Detailed information for compound 1483337

Basic information

Technical information
  • TDR Targets ID: 1483337
  • Name: N,N'-bis(phenylmethyl)butanediamide
  • MW: 296.364 | Formula: C18H20N2O2
  • H donors: 2 H acceptors: 2 LogP: 1.71 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccccc1)CCC(=O)NCc1ccccc1
  • InChi: 1S/C18H20N2O2/c21-17(19-13-15-7-3-1-4-8-15)11-12-18(22)20-14-16-9-5-2-6-10-16/h1-10H,11-14H2,(H,19,21)(H,20,22)
  • InChiKey: YNGRIMNXGLLGOZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N'-bis(benzyl)succinamide
  • ZINC03151984
  • BAS 01322420
  • ST001727
  • N,N'-Dibenzyl-succinamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0447 0.3186 0.3186
Trichomonas vaginalis aldo-keto reductase, putative 0.0447 0.3186 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0065 0.0392 0.1229
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0447 0.3186 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0447 0.3181 0.9984
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0022 0.0047
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0295 0.0295
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0004 0.0012
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0066 0.0404 0.1269
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0447 0.3186 1
Brugia malayi Latrophilin receptor protein 2 0.0061 0.0363 0.114
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0229 0.0708
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0788 0.2472
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0447 0.3186 0.3186
Echinococcus granulosus voltage gated potassium channel subunit 0.013 0.0866 0.0866
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0052 0.0162
Loa Loa (eye worm) hypothetical protein 0.0065 0.0392 0.1229
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0022 0.0068
Echinococcus granulosus chromobox protein 1 0.007 0.0433 0.0433
Brugia malayi hypothetical protein 0.0012 0.0007 0.0021
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.1197 0.3749
Schistosoma mansoni hypothetical protein 0.0061 0.0363 0.0363
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0623 0.0623
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0295 0.0926
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.116 0.116
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0022 0.0023
Trypanosoma cruzi aldo/keto reductase, putative 0.0447 0.3186 1
Trypanosoma brucei aldo-keto reductase, putative 0.0447 0.3186 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0022 0.0023
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0004 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0074 0.0458 0.1437
Schistosoma mansoni tubulin subunit alpha 0.002 0.0069 0.0069
Giardia lamblia DINP protein human, muc B family 0.0074 0.0458 0.1437
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0021
Trypanosoma cruzi DNA polymerase eta, putative 0.01 0.0647 0.203
Chlamydia trachomatis protoporphyrinogen oxidase 0.0065 0.0392 1
Trypanosoma brucei aldo/keto reductase, putative 0.013 0.0866 0.2718
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0087 0.0273
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0022 0.0023
Trypanosoma brucei DNA polymerase eta, putative 0.01 0.0647 0.203
Echinococcus multilocularis tubulin alpha 1C chain 0.002 0.0069 0.0069
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0406 0.0406
Loa Loa (eye worm) transcription factor SMAD2 0.0231 0.1603 0.503
Echinococcus multilocularis tubulin alpha chain 0.002 0.0069 0.0069
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.003 0.0094
Onchocerca volvulus 0.0014 0.0022 0.0056
Mycobacterium tuberculosis Possible toxin MazF4 0.0129 0.0864 0.1395
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0447 0.3186 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0376 0.0376
Trypanosoma brucei alpha tubulin 0.002 0.0069 0.0216
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0022 0.0023
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0016 0.0034 0.0107
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0022 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0928 0.0928
Schistosoma mansoni smad 0.0016 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0061 0.0363 0.0363
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0192 0.1321 0.4147
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0135 0.0422
Echinococcus granulosus smad 0.0016 0.0035 0.0035
Echinococcus granulosus cpg binding protein 0.0033 0.0157 0.0157
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0201 0.0201
Entamoeba histolytica hypothetical protein 0.0012 0.0004 0.0012
Echinococcus multilocularis chromobox protein 1 0.007 0.0433 0.0433
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0918 0.6618 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0229 0.072
Toxoplasma gondii aldose reductase, putative 0.0447 0.3186 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.022 0.069
Echinococcus granulosus tubulin alpha chain 0.002 0.0069 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0291 0.0913
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0016 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0022 0.0023
Echinococcus multilocularis dna polymerase kappa 0.0074 0.0458 0.0458
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0266 0.0835
Leishmania major alpha tubulin 0.002 0.0069 0.0216
Mycobacterium ulcerans oxidoreductase 0.0447 0.3186 0.4809
Leishmania major alpha tubulin 0.002 0.0069 0.0216
Mycobacterium tuberculosis Conserved protein 0.013 0.0866 0.1399
Brugia malayi topoisomerase 0.0012 0.0007 0.0021
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0016 0.0189
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0165 0.0256
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0012
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0022 0.0023
Schistosoma mansoni hypothetical protein 0.0029 0.0135 0.0135
Onchocerca volvulus 0.0031 0.0145 0.0445
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0016 0.0189
Trichomonas vaginalis hypothetical protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0035 0.0108
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0022 0.0249
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.013 0.0866 0.2718
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0447 0.3186 0.3186
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0007 0.0021
Mycobacterium tuberculosis Probable oxidoreductase 0.0447 0.3186 0.5178
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0087 0.0087
Giardia lamblia PHD finger protein 15 0.0029 0.0135 0.0422
Mycobacterium tuberculosis Toxin MazF9 0.0129 0.0864 0.1395
Trypanosoma cruzi ABC transporter, putative 0.004 0.0209 0.0656
Echinococcus multilocularis chromobox protein 2 0.0012 0.0004 0.0004
Mycobacterium tuberculosis Possible toxin MazF7 0.0129 0.0864 0.1395
Schistosoma mansoni cpg binding protein 0.0033 0.0157 0.0157
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0292 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0012
Plasmodium vivax SET domain protein, putative 0.0031 0.0144 0.1666
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.002 0.0069 0.0216
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0266 0.0422
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0016 0.0189
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0295 0.0926
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0033 0.0162 0.0251
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0371 0.0371
Entamoeba histolytica alcohol dehydrogenase, putative 0.013 0.0866 0.2718
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0016 0.0015
Plasmodium falciparum glutathione reductase 0.0013 0.0016 0.0189
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0853 0.6146 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0087 0.0273
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0198 0.2291
Echinococcus granulosus ATP binding cassette sub family G 0.004 0.0209 0.0209
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0004 0.0012
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0918 0.6618 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0074 0.0458 0.0734
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0035 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0928 0.0928
Echinococcus multilocularis protein patched 0.0051 0.0292 0.0292
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0192 0.1321 0.4147
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0368 0.1155
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0447 0.3186 0.3186
Echinococcus granulosus Tubulin alpha 1 chain 0.002 0.0069 0.0069
Leishmania major alpha tubulin 0.002 0.0069 0.0216
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0023
Entamoeba histolytica hypothetical protein 0.0043 0.0237 0.0744
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.018 0.018
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.003 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0237 0.0237
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0447 0.3186 0.3186
Trypanosoma brucei alpha tubulin 0.002 0.0069 0.0216
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0266 0.0393
Leishmania major alpha tubulin 0.002 0.0069 0.0216
Onchocerca volvulus 0.0012 0.0004 0.000000028929
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0004 0.0012
Schistosoma mansoni ets-related 0.0222 0.1539 0.1539
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0065 0.0392 0.4522
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0447 0.3186 0.3186
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0012
Onchocerca volvulus 0.0447 0.3181 0.9984
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.004 0.0209 0.0656
Echinococcus multilocularis aldo keto reductase 0.0447 0.3186 0.3186
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0788 0.2472
Echinococcus multilocularis zinc finger protein 0.0021 0.0076 0.0076
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0052 0.0162
Trypanosoma brucei protein kinase, putative 0.0051 0.0295 0.0926
Onchocerca volvulus 0.0447 0.3186 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0179 0.0561
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0295 0.0926
Echinococcus granulosus aldehyde reductase 0.0318 0.224 0.224
Mycobacterium tuberculosis Conserved hypothetical protein 0.0065 0.0392 0.0626
Toxoplasma gondii histone lysine-specific demethylase 0.0065 0.0392 0.1229
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0229 0.072
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0144 0.0453
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0007 0.0021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0068
Schistosoma mansoni zinc finger protein 0.0021 0.0076 0.0076
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0007 0.0077
Brugia malayi Tubulin alpha-2 chain 0.002 0.0069 0.0216
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0295 0.0926
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0368 0.0368
Brugia malayi PHD-finger family protein 0.0029 0.0135 0.0422
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0004 0.0012
Brugia malayi ABC transporter family protein 0.0034 0.0165 0.0518
Leishmania major DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0179 0.2063
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0022 0.0068
Trichomonas vaginalis aldo-keto reductase, putative 0.0447 0.3186 1
Schistosoma mansoni Smad4 0.0016 0.0035 0.0035
Giardia lamblia Alpha-tubulin 0.002 0.0069 0.0216
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0022 0.0249
Schistosoma mansoni hypothetical protein 0.0015 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0021
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0179 0.026
Onchocerca volvulus 0.0047 0.0266 0.0824
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0007 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0144 0.0144
Trypanosoma brucei alpha tubulin 0.002 0.0069 0.0216
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0216
Entamoeba histolytica alcohol dehydrogenase, putative 0.013 0.0866 0.2718
Trichomonas vaginalis aldo-keto reductase, putative 0.0447 0.3186 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0021
Trypanosoma cruzi ISWI complex protein 0.0015 0.0033 0.0102
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0016 0.0189
Onchocerca volvulus 0.0447 0.3186 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0065 0.0392 0.0582
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0392 0.4522
Brugia malayi tubulin alpha chain - mouse 0.002 0.0069 0.0216
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0022 0.0023
Trichomonas vaginalis tubulin epsilon chain, putative 0.002 0.0069 0.0216
Brugia malayi hypothetical protein 0.0043 0.0237 0.0744
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0087 0.0273
Brugia malayi MH2 domain containing protein 0.0016 0.0035 0.0108
Brugia malayi jmjC domain containing protein 0.0039 0.0206 0.0646
Echinococcus multilocularis aldo keto reductase 0.0447 0.3186 0.3186
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0087 0.0273
Brugia malayi hypothetical protein 0.0012 0.0007 0.0021
Schistosoma mansoni chromobox protein 0.007 0.0433 0.0433
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0295 0.0926
Trichomonas vaginalis aldo-keto reductase, putative 0.0447 0.3186 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0022 0.0068
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0068
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0023
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0447 0.3186 0.3186
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.004 0.0209 0.0306
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0266 0.0393
Trypanosoma brucei unspecified product 0.0051 0.0291 0.0913
Trichomonas vaginalis aldo-keto reductase, putative 0.013 0.0866 0.2718
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0074 0.0458 0.0458
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0368 0.0368
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0198 0.0623
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0555 0.0892
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0016 0.0016
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0016 0.0051
Loa Loa (eye worm) tubulin alpha chain 0.002 0.0069 0.0216
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.013 0.0866 0.2718
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0026 0.0082
Echinococcus multilocularis microtubule associated protein 2 0.1381 1 1
Entamoeba histolytica tubulin alpha-1 chain 0.002 0.0069 0.0216
Schistosoma mansoni patched 1 0.0051 0.0292 0.0292
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0447 0.3186 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0266 0.0393
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0198 0.0311
Echinococcus multilocularis Tubulin alpha 1 chain 0.002 0.0069 0.0069
Loa Loa (eye worm) oxidoreductase 0.0447 0.3186 1
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0007 0.0021
Leishmania major UDP-galactopyranose mutase 0.0065 0.0392 0.1229
Echinococcus multilocularis chromobox protein 1 0.007 0.0433 0.0433
Trypanosoma brucei DNA polymerase IV, putative 0.0074 0.0458 0.1437
Echinococcus granulosus aldo keto reductase 0.0447 0.3186 0.3186
Echinococcus multilocularis expressed conserved protein 0.0112 0.0735 0.0735
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0292 0.0292
Trypanosoma cruzi DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0052 0.0162
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0065 0.0392 0.1211
Brugia malayi Pre-SET motif family protein 0.0031 0.0144 0.0453
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0266 0.0393
Toxoplasma gondii alpha tubulin TUBA1 0.002 0.0069 0.0216
Giardia lamblia Alpha-tubulin 0.002 0.0069 0.0216
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0266 0.0835
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0022 0.0068
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0016 0.0016
Giardia lamblia Aldose reductase 0.0447 0.3186 1
Schistosoma mansoni chromobox protein 0.007 0.0433 0.0433
Trypanosoma brucei ISWI complex protein 0.0015 0.0033 0.0102
Onchocerca volvulus 0.0014 0.0022 0.0056
Echinococcus multilocularis cpg binding protein 0.0033 0.0157 0.0157
Plasmodium falciparum ABC transporter G family member 2 0.004 0.0209 0.2413
Echinococcus granulosus aldo keto reductase 0.0447 0.3186 0.3186
Plasmodium vivax glutathione reductase, putative 0.0038 0.0198 0.2291
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0406 0.1274
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0447 0.3186 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0007 0.0021
Loa Loa (eye worm) fli-1 protein 0.0222 0.1539 0.4829
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0016 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0295 0.0926
Echinococcus granulosus tar DNA binding protein 0.0061 0.0368 0.0368
Schistosoma mansoni zinc finger protein 0.0015 0.0033 0.0033
Brugia malayi Tubulin alpha-2 chain 0.002 0.0069 0.0216
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0065 0.0392 0.4522
Loa Loa (eye worm) latrophilin receptor protein 2 0.0061 0.0363 0.114
Trichomonas vaginalis set domain proteins, putative 0.024 0.1668 0.5237
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0016 0.0051
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0087 0.0273
Brugia malayi hypothetical protein 0.0012 0.0004 0.0012
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.116 0.116
Trypanosoma cruzi UDP-galactopyranose mutase 0.0065 0.0392 0.1229
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0007 0.0021
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0016 1
Brugia malayi Bromodomain containing protein 0.0032 0.0152 0.0477
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0135 0.0422
Mycobacterium ulcerans DNA polymerase IV 0.0074 0.0458 0.0683
Brugia malayi tubulin alpha-2 chain 0.002 0.0069 0.0216
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0555 0.1725
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0007 0.0021
Entamoeba histolytica hypothetical protein 0.0012 0.0007 0.0021
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.0029 0.0131 0.0131
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0098 0.0098
Echinococcus multilocularis tubulin alpha 1C chain 0.002 0.0069 0.0069
Brugia malayi DKFZp564C0469 protein 0.0012 0.0007 0.0021
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0135 0.0422
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0087 0.0273
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0033 0.0162 0.0162
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0022 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.003 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0291 0.0913
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0392 0.4522
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0065 0.0392 0.0392
Brugia malayi RNA binding protein 0.0061 0.0368 0.1155
Schistosoma mansoni alpha tubulin 0.002 0.0069 0.0069
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0022 0.0068
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0295 0.0295
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0016 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0049 0.0276 0.0865
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0007 0.0021
Schistosoma mansoni hypothetical protein 0.0021 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0051 0.0292 0.0917
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0007 0.0021
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0087 0.1003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0021
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0447 0.3186 0.3186
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0368 0.1155
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0266 0.0393
Trypanosoma cruzi aldo-keto reductase 0.0447 0.3186 1
Plasmodium falciparum glutathione reductase 0.0038 0.0198 0.2291
Leishmania major trypanothione reductase 0.0038 0.0198 0.0623
Schistosoma mansoni alpha tubulin 0.002 0.0069 0.0069
Echinococcus granulosus dna polymerase kappa 0.0074 0.0458 0.0458
Echinococcus multilocularis nibrin 0.0012 0.0007 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0928 0.0928
Brugia malayi Pre-SET motif family protein 0.0211 0.1457 0.4572
Trichomonas vaginalis aldo/keto reductase, putative 0.0447 0.3186 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0447 0.3186 0.3186
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0022 0.0068
Leishmania major DNA polymerase eta, putative 0.0049 0.0276 0.0865
Loa Loa (eye worm) hypothetical protein 0.0447 0.3186 1
Echinococcus granulosus peregrin 0.0032 0.0152 0.0152
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0016 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0021
Echinococcus granulosus Tubulin alpha 1 chain 0.002 0.0069 0.0069
Echinococcus granulosus tubulin alpha 3 chain 0.002 0.0069 0.0069
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0022 0.0068
Brugia malayi CHE-14 protein 0.0051 0.0292 0.0917
Schistosoma mansoni smad1 5 8 and 0.0016 0.0035 0.0035
Echinococcus granulosus peroxisome assembly protein 26 0.002 0.0069 0.0069
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0004 0.0012
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0295 0.0926
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0004 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0007 0.0021
Entamoeba histolytica aldose reductase, putative 0.0447 0.3186 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0295 0.0926
Echinococcus multilocularis tubulin alpha 3 chain 0.002 0.0069 0.0069
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0098 0.0098
Schistosoma mansoni microtubule-associated protein tau 0.1381 1 1
Leishmania major DNA polymerase kappa, putative 0.0023 0.0087 0.0273
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.027 0.027
Onchocerca volvulus 0.0014 0.0022 0.0056
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0069 0.0216
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0266 0.0835
Leishmania major DNA polymerase eta, putative 0.01 0.0647 0.203
Onchocerca volvulus 0.0447 0.3186 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0207 0.0651
Loa Loa (eye worm) tubulin alpha-3 chain 0.0014 0.0023 0.0073
Mycobacterium ulcerans DNA polymerase IV 0.0074 0.0458 0.0683
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0022 0.0023
Trypanosoma brucei unspecified product 0.0051 0.0291 0.0913
Brugia malayi glutamate-cysteine ligase modifier subunit 0.013 0.0866 0.2718
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0295 0.0926
Loa Loa (eye worm) hypothetical protein 0.0062 0.0376 0.1179
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0004 0.0044
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0022 0.0068
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0433 0.1359
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0022 0.0068
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.1457 0.4572
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0065 0.0392 0.4522
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0004 0.0012
Trichomonas vaginalis aldo-keto reductase, putative 0.0447 0.3186 1
Trypanosoma brucei trypanothione reductase 0.0038 0.0198 0.0623
Toxoplasma gondii alpha-tubulin I, putative 0.002 0.0069 0.0216
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0004 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Brugia malayi CHD4 protein 0.0015 0.003 0.0094
Schistosoma mansoni amine oxidase 0.0065 0.0392 0.0392
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0626 0.1948
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0007 0.0077
Toxoplasma gondii thioredoxin reductase 0.0038 0.0198 0.0623
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0051 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0928 0.0928
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0007 0.0007
Echinococcus granulosus ATP binding cassette sub family G 0.004 0.0209 0.0209
Treponema pallidum NADH oxidase 0.0013 0.0016 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0074 0.0458 0.0458
Giardia lamblia DNA damage repair protein 0.0023 0.0087 0.0273
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0022 0.0023
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0371 0.0371
Plasmodium vivax tubulin alpha chain, putative 0.002 0.0069 0.0794
Schistosoma mansoni aldo-keto reductase 0.0447 0.3186 0.3186
Leishmania major alpha tubulin 0.002 0.0069 0.0216
Loa Loa (eye worm) ABC transporter 0.0034 0.0165 0.0518
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0022 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0485 0.3462 0.3462
Onchocerca volvulus Alhambra homolog 0.0029 0.0135 0.0411
Leishmania major hypothetical protein, conserved 0.0015 0.0033 0.0102
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0406 0.1274
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0004 0.0012
Echinococcus granulosus expressed conserved protein 0.0112 0.0735 0.0735
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0456
Brugia malayi Calcitonin receptor-like protein seb-1 0.0192 0.1321 0.4147
Schistosoma mansoni DNA ligase IV 0.0012 0.0007 0.0007
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0074 0.0458 0.1437
Mycobacterium tuberculosis Toxin MazF3 0.0129 0.0864 0.1395
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0206 0.0206
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0295 0.0926
Brugia malayi Protein cec-1. 0.0012 0.0004 0.0012
Brugia malayi NADH-dependent xylose reductase 0.013 0.0866 0.2718
Schistosoma mansoni bromodomain containing protein 0.0065 0.0398 0.0398
Trichomonas vaginalis DNA polymerase eta, putative 0.0074 0.0458 0.1437
Schistosoma mansoni smad1 5 8 and 0.0016 0.0035 0.0035
Brugia malayi Ets-domain containing protein 0.0073 0.0453 0.1422
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0022 0.0022
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0022 0.0068
Brugia malayi hypothetical protein 0.0447 0.3181 0.9984
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0447 0.3186 1
Loa Loa (eye worm) oxidoreductase 0.0447 0.3186 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0016 0.0051
Echinococcus granulosus zinc finger protein 0.0021 0.0076 0.0076
Entamoeba histolytica hypothetical protein 0.0012 0.0004 0.0012
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0447 0.3186 1
Mycobacterium tuberculosis Possible toxin MazF1 0.0129 0.0864 0.1395
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0004 0.0044
Trypanosoma brucei ABC transporter, putative 0.004 0.0209 0.0656
Trichomonas vaginalis aldo-keto reductase, putative 0.0447 0.3186 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0447 0.3186 0.3186
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0004 0.0012
Echinococcus granulosus geminin 0.0485 0.3462 0.3462
Plasmodium vivax tubulin alpha chain, putative 0.002 0.0069 0.0794
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0447 0.3186 0.3186
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0295 0.0926
Onchocerca volvulus 0.013 0.0866 0.2709
Leishmania major prostaglandin f synthase, putative 0.0447 0.3186 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0231 0.1603 0.503
Loa Loa (eye worm) hypothetical protein 0.0061 0.0363 0.114
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0023 0.0087 0.0273
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0928 0.2912
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0022 0.0068
Echinococcus granulosus dna polymerase eta 0.01 0.0647 0.0647
Mycobacterium ulcerans dehydrogenase 0.0065 0.0392 0.0582
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0184 0.0184
Onchocerca volvulus 0.0065 0.0392 0.1218
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0074 0.0458 0.0458
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Entamoeba histolytica aldose reductase, putative 0.0447 0.3186 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0928 0.0928
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0022 0.0068
Loa Loa (eye worm) hypothetical protein 0.0175 0.1197 0.3757
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Echinococcus multilocularis aldehyde reductase 0.0318 0.224 0.224
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0447 0.3186 0.3186
Mycobacterium ulcerans hypothetical protein 0.0023 0.0087 0.0121
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0035 0.0108
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0447 0.3186 0.3186
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.005 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.027 0.027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0928 0.2912
Entamoeba histolytica aldose reductase, putative 0.0447 0.3186 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0447 0.3186 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0065 0.0392 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0207 0.0651
Leishmania major alpha tubulin 0.002 0.0069 0.0216
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0022 0.0068
Brugia malayi polk-prov protein 0.0023 0.0087 0.0273
Echinococcus granulosus nibrin 0.0012 0.0007 0.0007
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0453 0.0453
Leishmania major aldo-keto reductase-like protein 0.0447 0.3186 1
Echinococcus granulosus GPCR family 2 0.0061 0.0363 0.0363
Trypanosoma brucei ATP-binding cassette protein, putative 0.004 0.0209 0.0656
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0266 0.0816
Schistosoma mansoni hypothetical protein 0.0049 0.0279 0.0279
Brugia malayi MH1 domain containing protein 0.0016 0.0035 0.0108
Plasmodium falciparum protoporphyrinogen oxidase 0.0065 0.0392 0.4522
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0065 0.0392 0.1229
Trypanosoma cruzi DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0206 0.0206
Brugia malayi amine oxidase, flavin-containing family protein 0.0065 0.0392 0.1229
Trichomonas vaginalis aldo/keto reductase, putative 0.0447 0.3186 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0045 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0016 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0087 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0021
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0004 0.0012
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0295 0.0926
Mycobacterium tuberculosis Possible oxidoreductase 0.0065 0.0392 0.0626
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0016 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0021
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0179 0.2063
Onchocerca volvulus 0.0014 0.0022 0.0056
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.004 0.0209 0.0656
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0004 0.0012
Brugia malayi ImpB/MucB/SamB family protein 0.01 0.0647 0.203
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0237 0.0237
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0022 0.0023
Mycobacterium ulcerans hypothetical protein 0.013 0.0866 0.13
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0368 0.0368
Mycobacterium tuberculosis Probable reductase 0.0087 0.0555 0.0892
Loa Loa (eye worm) hypothetical protein 0.0047 0.0266 0.0835
Giardia lamblia ABC transporter 0.0039 0.0206 0.0645
Echinococcus multilocularis peroxisome assembly protein 26 0.002 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.0043 0.0237 0.0744
Schistosoma mansoni gabp alpha 0.0073 0.0453 0.0453
Entamoeba histolytica ABC transporter, putative 0.004 0.0209 0.0656
Echinococcus multilocularis protein dispatched 1 0.0058 0.0345 0.0345
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0266 0.0835
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0406 0.1274
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0626 0.1008
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0788 0.0788
Leishmania major DNA damage repair protein, putative 0.0023 0.0087 0.0273
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0368 0.0368
Brugia malayi N-terminal motif family protein 0.0175 0.1197 0.3757
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0266 0.0835
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0406 0.1274
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0072 0.0225
Schistosoma mansoni hypothetical protein 0.0061 0.0363 0.0363
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0077 0.0241
Loa Loa (eye worm) hypothetical protein 0.0047 0.0266 0.0835
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0021
Echinococcus granulosus aldo keto reductase 0.0447 0.3186 0.3186
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0022 0.0068
Mycobacterium ulcerans hypothetical protein 0.0129 0.0864 0.1296
Mycobacterium tuberculosis Conserved protein 0.0129 0.0864 0.1395
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.003 0.0093
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0035 0.0035
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0206 0.0646
Mycobacterium ulcerans monoamine oxidase 0.0065 0.0392 0.0582
Echinococcus granulosus tubulin alpha 3 chain 0.002 0.0069 0.0069
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0004 0.0012
Echinococcus multilocularis tubulin alpha chain 0.002 0.0069 0.0069
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0007 0.0021
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0074 0.0458 0.1437
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0266 0.0393
Loa Loa (eye worm) helicase 0.0012 0.0004 0.0012
Loa Loa (eye worm) RNA binding protein 0.0061 0.0368 0.1155
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Leishmania major alpha tubulin 0.002 0.0069 0.0216
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0266 0.0393
Schistosoma mansoni chromobox protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) tubulin alpha 2 0.0016 0.0034 0.0107
Echinococcus granulosus dnaJ subfamily B 0.0413 0.2931 0.2931
Echinococcus multilocularis hypothetical protein 0.002 0.0069 0.0069
Brugia malayi SET domain containing protein 0.0013 0.0017 0.0052
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0022 0.0068
Schistosoma mansoni hypothetical protein 0.0049 0.0279 0.0279
Plasmodium falciparum alpha tubulin 1 0.002 0.0069 0.0794
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0295 0.0295
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0052 0.0162
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0061 0.0363 0.114
Schistosoma mansoni hypothetical protein 0.0049 0.0279 0.0279
Schistosoma mansoni hypothetical protein 0.0049 0.0279 0.0279
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0022 0.0023
Leishmania major alpha tubulin 0.002 0.0069 0.0216
Mycobacterium tuberculosis Possible toxin MazF5 0.0129 0.0864 0.1395
Brugia malayi PHD-finger family protein 0.0027 0.0115 0.0362
Echinococcus multilocularis protoporphyrinogen oxidase 0.0065 0.0392 0.0392
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0219 0.0219
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.013 0.0866 0.2718
Loa Loa (eye worm) alpha-tubulin 0.002 0.0069 0.0216
Trichomonas vaginalis aldo-keto reductase, putative 0.0447 0.3186 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0016 0.0034 0.0107
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0016 0.0051
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0016 0.0051
Giardia lamblia Replication factor C, subunit 1 0.0012 0.0007 0.0021
Brugia malayi jmjC domain containing protein 0.0096 0.0623 0.1955
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.2931 0.2931
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0004 0.0012
Entamoeba histolytica hypothetical protein 0.0043 0.0237 0.0744
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0022 0.0023
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0363 0.114
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0266 0.0835
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0016 0.0051
Schistosoma mansoni smad1 5 8 and 0.0016 0.0035 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0928 0.0928
Entamoeba histolytica tubulin alpha chain, putative 0.002 0.0069 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0021
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0292 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0291 0.0913
Brugia malayi hypothetical protein 0.0065 0.0392 0.1229
Trypanosoma cruzi DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Echinococcus multilocularis Smad4 0.0016 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0087 0.0273
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0022 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0165 0.0256
Entamoeba histolytica hypothetical protein 0.0043 0.0237 0.0744
Onchocerca volvulus 0.0012 0.0007 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0266 0.0835
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0131 0.0412
Mycobacterium leprae Possible oxidoreductase 0.013 0.0866 0.2703
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0061 0.0363 0.0363
Echinococcus multilocularis Protein lozenge 0.0056 0.0329 0.0329
Plasmodium falciparum alpha tubulin 2 0.002 0.0069 0.0794
Trypanosoma cruzi ISWI complex protein 0.0015 0.0033 0.0102
Schistosoma mansoni hypothetical protein 0.0485 0.3462 0.3462
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0016 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0228 0.0228
Echinococcus granulosus Chromo domain 0.0012 0.0004 0.0004
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.004 0.0209 0.0306
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0022 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0012
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0069 0.0216
Trypanosoma cruzi UDP-galactopyranose mutase 0.0065 0.0392 0.1229
Plasmodium vivax aldehyde reductase, putative 0.013 0.0866 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0022 0.0068
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0087 0.1003
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0007 0.0021
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0478 0.0478
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0069 0.0216
Brugia malayi Fli-1 protein 0.0222 0.1539 0.4829
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0087 0.0273
Schistosoma mansoni cpg binding protein 0.0033 0.0157 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0012
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0004 0.0044
Leishmania major alpha tubulin 0.002 0.0069 0.0216
Plasmodium falciparum aldo-keto reductase, putative 0.013 0.0866 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0016 0.0051
Trypanosoma brucei unspecified product 0.0074 0.0458 0.1437
Trypanosoma cruzi ATP-binding cassette protein, putative 0.004 0.0209 0.0656
Echinococcus multilocularis Tubulin alpha 1 chain 0.002 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0441 0.1383
Echinococcus granulosus tubulin alpha chain 0.002 0.0069 0.0069
Trypanosoma brucei prostaglandin f synthase 0.0447 0.3186 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0016 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0346 0.1086
Giardia lamblia Aldose reductase 0.0447 0.3186 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0016 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0123 0.0387
Mycobacterium ulcerans oxidoreductase 0.0065 0.0392 0.0582
Brugia malayi MH1 domain containing protein 0.0016 0.0035 0.0108
Brugia malayi Tubulin alpha chain 0.002 0.0069 0.0216
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0368 0.1155
Brugia malayi Heterochromatin protein 1 0.007 0.0433 0.1359
Schistosoma mansoni hypothetical protein 0.0102 0.0663 0.0663
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0022 0.0023
Trichomonas vaginalis aldo-keto reductase, putative 0.013 0.0866 0.2718
Loa Loa (eye worm) hypothetical protein 0.005 0.0288 0.0904
Loa Loa (eye worm) hypothetical protein 0.0065 0.0392 0.1229
Echinococcus multilocularis tubulin subunit TubB 0.002 0.0069 0.0069
Echinococcus granulosus chromobox protein 1 0.007 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0035 0.0179 0.0561
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0047
Trichomonas vaginalis aldo-keto reductase, putative 0.013 0.0866 0.2718
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0012
Echinococcus multilocularis smad 0.0016 0.0035 0.0035
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0069 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) oxidoreductase 0.0447 0.3186 1
Schistosoma mansoni topbp1 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0012
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0447 0.3186 1
Echinococcus multilocularis ATP binding cassette sub family G 0.004 0.0209 0.0209
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0087 0.0273
Echinococcus multilocularis ATP binding cassette sub family G 0.004 0.0209 0.0209
Toxoplasma gondii aldo-keto reductase 0.013 0.0866 0.2718
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0016 0.0051
Schistosoma mansoni amine oxidase 0.0065 0.0392 0.0392
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0453 0.0453
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0107
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0022 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0022 0.0023
Trichomonas vaginalis aldo-keto reductase, putative 0.0447 0.3186 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.027 0.027
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.004 0.0209 0.0306
Trypanosoma cruzi alpha tubulin, putative 0.002 0.0069 0.0216
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0004 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0135 0.1553
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0004 0.0004
Trypanosoma cruzi aldo/keto reductase, putative 0.013 0.0866 0.2718
Trichomonas vaginalis aldo-keto reductase, putative 0.0447 0.3186 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0376 0.118
Echinococcus granulosus ATP binding cassette sub family G 0.004 0.0209 0.0209
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0447 0.3186 0.3186
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0003 0.0034
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0406 0.1274
Schistosoma mansoni potassium channel beta 0.013 0.0866 0.0866
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0022 0.0068
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0016 0.0051
Echinococcus granulosus tubulin alpha chain 0.002 0.0069 0.0069
Plasmodium falciparum aldehyde reductase, putative 0.013 0.0866 1
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0219 0.0219
Plasmodium falciparum thioredoxin reductase 0.0013 0.0016 0.0189
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0406 0.1274
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0021
Schistosoma mansoni tubulin subunit alpha 0.002 0.0069 0.0069
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0295 0.0926
Echinococcus multilocularis tubulin alpha 3 chain 0.002 0.0069 0.0069
Onchocerca volvulus 0.0447 0.3186 1
Trypanosoma brucei DNA polymerase IV, putative 0.0074 0.0458 0.1437
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0035 0.0035
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0406 0.1274
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0004 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0052 0.0162
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0004 0.0004
Brugia malayi Smad1 0.0016 0.0035 0.0108
Echinococcus granulosus tubulin alpha 1C chain 0.002 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.01 0.0647 0.203
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0555 0.0892
Onchocerca volvulus 0.0447 0.3186 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0179 0.0561
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0065 0.0392 0.4522
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0015 0.0015
Loa Loa (eye worm) alpha-tubulin 0.002 0.0069 0.0216
Echinococcus granulosus tubulin subunit TubB 0.002 0.0069 0.0069
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0035 0.0035
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0801 0.0801
Echinococcus granulosus lysine specific histone demethylase 1A 0.0065 0.0392 0.0392
Brugia malayi CXXC zinc finger family protein 0.0029 0.0131 0.0412
Mycobacterium ulcerans hypothetical protein 0.0047 0.0266 0.0393
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0022 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0447 0.3186 0.3186
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0123 0.0387
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0135 0.0135
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0004 0.0012
Echinococcus multilocularis GPCR, family 2 0.0061 0.0363 0.0363
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0132 0.0132
Echinococcus multilocularis geminin 0.0485 0.3462 0.3462
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0052 0.0162
Loa Loa (eye worm) runx1 0.0056 0.0329 0.1032
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.003 0.003
Mycobacterium leprae Conserved hypothetical protein 0.0318 0.224 0.7024
Trichomonas vaginalis alcohol dehydrogenase, putative 0.013 0.0866 0.2718
Loa Loa (eye worm) tubulin alpha chain 0.002 0.0069 0.0216
Loa Loa (eye worm) hypothetical protein 0.0065 0.0392 0.1229
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0016 0.0051
Brugia malayi glutathione reductase 0.0038 0.0198 0.0623
Echinococcus granulosus chromobox protein 2 0.0012 0.0004 0.0004
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0447 0.3186 0.3186
Echinococcus granulosus hypothetical protein 0.0447 0.3186 0.3186
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0045 0.0045
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0626 0.1008
Loa Loa (eye worm) oxidoreductase 0.0014 0.0022 0.0068
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0295 0.0926
Echinococcus granulosus tubulin alpha chain 0.002 0.0069 0.0069
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0035 0.0035
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0007 0.0021
Loa Loa (eye worm) hypothetical protein 0.0192 0.1321 0.4147
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0087 0.0273
Brugia malayi Thioredoxin reductase 0.0038 0.0198 0.0623
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0052 0.0162
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0045 0.0045
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0016 0.0051
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0447 0.3186 0.3186
Loa Loa (eye worm) tubulin alpha 2 0.0016 0.0034 0.0107
Mycobacterium tuberculosis Toxin MazF6 0.0129 0.0864 0.1395
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0144 0.0144
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0237 0.0237
Brugia malayi MH2 domain containing protein 0.0016 0.0035 0.0108
Loa Loa (eye worm) hypothetical protein 0.0131 0.0878 0.2755
Trichomonas vaginalis aldo-keto reductase, putative 0.0447 0.3186 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.002 0.0069 0.0216
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0007 0.0007
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0266 0.0816
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0022 0.0068
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0061 0.0363 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0295 0.0295
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0087 0.0273
Loa Loa (eye worm) hypothetical protein 0.0039 0.0207 0.0651
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0202 0.0202
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0016 0.0051
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0179 0.4468
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0029 0.0135 0.0422
Schistosoma mansoni hypothetical protein 0.0043 0.0237 0.0237
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0003 0.0034
Loa Loa (eye worm) oxidoreductase 0.0447 0.3186 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0016 0.0051
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0447 0.3186 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7067 0.7067
Brugia malayi Bromodomain containing protein 0.0077 0.0484 0.1519
Schistosoma mansoni aldo-keto reductase 0.0447 0.3186 0.3186
Schistosoma mansoni tubulin subunit alpha 0.002 0.0069 0.0069
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0022 0.0068
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0065 0.0392 0.0392
Brugia malayi SWIRM domain containing protein 0.0065 0.0392 0.1229
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0074 0.0458 0.0734
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0065 0.0392 0.0392
Echinococcus multilocularis aldo keto reductase 0.0447 0.3186 0.3186
Echinococcus multilocularis aldo keto reductase 0.0447 0.3186 0.3186
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0406 0.0406
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0061 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.0772
Trichomonas vaginalis aldo/keto reductase, putative 0.0447 0.3186 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0016 0.0015
Onchocerca volvulus 0.0447 0.3186 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0022 0.0068
Schistosoma mansoni ABC transporter 0.0034 0.0165 0.0165
Echinococcus granulosus tubulin alpha 1C chain 0.002 0.0069 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0022 0.0023
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0184 0.0184
Echinococcus multilocularis voltage gated potassium channel subunit 0.013 0.0866 0.0866
Plasmodium vivax ABC transporter G family member 2, putative 0.004 0.0209 0.2413
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0266 0.0835
Loa Loa (eye worm) hypothetical protein 0.0039 0.0202 0.0635
Brugia malayi TAR-binding protein 0.0061 0.0368 0.1155
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0202 0.0202
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0022 0.0068
Echinococcus granulosus Smad4 0.0016 0.0035 0.0035
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0447 0.3186 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0555 0.0892
Schistosoma mansoni topbp1 0.0012 0.0007 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0295 0.0295
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0201 0.0201
Entamoeba histolytica hypothetical protein 0.0012 0.0004 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0266 0.0835
Echinococcus multilocularis tubulin alpha chain 0.002 0.0069 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0022 0.0023
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0069 0.0216
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0087 0.0273
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0074 0.0458 0.0458
Leishmania major alpha tubulin 0.002 0.0069 0.0216
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0074 0.0458 0.1437
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.013 0.0866 1
Schistosoma mansoni pol-related 0.0447 0.3186 0.3186
Echinococcus multilocularis Chromo domain 0.0012 0.0004 0.0004
Brugia malayi latrophilin 2 splice variant baaae 0.0131 0.0878 0.2755
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0135 0.0135
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0928 0.0928
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0626 0.1008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.027 0.027
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0004 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0004 0.0044
Trichomonas vaginalis chromobox protein, putative 0.007 0.0433 0.1359
Echinococcus granulosus aldo keto reductase family 1, member B4 0.013 0.0866 0.0866
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.003 0.003
Loa Loa (eye worm) glutathione reductase 0.0038 0.0198 0.0623
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0069 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0555 0.0892
Leishmania major alpha tubulin 0.002 0.0069 0.0216
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0023
Trichomonas vaginalis chromobox protein, putative 0.007 0.0433 0.1359
Schistosoma mansoni hypothetical protein 0.0131 0.0878 0.0878
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0165 0.0256
Onchocerca volvulus 0.024 0.1668 0.5231
Trichomonas vaginalis tubulin epsilon chain, putative 0.002 0.0069 0.0216
Schistosoma mansoni hypothetical protein 0.0061 0.0363 0.0363
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0623 0.0623
Trypanosoma brucei alpha tubulin 0.002 0.0069 0.0216
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0004 0.0004
Brugia malayi MH2 domain containing protein 0.0231 0.1603 0.503
Schistosoma mansoni chromobox protein 0.0012 0.0004 0.0004
Echinococcus multilocularis 0.0065 0.0392 0.0392
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0022 0.0023
Brugia malayi PHD-finger family protein 0.0013 0.0016 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0165 0.0256
Echinococcus granulosus alpha tubulin 0.002 0.0069 0.0069
Schistosoma mansoni lozenge 0.0056 0.0329 0.0329
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0198 0.0623
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0065 0.0392 0.1229
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.013 0.0866 0.2718
Loa Loa (eye worm) hypothetical protein 0.0035 0.0179 0.0561
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0012
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0135 0.0135
Loa Loa (eye worm) oxidoreductase 0.0447 0.3186 1
Schistosoma mansoni alpha tubulin 0.002 0.0069 0.0069
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0061 0.0363 0.0363
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0022 0.0023
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0447 0.3186 0.3186
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0051
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0406 0.0406
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0016 0.0051
Echinococcus granulosus tubulin alpha chain 0.002 0.0069 0.0069
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.004 0.0209 0.0656
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0022 0.0023
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0004 0.0012
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0004 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0007 0.0021
Echinococcus granulosus Chromobox protein 3 0.0012 0.0004 0.0004
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0207 0.064
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.0458 0.1437
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0206 0.0206
Plasmodium falciparum thioredoxin reductase 0.0038 0.0198 0.2291
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0266 0.0422
Echinococcus granulosus Tubulin alpha 1 chain 0.002 0.0069 0.0069
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0022 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0022 0.0023
Echinococcus multilocularis peregrin 0.0032 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0119 0.0788 0.2472
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0007 0.0021
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0016 0.0016
Plasmodium falciparum phd finger protein, putative 0.0029 0.0135 0.1553
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0022 0.0023
Trichomonas vaginalis aldo-keto reductase, putative 0.0447 0.3186 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0074 0.0458 0.1437
Brugia malayi ImpB/MucB/SamB family protein 0.0074 0.0458 0.1437
Brugia malayi Ets-domain containing protein 0.0073 0.0453 0.1422
Brugia malayi alpha-tubulin 0.002 0.0069 0.0216
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0368 0.0368
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0052 0.0162
Echinococcus multilocularis dna polymerase eta 0.01 0.0647 0.0647
Onchocerca volvulus 0.0042 0.0228 0.0705
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0016 0.0051
Mycobacterium tuberculosis Toxin MazF2 0.0129 0.0864 0.1395
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0447 0.3186 0.3186
Brugia malayi chromobox protein homolog 3 0.0039 0.0207 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0292 0.0917
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0866 0.2718
Loa Loa (eye worm) hypothetical protein 0.0447 0.3181 0.9984
Brugia malayi Bromodomain containing protein 0.0039 0.0202 0.0634
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0453 0.1422
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0276 0.0865
Loa Loa (eye worm) Smad1 0.0016 0.0035 0.0108
Echinococcus multilocularis Tubulin alpha 1 chain 0.002 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0048 0.027 0.0847
Onchocerca volvulus 0.0029 0.0131 0.0401
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0788 0.0788
Schistosoma mansoni hypothetical protein 0.0413 0.2931 0.2931
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0555 0.0892
Loa Loa (eye worm) hypothetical protein 0.0035 0.0179 0.0561
Echinococcus multilocularis ATP binding cassette sub family G 0.004 0.0209 0.0209
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0014 0.0023 0.0073
Leishmania major alpha tubulin 0.002 0.0069 0.0216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0073
Brugia malayi MAP kinase sur-1 0.0051 0.0295 0.0926
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0292 0.0917
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0016 0.0253
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.004 0.0209 0.0209
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0447 0.3186 0.3186
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0179 0.0279
Loa Loa (eye worm) hypothetical protein 0.0047 0.0266 0.0835
Schistosoma mansoni DNA polymerase eta 0.01 0.0647 0.0647
Trypanosoma brucei RNA helicase, putative 0.0102 0.0663 0.2082
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0368 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0021
Echinococcus multilocularis tubulin alpha chain 0.002 0.0069 0.0069
Echinococcus multilocularis tubulin alpha chain 0.002 0.0069 0.0069

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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