Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.035 | 0.4032 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.0729 | 0.0729 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.0729 | 0.1082 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.035 | 0.4032 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.035 | 0.4032 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0136 | 0 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.0636 | 0.0944 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.035 | 0.4032 | 0.806 |
Echinococcus multilocularis | integrin beta 2 | 0.0493 | 0.6739 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.035 | 0.4032 | 0.4032 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0136 | 0 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.035 | 0.4032 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.035 | 0.4032 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0136 | 0 | 0.5 |
Echinococcus granulosus | integrin beta 2 | 0.0493 | 0.6739 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0136 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0136 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.035 | 0.4032 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0136 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.035 | 0.4032 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.035 | 0.4032 | 0.4032 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0136 | 0 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0665 | 1 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.035 | 0.4032 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.035 | 0.4032 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.035 | 0.4032 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.035 | 0.4032 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.035 | 0.4032 | 0.5 |
Schistosoma mansoni | integrin beta subunit | 0.0392 | 0.4827 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5623 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.