Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0137 | 0.0137 |
Schistosoma mansoni | gliotactin | 0.0027 | 0.0137 | 0.016 |
Onchocerca volvulus | 0.0037 | 0.0765 | 0.0637 | |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.859 | 0.859 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.1412 | 0.1292 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1924 | 0.2114 |
Schistosoma mansoni | acetylcholinesterase | 0.0027 | 0.0137 | 0.016 |
Brugia malayi | Carboxylesterase family protein | 0.016 | 0.859 | 0.857 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.016 | 0.859 | 0.859 |
Echinococcus granulosus | acetylcholinesterase | 0.016 | 0.859 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.016 | 0.859 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.016 | 0.859 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0538 | 0.1107 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0146 | 0.0011 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.3758 | 0.4284 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1924 | 0.224 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0146 | 0.0011 |
Loa Loa (eye worm) | carboxylesterase | 0.0027 | 0.0137 | 0.0137 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.3758 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2994 | 0.338 |
Onchocerca volvulus | 0.0182 | 1 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0027 | 0.0137 | 0.016 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1924 | 0.1924 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.1412 | 0.352 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1924 | 0.1812 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.3758 | 0.4284 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.3758 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.3758 | 0.3758 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0027 | 0.0137 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3839 | 0.3839 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0027 | 0.0137 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0137 | 0.0137 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.3269 | 0.3805 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.859 | 0.859 |
Echinococcus multilocularis | acetylcholinesterase | 0.016 | 0.859 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0146 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1541 | 0.1541 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1924 | 0.2114 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.1639 | 0.1523 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.4167 | 0.4086 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0027 | 0.0137 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0137 | 0.0137 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.3758 | 0.4376 |
Loa Loa (eye worm) | carboxylesterase | 0.016 | 0.859 | 0.859 |
Brugia malayi | Carboxylesterase family protein | 0.016 | 0.859 | 0.857 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0765 | 0.0765 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1924 | 0.224 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1173 | 0.1225 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0027 | 0.0137 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1412 | 0.1412 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.016 | 0.859 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0027 | 0.0137 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.1639 | 0.4148 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1173 | 0.1225 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.1412 | 0.352 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.3758 | 0.4284 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1359 | 0.1359 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.1639 | 0.4148 |
Loa Loa (eye worm) | carboxylesterase | 0.0027 | 0.0137 | 0.0137 |
Echinococcus granulosus | carboxylesterase 5A | 0.016 | 0.859 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1924 | 0.2114 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1924 | 0.2114 |
Echinococcus multilocularis | acetylcholinesterase | 0.016 | 0.859 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0027 | 0.0137 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0027 | 0.0137 | 0.016 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.3758 | 0.4376 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1687 | 0.1687 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.3758 | 0.4284 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1924 | 0.224 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1354 | 0.1234 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0538 | 0.1107 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0027 | 0.0137 | 0.016 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2994 | 0.338 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0328 | 0.0193 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.3758 | 0.3672 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0137 | 0.0137 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.1412 | 0.1292 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0137 | 0.0137 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2512 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 1.9953 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.