Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0338 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.0123 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0132 | 0.2916 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0338 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0338 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0132 | 0.2916 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0132 | 0.2916 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0338 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0132 | 0.2916 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0338 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0338 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0338 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0132 | 0.2916 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0338 | 1 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0123 | 0.0422 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0338 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.1272 | 0.4361 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.1272 | 0.4361 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0132 | 0.2916 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0338 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0132 | 0.2916 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0123 | 0.0422 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0338 | 1 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0132 | 0.2916 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0338 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0132 | 0.2916 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.1272 | 0.1272 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0338 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0132 | 0.2916 | 0.2916 |
Leishmania major | dihydroorotate dehydrogenase | 0.0338 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0132 | 0.2916 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.1272 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0132 | 0.2916 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.