Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1315 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0518 | 0.0559 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.1315 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.1315 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1315 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7332 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3186 | 0.4076 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0851 | 0.0739 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1315 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0851 | 0.0679 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.1315 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.1315 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4357 | 0.4709 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0518 | 0.0242 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1315 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1315 | 0.1421 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9254 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3186 | 0.4076 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7332 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3611 | 0.3902 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4024 | 0.4348 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3599 | 0.2673 |
Brugia malayi | hypothetical protein | 0.003 | 0.1315 | 0.0059 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7956 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0851 | 0.0739 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.