Detailed information for compound 1483741

Basic information

Technical information
  • TDR Targets ID: 1483741
  • Name: 2-(2-cyanophenyl)sulfinyl-N-phenylbenzamide
  • MW: 346.402 | Formula: C20H14N2O2S
  • H donors: 2 H acceptors: 3 LogP: 4.07 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccccc1[S+](c1ccccc1C(=O)Nc1ccccc1)[O-]
  • InChi: 1S/C20H14N2O2S/c21-14-15-8-4-6-12-18(15)25(24)19-13-7-5-11-17(19)20(23)22-16-9-2-1-3-10-16/h1-13H,(H,22,23)
  • InChiKey: FOMBJAKYTFWOIR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(2-cyanophenyl)sulfinyl-N-phenyl-benzamide
  • 2L-358S
  • 2-[(2-cyanophenyl)sulfinyl]-N-phenylbenzenecarboxamide
  • Oprea1_830614
  • MLS000707126
  • SMR000334517

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia FtsJ cell division protein, putative 0.0015 0.0258 0.0206
Trypanosoma brucei ribosomal RNA methyltransferase, putative 0.0009 0.0103 0.0103
Trichomonas vaginalis fk506-binding protein, putative 0.0039 0.0912 0.1171
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0284 0.7595 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0284 0.7595 1
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein 0.0009 0.0103 0.0882
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1935 0.1935
Plasmodium falciparum ribosomal RNA methyltransferase, putative 0.0015 0.0258 0.0308
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0797 0.0773
Trichomonas vaginalis fk506-binding protein, putative 0.0284 0.7595 1
Plasmodium vivax ribosomal RNA large subunit methyltransferase J, putative 0.0015 0.0258 0.0308
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0039 0.0912 0.5
Trichomonas vaginalis ribosomal RNA methyltransferase, putative 0.0009 0.0103 0.0103
Loa Loa (eye worm) FKBP5 protein 0.0284 0.7595 0.7595
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0797 0.1019
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0912 0.1171
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0039 0.0912 1
Echinococcus granulosus cap specific mRNA 0.0009 0.0103 0.0078
Onchocerca volvulus 0.0039 0.0922 1
Trypanosoma brucei rRNA methyltransferase, putative 0.0009 0.0103 0.0103
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0545 0.059
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0284 0.7595 0.7595
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0039 0.0912 0.117
Loa Loa (eye worm) hypothetical protein 0.0015 0.0258 0.0258
Echinococcus multilocularis snurportin 1 0.0372 1 1
Trichomonas vaginalis ribosomal RNA methyltransferase, putative 0.0009 0.0103 0.0103
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0039 0.0912 0.0912
Entamoeba histolytica hypothetical protein 0.0028 0.0617 0.0777
Trichomonas vaginalis fk506-binding protein, putative 0.0039 0.0912 0.1171
Schistosoma mansoni hypothetical protein 0.0372 1 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0617 0.0781
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0039 0.0912 1
Leishmania major GTP-binding protein, putative 0.0026 0.0545 0.0687
Echinococcus multilocularis ribosomal RNA large subunit methyltransferase 0.0015 0.0258 0.0233
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0545 0.0687
Echinococcus multilocularis 0.0039 0.0912 0.0889
Trypanosoma brucei ribosomal RNA methyltransferase, putative 0.0009 0.0103 0.0103
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0039 0.0912 1
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0039 0.0912 0.1171
Loa Loa (eye worm) hypothetical protein 0.0245 0.6539 0.6539
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0284 0.7595 1
Schistosoma mansoni immunophilin 0.0285 0.764 0.7634
Plasmodium falciparum importin beta, putative 0.0035 0.0797 0.1019
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0284 0.7595 0.7589
Schistosoma mansoni ran 0.0026 0.0545 0.0521
Trypanosoma brucei 2'-O-ribose RNA methyltransferase SPB1 homolog 0.0015 0.0258 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0912 0.1171
Schistosoma mansoni hypothetical protein 0.0009 0.0103 0.0078
Leishmania major importin beta-1 subunit, putative 0.0028 0.0617 0.0781
Schistosoma mansoni ribosomal RNA methyltransferase 0.0009 0.0103 0.0078
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0285 0.764 0.7634
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0617 0.0781
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1935 0.1935
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0545 0.0521
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0912 0.1171
Echinococcus granulosus tar DNA binding protein 0.0076 0.1935 0.1915
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0284 0.7606 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0039 0.0912 0.0912
Leishmania major hypothetical protein, conserved 0.0009 0.0103 0.0103
Brugia malayi rRNA methyltransferase 0.0015 0.0258 0.0307
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0912 0.1079
Schistosoma mansoni immunophilin 0.0246 0.6573 0.6564
Brugia malayi protein R74.7 0.0009 0.0103 0.0103
Echinococcus multilocularis rrna methyltransferase 3 0.0015 0.0258 0.0233
Plasmodium vivax ribosomal RNA methyltransferase, putative 0.0009 0.0103 0.0103
Leishmania major ribosomal RNA methyltransferase-like protein 0.0009 0.0103 0.0103
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0284 0.7595 1
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0039 0.0912 0.5
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0545 0.059
Echinococcus granulosus rrna methyltransferase 3 0.0015 0.0258 0.0233
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein 0.0009 0.0103 0.0882
Plasmodium falciparum ribosomal RNA methyltransferase, putative 0.0009 0.0103 0.0103
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0284 0.7595 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0912 0.1164
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0039 0.0912 0.1079
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0617 0.0685
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0039 0.0912 0.1079
Echinococcus granulosus importin subunit beta 1 0.0035 0.0797 0.0773
Loa Loa (eye worm) hypothetical protein 0.0039 0.0912 0.0912
Trypanosoma brucei methyltransferase, putative 0.0009 0.0103 0.0103
Loa Loa (eye worm) importin-beta domain-containing protein 0.0007 0.0025 0.0025
Entamoeba histolytica Ran family GTPase 0.0026 0.0545 0.0683
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1935 0.2519
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0912 0.1171
Giardia lamblia Hypothetical protein 0.0039 0.0912 0.1079
Brugia malayi Importin beta-1 subunit 0.0035 0.0797 0.1018
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0039 0.0912 0.117
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0284 0.7595 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0284 0.7595 1
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein 0.0009 0.0103 0.0882
Trichomonas vaginalis fk506 binding protein, putative 0.0039 0.0912 0.1171
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0284 0.7595 1
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0039 0.0912 0.1079
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0039 0.0912 0.0889
Toxoplasma gondii hypothetical protein 0.0009 0.0103 0.0882
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein 0.0015 0.0258 0.2626
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0912 0.1171
Trichomonas vaginalis ribosomal RNA methyltransferase, putative 0.0009 0.0103 0.0103
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0039 0.0912 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0284 0.7595 1
Plasmodium vivax FtsJ-like methyltransferase, putative 0.0015 0.0258 0.0308
Echinococcus multilocularis cap specific mRNA 0.0009 0.0103 0.0078
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0284 0.7595 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0617 0.0781
Leishmania major peptidylprolyl isomerase-like protein 0.0284 0.7595 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1935 0.1915
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0545 0.0687
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0285 0.764 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0912 0.1171
Brugia malayi TAR-binding protein 0.0076 0.1935 0.2519
Leishmania major fk506-binding protein 1-like protein 0.0284 0.7595 1
Leishmania major FtsJ-like methyltransferase, putative 0.0009 0.0103 0.0103
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0545 0.0545
Schistosoma mansoni fk506 binding protein 0.0039 0.0912 0.0889
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0284 0.7595 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0797 0.1019
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0912 0.1079
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0284 0.7595 0.7589
Brugia malayi ribosomal RNA methyltransferase 0.0015 0.0258 0.0307
Schistosoma mansoni immunophilin 0.0285 0.764 0.7634
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0039 0.0912 0.1171
Echinococcus multilocularis cell division protein 0.0009 0.0103 0.0078
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0797 0.87
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0545 0.0686
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1935 0.1915
Loa Loa (eye worm) hypothetical protein 0.0035 0.0797 0.0797
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0039 0.0912 0.1171
Schistosoma mansoni ribosomal RNA methyltransferase 0.0015 0.0258 0.0233
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0912 0.1079
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1935 0.1915
Brugia malayi RNA, U transporter 1 0.0099 0.255 0.3331
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0545 0.059
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0009 0.0103 0.0103
Brugia malayi FtsJ-like methyltransferase family protein 0.0009 0.0103 0.0103
Trichomonas vaginalis ribosomal RNA methyltransferase, putative 0.0015 0.0258 0.0308
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0912 0.1079
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0912 0.1079
Plasmodium vivax importin-beta 2, putative 0.0035 0.0797 0.1019
Schistosoma mansoni ran 0.0026 0.0545 0.0521
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0284 0.7595 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0912 0.1171
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0545 0.0687
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0039 0.0912 0.117
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0545 0.5867
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1935 0.1915
Brugia malayi RNA binding protein 0.0076 0.1935 0.2519
Schistosoma mansoni hypothetical protein 0.0039 0.0912 0.0889
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0039 0.0912 1
Echinococcus granulosus cell division protein 0.0009 0.0103 0.0078
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0041 0.0956 0.0933
Loa Loa (eye worm) hypothetical protein 0.0009 0.0103 0.0103
Trichomonas vaginalis immunophilin, putative 0.0284 0.7595 1
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0039 0.0912 1
Loa Loa (eye worm) ribosomal RNA methyltransferase 0.0015 0.0258 0.0258
Entamoeba histolytica ribosomal RNA methyltransferase, putative 0.0015 0.0258 0.0306
Loa Loa (eye worm) RNA binding protein 0.0076 0.1935 0.1935
Schistosoma mansoni importin beta-1 0.0035 0.0797 0.0773
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0284 0.7595 1
Loa Loa (eye worm) kap beta 3 protein 0.0007 0.0025 0.0025
Schistosoma mansoni cell division protein ftsj 0.0015 0.0258 0.0233
Plasmodium falciparum large subunit rRNA methyltransferase, putative 0.0015 0.0258 0.0308
Brugia malayi FtsJ-like methyltransferase family protein 0.0009 0.0103 0.0103
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0285 0.764 1
Toxoplasma gondii ribosomal RNA large subunit methyltransferase FTSJ1, putative 0.0009 0.0103 0.0882
Loa Loa (eye worm) hypothetical protein 0.0009 0.0103 0.0103
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0039 0.0912 0.0912
Mycobacterium ulcerans hypothetical protein 0.0039 0.0912 0.1079
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0285 0.764 0.7634
Trichomonas vaginalis ran, putative 0.0026 0.0545 0.0687
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0284 0.7595 0.9986
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0103 0.0103
Echinococcus multilocularis fk506 binding protein 0.0284 0.7595 0.7589
Onchocerca volvulus 0.0039 0.0912 0.9842
Entamoeba histolytica ribosomal RNA methyltransferase, putative 0.0009 0.0103 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0912 0.1171
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0246 0.6573 0.6564
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0039 0.0912 0.1164
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0039 0.0912 0.0891
Toxoplasma gondii ribosomal RNA methyltransferase (FtsJ) family protein 0.0015 0.0258 0.2626
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0284 0.7595 1
Echinococcus granulosus putative ribosomal RNA methyltransferase/cell division FtsJ protein 0.0015 0.0258 0.0233
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0246 0.6573 0.6564
Leishmania major methyltransferase, putative,ensangp00000010174-like protein 0.0009 0.0103 0.0103
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0545 0.0521
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0039 0.0912 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1935 0.1915
Echinococcus granulosus FK506 binding protein 2 0.0039 0.0912 0.0889
Loa Loa (eye worm) hypothetical protein 0.0009 0.0103 0.0103
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1935 0.1915

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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