Detailed information for compound 1483805

Basic information

Technical information
  • TDR Targets ID: 1483805
  • Name: 5-fluoro-1-[4-fluoro-3-oxo-6-[tri(phenyl)meth oxymethyl]-6H-pyran-2-yl]pyrimidine-2,4-dione
  • MW: 516.492 | Formula: C29H22F2N2O5
  • H donors: 1 H acceptors: 3 LogP: 4.32 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: FC1=CC(COC(c2ccccc2)(c2ccccc2)c2ccccc2)OC(C1=O)n1cc(F)c(=O)[nH]c1=O
  • InChi: 1S/C29H22F2N2O5/c30-23-16-22(38-27(25(23)34)33-17-24(31)26(35)32-28(33)36)18-37-29(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-17,22,27H,18H2,(H,32,35,36)
  • InChiKey: JHTZZJGCWZYBMV-UHFFFAOYSA-N  


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Synonyms

  • 5-fluoro-1-[4-fluoro-3-keto-6-[tri(phenyl)methoxymethyl]-6H-pyran-2-yl]pyrimidine-2,4-quinone
  • 5-Fluoro-1-(4-fluoro-3-oxo-6-((trityloxy)methyl)-3,6-dihydro-2H-pyran-2-yl)-2,4(1H,3H)-pyrimidinedione
  • AIDS-152373
  • AIDS152373
  • NSC696250
  • NCI60_034383

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens fatty acid synthase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Plasmodium falciparum heat shock protein 90, putative Starlite/ChEMBL No references
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Polyketide synthase Pks2 Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas Get druggable targets OG5_126633 All targets in OG5_126633
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable polyketide synthase Pks15 Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii heat shock protein 83 Get druggable targets OG5_144951 All targets in OG5_144951
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Polyketide synthase Pks12 Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Babesia bovis heat shock protein 90 Get druggable targets OG5_144951 All targets in OG5_144951
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) acyl carrier protein Get druggable targets OG5_126633 All targets in OG5_126633
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable polyketide synthase Pks5 Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Mycobacterium tuberculosis Probable polyketide synthase Pks7 Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum Soraphen polyketide synthase A, related Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii Hsp90 domain-containing protein Get druggable targets OG5_144951 All targets in OG5_144951
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii AMP-binding enzyme domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks8 Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Fatty acid synthase homolog Get druggable targets OG5_126633 All targets in OG5_126633
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum KR domain domain-containing protein, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0379 0.0516
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Loa Loa (eye worm) fatty acid synthase 0.003 0.1019 0.1458
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0491 0.0475
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0491 0.0475
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.2378 0.4183
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.2299 0.4024
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0045 0.178 0.8359
Toxoplasma gondii type I fatty acid synthase, putative 0.0032 0.1132 0.101
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0491 0.2304
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0746 0.3501
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2013 0.3445
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.2013 0.2042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0142 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.5251 1
Trypanosoma brucei heat shock protein, putative 0.0055 0.2299 0.4024
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0701 0.0692
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0136 0.011
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0489 0.0727
Schistosoma mansoni hypothetical protein 0.0019 0.0489 0.0474
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0341 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0701 0.0789
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.2299 0.4024
Trypanosoma brucei heat shock protein, putative 0.0055 0.2299 0.4024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2542 0.3777
Giardia lamblia Grp94/Hsp90 0.0052 0.213 0.3897
Plasmodium vivax heat shock protein 86, putative 0.0055 0.2299 0.1902
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Brugia malayi MH2 domain containing protein 0.001 0.0029 0.0043
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0491 0.036
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0985 0.1363
Schistosoma mansoni endoplasmin 0.0055 0.2299 0.2336
Leishmania major hypothetical protein, conserved 0.003 0.1057 0.151
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.5251 1
Schistosoma mansoni DNA helicase recq1 0.0012 0.0136 0.011
Mycobacterium leprae Polyketide synthase Pks13 0.0045 0.178 0.8352
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0701 0.3294
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0032 0.1132 0.5292
Loa Loa (eye worm) hypothetical protein 0.003 0.1057 0.1515
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0341 0.0059
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.213 0.5
Giardia lamblia Kinase, PLK 0.0115 0.5251 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0037 0.1373 0.2148
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.002 0.0531 0.2456
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0701 0.0789
Trypanosoma brucei heat shock protein, putative 0.0055 0.2299 0.4024
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0029 0.0993 0.4661
Schistosoma mansoni hypothetical protein 0.0019 0.0489 0.0474
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0136 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.5251 0.5374
Echinococcus granulosus lamin 0.0026 0.0839 0.0833
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0491 0.0475
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.2013 0.3445
Loa Loa (eye worm) heat shock protein 75 0.0037 0.1373 0.1979
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.1039 0.4877
Trypanosoma brucei unspecified product 0.0016 0.0341 0.0059
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0839 0.1193
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.1039 0.4877
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.2299 0.4024
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Brugia malayi MH1 domain containing protein 0.001 0.0029 0.0043
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0166 0.0141
Trypanosoma brucei polo-like protein kinase 0.0115 0.5251 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0136 0.011
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0701 0.0991
Trichomonas vaginalis endoplasmin, putative 0.004 0.1542 0.2491
Schistosoma mansoni hypothetical protein 0.0019 0.0489 0.0474
Trichomonas vaginalis heat shock protein, putative 0.0047 0.19 0.3216
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0489 0.0474
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0985 0.1363
Schistosoma mansoni intermediate filament proteins 0.0026 0.0839 0.0833
Mycobacterium leprae Probable polyketide synthase Pks1 0.0032 0.1132 0.5292
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0701 0.0692
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0985 0.0984
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0489 0.0474
Brugia malayi isocitrate dehydrogenase 0.0019 0.0491 0.0729
Brugia malayi Endoplasmin precursor 0.0055 0.2299 0.3416
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0491 0.0363
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0136 0.0000000002756
Echinococcus granulosus heat shock protein 0.0055 0.2299 0.2336
Loa Loa (eye worm) hypothetical protein 0.0013 0.0166 0.0202
Mycobacterium ulcerans polyketide synthase Pks13 0.0045 0.178 0.8359
Echinococcus multilocularis GPCR, family 2 0.0019 0.0489 0.0474
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0701 0.0789
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Plasmodium vivax heat shock protein, putative 0.021 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.2013 0.3445
Trypanosoma brucei unspecified product 0.0023 0.0701 0.0789
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0491 0.0363
Schistosoma mansoni DNA polymerase eta 0.0023 0.0701 0.0692
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.5251 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0489 0.0678
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Mycobacterium tuberculosis Probable thioesterase TesA 0.0025 0.0789 0.3703
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.2013 0.2042
Leishmania major DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.2299 0.4024
Plasmodium vivax heat shock protein 90, putative 0.0037 0.1373 0.0928
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.1057 0.151
Trichomonas vaginalis heat shock protein, putative 0.0052 0.213 0.368
Schistosoma mansoni endoplasmin 0.0055 0.2299 0.2336
Echinococcus multilocularis endoplasmin 0.0052 0.213 0.2162
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0701 0.0692
Mycobacterium ulcerans polyketide synthase 0.003 0.1039 0.4877
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.002 0.0531 0.2492
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0491 0.0475
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.5251 1
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Leishmania major heat shock protein, putative 0.0037 0.1373 0.2148
Echinococcus granulosus dna polymerase eta 0.0023 0.0701 0.0692
Schistosoma mansoni heat shock protein 0.0055 0.2299 0.2336
Mycobacterium ulcerans thioesterase TesA 0.0025 0.0789 0.3703
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.19 0.3216
Loa Loa (eye worm) hypothetical protein 0.0019 0.0489 0.0678
Trypanosoma brucei heat shock protein, putative 0.0055 0.2299 0.4024
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0517 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0701 0.3294
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0024 0.0746 0.3501
Trypanosoma cruzi Heat shock protein 83, putative 0.0055 0.2299 0.4024
Mycobacterium ulcerans heat shock protein 90 0.0052 0.213 1
Trichomonas vaginalis heat shock protein, putative 0.0032 0.1143 0.1684
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0491 0.0475
Echinococcus multilocularis heat shock protein 0.0055 0.2299 0.2336
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.1057 0.0934
Loa Loa (eye worm) hypothetical protein 0.006 0.2542 0.3702
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0136 0.0202
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0115 0.5251 0.5374
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0017 0.0391 0.1838
Echinococcus multilocularis heat shock protein 90 0.0055 0.2299 0.2336
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.001 0.0054 0.0256
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.003 0.1039 0.4853
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.003 0.1039 0.4853
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0235 0.0304
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.6731 0.9871
Toxoplasma gondii heat shock protein 75, putative 0.0037 0.1373 0.1254
Toxoplasma gondii heat shock protein HSP90 0.0055 0.2299 0.2193
Trypanosoma brucei Heat shock protein 83, putative 0.0055 0.2299 0.4024
Loa Loa (eye worm) hypothetical protein 0.0051 0.2058 0.2989
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Loa Loa (eye worm) hypothetical protein 0.0146 0.6818 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0701 0.3294
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2542 0.3702
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0341 0.0059
Echinococcus multilocularis lamin 0.0026 0.0839 0.0833
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.5251 1
Schistosoma mansoni kinase 0.0058 0.2453 0.2495
Mycobacterium ulcerans polyketide synthase Pks9 0.002 0.0531 0.2492
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0235 0.0349
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.1039 0.4877
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Mycobacterium ulcerans fatty acid synthase Fas 0.0009 0.001 0.0047
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.1039 0.4877
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.2299 0.4024
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.0606 0.0477
Giardia lamblia DINP protein human, muc B family 0.0023 0.0701 0.1106
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0491 0.036
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0701 0.3294
Brugia malayi intermediate filament protein 0.0026 0.0839 0.1246
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.2013 0.3445
Brugia malayi heat shock protein 90 0.0055 0.2299 0.3416
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0491 0.068
Onchocerca volvulus Fatty acid synthase homolog 0.0054 0.2242 0.3181
Schistosoma mansoni hypothetical protein 0.0041 0.1592 0.1608
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0491 0.036
Trypanosoma brucei heat shock protein, putative 0.0055 0.2299 0.4024
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.1132 0.5314
Brugia malayi MH2 domain containing protein 0.001 0.0029 0.0043
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0491 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0701 0.0789
Echinococcus multilocularis lamin dm0 0.0026 0.0839 0.0833
Trichomonas vaginalis heat shock protein, putative 0.004 0.1542 0.2491
Loa Loa (eye worm) hypothetical protein 0.0012 0.0136 0.0158
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0701 0.1042
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0681 0.0671
Schistosoma mansoni hypothetical protein 0.0205 0.9746 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.094 0.1342
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0505 0.0374
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0701 0.0789
Treponema pallidum heat shock protein 90 0.0052 0.213 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0032 0.1132 0.5292
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2542 0.3777
Brugia malayi Smad1 0.001 0.0029 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0491 0.0363
Trypanosoma brucei heat shock protein 84, putative 0.0037 0.1373 0.2148
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.1057 0.151
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0701 0.0789
Trypanosoma brucei heat shock protein, putative 0.0055 0.2299 0.4024
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0701 0.0789
Loa Loa (eye worm) acyl carrier protein 0.0014 0.0229 0.0294
Schistosoma mansoni hypothetical protein 0.0014 0.022 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0701 0.0789
Echinococcus granulosus GPCR family 2 0.0019 0.0489 0.0474
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2013 0.3445
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.003 0.1039 0.4877
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0839 0.1246
Echinococcus multilocularis geminin 0.0205 0.9746 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.1039 0.4877
Plasmodium falciparum heat shock protein 90 0.0055 0.2299 0.2193
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0839 0.1193
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.1057 0.0934
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0012 0.0145 0.0683
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.5251 1
Brugia malayi MH2 domain containing protein 0.0144 0.6731 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0491 0.0363
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0701 0.0692
Echinococcus granulosus lamin dm0 0.0026 0.0839 0.0833
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0025 0.0789 0.3673
Brugia malayi MAP kinase sur-1 0.005 0.2013 0.2991
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.003 0.1039 0.1543
Mycobacterium ulcerans polyketide synthase 0.0032 0.1132 0.5314
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2013 0.3445
Echinococcus granulosus mitogen activated protein kinase 0.005 0.2013 0.2042
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.2013 0.1903
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.022 0.0197
Echinococcus multilocularis dna polymerase eta 0.0023 0.0701 0.0692
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.1132 0.5314
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0491 0.0363
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0037 0.1373 0.121
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0489 0.0727
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.213 0.368
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0024 0.0746 0.347
Echinococcus multilocularis musashi 0.0026 0.0839 0.0833
Plasmodium falciparum endoplasmin, putative 0.004 0.1542 0.1426
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0045 0.178 0.8359
Loa Loa (eye worm) hypothetical protein 0.0026 0.0815 0.1157
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.5251 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0701 0.1042
Brugia malayi hypothetical protein 0.003 0.1057 0.1571
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0009 0.001 0.0047
Toxoplasma gondii Hsp90 domain-containing protein 0.021 1 1
Trypanosoma brucei protein kinase, putative 0.005 0.2013 0.3445
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Brugia malayi serine/threonine-protein kinase plk-2 0.0115 0.5251 0.7802
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0115 0.5251 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.094 0.4414
Schistosoma mansoni lamin 0.0026 0.0839 0.0833
Echinococcus granulosus intermediate filament protein 0.0026 0.0839 0.0833
Schistosoma mansoni lamin 0.0026 0.0839 0.0833
Trypanosoma cruzi heat shock protein, putative 0.0037 0.1373 0.2148
Schistosoma mansoni serine/threonine protein kinase 0.005 0.2013 0.2042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0142 0.0167
Schistosoma mansoni hypothetical protein 0.0019 0.0489 0.0474
Trypanosoma brucei heat shock protein, putative 0.0055 0.2299 0.4024
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0136 0.011
Trichomonas vaginalis heat shock protein, putative 0.0055 0.2299 0.4024
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.19 0.3449
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.6731 0.9871
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.5251 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0136 0.0202
Leishmania major DNA polymerase eta, putative 0.0023 0.0701 0.0789
Schistosoma mansoni heat shock protein 0.0055 0.2299 0.2336
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.213 1
Onchocerca volvulus 0.0028 0.094 0.023
Schistosoma mansoni hypothetical protein 0.0205 0.9746 1
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.2013 0.2042
Echinococcus multilocularis heat shock protein 90 0.0047 0.19 0.1926
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.1057 0.151
Onchocerca volvulus 0.0052 0.2149 0.297
Schistosoma mansoni DNA helicase recq5 0.0012 0.0136 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0701 0.0991
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0022 0.0616 0.2893
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0701 0.0692
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.002 0.0512 0.0381
Loa Loa (eye worm) hypothetical protein 0.0041 0.1592 0.2302
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0029 0.0993 0.4661
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0491 0.0475
Trypanosoma brucei unspecified product 0.0016 0.0341 0.0059
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.2299 0.4024
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0115 0.5251 0.5374
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.2013 0.3445
Trichomonas vaginalis heat shock protein, putative 0.0052 0.213 0.368
Trypanosoma brucei heat shock protein, putative 0.0055 0.2299 0.4024
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.2299 0.4229
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.2013 0.3445
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0297 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0028 0.094 0.1397
Loa Loa (eye worm) endoplasmin 0.0055 0.2299 0.3344
Brugia malayi hypothetical protein 0.002 0.0519 0.0771
Plasmodium falciparum heat shock protein 90, putative 0.0032 0.1143 0.1021
Echinococcus granulosus heat shock protein 90 0.0055 0.2299 0.2336
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0037 0.1373 0.1383
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0166 0.0141
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0489 0.0474
Loa Loa (eye worm) heat shock protein 90 0.0055 0.2299 0.3344
Brugia malayi MH1 domain containing protein 0.001 0.0029 0.0043
Echinococcus granulosus heat shock protein 90 0.0047 0.19 0.1926
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0057 0.2381 0.3538
Loa Loa (eye worm) RecQ helicase 0.0029 0.0985 0.1408
Brugia malayi Hsp90 protein 0.0037 0.1373 0.2039
Entamoeba histolytica serine/threonine protein kinase, putative 0.0115 0.5251 1
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0491 0.0729
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.2013 0.3445
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0489 0.0474
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.2378 0.4183
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.1057 0.0934
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0037 0.1373 0.1383
Echinococcus granulosus bloom syndrome protein 0.0029 0.0985 0.0984
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Echinococcus granulosus geminin 0.0205 0.9746 1
Toxoplasma gondii heat shock protein 90, putative 0.0055 0.2299 0.2193
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0032 0.1132 0.5314
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0695 0.0776
Onchocerca volvulus Serine\/threonine kinase homolog 0.0115 0.5251 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0701 0.0692
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.2299 0.4024
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0047 0.19 0.1926
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.2299 0.4024
Giardia lamblia Kinase, CMGC MAPK 0.005 0.2013 0.367
Plasmodium vivax endoplasmin, putative 0.0055 0.2299 0.1902
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.1039 0.4877
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0115 0.5251 0.7692
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.2013 0.3445
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0032 0.1132 0.5314
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0701 0.0789
Schistosoma mansoni heat shock protein 0.0037 0.1373 0.1383
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0985 0.1463
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1592 0.2365
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.5251 1
Echinococcus granulosus endoplasmin 0.0052 0.213 0.2162
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.213 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0025 0.0765 0.3594
Loa Loa (eye worm) hypothetical protein 0.0026 0.0839 0.1193
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.1057 0.0596
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0701 0.0789
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0032 0.1132 0.5314
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.19 0.3216
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.022 0.0197
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2013 0.3445
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.2013 0.2922
Leishmania major heat shock protein 83-1 0.0055 0.2299 0.4024
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0809 0.0683
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0136 0.0158
Mycobacterium ulcerans thioesterase 0.0025 0.0789 0.3703

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 0.718 uM PUBCHEM_BIOASSAY: Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (functional) = 2.604 uM PUBCHEM_BIOASSAY: HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
GI50 (functional) -6.228 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.954 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.869 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.784 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.756 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.751 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.712 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.676 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.658 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.478 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.746 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 7.69 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 8.13 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3109 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9093 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9935 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 5.9728 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Confirmation of Cherrypicks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.1216 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Cherrypicks in WT IDH1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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