Detailed information for compound 1483857

Basic information

Technical information
  • TDR Targets ID: 1483857
  • Name: 3-[2-[4-(3-chlorophenyl)piperazin-1-yl]-9-met hyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]-2-cyano -N-prop-2-enylprop-2-enamide
  • MW: 488.969 | Formula: C26H25ClN6O2
  • H donors: 1 H acceptors: 3 LogP: 3.33 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCNC(=O)/C(=C/c1c(nc2n(c1=O)cccc2C)N1CCN(CC1)c1cccc(c1)Cl)/C#N
  • InChi: 1S/C26H25ClN6O2/c1-3-9-29-25(34)19(17-28)15-22-24(30-23-18(2)6-5-10-33(23)26(22)35)32-13-11-31(12-14-32)21-8-4-7-20(27)16-21/h3-8,10,15-16H,1,9,11-14H2,2H3,(H,29,34)/b19-15+
  • InChiKey: XSPDTZVPVCVXCX-XDJHFCHBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-3-[2-[4-(3-chlorophenyl)piperazin-1-yl]-9-methyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-prop-2-enylprop-2-enamide
  • (E)-N-allyl-3-[2-[4-(3-chlorophenyl)piperazin-1-yl]-9-methyl-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-prop-2-enamide
  • N-allyl-3-[2-[4-(3-chlorophenyl)piperazin-1-yl]-9-methyl-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-prop-2-enamide
  • (E)-N-allyl-3-[2-[4-(3-chlorophenyl)-1-piperazinyl]-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-cyanoprop-2-enamide
  • N-allyl-3-[2-[4-(3-chlorophenyl)-1-piperazinyl]-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-cyanoprop-2-enamide
  • N-allyl-3-[2-[4-(3-chlorophenyl)piperazin-1-yl]-4-keto-9-methyl-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-acrylamide
  • (E)-N-allyl-3-[2-[4-(3-chlorophenyl)piperazin-1-yl]-4-keto-9-methyl-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-acrylamide
  • 3-[2-[4-(3-chlorophenyl)piperazin-1-yl]-9-methyl-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-prop-2-enyl-prop-2-enamide
  • (E)-3-[2-[4-(3-chlorophenyl)piperazin-1-yl]-9-methyl-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-prop-2-enyl-prop-2-enamide
  • STOCK3S-45555

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128629 All targets in OG5_128629
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cathepsin CPL 0.0169 0.5396 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Leishmania major cysteine peptidase A (CPA) 0.0169 0.5396 1
Trypanosoma cruzi cysteine peptidase, putative 0.0169 0.5396 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Giardia lamblia Cathepsin B precursor 0.0031 0 0.5
Plasmodium falciparum cysteine proteinase falcipain 1 0.0087 0.2188 0.4054
Loa Loa (eye worm) hypothetical protein 0.0056 0.0966 0.1119
Leishmania major cathepsin L-like protease 0.0169 0.5396 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8638 1
Giardia lamblia Cathepsin B precursor 0.0031 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0113 0.3209 0.3715
Brugia malayi Cathepsin L-like precursor 0.0169 0.5396 0.6247
Entamoeba histolytica cysteine proteinase 1, putative 0.0087 0.2188 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0169 0.5396 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.5396 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Giardia lamblia Cathepsin B precursor 0.0031 0 0.5
Giardia lamblia Cysteine protease 0.0031 0 0.5
Trypanosoma cruzi cysteine proteinase, putative 0.0087 0.2188 0.4054
Onchocerca volvulus 0.0169 0.5396 0.5396
Brugia malayi Cathepsin L-like precursor 0.0169 0.5396 0.6247
Plasmodium vivax SET domain protein, putative 0.0036 0.0193 0.0358
Echinococcus multilocularis cathepsin L cysteine protease 0.0169 0.5396 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0169 0.5396 0.5396
Loa Loa (eye worm) hypothetical protein 0.0169 0.5396 0.6247
Plasmodium vivax unspecified product 0.0056 0.0966 0.1791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Plasmodium vivax vivapain-1 0.0087 0.2188 0.4054
Leishmania major cathepsin L-like protease 0.0169 0.5396 1
Giardia lamblia Cysteine protease 0.0031 0 0.5
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0169 0.5396 0.6247
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Loa Loa (eye worm) hypothetical protein 0.0056 0.0966 0.1119
Plasmodium vivax vivapain-2 0.0169 0.5396 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0169 0.5396 1
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.2188 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0113 0.3209 0.5946
Giardia lamblia Cathepsin L precursor 0.0031 0 0.5
Leishmania major cathepsin L-like protease 0.0169 0.5396 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Onchocerca volvulus Cathepsin F homolog 0.0169 0.5396 0.5396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.5396 1
Trypanosoma cruzi cysteine peptidase, putative 0.0169 0.5396 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0169 0.5396 1
Onchocerca volvulus 0.0169 0.5396 0.5396
Loa Loa (eye worm) hypothetical protein 0.0113 0.3209 0.3715
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0169 0.5396 1
Onchocerca volvulus 0.0169 0.5396 0.5396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.5396 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0169 0.5396 0.5396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Loa Loa (eye worm) cysteine protease 0.0169 0.5396 0.6247
Echinococcus granulosus cathepsin L cysteine proteinase 0.0169 0.5396 1
Onchocerca volvulus Cathepsin L homolog 0.0169 0.5396 0.5396
Giardia lamblia Cathepsin L precursor 0.0031 0 0.5
Plasmodium falciparum cysteine proteinase falcipain 3 0.0169 0.5396 1
Trypanosoma cruzi cysteine peptidase, putative 0.0169 0.5396 1
Schistosoma mansoni cathepsin F (C01 family) 0.0169 0.5396 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.2188 0.4054
Trypanosoma cruzi cysteine proteinase, putative 0.0087 0.2188 0.4054
Plasmodium vivax vivapain-3 0.0087 0.2188 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.2188 0.4054
Giardia lamblia Hypothetical protein 0.0031 0 0.5
Giardia lamblia Cathepsin B precursor 0.0031 0 0.5
Echinococcus granulosus cathepsin L 0.0087 0.2188 0.4054
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Onchocerca volvulus 0.0169 0.5396 0.5396
Loa Loa (eye worm) hypothetical protein 0.0113 0.3209 0.3715
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0193 0.0358
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.2188 0.4054
Brugia malayi Cathepsin L-like cysteine proteinase 0.0113 0.3209 0.3715
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.5396 1
Echinococcus multilocularis cysteine protease 0.0169 0.5396 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0193 0.0223
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0056 0.0966 0.1119
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.2691 0.4987
Trypanosoma cruzi cysteine peptidase, putative 0.0169 0.5396 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0169 0.5396 0.5396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.2188 0.2188
Entamoeba histolytica cysteine proteinase, putative 0.0169 0.5396 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0087 0.2188 0.4054
Brugia malayi Cathepsin L-like precursor 0.0169 0.5396 0.6247
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0031 0 0.5
Leishmania major cathepsin L-like protease 0.0169 0.5396 1
Leishmania major cathepsin L-like protease 0.0169 0.5396 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0193 0.0358
Echinococcus multilocularis cathepsin L 0.0087 0.2188 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.3209 0.3209
Brugia malayi Cathepsin L-like precursor 0.0169 0.5396 0.6247
Brugia malayi cathepsin F-like cysteine proteinase 0.0056 0.0966 0.1119
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.3209 0.5946
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0169 0.5396 0.5396
Giardia lamblia Cathepsin B precursor 0.0031 0 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0169 0.5396 0.5396
Schistosoma mansoni cathepsin F (C01 family) 0.0169 0.5396 1
Brugia malayi Cathepsin L-like precursor 0.0056 0.0966 0.1119
Loa Loa (eye worm) fibroinase 0.0169 0.5396 0.6247
Giardia lamblia Encystation-specific protease 0.0031 0 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0169 0.5396 0.5396
Echinococcus multilocularis cysteine protease 0.0169 0.5396 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.5396 1
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.2188 0.4054
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0031 0 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.5396 1
Leishmania major cathepsin L-like protease 0.0169 0.5396 1
Giardia lamblia Cathepsin L-like protease 0.0031 0 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.2188 0.4054
Plasmodium vivax vivapain-2 0.0169 0.5396 1
Giardia lamblia Cathepsin L precursor 0.0031 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0193 0.0223
Onchocerca volvulus 0.0113 0.3209 0.3209
Onchocerca volvulus Cathepsin L homolog 0.0169 0.5396 0.5396
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.2691 0.4987
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0169 0.5396 0.5396
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0056 0.0966 0.1119
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.2188 0.2533
Giardia lamblia Cathepsin B precursor 0.0031 0 0.5
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0031 0 0.5
Brugia malayi Cathepsin L-like precursor 0.0169 0.5396 0.6247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0169 0.5396 0.6247
Brugia malayi Papain family cysteine protease containing protein 0.0169 0.5396 0.6247
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0966 0.1791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.2188 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0169 0.5396 0.5396
Giardia lamblia Cathepsin L precursor 0.0031 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0113 0.3209 0.5946
Giardia lamblia Cathepsin L precursor 0.0031 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Echinococcus granulosus cysteine protease 0.0087 0.2188 0.4054
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.2188 0.4054
Leishmania major cathepsin L-like protease 0.0169 0.5396 1
Plasmodium vivax unspecified product 0.0087 0.2188 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.5396 1
Onchocerca volvulus 0.0169 0.5396 0.5396
Onchocerca volvulus 0.0169 0.5396 0.5396
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0141 0.0261
Schistosoma mansoni cathepsin s 0.0056 0.0966 0.1791
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0169 0.5396 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0193 0.0358
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0193 0.0358
Giardia lamblia Cysteine protease 0.0031 0 0.5
Echinococcus granulosus cathepsin l1 0.0169 0.5396 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0193 0.0358
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0169 0.5396 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0966 0.1119
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0193 0.0358
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.5396 1
Brugia malayi Pre-SET motif family protein 0.0251 0.8638 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.2188 0.4054
Onchocerca volvulus 0.0036 0.0193 0.0193
Trypanosoma cruzi cruzipain precursor, putative 0.0169 0.5396 1
Brugia malayi Cathepsin L-like precursor 0.0113 0.3209 0.3715
Leishmania major cathepsin L-like protease 0.0169 0.5396 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.3209 0.3209
Giardia lamblia Cathepsin L-like protease 0.0031 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0169 0.5396 0.5396
Giardia lamblia Cathepsin B precursor 0.0031 0 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.5396 1
Onchocerca volvulus 0.0169 0.5396 0.5396
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0169 0.5396 0.5396
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0193 0.0358
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Giardia lamblia Cathepsin B precursor 0.0031 0 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.2188 0.4054
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0193 0.0358
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.2188 0.2533
Brugia malayi cathepsin L-like precursor 0.0113 0.3209 0.3715
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0169 0.5396 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.5396 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.5396 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Entamoeba histolytica cysteine proteinase 2 0.0087 0.2188 0.4054
Loa Loa (eye worm) ctsf protein 0.0169 0.5396 0.6247
Giardia lamblia Cysteine protease 0.0031 0 0.5
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Echinococcus granulosus cathepsin l1 0.0113 0.3209 0.5946
Trypanosoma cruzi cruzipain precursor, putative 0.0056 0.0966 0.1791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Echinococcus granulosus cathepsin L cysteine protease 0.0087 0.2188 0.4054
Giardia lamblia Cathepsin L precursor 0.0031 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0169 0.5396 0.5396
Trypanosoma cruzi cysteine protease, putative 0.0087 0.2188 0.4054
Loa Loa (eye worm) hypothetical protein 0.01 0.2691 0.3116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.5396 0.5396
Brugia malayi Cathepsin L-like precursor 0.0113 0.3209 0.3715
Giardia lamblia Hypothetical protein 0.0031 0 0.5
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Brugia malayi Cathepsin L-like precursor 0.0169 0.5396 0.6247
Entamoeba histolytica cysteine protease, putative 0.0169 0.5396 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.2188 0.4054
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.2188 0.2188
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0031 0 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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