TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 495.567 | Formula: C27H33N3O6
H donors: 0 H acceptors: 3 LogP: 2.32 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: C=CCN1c2ccccc2C23C1C(=C(N=C3N(C(=O)CC2)CCCOC(C)C)C(=O)OC)C(=O)OC
InChi: 1S/C27H33N3O6/c1-6-14-29-19-11-8-7-10-18(19)27-13-12-20(31)30(15-9-16-36-17(2)3)26(27)28-22(25(33)35-5)21(23(27)29)24(32)34-4/h6-8,10-11,17,23H,1,9,12-16H2,2-5H3
InChiKey: QWHURDFEOLMYIH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0015	0.0999	0.4205
Schistosoma mansoni	sugar transporter	0.0015	0.0999	0.0999
Onchocerca volvulus	Putative transporter	0.0015	0.0999	0.4205
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0057	0.0057
Schistosoma mansoni	cpg binding protein	0.0029	0.2377	0.2377
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.2775	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.188	0.188
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0218	0.0218
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0057	0.0057
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	1	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0999	0.0999
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0057	0.0057
Brugia malayi	hypothetical protein	0.0005	0.0057	0.0057
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.188	1
Brugia malayi	hypothetical protein	0.0015	0.0999	0.0999
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.2775	0.2648
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0999	0.3057
Schistosoma mansoni	hypothetical protein	0.0105	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Trichomonas vaginalis	conserved hypothetical protein	0.0105	1	1
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0999	0.3057
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.1302	0.4241
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0999	0.0841
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.053	0.053
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.4066	0.4066
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.053	0.053
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.053	0.053
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0397	0.0397
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.2028	0.1851
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.2775	0.2648
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.4066	0.4066
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0999	0.0999
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0218	0.0218
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0218	0.0546
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.053	0.053
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0999	0.3057
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0218	0.0546
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.053	0.053
Brugia malayi	nuclear hormone receptor	0.001	0.053	0.053
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0999	0.4704
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.053	0.053
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0999	0.0999
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0218	0.0546
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	1	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0235	0.0235
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.188	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.053	0.053
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Loa Loa (eye worm)	hypothetical protein	0.001	0.053	0.053
Onchocerca volvulus		0.0015	0.0999	0.4205
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.053	0.053
Echinococcus granulosus	solute carrier family 22	0.0015	0.0999	0.0999
Echinococcus granulosus	solute carrier family 22	0.0015	0.0999	0.0999
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0057	0.0057
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.0218	0.0218
Trypanosoma brucei	glucose transporter, putative	0.0033	0.2775	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0999	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0025	0.2028	0.2028
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.2028	0.708
Loa Loa (eye worm)	hypothetical protein	0.0024	0.188	0.188
Trypanosoma brucei	glucose transporter, putative	0.0033	0.2775	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	1	1
Brugia malayi	nuclear receptor NHR-88	0.001	0.053	0.053
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.053	0.053
Schistosoma mansoni	thyroid hormone receptor	0.001	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.0024	0.188	0.188
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Leishmania major	glucose transporter, lmgt1	0.0033	0.2775	1
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.2775	1
Schistosoma mansoni	sugar transporter	0.0015	0.0999	0.0999
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.188	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0409	0.0409
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0018	0.1285	0.1285
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0999	0.4993
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0235	0.0235
Onchocerca volvulus		0.0024	0.188	0.7908
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.001	0.053	0.053
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.1189	0.6071
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.053	0.053
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.053	0.053
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0218	0.0546
Trypanosoma cruzi	hexose transporter	0.0033	0.2775	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0218	0.0218
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0999	0.0999
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0218	0.0046
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0409	0.0409
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.1285	0.5
Plasmodium vivax	sugar transporter, putative	0.0015	0.0999	0.0799
Onchocerca volvulus		0.0015	0.0999	0.4205
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.4066	0.4066
Trypanosoma brucei	glucose transporter, putative	0.0033	0.2775	1
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0999	0.3057
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.188	0.6499
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0649	0.0649
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0218	0.0218
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.053	0.053
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0218	0.0218
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0999	0.0999
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.053	0.053
Plasmodium falciparum	hexose transporter	0.0105	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.053	0.053
Trypanosoma brucei	glucose transporter, putative	0.0033	0.2775	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.2028	0.1851
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.053	0.053
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Trypanosoma brucei	glucose transporter, putative	0.0033	0.2775	1
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0218	0.0046
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.1285	0.1091
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0999	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0218	0.0218
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.053	0.053
Brugia malayi	major facilitator superfamily protein	0.0015	0.0999	0.0999
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	1	1
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0999	0.0999
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0999	0.0999
Trypanosoma brucei	glucose transporter 2A	0.0033	0.2775	1
Echinococcus granulosus	General substrate transporter	0.009	0.8527	0.8527
Schistosoma mansoni	glucose transport protein	0.0105	1	1
Onchocerca volvulus		0.0015	0.0999	0.4205
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.053	0.053
Echinococcus multilocularis	cpg binding protein	0.003	0.2539	0.2539
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.1189	0.6071
Onchocerca volvulus		0.0015	0.0999	0.4205
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0999	0.0841
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0218	0.0218
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.053	0.053
Schistosoma mansoni	cpg binding protein	0.003	0.2539	0.2539
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0999	0.4993
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0057	0.0057
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.053	0.053
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0999	0.0799
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.188	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.188	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.2028	0.1851
Schistosoma mansoni	nuclear hormone receptor	0.001	0.053	0.053
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0218	0.0546
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0218	0.0218
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0218	0.0546
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.053	0.053
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.1285	0.1091
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0218	0.0218
Onchocerca volvulus		0.0015	0.0999	0.4205
Giardia lamblia	Hexose transporter	0.0015	0.0999	0.5
Trypanosoma brucei	glucose transporter, putative	0.0033	0.2775	1
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.2775	1
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.0218	0.0218
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0235	0.0235
Giardia lamblia	Sugar-proton symporter	0.0015	0.0999	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.053	0.053
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0999	0.4704
Onchocerca volvulus		0.0015	0.0999	0.4205
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.2775	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.053	0.2229
Brugia malayi	major facilitator superfamily protein	0.0015	0.0999	0.0999
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.053	0.053
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.053	0.053
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.188	0.188
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0057	0.0057
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Onchocerca volvulus		0.0015	0.0999	0.4205
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0057	0.0057
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.053	0.053
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.188	1
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0999	0.4704
Brugia malayi	Sugar transporter family protein	0.0015	0.0999	0.0999
Schistosoma mansoni	glucose transport protein	0.0105	1	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.4926	0.4814
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.2775	0.2648
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.053	0.053
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.053	0.053
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0999	0.0999
Onchocerca volvulus		0.0015	0.0999	0.4205
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.2775	1
Schistosoma mansoni	sugar transporter	0.0015	0.0999	0.0999
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0235	0.0235
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Schistosoma mansoni	hypothetical protein	0.0011	0.0649	0.0649
Onchocerca volvulus		0.0007	0.0218	0.0916
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.188	1
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0105	1	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.2028	0.708
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0999	0.3057
Echinococcus granulosus	cpg binding protein	0.003	0.2539	0.2539
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0218	0.0218
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.4066	0.4066
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0218	0.0546
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Brugia malayi	hypothetical protein	0.0016	0.1142	0.1142
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.2775	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0235	0.0235
Onchocerca volvulus		0.001	0.053	0.2229
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0218	0.0218
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0999	0.0799
Trypanosoma brucei	glucose transporter 1E	0.0033	0.2775	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.053	0.053
Leishmania major	glucose transporter, lmgt3	0.0033	0.2775	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.053	0.053
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.4066	0.4066
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0057	0.0057
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0218	0.0546
Brugia malayi	ecdysteroid receptor	0.001	0.053	0.053
Brugia malayi	CXXC zinc finger family protein	0.0029	0.2377	0.2377
Trypanosoma brucei	glucose transporter, putative	0.0033	0.2775	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0057	0.0057
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.053	0.053
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.188	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.188	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.053	0.053
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.188	0.188
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0057	0.0057
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.053	0.2229
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Loa Loa (eye worm)	sugar transporter	0.0105	1	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0999	0.0799
Schistosoma mansoni	sugar transporter	0.0015	0.0999	0.0999
Trypanosoma brucei	glucose transporter, putative	0.0033	0.2775	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.188	1
Schistosoma mansoni	coup transcription factor	0.001	0.053	0.053
Brugia malayi	nuclear receptor RXR	0.0005	0.0057	0.0057
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0649	0.0649
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.2775	1
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.053	0.053
Brugia malayi	Sugar transporter family protein	0.0015	0.0999	0.0999
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.188	0.6499
Loa Loa (eye worm)	hypothetical protein	0.0018	0.1285	0.1285
Onchocerca volvulus		0.0007	0.0218	0.0916
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.188	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0999	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.2377	0.2377
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0409	0.0409
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.053	0.053
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.053	0.053
Loa Loa (eye worm)	sugar transporter	0.0015	0.0999	0.0999
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.053	0.053
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.053	0.053
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.1285	0.6421
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.188	1
Mycobacterium ulcerans	hypothetical protein	0.0024	0.188	1
Brugia malayi	steroid hormone receptor	0.001	0.053	0.053
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0999	0.0841
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0999	0.3057
Plasmodium vivax	hexose transporter	0.0105	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.4066	0.4066
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.2028	0.708
Onchocerca volvulus		0.0015	0.0999	0.4205
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.4066	0.4066
Brugia malayi	hypothetical protein	0.0015	0.0999	0.0999
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0999	0.5
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.2775	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Brugia malayi	hypothetical protein	0.0025	0.2028	0.2028
Brugia malayi	hypothetical protein	0.0015	0.0999	0.0999
Schistosoma mansoni	glucose transport protein	0.0105	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.053	0.053
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.053	0.053
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Onchocerca volvulus		0.0015	0.0999	0.4205
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0999	0.0999
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.053	0.053
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0999	0.0999
Toxoplasma gondii	facilitative glucose transporter GT1	0.0105	1	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0999	0.0999
Onchocerca volvulus		0.0015	0.0999	0.4205
Onchocerca volvulus		0.0007	0.0218	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0057	0.0057
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.2028	0.1851
Onchocerca volvulus		0.0015	0.0999	0.4205
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.188	1
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0218	0.0218
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.053	0.053
Onchocerca volvulus		0.0007	0.0218	0.0916
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.188	1
Schistosoma mansoni	glucose transporter	0.0015	0.0999	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0018	0.1285	0.1285
Leishmania major	hypothetical protein, conserved	0.0015	0.0999	0.3057
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.2775	0.2648
Onchocerca volvulus		0.0015	0.0999	0.4205
Leishmania major	glucose transporter, lmgt2	0.0033	0.2775	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0999	0.0841
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0999	0.0841
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.4066	0.4066
Echinococcus granulosus	FTZ F1 alpha	0.001	0.053	0.053
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0218	0.0546
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.188	0.188
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.053	0.053
Schistosoma mansoni	cpg binding protein	0.003	0.2539	0.2539
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.188	0.6499
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.053	0.053
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.053	0.053
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0999	0.0999
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.0018	0.1285	0.1285
Leishmania major	hypothetical protein, conserved	0.0025	0.2028	0.708
Onchocerca volvulus		0.0029	0.2377	1
Brugia malayi	hypothetical protein	0.0005	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.001	0.053	0.053
Mycobacterium ulcerans	sugar transporter	0.0015	0.0999	0.4704
Onchocerca volvulus		0.0015	0.0999	0.4205
Loa Loa (eye worm)	hypothetical protein	0.001	0.053	0.053
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.4066	0.4066
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.053	0.053
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0999	0.0999
Schistosoma mansoni	thyroid hormone receptor	0.001	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0999	0.0999
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.2775	0.2648
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.1189	0.6071
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0999	0.0841
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.053	0.053
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.053	0.053
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.053	0.053
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.1285	0.6617
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.053	0.2229
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0999	0.0999
Echinococcus multilocularis	General substrate transporter	0.009	0.8527	0.8527
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0057	0.0057
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0999	0.0999
Loa Loa (eye worm)	hypothetical protein	0.001	0.053	0.053
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.1189	0.6071
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0218	0.0546
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0999	0.0841
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.5572	0.5572
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.053	0.053
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.2775	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0018	0.1285	0.1285
Onchocerca volvulus		0.0015	0.0999	0.4205
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0218	0.0546
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.053	0.053
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0999	0.0799
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0999	0.0841

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1716304

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1483776