Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0178 | 0.2205 | 0.2205 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0054 | 0.0397 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0851 | 0.0588 |
Onchocerca volvulus | 0.012 | 0.1359 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.012 | 0.1359 | 0.5 |
Onchocerca volvulus | 0.012 | 0.1359 | 0.5 | |
Brugia malayi | Bromodomain containing protein | 0.0095 | 0.099 | 0.0894 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.012 | 0.1359 | 0.1359 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1359 | 0.111 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.012 | 0.1359 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.012 | 0.1359 | 0.1359 |
Brugia malayi | Carboxylesterase family protein | 0.012 | 0.1359 | 0.1267 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.0292 | 0.5 |
Onchocerca volvulus | 0.012 | 0.1359 | 0.5 | |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.0292 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.012 | 0.1359 | 0.1267 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1359 | 0.111 |
Schistosoma mansoni | zinc finger protein | 0.0028 | 0.001 | 0.001 |
Brugia malayi | Carboxylesterase family protein | 0.012 | 0.1359 | 0.1267 |
Schistosoma mansoni | acetylcholinesterase | 0.012 | 0.1359 | 0.1359 |
Echinococcus multilocularis | neuroligin | 0.012 | 0.1359 | 0.1359 |
Loa Loa (eye worm) | acetyltransferase | 0.0178 | 0.2205 | 0.198 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.012 | 0.1359 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.012 | 0.1359 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.012 | 0.1359 | 0.1267 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0711 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.012 | 0.1359 | 0.1359 |
Schistosoma mansoni | gliotactin | 0.012 | 0.1359 | 0.1359 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0076 | 0.0719 | 0.0719 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0054 | 0.0397 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0711 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.012 | 0.1359 | 0.1359 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.012 | 0.1359 | 0.1359 |
Brugia malayi | Carboxylesterase family protein | 0.0711 | 1 | 1 |
Onchocerca volvulus | 0.012 | 0.1359 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0711 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.012 | 0.1359 | 0.1267 |
Schistosoma mansoni | bromodomain containing protein | 0.0081 | 0.0783 | 0.0783 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.012 | 0.1359 | 0.1359 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.012 | 0.1359 | 0.1359 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0054 | 0.0397 | 0.0397 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0178 | 0.2205 | 0.2205 |
Echinococcus granulosus | acetylcholinesterase | 0.0711 | 1 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0028 | 0.001 | 0.001 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0178 | 0.2205 | 0.2122 |
Onchocerca volvulus | 0.012 | 0.1359 | 0.5 | |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0237 | 0.0237 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0711 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.012 | 0.1359 | 0.1359 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.012 | 0.1359 | 0.1359 |
Loa Loa (eye worm) | carboxylesterase | 0.012 | 0.1359 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1359 | 0.111 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0054 | 0.0397 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1359 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1359 | 0.111 |
Brugia malayi | Bromodomain containing protein | 0.0051 | 0.0341 | 0.0239 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.2091 | 0.2091 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0418 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0384 | 0.0108 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.012 | 0.1359 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.012 | 0.1359 | 0.111 |
Echinococcus granulosus | acetylcholinesterase | 0.0711 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0711 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0711 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0711 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0711 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.012 | 0.1359 | 0.1359 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0237 | 0.0237 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1359 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1359 | 0.111 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.0292 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0028 | 0.001 | 0.001 |
Echinococcus granulosus | carboxylesterase 5A | 0.0711 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.012 | 0.1359 | 0.1359 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0076 | 0.0719 | 0.0719 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.012 | 0.1359 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.012 | 0.1359 | 0.1359 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5012 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.