Detailed information for compound 1484155

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 247.21 | Formula: C10H9N5O3
  • H donors: 1 H acceptors: 6 LogP: -0.41 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCC(=O)N1c1nc2n(n1)c(O)cc(n2)C
  • InChi: 1S/C10H9N5O3/c1-5-4-8(18)15-9(11-5)12-10(13-15)14-6(16)2-3-7(14)17/h4,18H,2-3H2,1H3
  • InChiKey: JHHPBWJSRSFVSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0279 0.2841 0.2764
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0377 0.0377
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.1438 0.1438
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0182 0.0067
Loa Loa (eye worm) prolyl oligopeptidase 0.0203 0.2041 0.2026
Loa Loa (eye worm) oxidoreductase 0.0964 1 1
Echinococcus granulosus geminin 0.0178 0.1782 0.1782
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0983 0.0983
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0964 1 1
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0024 0.0173 0.0068
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0964 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0683 0.0665
Brugia malayi prolyl oligopeptidase family protein 0.0024 0.0173 0.0155
Trichomonas vaginalis aldo-keto reductase, putative 0.0964 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0424 0.0406
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0964 1 1
Echinococcus granulosus aldo keto reductase 0.0964 1 1
Echinococcus multilocularis voltage gated potassium channel subunit 0.0279 0.2841 0.2841
Loa Loa (eye worm) oxidoreductase 0.0964 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.024 0.0221
Echinococcus multilocularis geminin 0.0178 0.1782 0.1782
Echinococcus multilocularis expressed conserved protein 0.0095 0.0918 0.0918
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0182 0.0067
Onchocerca volvulus 0.0279 0.2841 0.2715
Loa Loa (eye worm) oxidoreductase 0.0964 1 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0964 1 1
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0279 0.2841 0.2715
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.2841 0.2715
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0024 0.0173 0.0173
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0964 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0182 0.0077
Echinococcus multilocularis aldo keto reductase 0.0964 1 1
Plasmodium falciparum peptidase, putative 0.0024 0.0173 0.0209
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.024 0.0068
Brugia malayi prolyl oligopeptidase family protein 0.0024 0.0173 0.0155
Loa Loa (eye worm) hypothetical protein 0.0964 1 1
Mycobacterium tuberculosis Probable peptidase 0.0024 0.0173 0.0068
Echinococcus multilocularis acylamino acid releasing enzyme 0.0024 0.0173 0.0173
Trypanosoma cruzi aldo/keto reductase, putative 0.0279 0.2841 0.2715
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0377 0.0358
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0182 0.0067
Loa Loa (eye worm) oxidoreductase 0.0964 1 1
Echinococcus granulosus aldo keto reductase 0.0964 1 1
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0279 0.2841 0.2715
Echinococcus granulosus aldehyde reductase 0.0685 0.7081 0.7081
Toxoplasma gondii aldo-keto reductase 0.0279 0.2841 0.2715
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0024 0.0173 0.0058
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0279 0.2841 0.2827
Echinococcus multilocularis aldehyde reductase 0.0685 0.7081 0.7081
Onchocerca volvulus 0.0964 1 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0024 0.0173 0.0154
Schistosoma mansoni cpg binding protein 0.0032 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0025 0.0182 0.0163
Echinococcus granulosus expressed conserved protein 0.0095 0.0918 0.0918
Echinococcus multilocularis cpg binding protein 0.0032 0.0255 0.0255
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0203 0.2041 0.2041
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0999 0.0999
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0151 0.1498 0.1348
Trypanosoma brucei prostaglandin f synthase 0.0964 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0725 0.75 0.75
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.024 0.0068
Echinococcus granulosus microtubule associated protein 2 0.0725 0.75 0.75
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0964 1 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0182 0.0077
Echinococcus granulosus acylamino acid releasing enzyme 0.0024 0.0173 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0424 0.0424
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0424 0.0407
Mycobacterium ulcerans hypothetical protein 0.0025 0.0182 0.0067
Onchocerca volvulus 0.0025 0.0182 0.0009
Onchocerca volvulus 0.0964 1 1
Brugia malayi hypothetical protein 0.0078 0.0737 0.072
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0203 0.2041 0.1901
Echinococcus granulosus prolyl endopeptidase 0.0024 0.0173 0.0173
Brugia malayi prolyl oligopeptidase family protein 0.0203 0.2041 0.2027
Onchocerca volvulus 0.0964 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0964 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.024 0.0454
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0964 1 1
Brugia malayi NADH-dependent xylose reductase 0.0279 0.2841 0.2828
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0279 0.2841 0.2715
Echinococcus multilocularis dnaJ subfamily B 0.043 0.4413 0.4413
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0097
Trichomonas vaginalis aldo-keto reductase, putative 0.0964 1 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0024 0.0173 0.0173
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0151 0.1498 0.1498
Schistosoma mansoni pol-related 0.0964 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0964 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0964 1 1
Plasmodium falciparum aldehyde reductase, putative 0.0279 0.2841 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0964 1 1
Echinococcus multilocularis aldo keto reductase 0.0964 1 1
Schistosoma mansoni cpg binding protein 0.0032 0.0255 0.0255
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0279 0.2841 0.2841
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0102 0.0988 0.0829
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0424 0.0424
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0852 0.8827 0.8827
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0983 0.0824
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0151 0.1498 0.1348
Trichomonas vaginalis aldo-keto reductase, putative 0.0964 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0279 0.2841 0.2715
Trichomonas vaginalis aldo/keto reductase, putative 0.0964 1 1
Echinococcus multilocularis aldo keto reductase 0.0964 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0964 1 1
Schistosoma mansoni hypothetical protein 0.0014 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0097
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0182 0.0009
Trichomonas vaginalis aldo-keto reductase, putative 0.0964 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0964 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0097
Mycobacterium ulcerans oxidoreductase 0.0964 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0182 0.0009
Loa Loa (eye worm) hypothetical protein 0.0101 0.0983 0.0965
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0182 0.0009
Brugia malayi hypothetical protein 0.0159 0.1581 0.1566
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0182 0.0009
Entamoeba histolytica aldose reductase, putative 0.0964 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0424 0.0424
Echinococcus granulosus voltage gated potassium channel subunit 0.0279 0.2841 0.2841
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.024 0.0068
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0964 1 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0182 0.0164
Brugia malayi CHE-14 protein 0.0044 0.0377 0.036
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0203 0.2041 0.2041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0591 0.0591
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0024 0.0173 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0182 0.0067
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0964 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0964 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0964 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.1438 0.1438
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0964 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0279 0.2841 0.2715
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0151 0.1498 0.1348
Loa Loa (eye worm) hypothetical protein 0.0025 0.0182 0.0163
Leishmania major aldo-keto reductase-like protein 0.0964 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0964 1 1
Mycobacterium ulcerans hypothetical protein 0.0279 0.2841 0.2757
Plasmodium falciparum aldo-keto reductase, putative 0.0279 0.2841 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0182 0.0067
Schistosoma mansoni cpg binding protein 0.003 0.0237 0.0237
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0116 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.024 0.0068
Entamoeba histolytica aldose reductase, putative 0.0964 1 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0983 0.0966
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0064 0.0064
Onchocerca volvulus 0.0159 0.1581 0.1433
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0182 0.0067
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0154
Onchocerca volvulus 0.0964 1 1
Echinococcus multilocularis microtubule associated protein 2 0.0725 0.75 0.75
Loa Loa (eye worm) hypothetical protein 0.0159 0.1581 0.1565
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0203 0.2041 0.2041
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0964 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0964 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0964 1 1
Onchocerca volvulus 0.003 0.0237 0.0065
Schistosoma mansoni hypothetical protein 0.0178 0.1782 0.1782
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0279 0.2841 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0097
Loa Loa (eye worm) hypothetical protein 0.0053 0.0479 0.0461
Trichomonas vaginalis aldo-keto reductase, putative 0.0964 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0964 1 1
Onchocerca volvulus 0.0964 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0964 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0182 0.0009
Echinococcus granulosus Dipeptidyl peptidase 9 0.0151 0.1498 0.1498
Loa Loa (eye worm) hypothetical protein 0.0078 0.0737 0.0719
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0279 0.2841 0.2828
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0182 0.0009
Brugia malayi hypothetical protein 0.002 0.0127 0.0109
Schistosoma mansoni hypothetical protein 0.043 0.4413 0.4413
Echinococcus granulosus aldo keto reductase 0.0964 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0964 1 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0237 0.0219
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0024 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0025 0.0182 0.0163
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0173 0.0209
Schistosoma mansoni patched 1 0.0044 0.0377 0.0377
Echinococcus multilocularis prolyl endopeptidase 0.0024 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0042 0.0361 0.0361
Brugia malayi hypothetical protein 0.003 0.024 0.0222
Trichomonas vaginalis aldo-keto reductase, putative 0.0964 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0685 0.7081 0.7029
Onchocerca volvulus 0.0964 1 1
Trypanosoma brucei aldo/keto reductase, putative 0.0279 0.2841 0.2715
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0964 1 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0151 0.1498 0.1498
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0151 0.1498 0.1348
Plasmodium vivax aldehyde reductase, putative 0.0279 0.2841 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0964 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0964 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0964 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0964 1 1
Schistosoma mansoni hypothetical protein 0.0178 0.1782 0.1782
Giardia lamblia Aldose reductase 0.0964 1 1
Schistosoma mansoni aldo-keto reductase 0.0964 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0424 0.0424
Echinococcus multilocularis aldo keto reductase 0.0964 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0424 0.0424
Mycobacterium leprae Possible oxidoreductase 0.0279 0.2841 0.2715
Trichomonas vaginalis aldo-keto reductase, putative 0.0964 1 1
Giardia lamblia Aldose reductase 0.0964 1 1
Toxoplasma gondii aldose reductase, putative 0.0964 1 1
Entamoeba histolytica aldose reductase, putative 0.0964 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.024 0.0454
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0019 0.0019
Schistosoma mansoni potassium channel beta 0.0279 0.2841 0.2841
Echinococcus granulosus hypothetical protein 0.0964 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0377 0.0207
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0237 0.0218
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0116 0.0011
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0182 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0424 0.0424
Trichomonas vaginalis aldo-keto reductase, putative 0.0964 1 1
Trypanosoma cruzi aldo-keto reductase 0.0964 1 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0279 0.2841 0.2715
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0154
Brugia malayi prolyl oligopeptidase family protein 0.0024 0.0173 0.0155
Brugia malayi prolyl oligopeptidase family protein 0.0151 0.1498 0.1482
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0519 0.0352
Schistosoma mansoni hypothetical protein 0.0042 0.0361 0.0361
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0182 0.0067
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0964 1 1
Schistosoma mansoni hypothetical protein 0.0042 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0044 0.0377 0.0358
Echinococcus granulosus cpg binding protein 0.0032 0.0255 0.0255
Loa Loa (eye worm) oxidoreductase 0.0964 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0964 1 1
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0377 0.0377
Schistosoma mansoni aldo-keto reductase 0.0964 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0964 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0983 0.0983
Echinococcus granulosus dnaJ subfamily B 0.043 0.4413 0.4413
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.024 0.0454
Leishmania major prostaglandin f synthase, putative 0.0964 1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0064 0.0064
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0182 0.0009
Trypanosoma cruzi aldo/keto reductase, putative 0.0964 1 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0182 0.0164
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0279 0.2841 0.2715
Trypanosoma brucei aldo-keto reductase, putative 0.0964 1 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0182 0.0164
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0151 0.1498 0.1348
Echinococcus multilocularis protein dispatched 1 0.005 0.0441 0.0441
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0019 0.0019
Trichomonas vaginalis aldo-keto reductase, putative 0.0964 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0279 0.2841 0.2715
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0097
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0964 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0424 0.0424
Entamoeba histolytica alcohol dehydrogenase, putative 0.0279 0.2841 0.2715
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0964 1 1
Schistosoma mansoni hypothetical protein 0.0042 0.0361 0.0361
Leishmania major hypothetical protein, conserved 0.003 0.024 0.0068
Echinococcus multilocularis protein patched 0.0044 0.0377 0.0377

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0738 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.