schistosoma mansoni hypothetical protein 0.0041 0.0052 0.0052
Onchocerca volvulus 0.0848 0.689 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0068 0.0279 0.0279
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0848 0.689 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0058 0.0058
Brugia malayi Cathepsin L-like precursor 0.0068 0.0279 0.0405
Onchocerca volvulus Cathepsin L homolog 0.0068 0.0279 0.0323
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0038 0.0023 0.0023
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0068 0.0279 0.0227
Echinococcus multilocularis cysteine protease 0.0068 0.0279 0.0279
Onchocerca volvulus 0.0065 0.0251 0.0282
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0143 0.0917 0.0917
Echinococcus multilocularis insulin receptor 0.0149 0.0968 0.0968
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0279 0.0405
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0068 0.0279 0.0279
Onchocerca volvulus 0.0065 0.0251 0.0282
Loa Loa (eye worm) aminopeptidase N 0.0065 0.0251 0.0199
Onchocerca volvulus 0.0068 0.0279 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0058 0.0006
Trypanosoma cruzi aminopeptidase, putative 0.0065 0.0251 0.0364
Plasmodium falciparum cysteine proteinase falcipain 3 0.0068 0.0279 0.0405
Brugia malayi Protein kinase domain containing protein 0.0149 0.0968 0.1405
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0058 0.0058
Leishmania major cysteine peptidase A (CPA) 0.0068 0.0279 0.0042
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0065 0.0251 0.0251
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0065 0.0251 0.0251
Brugia malayi Furin-like cysteine rich region family protein 0.0458 0.3582 0.5198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0058 0.0006
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0065 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0042 0.0058 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0052 0.0076
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0268 0.1976 0.2868
Echinococcus granulosus epidermal growth factor receptor 0.0248 0.1804 0.1804
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0143 0.0917 0.0917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Loa Loa (eye worm) cysteine protease 0.0068 0.0279 0.0227
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0848 0.689 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0058 0.0085
Onchocerca volvulus 0.0068 0.0279 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0058 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0058 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0404 0.3123 0.4532
Brugia malayi Peptidase family M1 containing protein 0.0065 0.0251 0.0364
Leishmania major cathepsin L-like protease 0.0068 0.0279 0.0042
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0848 0.689 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0065 0.0251 0.0251
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0058 0.0058
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0158 0.1046 0.1046
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Loa Loa (eye worm) ctsf protein 0.0068 0.0279 0.0227
Loa Loa (eye worm) fibroinase 0.0068 0.0279 0.0227
Echinococcus granulosus mitogen activated protein kinase 3 0.0268 0.1976 0.1976
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0158 0.1046 0.1046
Echinococcus multilocularis cathepsin L cysteine protease 0.0068 0.0279 0.0279
Brugia malayi TATA binding protein associated factor 0.0065 0.0251 0.0364
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0268 0.1976 0.1933
Plasmodium vivax vivapain-2 0.0068 0.0279 0.0405
Schistosoma mansoni tyrosine kinase 0.0158 0.1046 0.1046
Brugia malayi Peptidase family M1 containing protein 0.0065 0.0251 0.0364
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0058 0.0058
Schistosoma mansoni tyrosine kinase 0.0158 0.1046 0.1046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Onchocerca volvulus 0.0068 0.0279 0.0323
Trypanosoma brucei protein kinase, putative 0.0268 0.1976 0.2868
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0149 0.0968 0.0968
Schistosoma mansoni cathepsin F (C01 family) 0.0068 0.0279 0.0279
Trypanosoma brucei aminopeptidase, putative 0.0065 0.0251 0.0364
Trichomonas vaginalis CMGC family protein kinase 0.0268 0.1976 0.6327
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0158 0.1046 0.1046
Loa Loa (eye worm) hypothetical protein 0.0045 0.0089 0.0036
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0065 0.0251 0.0364
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0248 0.1804 0.1804
Loa Loa (eye worm) TK/INSR protein kinase 0.0149 0.0968 0.0921
Schistosoma mansoni cathepsin F (C01 family) 0.0068 0.0279 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Onchocerca volvulus 0.0045 0.0089 0.0045
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0058 0.0058
Echinococcus granulosus tyrosine protein kinase Lyn 0.0161 0.1067 0.1067
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0065 0.0251 0.0251
Echinococcus multilocularis tyrosine protein kinase Srms 0.0143 0.0917 0.0917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0089 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0058 0.0085
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0279 0.0405
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0214 0.031
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0158 0.1046 0.1046
Trichomonas vaginalis CMGC family protein kinase 0.0268 0.1976 0.6327
Echinococcus multilocularis 0.014 0.0893 0.0893
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0058 0.0085
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0279 0.0405
Echinococcus granulosus cathepsin L cysteine proteinase 0.0068 0.0279 0.0279
Entamoeba histolytica protein kinase, putative 0.0128 0.0785 1
Brugia malayi Cathepsin L-like precursor 0.0068 0.0279 0.0405
Echinococcus multilocularis epidermal growth factor receptor 0.0248 0.1804 0.1804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1215 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0045 0.0089 0.0129
Echinococcus granulosus tyrosine protein kinase HCK 0.0128 0.0785 0.0785
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0058 0.0085
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0058 0.0058
Echinococcus multilocularis c src tyrosine kinase 0.0038 0.0023 0.0023
Schistosoma mansoni tyrosine kinase 0.0241 0.1746 0.1746
Plasmodium vivax vivapain-2 0.0068 0.0279 0.0405
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0065 0.0251 0.0364
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0158 0.1046 0.1046
Echinococcus granulosus cathepsin l1 0.0068 0.0279 0.0279
Brugia malayi nuclear receptor NHR-88 0.0042 0.0058 0.0085
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0058 0.0058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0058 0.0058
Brugia malayi SRC-1 0.0158 0.1046 0.1518
Loa Loa (eye worm) hypothetical protein 0.0068 0.0279 0.0227
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0058 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0279 0.0405
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0068 0.0279 0.0893
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0058 0.0058
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0268 0.1976 0.2868
Schistosoma mansoni tyrosine kinase 0.0038 0.0023 0.0023
Leishmania major cathepsin L-like protease 0.0068 0.0279 0.0042
Schistosoma mansoni tyrosine kinase 0.0248 0.1804 0.1804
Loa Loa (eye worm) hypothetical protein 0.0045 0.0089 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1215 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0068 0.0279 0.0279
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0068 0.0279 0.0893
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0065 0.0251 0.0251
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0065 0.0251 0.0803
Brugia malayi ecdysteroid receptor 0.0042 0.0058 0.0085
Loa Loa (eye worm) SRC-1 0.0158 0.1046 0.0999
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0058 0.0006
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0038 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0068 0.0279 0.0893
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0136 0.0858 0.0858
Echinococcus multilocularis cysteine protease 0.0068 0.0279 0.0279
Leishmania major cathepsin L-like protease 0.0068 0.0279 0.0042
Loa Loa (eye worm) thymidylate synthase 0.0848 0.689 0.6874
Trypanosoma brucei Aminopeptidase M1, putative 0.0065 0.0251 0.0364
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0279 0.0893
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0065 0.0251 0.0803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0089 0.0284
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0068 0.0279 0.0893
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0058 0.0085
Echinococcus granulosus tyrosine kinase 0.0143 0.0917 0.0917
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0065 0.0251 0.0251

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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