TDR Targets

Basic information

Technical information

TDR Targets ID: 1483852
Name: 1-(3,4-dihydro-1H-isoquinolin-2-yl)-2-[4-(3,4 -dimethoxyphenyl)sulfonylpiperazin-1-yl]ethan one
MW: 459.558 | Formula: C23H29N3O5S
H donors: 0 H acceptors: 3 LogP: 1.88 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)S(=O)(=O)N1CCN(CC1)CC(=O)N1CCc2c(C1)cccc2
InChi: 1S/C23H29N3O5S/c1-30-21-8-7-20(15-22(21)31-2)32(28,29)26-13-11-24(12-14-26)17-23(27)25-10-9-18-5-3-4-6-19(18)16-25/h3-8,15H,9-14,16-17H2,1-2H3
InChiKey: XIWOLQSTIWRNTL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(3,4-dihydro-1H-isoquinolin-2-yl)-2-[4-(3,4-dimethoxyphenyl)sulfonyl-1-piperazinyl]ethanone
T5529139

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.4706	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0103	0.2673	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0051	0.059	0.0686
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Brugia malayi	Cathepsin L-like precursor	0.0051	0.059	0.0686
Entamoeba histolytica	cysteine proteinase, putative	0.0154	0.4706	1
Entamoeba histolytica	cysteine protease, putative	0.0154	0.4706	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Brugia malayi	Cathepsin L-like precursor	0.0154	0.4706	0.5465
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.4706	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0154	0.4706	0.5465
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0768	0.1631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0296	0.0629
Entamoeba histolytica	cysteine proteinase 2	0.0079	0.1725	0.3241
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.4706	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2673	0.1146
Echinococcus multilocularis	cysteine protease	0.0154	0.4706	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.059	0.0686
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0768	0.0891
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.4706	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0154	0.4706	0.3602
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0051	0.059	0.0686
Echinococcus multilocularis	cysteine protease	0.0154	0.4706	1
Echinococcus granulosus	cathepsin L	0.0079	0.1725	0.3666
Onchocerca volvulus	Cathepsin L homolog	0.0154	0.4706	0.4706
Onchocerca volvulus		0.0154	0.4706	0.4706
Schistosoma mansoni	cathepsin F (C01 family)	0.0154	0.4706	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.4706	0.3602
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2673	0.3105
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.4706	0.3602
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.1725	0.3241
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.1725	0.2757
Echinococcus multilocularis	cathepsin L	0.0079	0.1725	0.3666
Trypanosoma cruzi	cysteine protease, putative	0.0079	0.1725	0.2757
Brugia malayi	Cathepsin L-like precursor	0.0154	0.4706	0.5465
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0079	0.1725	0.3666
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.4706	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.4706	1
Leishmania major	cathepsin L-like protease	0.0154	0.4706	0.5
Plasmodium vivax	unspecified product	0.0051	0.059	0.1255
Brugia malayi	hypothetical protein	0.0043	0.0296	0.0344
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.4706	0.3602
Onchocerca volvulus		0.0154	0.4706	0.4706
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0296	0.0629
Trypanosoma cruzi	cruzipain precursor, putative	0.0154	0.4706	1
Schistosoma mansoni	cathepsin s	0.0051	0.059	0.1255
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.1725	0.3241
Brugia malayi	Pre-SET motif family protein	0.0251	0.8611	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.4706	1
Loa Loa (eye worm)	fibroinase	0.0154	0.4706	0.5465
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0103	0.2673	0.5061
Leishmania major	cathepsin L-like protease	0.0154	0.4706	0.5
Brugia malayi	cathepsin L-like precursor	0.0103	0.2673	0.3105
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0154	0.4706	1
Brugia malayi	Cathepsin L-like precursor	0.0154	0.4706	0.5465
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0154	0.4706	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0079	0.1725	0.2757
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0768	0.1631
Trypanosoma cruzi	cysteine proteinase, putative	0.0079	0.1725	0.2757
Echinococcus granulosus	cathepsin l1	0.0103	0.2673	0.5681
Leishmania major	cathepsin L-like protease	0.0154	0.4706	0.5
Brugia malayi	Cathepsin L-like precursor	0.0154	0.4706	0.5465
Leishmania major	cathepsin L-like protease	0.0154	0.4706	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0079	0.1725	0.2003
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0079	0.1725	0.3666
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Echinococcus granulosus	cathepsin l1	0.0154	0.4706	1
Brugia malayi	Cathepsin L-like precursor	0.0103	0.2673	0.3105
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Onchocerca volvulus		0.0154	0.4706	0.4706
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.4706	0.3602
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.1725	0.3241
Brugia malayi	cathepsin F-like cysteine proteinase	0.0051	0.059	0.0686
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Plasmodium vivax	vivapain-3	0.0079	0.1725	0.3666
Entamoeba histolytica	cysteine proteinase, putative	0.0103	0.2673	0.5391
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Plasmodium vivax	vivapain-1	0.0079	0.1725	0.3666
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Schistosoma mansoni	cathepsin F (C01 family)	0.0154	0.4706	1
Onchocerca volvulus		0.0154	0.4706	0.4706
Trichomonas vaginalis	set domain proteins, putative	0.0286	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0079	0.1725	0.2757
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.4706	0.3602
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0154	0.4706	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.4706	0.5465
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0768	0.1631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Leishmania major	cathepsin L-like protease	0.0154	0.4706	0.5
Loa Loa (eye worm)	hypothetical protein	0.0051	0.059	0.0686
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.8611	1
Onchocerca volvulus	Cathepsin F homolog	0.0154	0.4706	0.4706
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.2673	0.1146
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.4706	0.5465
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.4706	0.3602
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Leishmania major	cathepsin L-like protease	0.0154	0.4706	0.5
Leishmania major	cysteine peptidase A (CPA)	0.0154	0.4706	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0296	0.0629
Entamoeba histolytica	cysteine proteinase, putative	0.0154	0.4706	1
Onchocerca volvulus		0.0154	0.4706	0.4706
Schistosoma mansoni	hypothetical protein	0.0043	0.0296	0.0629
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.4706	0.3602
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.1725	0.3241
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0154	0.4706	0.5465
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0768	0.1631
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0768	0.0891
Plasmodium vivax	unspecified product	0.0079	0.1725	0.3666
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.4706	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0154	0.4706	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0103	0.2673	0.5681
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0154	0.4706	1
Toxoplasma gondii	cathepsin CPL	0.0154	0.4706	1
Onchocerca volvulus		0.0154	0.4706	0.4706
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.4706	1
Plasmodium vivax	vivapain-2	0.0154	0.4706	1
Leishmania major	cathepsin L-like protease	0.0154	0.4706	0.5
Onchocerca volvulus		0.0154	0.4706	0.4706
Brugia malayi	Cathepsin L-like precursor	0.0154	0.4706	0.5465
Plasmodium vivax	vivapain-2	0.0154	0.4706	1
Onchocerca volvulus		0.0103	0.2673	0.2673
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.4706	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0154	0.4706	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0154	0.4706	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.4706	0.3602
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.4706	0.3602
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.4706	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.4706	0.3602
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.4706	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0154	0.4706	0.3602
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0768	0.1631
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0079	0.1725	0.3666
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0768	0.1631
Brugia malayi	Papain family cysteine protease containing protein	0.0079	0.1725	0.2003
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Brugia malayi	Cathepsin L-like precursor	0.0103	0.2673	0.3105
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.4706	1
Echinococcus granulosus	cysteine protease	0.0079	0.1725	0.3666
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2673	0.3105
Brugia malayi	Cathepsin L-like precursor	0.0154	0.4706	0.5465
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0154	0.4706	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1725	0.3241
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0051	0.059	0.0686
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.4706	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0154	0.4706	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0079	0.1725	0.3241
Onchocerca volvulus	Cathepsin L homolog	0.0154	0.4706	0.4706
Echinococcus granulosus	cathepsin L cysteine protease	0.0079	0.1725	0.3666
Leishmania major	cathepsin L-like protease	0.0154	0.4706	0.5
Loa Loa (eye worm)	cysteine protease	0.0154	0.4706	0.5465
Loa Loa (eye worm)	ctsf protein	0.0154	0.4706	0.5465
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0768	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2673	0.3105
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.4706	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.5849 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	10.3225 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1723328

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1483852