Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0149 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4071 | 0.4071 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0319 | 0.142 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4071 | 0.4071 |
Onchocerca volvulus | 0.0133 | 0.8644 | 0.8644 | |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.2243 | 0.2243 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.2243 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4071 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.2243 | 0.5511 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.0934 | 0.4164 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4071 | 0.4071 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2243 | 0.2243 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4071 | 0.4071 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0319 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.0934 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4071 | 0.4071 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4071 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.0934 | 0.4164 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0319 | 0.0319 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0319 | 0.142 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4071 | 0.4071 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0149 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0319 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4071 | 0.4071 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.2243 | 0.5511 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.2243 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.2243 | 1 |
Onchocerca volvulus | 0.0149 | 1 | 1 | |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0319 | 0.3411 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4071 | 0.4071 |
Brugia malayi | hypothetical protein | 0.003 | 0.0319 | 0.0319 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4071 | 0.4071 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.2243 | 0.2243 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4071 | 0.4071 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0319 | 0.142 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4071 | 0.4071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3981 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.