Detailed information for compound 1483167

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 194.21 | Formula: C8H6N2O2S
  • H donors: 2 H acceptors: 1 LogP: 0.78 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1NC(=O)C(=Cc2ccco2)N1
  • InChi: 1S/C8H6N2O2S/c11-7-6(9-8(13)10-7)4-5-2-1-3-12-5/h1-4H,(H2,9,10,11,13)
  • InChiKey: GARSQZBFJYWLJC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.0061 0.0025 0.0023
Brugia malayi hypothetical protein 0.0061 0.0025 0.0023
Onchocerca volvulus 0.0061 0.0025 0.5
Brugia malayi larval opioid receptor 0.0061 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus multilocularis serotonin receptor 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0025 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0025 0.006
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0061 0.0025 0.0023
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2507 0.387 1
Brugia malayi Thioredoxin reductase 0.0057 0.0019 0.0016
Plasmodium falciparum dihydroorotate dehydrogenase 0.6408 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0061 0.0025 0.0023
Loa Loa (eye worm) G-protein coupled receptor 0.0061 0.0025 0.0519
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus granulosus somatostatin receptor 0.0061 0.0025 0.006
Schistosoma mansoni amine GPCR 0.0061 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.2507 0.387 1
Echinococcus granulosus G protein coupled receptor 139 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Loa Loa (eye worm) glutaminase 2 0.033 0.0448 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0061 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.0025 0.0023
Brugia malayi GnHR receptor homolog 0.0061 0.0025 0.0023
Echinococcus multilocularis neuropeptide Y receptor 0.0061 0.0025 0.006
Brugia malayi Serotonin receptor 0.0061 0.0025 0.0023
Echinococcus granulosus peptide allatostatin:somatostatin 0.0061 0.0025 0.006
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0061 0.0025 0.006
Schistosoma mansoni biogenic amine receptor 0.0061 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0134 0.0131
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0019 0.037
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0156 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Brugia malayi Zinc finger, C2H2 type family protein 0.2502 0.3861 0.386
Schistosoma mansoni alpha-1 adrenergic receptor 0.0061 0.0025 0.0023
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.0025 0.006
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0061 0.0025 0.006
Brugia malayi neuropeptide F receptor 0.0061 0.0025 0.0023
Onchocerca volvulus 0.0061 0.0025 0.5
Echinococcus granulosus fmrfamide receptor 0.0061 0.0025 0.006
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0061 0.0025 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0061 0.0025 0.006
Echinococcus multilocularis G-protein coupled receptor, putative 0.0061 0.0025 0.006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0025 0.006
Brugia malayi neuropeptide F receptor 0.0061 0.0025 0.0023
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.6408 1 1
Echinococcus multilocularis fmrfamide receptor 0.0061 0.0025 0.006
Echinococcus granulosus g protein coupled receptor 0.0061 0.0025 0.006
Brugia malayi glutathione reductase 0.0057 0.0019 0.0016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.0025 0.006
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0134 0.0131
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0061 0.0025 0.006
Brugia malayi Phosphoglycerate kinase 0.0075 0.0047 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0025 0.0023
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0061 0.0025 0.0023
Schistosoma mansoni opsin-like receptor 0.0061 0.0025 0.0023
Leishmania major DNA polymerase eta, putative 0.0077 0.0051 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0025 0.0023
Onchocerca volvulus 0.0061 0.0025 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Trichomonas vaginalis glutaminase, putative 0.033 0.0448 0.1152
Leishmania major hypothetical protein, conserved 0.0257 0.0333 0.0333
Onchocerca volvulus 0.0061 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.0025 0.006
Schistosoma mansoni glutaminase 0.033 0.0448 0.0446
Schistosoma mansoni opsin-like receptor 0.0061 0.0025 0.0023
Loa Loa (eye worm) RNA binding protein 0.0076 0.0049 0.1054
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0049 0.0047
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.0252 0.0252
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0061 0.0025 0.0023
Brugia malayi sulfakinin receptor protein 0.0061 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Brugia malayi Tachykinin-like peptides receptor 99D 0.0061 0.0025 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0049 0.0047
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0047 0.0047
Brugia malayi follicle stimulating hormone receptor 0.0061 0.0025 0.0023
Loa Loa (eye worm) neuropeptide F receptor 0.0061 0.0025 0.0519
Echinococcus multilocularis g protein coupled receptor 0.0061 0.0025 0.006
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.6408 1 1
Brugia malayi glutaminase DH11.1 0.033 0.0448 0.0446
Schistosoma mansoni DNA polymerase eta 0.0077 0.0051 0.0048
Onchocerca volvulus 0.0061 0.0025 0.5
Echinococcus multilocularis g protein coupled receptor 0.0061 0.0025 0.006
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0061 0.0025 0.0023
Onchocerca volvulus Neuropeptide F receptor homolog 0.0061 0.0025 0.5
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2502 0.3861 0.9979
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.0252 0.0252
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0061 0.0025 0.006
Onchocerca volvulus 0.0061 0.0025 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0051 0.0051
Loa Loa (eye worm) TYRA-2 protein 0.0061 0.0025 0.0519
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.6408 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0061 0.0025 0.006
Echinococcus multilocularis g-protein coupled receptor 0.0061 0.0025 0.006
Echinococcus granulosus neuropeptide Y receptor 0.0061 0.0025 0.006
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.6408 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0025 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0333 0.0333
Echinococcus granulosus biogenic amine 5HT receptor 0.0061 0.0025 0.006
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.0047 0.0047
Loa Loa (eye worm) glutathione reductase 0.0057 0.0019 0.037
Onchocerca volvulus 0.0061 0.0025 0.5
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.0252 0.0646
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0061 0.0025 0.0023
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0061 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.0047 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0049 0.0047
Schistosoma mansoni amine GPCR 0.0061 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0051 0.0048
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0061 0.0025 0.0519
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0061 0.0025 0.006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0025 0.006
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0156 0.0154
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.0025 0.006
Schistosoma mansoni myosin xvIII 0.0061 0.0025 0.0023
Echinococcus multilocularis neuropeptide receptor 0.0061 0.0025 0.006
Brugia malayi G protein-coupled receptor 0.0061 0.0025 0.0023
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.0252 0.0234
Echinococcus granulosus g protein coupled receptor 0.0061 0.0025 0.006
Brugia malayi Dopamine receptor 0.0061 0.0025 0.0023
Mycobacterium ulcerans glutaminase 0.033 0.0448 0.0446
Onchocerca volvulus 0.0061 0.0025 0.5
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0019 0.0019
Echinococcus granulosus neuropeptide FF receptor 2 0.0061 0.0025 0.006
Brugia malayi putative neuropeptide receptor NPR1 0.0061 0.0025 0.0023
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0156 0.0154
Leishmania major DNA polymerase kappa, putative 0.0047 0.0002 0.0002
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.0252 0.012
Brugia malayi RE15519p 0.0061 0.0025 0.0023
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0047 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0049 0.0047
Brugia malayi hypothetical protein 0.0061 0.0025 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0049 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0002 0.0002
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0061 0.0025 0.006
Schistosoma mansoni opsin-like receptor 0.0061 0.0025 0.0023
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.6408 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0061 0.0025 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0025 0.0023
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0049 0.1054
Leishmania major dihydroorotate dehydrogenase 0.6408 1 1
Echinococcus multilocularis dna polymerase eta 0.0077 0.0051 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0025 0.006
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0061 0.0025 0.006
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.0252 0.0252
Echinococcus granulosus neuropeptide s receptor 0.0061 0.0025 0.006
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.2502 0.3861 0.9979
Brugia malayi ORL1-like opioid receptor 0.0061 0.0025 0.0023
Echinococcus multilocularis dro:myosuppressin receptor 0.0061 0.0025 0.006
Schistosoma mansoni amine GPCR 0.0061 0.0025 0.0023
Onchocerca volvulus 0.0061 0.0025 0.5
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.0252 0.0646
Onchocerca volvulus 0.0061 0.0025 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0061 0.0025 0.0023
Schistosoma mansoni neuropeptide receptor 0.0061 0.0025 0.0023
Echinococcus granulosus g-protein coupled receptor 0.0061 0.0025 0.006
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.0252 0.0252
Echinococcus multilocularis neuropeptide FF receptor 2 0.0061 0.0025 0.006
Onchocerca volvulus 0.0061 0.0025 0.5
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0047 0.0047
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.2507 0.387 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0025 0.006
Brugia malayi Serotonin receptor 0.0061 0.0025 0.0023
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0002 0.0002
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0019 0.0043
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Brugia malayi G-protein coupled receptor 0.0061 0.0025 0.0023
Brugia malayi RNA binding protein 0.0076 0.0049 0.0047
Echinococcus multilocularis serotonin receptor 0.0061 0.0025 0.006
Echinococcus multilocularis neuropeptide Y receptor 0.0061 0.0025 0.006
Schistosoma mansoni dihydroorotate dehydrogenase 0.6408 1 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2507 0.387 1
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.0252 0.0252
Brugia malayi hypothetical protein 0.0061 0.0025 0.0023
Brugia malayi hypothetical protein 0.0061 0.0025 0.0023
Echinococcus multilocularis neuropeptides capa receptor 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.0252 0.025
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Schistosoma mansoni amine GPCR 0.0061 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Schistosoma mansoni histamine h1 receptor 0.0061 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Schistosoma mansoni neuropeptide receptor 0.0061 0.0025 0.0023
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.0252 0.0646
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.0333 0.0331
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.0025 0.0023
Brugia malayi Cytochrome P450 family protein 0.0059 0.0021 0.0019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.0025 0.0023
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus multilocularis neuropeptide s receptor 0.0061 0.0025 0.006
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.0252 0.025
Onchocerca volvulus 0.0061 0.0025 0.5
Echinococcus granulosus hypothetical protein 0.0061 0.0025 0.006
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0061 0.0025 0.0023
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0061 0.0025 0.0023
Echinococcus granulosus neuropeptide receptor A26 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0061 0.0025 0.0519
Schistosoma mansoni growth hormone secretagogue receptor 0.0061 0.0025 0.0023
Echinococcus granulosus neuropeptides capa receptor 0.0061 0.0025 0.006
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0061 0.0025 0.006
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.0252 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0061 0.0025 0.0519
Schistosoma mansoni hypothetical protein 0.0061 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Brugia malayi hypothetical protein 0.0061 0.0025 0.0023
Schistosoma mansoni neuropeptide F-like receptor 0.0061 0.0025 0.0023
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0047 0.0047
Echinococcus granulosus tar DNA binding protein 0.0076 0.0049 0.0121
Mycobacterium tuberculosis Probable reductase 0.013 0.0134 0.0131
Echinococcus granulosus allatostatin A receptor 0.0061 0.0025 0.006
Schistosoma mansoni adenoreceptor 0.0061 0.0025 0.0023
Echinococcus granulosus g protein coupled receptor 0.0061 0.0025 0.006
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0061 0.0025 0.0023
Echinococcus granulosus biogenic amine 5HT receptor 0.0061 0.0025 0.006
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0061 0.0025 0.006
Brugia malayi Melatonin receptor type 1A 0.0061 0.0025 0.0023
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.2507 0.387 1
Brugia malayi hypothetical protein 0.0061 0.0025 0.0023
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.0252 0.025
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0134 0.0131
Echinococcus granulosus neuropeptide Y receptor 0.0061 0.0025 0.006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0061 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0021 0.0426
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0025 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0025 0.0023
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.6408 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.0252 0.025
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.6408 1 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.2507 0.387 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Brugia malayi putative neuropeptide receptor 0.0061 0.0025 0.0023
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.0252 0.0646
Brugia malayi hypothetical protein 0.0061 0.0025 0.0023
Brugia malayi hypothetical protein 0.0061 0.0025 0.0023
Echinococcus multilocularis somatostatin receptor 0.0061 0.0025 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0025 0.0023
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0061 0.0025 0.0023
Loa Loa (eye worm) glutaminase 0.033 0.0448 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0025 0.006
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0061 0.0025 0.006
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0061 0.0025 0.006
Echinococcus granulosus 7tm_1 domain containing protein 0.0061 0.0025 0.006
Echinococcus granulosus neuropeptide receptor 0.0061 0.0025 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0025 0.0023
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0061 0.0025 0.0519
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2502 0.3861 0.9979
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.0252 0.0646
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0025 0.006
Schistosoma mansoni hypothetical protein 0.0061 0.0025 0.0023
Echinococcus granulosus sex peptide receptor 0.0061 0.0025 0.006
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0049 0.0047
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus granulosus neuropeptide receptor 0.0061 0.0025 0.006
Echinococcus granulosus dna polymerase eta 0.0077 0.0051 0.0125
Brugia malayi Dopamine receptor protein 2 0.0061 0.0025 0.0023
Onchocerca volvulus 0.0061 0.0025 0.5
Echinococcus multilocularis sex peptide receptor 0.0061 0.0025 0.006
Treponema pallidum phosphoglycerate kinase 0.0206 0.0252 0.5
Loa Loa (eye worm) hypothetical protein 0.0206 0.0252 0.5605
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.0047 0.0045
Echinococcus multilocularis fmrfamide receptor 0.0061 0.0025 0.006
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0061 0.0025 0.006
Onchocerca volvulus 0.0061 0.0025 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0002 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.0061 0.0025 0.0519
Echinococcus multilocularis allatostatin A receptor 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0061 0.0025 0.006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0049 0.1054
Brugia malayi AKH receptor 0.0061 0.0025 0.0023
Schistosoma mansoni biogenic amine receptor 0.0061 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Schistosoma mansoni hypothetical protein 0.0061 0.0025 0.0023
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.6408 1 1
Brugia malayi TAR-binding protein 0.0076 0.0049 0.0047
Echinococcus multilocularis g protein coupled receptor 0.0061 0.0025 0.006
Brugia malayi Dopamine receptor protein 1 0.0061 0.0025 0.0023
Onchocerca volvulus 0.0061 0.0025 0.5
Brugia malayi hypothetical protein 0.0061 0.0025 0.0023
Echinococcus multilocularis G protein coupled receptor 139 0.0061 0.0025 0.006
Echinococcus granulosus tachykinin peptides receptor 99D 0.0061 0.0025 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0025 0.0023
Schistosoma mansoni neuropeptide receptor 0.0061 0.0025 0.0023
Trypanosoma brucei trypanothione reductase 0.0057 0.0019 0.0016
Leishmania major trypanothione reductase 0.0057 0.0019 0.0019
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0061 0.0025 0.0023
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.0252 0.025
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0134 0.0131
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0051 0.0048
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0047 0.0047
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.0252 0.025
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.6408 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0061 0.0025 0.0023
Brugia malayi hypothetical protein 0.0061 0.0025 0.0023
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0061 0.0025 0.0519
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.6408 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0061 0.0025 0.0519
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Onchocerca volvulus 0.0061 0.0025 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0061 0.0025 0.0023
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2502 0.3861 0.3861
Echinococcus granulosus orexin receptor type 2 0.0061 0.0025 0.006
Echinococcus granulosus dro:myosuppressin receptor 0.0061 0.0025 0.006
Echinococcus granulosus neuropeptides capa receptor 0.0061 0.0025 0.006
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0134 0.0131
Giardia lamblia Phosphoglycerate kinase 0.0206 0.0252 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2502 0.3861 0.9979
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0025 0.0023
Echinococcus granulosus 7TM GPCR rhodopsin 0.0061 0.0025 0.006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0061 0.0025 0.0023
Echinococcus granulosus serotonin receptor 0.0061 0.0025 0.006
Echinococcus multilocularis orexin receptor type 2 0.0061 0.0025 0.006
Schistosoma mansoni hypothetical protein 0.0061 0.0025 0.0023
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0061 0.0025 0.0023
Loa Loa (eye worm) melatonin receptor type 1A 0.0061 0.0025 0.0519
Brugia malayi G-protein coupled receptor 0.0061 0.0025 0.0023
Schistosoma mansoni neuropeptide f receptor 76f 0.0061 0.0025 0.0023
Onchocerca volvulus 0.0061 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus multilocularis neuropeptides capa receptor 0.0061 0.0025 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0002 0.0002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0156 0.0154
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.0252 0.0234
Loa Loa (eye worm) hypothetical protein 0.0077 0.0051 0.1085
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0025 0.006
Schistosoma mansoni biogenic amine receptor 0.0061 0.0025 0.0023
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0019 0.0016
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.2507 0.387 1
Schistosoma mansoni amine GPCR 0.0061 0.0025 0.0023
Toxoplasma gondii thioredoxin reductase 0.0057 0.0019 0.0019
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0019 0.0043
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0519
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0049 0.0121
Echinococcus multilocularis neuropeptide receptor 0.0061 0.0025 0.006
Brugia malayi Phosphoglycerate kinase 0.0206 0.0252 0.025
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.6408 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 35.684 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 94.134 uM PubChem BioAssay. Counterscreen for inhibitors of T-cell receptor (TCR)-CD3 interaction: Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled BSA probe. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 33.5875 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 37.933 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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