Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0541 | 0.0515 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0185 | 0.0158 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0064 | 0.0624 | 0.0598 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0541 | 0.0515 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0668 | 0.1917 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0505 | 1 | 1 |
Onchocerca volvulus | 0.0286 | 0.534 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.3251 | 0.3232 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0258 | 0.4738 | 0.4723 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0258 | 0.4738 | 0.4738 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.4603 | 0.4587 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0185 | 0.0158 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0321 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0541 | 0.0515 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0185 | 0.0158 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0505 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0321 | 0.0294 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0064 | 0.0624 | 0.0598 |
Brugia malayi | jmjC domain containing protein | 0.0064 | 0.0624 | 0.0598 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0321 | 0.0294 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0185 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0505 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0379 | 0.0352 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0193 | 0.3368 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.4738 | 0.4723 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0064 | 0.0624 | 0.0624 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0668 | 0.0642 |
Onchocerca volvulus | 0.0053 | 0.0379 | 0.0661 | |
Schistosoma mansoni | jumonji domain containing protein | 0.0064 | 0.0624 | 0.0598 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0321 | 0.0294 |
Echinococcus multilocularis | geminin | 0.0188 | 0.3251 | 0.3232 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0064 | 0.0624 | 0.0598 |
Brugia malayi | hypothetical protein | 0.0258 | 0.4738 | 0.4723 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0185 | 0.5 |
Echinococcus granulosus | geminin | 0.0188 | 0.3251 | 0.3251 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0137 | 0.0109 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.0379 | 0.0352 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0137 | 0.0109 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0321 | 0.0294 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.0624 | 0.0598 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0193 | 0.3368 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0321 | 0.0321 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0321 | 0.0321 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0668 | 0.0668 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0321 | 0.0294 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0185 | 0.0185 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.534 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.0379 | 0.0352 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0028 | 0.0028 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0668 | 0.0642 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0321 | 0.0294 |
Schistosoma mansoni | dihydrofolate reductase | 0.0505 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0505 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0505 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0505 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0505 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0193 | 0.3368 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0064 | 0.0624 | 0.0624 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.3251 | 0.3232 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0668 | 0.0642 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0185 | 0.0158 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0064 | 0.0624 | 0.0598 |
Brugia malayi | jmjC domain containing protein | 0.0064 | 0.0624 | 0.0598 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0541 | 0.0515 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0193 | 0.3368 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0505 | 1 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.4603 | 0.4587 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0185 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0137 | 0.0109 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0193 | 0.3368 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0193 | 0.3368 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0185 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.122 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.