Detailed information for compound 1484153

Basic information

Technical information
  • TDR Targets ID: 1484153
  • Name: (Z)-4-[[2-[4-(2-methylphenyl)piperazin-1-yl]p henyl]amino]-4-oxobut-2-enoic acid
  • MW: 365.426 | Formula: C21H23N3O3
  • H donors: 2 H acceptors: 3 LogP: 2.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1N1CCN(CC1)c1ccccc1C)/C=C\C(=O)O
  • InChi: 1S/C21H23N3O3/c1-16-6-2-4-8-18(16)23-12-14-24(15-13-23)19-9-5-3-7-17(19)22-20(25)10-11-21(26)27/h2-11H,12-15H2,1H3,(H,22,25)(H,26,27)/b11-10-
  • InChiKey: BDQAIZFJKVJOKE-KHPPLWFESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (Z)-4-[[2-[4-(2-methylphenyl)piperazin-1-yl]phenyl]amino]-4-oxo-but-2-enoic acid
  • (Z)-4-[[2-[4-(2-methylphenyl)-1-piperazinyl]phenyl]amino]-4-oxobut-2-enoic acid
  • (Z)-4-keto-4-[[2-[4-(2-methylphenyl)piperazin-1-yl]phenyl]amino]but-2-enoic acid
  • 4-{2-[4-(2-methylphenyl)-1-piperazinyl]anilino}-4-oxo-2-butenoic acid
  • MLS001182516
  • SMR000477804
  • AQ-360/43091285

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens tumor susceptibility 101 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus multilocularis tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01931 tumor suppressor protein 101 [EC:6.3.2.19], putative Get druggable targets OG5_128950 All targets in OG5_128950
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis aldo-keto reductase, putative 0.0966 1 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.028 0.2827 0.2826
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0109 0.006
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0499 0.0498
Echinococcus multilocularis prolyl endopeptidase 0.0025 0.0167 0.0166
Echinococcus granulosus expressed conserved protein 0.0096 0.091 0.0909
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.048 0.048
Onchocerca volvulus 0.0966 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0166 0.0057
Loa Loa (eye worm) hypothetical protein 0.0025 0.0166 0.0165
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1416 0.1339
Schistosoma mansoni microtubule-associated protein tau 0.0733 0.7566 0.7539
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0499 0.0415
Echinococcus granulosus aldo keto reductase 0.0966 1 1
Mycobacterium tuberculosis Probable reductase 0.013 0.1264 0.1186
Trichomonas vaginalis aldo-keto reductase, putative 0.028 0.2827 0.2792
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0109 0.0037
Echinococcus multilocularis protein dispatched 1 0.005 0.0428 0.0427
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0966 1 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0109 0.0108
Trypanosoma cruzi oligopeptidase b 0.0025 0.0167 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0166 0.0067
Loa Loa (eye worm) hypothetical protein 0.0082 0.0759 0.0758
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0966 1 1
Trichomonas vaginalis hypothetical protein 0.0041 0.033 0.0282
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0109 0.006
Loa Loa (eye worm) hypothetical protein 0.0044 0.0363 0.0362
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0109 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.048 0.0479
Echinococcus granulosus geminin 0.018 0.1784 0.1783
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.1436 0.1435
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0166 0.0117
Mycobacterium ulcerans hypothetical protein 0.0025 0.0166 0.0067
Trichomonas vaginalis aldo-keto reductase, putative 0.0966 1 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0109 0.0021
Entamoeba histolytica aldose reductase, putative 0.0966 1 1
Brugia malayi prolyl oligopeptidase family protein 0.0025 0.0167 0.0167
Giardia lamblia Alanyl dipeptidyl peptidase 0.0025 0.0167 0.0058
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.048 0.0479
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0027 0.0183 0.0135
Mycobacterium leprae Conserved hypothetical protein 0.0686 0.7075 0.7026
Loa Loa (eye worm) hypothetical protein 0.0103 0.0976 0.0974
Leishmania major hypothetical protein, conserved 0.0027 0.0183 0.0075
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0025 0.0167 0.0118
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0158 0.1559 0.1517
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0109 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0098
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0966 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0109 0.006
Onchocerca volvulus Prolyl endopeptidase homolog 0.0025 0.0167 0.0001
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0109 1
Trypanosoma brucei prolyl oligopeptidase, putative 0.0025 0.0167 0.0118
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.028 0.2827 0.2748
Loa Loa (eye worm) oxidoreductase 0.0966 1 1
Echinococcus granulosus acylamino acid releasing enzyme 0.0025 0.0167 0.0166
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0025 0.0167 0.0118
Leishmania major trypanothione reductase 0.0057 0.0499 0.0394
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0166 0.0166
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0109 0.006
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0025 0.0167 0.0068
Leishmania major prostaglandin f synthase, putative 0.0966 1 1
Brugia malayi hypothetical protein 0.0084 0.078 0.078
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0158 0.1559 0.1517
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0966 1 1
Schistosoma mansoni pol-related 0.0966 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0166 0.0057
Echinococcus multilocularis aldo keto reductase 0.0966 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0966 1 1
Brugia malayi NADH-dependent xylose reductase 0.028 0.2827 0.2827
Onchocerca volvulus 0.0031 0.0222 0.0057
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0213 0.213 0.2129
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0166 0.0067
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0055 0.0055
Trypanosoma brucei oligopeptidase b 0.0025 0.0167 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0166 0.0078
Echinococcus multilocularis acylamino acid releasing enzyme 0.0025 0.0167 0.0166
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0166 0.0166
Entamoeba histolytica prolyl oligopeptidase family protein 0.0025 0.0167 0.0118
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0109 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0167 0.0118
Trypanosoma brucei prostaglandin f synthase 0.0966 1 1
Toxoplasma gondii aldo-keto reductase 0.028 0.2827 0.2748
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0966 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0966 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0966 1 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0966 1 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0166 0.0166
Onchocerca volvulus 0.0966 1 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0158 0.1559 0.1558
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0098
Trichomonas vaginalis aldo-keto reductase, putative 0.0966 1 1
Loa Loa (eye worm) glutathione reductase 0.0057 0.0499 0.0498
Loa Loa (eye worm) oxidoreductase 0.0966 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.048 0.0479
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0025 0.0167 0.0118
Mycobacterium ulcerans hypothetical protein 0.028 0.2827 0.2755
Onchocerca volvulus 0.0966 1 1
Schistosoma mansoni hypothetical protein 0.0042 0.0346 0.024
Plasmodium falciparum glutathione reductase 0.002 0.0109 0.0037
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0966 1 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0025 0.0167 0.0118
Schistosoma mansoni hypothetical protein 0.0435 0.4445 0.4383
Trichomonas vaginalis aldo-keto reductase, putative 0.0966 1 1
Schistosoma mansoni aldo-keto reductase 0.0966 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0966 1 1
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0025 0.0167 0.0118
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0025 0.0167 0.0118
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0109 0.0037
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0025 0.0167 0.0058
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0499 0.0498
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0966 1 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0109 0.001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0862 0.8907 0.8907
Schistosoma mansoni tsg101-related 0.007 0.0634 0.053
Loa Loa (eye worm) prolyl oligopeptidase 0.0025 0.0167 0.0166
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0109 0.006
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0213 0.213 0.2129
Entamoeba histolytica aldose reductase, putative 0.0966 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0363 0.0315
Echinococcus granulosus aldo keto reductase 0.0966 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0167 0.0166
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.028 0.2827 0.2748
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0158 0.1559 0.1466
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0025 0.0167 0.0058
Trypanosoma cruzi oligopeptidase b 0.0025 0.0167 0.0118
Loa Loa (eye worm) hypothetical protein 0.0025 0.0167 0.0166
Entamoeba histolytica hypothetical protein, conserved 0.0025 0.0167 0.0118
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0976 0.0974
Trypanosoma brucei aldo-keto reductase, putative 0.0966 1 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0025 0.0167 0.0058
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0363 0.0362
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0158 0.1559 0.1517
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0025 0.0167 0.0058
Trypanosoma cruzi aldo-keto reductase 0.0966 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1416 0.1271
Echinococcus multilocularis aldo keto reductase 0.0966 1 1
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0025 0.0167 0.0058
Entamoeba histolytica alcohol dehydrogenase, putative 0.028 0.2827 0.2792
Echinococcus multilocularis cpg binding protein 0.0032 0.024 0.0238
Brugia malayi prolyl oligopeptidase family protein 0.0025 0.0167 0.0167
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0109 0.006
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0025 0.0167 0.0058
Schistosoma mansoni tsg101-related 0.0057 0.05 0.0395
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0025 0.0167 0.0058
Trypanosoma cruzi aldo/keto reductase, putative 0.028 0.2827 0.2792
Onchocerca volvulus 0.0966 1 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.028 0.2827 1
Brugia malayi glutathione reductase 0.0057 0.0499 0.0499
Echinococcus granulosus Dipeptidyl peptidase 9 0.0158 0.1559 0.1558
Brugia malayi CXXC zinc finger family protein 0.0031 0.0222 0.0222
Toxoplasma gondii hypothetical protein 0.0025 0.0167 0.0058
Mycobacterium tuberculosis Probable oxidoreductase 0.0966 1 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0966 1 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1264 0.1117
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0966 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0167 0.0118
Echinococcus multilocularis dnaJ subfamily B 0.0435 0.4445 0.4444
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0166 0.0067
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0966 1 1
Trypanosoma cruzi prolyl endopeptidase 0.0025 0.0167 0.0118
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0109 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0167 0.0118
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0084 0.078 0.0779
Echinococcus granulosus aldo keto reductase family 1, member B4 0.028 0.2827 0.2826
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0027 0.0183 0.0135
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0966 1 1
Plasmodium vivax glutathione reductase, putative 0.0057 0.0499 0.1467
Loa Loa (eye worm) oxidoreductase 0.0966 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0109 0.001
Trichomonas vaginalis aldo-keto reductase, putative 0.0966 1 1
Schistosoma mansoni tsg101-related 0.007 0.0634 0.053
Echinococcus granulosus hypothetical protein 0.0966 1 1
Leishmania major aldo-keto reductase-like protein 0.0966 1 1
Mycobacterium ulcerans oxidoreductase 0.0966 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1264 0.1186
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0109 0.006
Trichomonas vaginalis aldo/keto reductase, putative 0.0966 1 1
Plasmodium falciparum thioredoxin reductase 0.0057 0.0499 0.1467
Brugia malayi prolyl oligopeptidase family protein 0.0158 0.1559 0.1559
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0363 0.0362
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0363 0.0362
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.1436 0.1435
Schistosoma mansoni cpg binding protein 0.0031 0.0222 0.0113
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.028 0.2827 0.2748
Trichomonas vaginalis conserved hypothetical protein 0.028 0.2827 0.2792
Echinococcus granulosus dnaJ subfamily B 0.0435 0.4445 0.4444
Trichomonas vaginalis aldo-keto reductase, putative 0.0966 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0507 0.0402
Mycobacterium tuberculosis Probable peptidase 0.0025 0.0167 0.0079
Trichomonas vaginalis aldo/keto reductase, putative 0.0966 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0467 0.0465
Trichomonas vaginalis aldo-keto reductase, putative 0.0966 1 1
Giardia lamblia Aldose reductase 0.0966 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1264 0.1186
Schistosoma mansoni patched 1 0.0044 0.0363 0.0256
Schistosoma mansoni hypothetical protein 0.0042 0.0346 0.024
Echinococcus multilocularis protein patched 0.0044 0.0363 0.0362
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0966 1 1
Giardia lamblia Alanyl dipeptidyl peptidase 0.0025 0.0167 0.0058
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0099 0.0011
Trichomonas vaginalis aldo-keto reductase, putative 0.028 0.2827 0.2792
Echinococcus multilocularis aldehyde reductase 0.0686 0.7075 0.7075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0098
Echinococcus granulosus prolyl endopeptidase 0.0025 0.0167 0.0166
Trypanosoma cruzi aldo/keto reductase, putative 0.0966 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0966 1 1
Echinococcus multilocularis geminin 0.018 0.1784 0.1783
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0098
Onchocerca volvulus 0.0966 1 1
Schistosoma mansoni hypothetical protein 0.018 0.1784 0.1693
Trichomonas vaginalis aldo-keto reductase, putative 0.0966 1 1
Mycobacterium leprae Possible oxidoreductase 0.028 0.2827 0.2706
Schistosoma mansoni potassium channel beta 0.028 0.2827 0.2748
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.048 0.0479
Plasmodium falciparum aldo-keto reductase, putative 0.028 0.2827 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0579 0.0475
Toxoplasma gondii aldose reductase, putative 0.0966 1 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0992 0.0892
Plasmodium vivax aldehyde reductase, putative 0.028 0.2827 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0025 0.0167 0.0118
Leishmania major oligopeptidase b 0.0025 0.0167 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.048 0.0375
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0057 0.05 0.0452
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0167 0.0247
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0109 0.006
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1264 0.1186
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0166 0.0067
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0166 0.0117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0109 0.006
Echinococcus granulosus microtubule associated protein 2 0.0733 0.7566 0.7565
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0109 0.0109
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0025 0.0167 0.0118
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0109 0.5
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0025 0.0167 0.0001
Schistosoma mansoni aldo-keto reductase 0.0966 1 1
Trypanosoma brucei trypanothione reductase 0.0057 0.0499 0.0452
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0966 1 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0363 0.0362
Loa Loa (eye worm) hypothetical protein 0.0077 0.0702 0.0701
Trichomonas vaginalis alcohol dehydrogenase, putative 0.028 0.2827 0.2792
Schistosoma mansoni cpg binding protein 0.0032 0.024 0.0132
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0025 0.0167 0.0079
Schistosoma mansoni hypothetical protein 0.0042 0.0346 0.024
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0109 0.5
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0966 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0966 1 1
Toxoplasma gondii thioredoxin reductase 0.0057 0.0499 0.0394
Brugia malayi CHE-14 protein 0.0044 0.0363 0.0363
Echinococcus multilocularis aldo keto reductase 0.0966 1 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.028 0.2827 0.2792
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0976 0.0974
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0499 0.1467
Schistosoma mansoni hypothetical protein 0.018 0.1784 0.1693
Echinococcus multilocularis voltage gated potassium channel subunit 0.028 0.2827 0.2826
Mycobacterium tuberculosis Conserved protein 0.028 0.2827 0.2763
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1264 0.1186
Brugia malayi prolyl oligopeptidase family protein 0.0025 0.0167 0.0167
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0109 0.006
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0976 0.0976
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0966 1 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0025 0.0167 0.0118
Treponema pallidum NADH oxidase 0.002 0.0109 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0166 0.0117
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0966 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0166 0.0057
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0966 1 1
Brugia malayi hypothetical protein 0.0082 0.0759 0.0759
Loa Loa (eye worm) prolyl oligopeptidase 0.0213 0.213 0.2129
Loa Loa (eye worm) oxidoreductase 0.0966 1 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.1581 0.158
Entamoeba histolytica aldose reductase, putative 0.0966 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0966 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0499 0.0498
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1416 0.1339
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0166 0.0078
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0084 0.078 0.0779
Trichomonas vaginalis aldo-keto reductase, putative 0.028 0.2827 0.2792
Echinococcus granulosus voltage gated potassium channel subunit 0.028 0.2827 0.2826
Trichomonas vaginalis aldo/keto reductase, putative 0.0966 1 1
Loa Loa (eye worm) oxidoreductase 0.0966 1 1
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0158 0.1559 0.1517
Echinococcus granulosus aldo keto reductase 0.0966 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0166 0.0067
Loa Loa (eye worm) hypothetical protein 0.0084 0.078 0.0779
Brugia malayi Thioredoxin reductase 0.0057 0.0499 0.0499
Echinococcus granulosus cpg binding protein 0.0032 0.024 0.0238
Schistosoma mansoni hypothetical protein 0.0042 0.0346 0.024
Onchocerca volvulus 0.028 0.2827 0.2706
Plasmodium falciparum aldehyde reductase, putative 0.028 0.2827 1
Trypanosoma brucei aldo/keto reductase, putative 0.028 0.2827 0.2792
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0109 0.006
Onchocerca volvulus 0.0161 0.1581 0.1439
Echinococcus granulosus aldehyde reductase 0.0686 0.7075 0.7075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0098
Schistosoma mansoni cpg binding protein 0.0032 0.024 0.0132
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0222 0.022
Plasmodium falciparum peptidase, putative 0.0025 0.0167 0.0247
Toxoplasma gondii prolyl endopeptidase 0.0025 0.0167 0.0058
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0166 0.0067
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0055 0.0055
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0025 0.0167 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.048 0.0375
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0158 0.1559 0.1466
Loa Loa (eye worm) hypothetical protein 0.0025 0.0166 0.0165
Giardia lamblia Aldose reductase 0.0966 1 1
Echinococcus multilocularis aldo keto reductase 0.0966 1 1
Plasmodium falciparum thioredoxin reductase 0.002 0.0109 0.0037
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0109 0.006
Echinococcus multilocularis microtubule associated protein 2 0.0733 0.7566 0.7565
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0966 1 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0213 0.213 0.1997
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0966 1 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0213 0.213 0.2043
Brugia malayi glutamate-cysteine ligase modifier subunit 0.028 0.2827 0.2827
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0966 1 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0166 0.0067
Echinococcus multilocularis expressed conserved protein 0.0096 0.091 0.0909
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0966 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.048 0.0375
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1264 0.1186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.048 0.0479
Trichomonas vaginalis aldo-keto reductase, putative 0.0966 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0966 1 1
Brugia malayi hypothetical protein 0.0161 0.1581 0.1581
Onchocerca volvulus 0.0966 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0109 0.006
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0109 0.0108
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1416 0.1339
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0966 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0109 0.006
Brugia malayi prolyl oligopeptidase family protein 0.0213 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0025 0.0166 0.0165
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0976 0.0931
Loa Loa (eye worm) hypothetical protein 0.0966 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0966 1 1
Trypanosoma brucei prolyl endopeptidase 0.0025 0.0167 0.0118
Plasmodium falciparum glutathione reductase 0.0057 0.0499 0.1467
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0107 0.1023 0.0924
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0499 0.0452

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1634 uM PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation in TR assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5749 uM PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.