Detailed information for compound 148472

Basic information

Technical information
  • TDR Targets ID: 148472
  • Name: 1-chloro-6-ethyl-6-phenylpyrrolo[2,1-d][1,5]b enzothiazepin-7-one
  • MW: 353.865 | Formula: C20H16ClNOS
  • H donors: 0 H acceptors: 1 LogP: 5.79 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1(Sc2cccc(c2n2c(C1=O)ccc2)Cl)c1ccccc1
  • InChi: 1S/C20H16ClNOS/c1-2-20(14-8-4-3-5-9-14)19(23)16-11-7-13-22(16)18-15(21)10-6-12-17(18)24-20/h3-13H,2H2,1H3
  • InChiKey: OKAFEYOTXFKGMK-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-chloro-6-ethyl-6-phenyl-pyrrolo[2,1-d][1,5]benzothiazepin-7-one
  • 1-chloro-6-ethyl-6-phenyl-7-pyrrolo[2,1-d][1,5]benzothiazepinone
  • AIDS051862
  • (+/-)-1-chloro-6-ethyl-6-phenylpyrrolo[2,1-d][1,5]benzothiazepin-7(6H)-one
  • AIDS-051862

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.1029 0.8705 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0079 0.0509 0.1381
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0204 0.0437
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0079 0.0509 0.1381
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0079 0.0509 0.1381
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0194 0.1499 0.4437
Schistosoma mansoni GTP-binding protein alpha subunit 0.0044 0.0204 0.0234
Brugia malayi mothers against decapentaplegic homolog 3 0.0027 0.0057 0.0021
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0044 0.0204 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.018 0.0363
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0079 0.0509 0.1381
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0027 0.0062 0.0048
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0079 0.0509 0.1381
Brugia malayi MH2 domain containing protein 0.0027 0.0057 0.0021
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0027 0.0062 0.0071
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0027 0.0062 0.0048
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0194 0.1499 0.1722
Giardia lamblia 20S proteasome alpha subunit 3 0.0079 0.0509 0.1381
Echinococcus granulosus ubiquitin specific protease 41 0.0027 0.0062 0.0048
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0313 0.2526 0.2619
Leishmania major proteasome beta 2 subunit, putative 0.0194 0.1499 0.4437
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0027 0.0062 0.0048
Brugia malayi RNA binding protein 0.0466 0.3844 0.3822
Loa Loa (eye worm) hypothetical protein 0.0044 0.0204 0.0204
Giardia lamblia DINP protein human, muc B family 0.0059 0.0338 0.0853
Giardia lamblia 20S proteasome alpha subunit 4 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0027 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0373 0.3046 0.3499
Echinococcus granulosus 5'partial|Ubiquitin carboxyl terminal hydrolase 48 0.0027 0.0062 0.0048
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0338 0.0853
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0338 0.0337
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0466 0.3844 0.3844
Echinococcus multilocularis proteasome subunit alpha type 2 0.0079 0.0509 0.0515
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0403 0.3301 1
Brugia malayi proteasome subunit alpha type 6 0.0079 0.0509 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Echinococcus granulosus dna polymerase eta 0.0088 0.0583 0.0592
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0027 0.0062 0.0048
Schistosoma mansoni calpain-7 (C02 family) 0.0027 0.0062 0.0071
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0403 0.3301 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 20 0.0027 0.0062 0.0048
Echinococcus granulosus Proteasome subunit alpha beta 0.0079 0.0509 0.0515
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0044 0.0204 0.0196
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0027 0.0062 0.0048
Echinococcus granulosus proteasome subunit alpha type 2 0.0079 0.0509 0.0515
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.1439 0.1485
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0027 0.0062 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1018 0.8607 0.8966
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Schistosoma mansoni tar DNA-binding protein 0.0466 0.3844 0.4416
Schistosoma mansoni smad 0.006 0.0342 0.0392
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0079 0.0509 0.0509
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0044 0.0204 0.0234
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0338 0.0853
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0044 0.0204 0.0168
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0027 0.0062 0.0048
Echinococcus multilocularis proteasome subunit beta type 7 0.0079 0.0509 0.0515
Plasmodium vivax proteasome subunit beta type-6, putative 0.0079 0.0509 0.1381
Echinococcus granulosus death domain containing protein 0.0108 0.0757 0.0773
Brugia malayi Immunoglobulin I-set domain containing protein 0.0108 0.0757 0.0723
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0403 0.3301 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.006 0.0342 0.034
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0016 0.0018
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0027 0.0062 0.0071
Echinococcus granulosus ubiquitin specific peptidase 30 (C19 family) 0.0027 0.0062 0.0048
Echinococcus multilocularis ubiquitin specific peptidase 42 (C19 family) 0.0027 0.0062 0.0048
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0044 0.0204 0.0437
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0108 0.0757 0.0773
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0027 0.0062 0.0071
Brugia malayi MH1 domain containing protein 0.0033 0.0111 0.0076
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0027 0.0062 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0044 0.0204 0.0204
Brugia malayi hypothetical protein 0.0136 0.1 0.0968
Leishmania major proteasome beta-1 subunit, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 16 0.0027 0.0062 0.0048
Echinococcus granulosus mothers against decapentaplegic 2 0.0027 0.0057 0.0043
Schistosoma mansoni ankyrin 23/unc44 0.0108 0.0757 0.0869
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0283 0.0278
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0027 0.0062 0.0071
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0079 0.0509 0.1381
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0079 0.0509 0.1381
Schistosoma mansoni hypothetical protein 0.0286 0.2296 0.2637
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0027 0.0062 0.0048
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0079 0.0509 0.0509
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0227 0.0221
Loa Loa (eye worm) hypothetical protein 0.0108 0.0761 0.0761
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0079 0.0509 0.0515
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0146 0.0136
Echinococcus granulosus proteasome prosome macropain 0.0403 0.3301 0.3428
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0079 0.0509 0.0515
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0079 0.0509 0.1381
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Echinococcus granulosus Ubiquitin carboxyl terminal hydrolase 48 0.0027 0.0062 0.0048
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0079 0.0509 0.0585
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0204 0.0437
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0079 0.0509 0.0585
Schistosoma mansoni hypothetical protein 0.0806 0.6781 0.779
Brugia malayi proteasome subunit beta type 2 0.0194 0.1499 0.1468
Echinococcus multilocularis Smad4 0.006 0.0342 0.034
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0079 0.0509 0.1381
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0403 0.3301 1
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0079 0.0509 0.0515
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0044 0.0204 0.0234
Brugia malayi hypothetical protein 0.0037 0.0146 0.0111
Plasmodium vivax proteasome subunit beta type-3, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0136 0.1 0.1
Leishmania major DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Schistosoma mansoni hypothetical protein 0.1029 0.8705 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Giardia lamblia 20S proteasome alpha subunit 6 0.0079 0.0509 0.1381
Echinococcus granulosus proteasome subunit beta type 7 0.0079 0.0509 0.0515
Trypanosoma brucei unspecified product 0.0041 0.018 0.0363
Brugia malayi hypothetical protein 0.0156 0.1169 0.1137
Brugia malayi hypothetical protein 0.0044 0.0204 0.0168
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0079 0.0509 0.0515
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0079 0.0509 0.1381
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0338 0.0337
Brugia malayi ImpB/MucB/SamB family protein 0.0088 0.0583 0.0549
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0027 0.0062 0.0071
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0044 0.0204 0.0168
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0079 0.0509 0.1381
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0313 0.2526 0.7607
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0313 0.2526 0.7607
Schistosoma mansoni smad1 5 8 and 0.006 0.0342 0.0392
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0079 0.0509 0.1381
Leishmania major DNA polymerase eta, putative 0.0088 0.0583 0.1608
Onchocerca volvulus 0.0027 0.0062 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.0169 0.0169
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0079 0.0509 0.1381
Brugia malayi Calcitonin receptor-like protein seb-1 0.1179 1 1
Echinococcus granulosus mothers against decapentaplegic 5 0.006 0.0342 0.034
Toxoplasma gondii proteasome subunit 0.0079 0.0509 0.1381
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0227 0.0221
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0338 0.0853
Echinococcus multilocularis Ankyrin 0.0108 0.0761 0.0777
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0079 0.0509 0.1381
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 20 0.0027 0.0062 0.0048
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0313 0.2526 0.7607
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0079 0.0509 0.1381
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Loa Loa (eye worm) nuclear factor I 0.0033 0.0111 0.0111
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0313 0.2526 0.2619
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0044 0.0204 0.0437
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0079 0.0509 0.1381
Echinococcus granulosus ubiquitin specific peptidase c family 0.0027 0.0062 0.0048
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0027 0.0062 0.0048
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0403 0.3301 0.3792
Echinococcus multilocularis mothers against decapentaplegic 2 0.0027 0.0057 0.0043
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 0.0027 0.0062 0.0048
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0079 0.0509 0.1381
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0079 0.0509 0.1381
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0027 0.0062 0.0071
Echinococcus granulosus nuclear factor of activated T cells 5 0.1133 0.9598 1
Echinococcus multilocularis GPCR, family 2 0.0373 0.3046 0.3162
Onchocerca volvulus 0.0156 0.1169 0.8363
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0227 0.0227
Onchocerca volvulus 0.0027 0.0062 0.004
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0079 0.0509 0.1381
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0079 0.0509 0.1381
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0079 0.0509 0.1381
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0044 0.0204 0.0234
Plasmodium falciparum ataxin-2 like protein, putative 0.0136 0.1 0.2896
Leishmania major proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0108 0.0757 0.0869
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0079 0.0509 0.1381
Brugia malayi ubiquitin specific protease 14 0.0027 0.0062 0.0026
Schistosoma mansoni hypothetical protein 0.0373 0.3046 0.3499
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0027 0.0062 0.0048
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0079 0.0509 0.1381
Leishmania major proteasome alpha 1 subunit, putative 0.0079 0.0509 0.1381
Brugia malayi MH2 domain containing protein 0.006 0.0342 0.0307
Entamoeba histolytica hypothetical protein 0.0037 0.0146 0.0259
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0194 0.1499 0.4437
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0338 0.0389
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0146 0.0168
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0373 0.3046 0.3162
Schistosoma mansoni tar DNA-binding protein 0.0466 0.3844 0.4416
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0079 0.0509 0.0585
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0079 0.0509 0.0515
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0057 0.0057
Echinococcus multilocularis mothers against decapentaplegic 6 0.0027 0.0057 0.0043
Onchocerca volvulus 0.0044 0.0204 0.1105
Brugia malayi Smad1 0.006 0.0342 0.0307
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0313 0.2526 0.7607
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0044 0.0204 0.0234
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1179 1 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0283 0.0278
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1018 0.8607 0.8966
Plasmodium vivax proteasome subunit beta type-4, putative 0.0079 0.0509 0.1381
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0027 0.0062 0.0071
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0044 0.0204 0.0234
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0044 0.0204 0.0204
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0227 0.0261
Echinococcus granulosus expressed protein 0.0044 0.0204 0.0196
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.023 0.0518
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0373 0.3046 0.3162
Echinococcus multilocularis proteasome subunit beta type 6 0.0079 0.0509 0.0515
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) MBCTL1 0.0053 0.0283 0.0283
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0079 0.0509 0.1381
Mycobacterium ulcerans proteasome PrcB 0.0403 0.3301 1
Echinococcus multilocularis expressed protein 0.0044 0.0204 0.0196
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0044 0.0204 0.0204
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0194 0.1499 0.4437
Echinococcus granulosus netrin receptor unc 5 0.0108 0.0757 0.0773
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Echinococcus granulosus dna polymerase kappa 0.0059 0.0338 0.0337
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0079 0.0509 0.1381
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0338 0.0853
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0079 0.0509 0.0585
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0373 0.3046 0.3162
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0079 0.0509 0.0585
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0088 0.0583 0.0583
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0079 0.0509 0.1381
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0079 0.0509 0.0585
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0061 0.0353 0.0352
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0079 0.0509 0.0585
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0079 0.0509 0.0515
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0027 0.0062 0.0071
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0204 0.0437
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0466 0.3844 0.4416
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0194 0.1499 0.4437
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0079 0.0509 0.1381
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0027 0.0062 0.0071
Loa Loa (eye worm) transcription factor SMAD2 0.0876 0.7385 0.7385
Plasmodium vivax proteasome subunit beta type-1, putative 0.0313 0.2526 0.7607
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0079 0.0509 0.0509
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0194 0.1499 0.1548
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0079 0.0509 0.1381
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0403 0.3301 1
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0313 0.2526 0.2902
Echinococcus multilocularis smad 0.006 0.0342 0.034
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0079 0.0509 0.1381
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Brugia malayi proteasome subunit alpha type 3 0.0079 0.0509 0.0475
Schistosoma mansoni DNA polymerase eta 0.0088 0.0583 0.067
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.018 0.0363
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0044 0.0204 0.0168
Brugia malayi mbt repeat family protein 0.0046 0.0227 0.0192
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0338 0.0853
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0338 0.0853
Entamoeba histolytica hypothetical protein 0.0037 0.0146 0.0259
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Leishmania major proteasome beta 7 subunit, putative 0.0079 0.0509 0.1381
Brugia malayi MH1 domain containing protein 0.006 0.0342 0.0307
Leishmania major proteasome alpha 3 subunit, putative 0.0079 0.0509 0.1381
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0403 0.3301 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0328 0.0326
Brugia malayi proteasome subunit alpha type 2 0.0079 0.0509 0.0475
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0079 0.0509 0.1381
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0108 0.0757 0.0773
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0027 0.0062 0.0071
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0027 0.0062 0.0048
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0373 0.3046 0.3499
Echinococcus multilocularis mothers against decapentaplegic 5 0.006 0.0342 0.034
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0044 0.0204 0.0196
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0079 0.0509 0.0585
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0079 0.0509 0.1381
Plasmodium falciparum ataxin-2 like protein, putative 0.0136 0.1 0.2896
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Trypanosoma brucei PAB1-binding protein , putative 0.0136 0.1 0.2896
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1018 0.8607 0.9888
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1018 0.8607 0.8966
Loa Loa (eye worm) PAS-3 protein 0.0079 0.0509 0.0509
Brugia malayi proteasome subunit alpha type 4 0.0079 0.0509 0.0475
Plasmodium vivax proteasome subunit beta type-7, putative 0.0079 0.0509 0.1381
Giardia lamblia Proteasome subunit beta type 3 0.0079 0.0509 0.1381
Echinococcus multilocularis nuclear factor of activated T cells 5 0.1133 0.9598 1
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0079 0.0509 0.1381
Mycobacterium ulcerans proteasome PrcA 0.0079 0.0509 0.0577
Schistosoma mansoni bromodomain containing protein 0.0062 0.0358 0.0412
Loa Loa (eye worm) hypothetical protein 0.0156 0.1169 0.1169
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0027 0.0062 0.0048
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0227 0.0221
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0283 0.0278
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0373 0.3046 0.3046
Echinococcus granulosus GPCR family 2 0.0373 0.3046 0.3162
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0044 0.0204 0.0168
Brugia malayi RNA recognition motif domain containing protein 0.0466 0.3844 0.3822
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0338 0.0389
Schistosoma mansoni calpain-7 (C02 family) 0.0027 0.0062 0.0071
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0079 0.0509 0.0585
Brugia malayi MH1 domain containing protein 0.006 0.0342 0.0307
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.1018 0.8607 0.8602
Loa Loa (eye worm) hypothetical protein 0.0044 0.0204 0.0204
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0373 0.3046 0.3162
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0061 0.0353 0.0352
Echinococcus granulosus proteasome subunit beta type 6 0.0079 0.0509 0.0515
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0283 0.0278
Toxoplasma gondii proteasome subunit beta type, putative 0.0403 0.3301 1
Schistosoma mansoni smad1 5 8 and 0.006 0.0342 0.0392
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0044 0.0204 0.0168
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0079 0.0509 0.0585
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0283 0.0325
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0027 0.0062 0.0048
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0044 0.0204 0.0196
Schistosoma mansoni smad 0.0027 0.0057 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0079 0.0509 0.1381
Giardia lamblia 20S proteasome alpha subunit 2 0.0079 0.0509 0.1381
Toxoplasma gondii proteasome subunit alpha type, putative 0.0079 0.0509 0.1381
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0079 0.0509 0.1381
Brugia malayi proteasome subunit beta type 1 0.0313 0.2526 0.2499
Entamoeba histolytica hypothetical protein 0.0037 0.0146 0.0259
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0108 0.0761 0.0874
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) proteasome subunit beta type 2 0.0194 0.1499 0.1499
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0079 0.0509 0.1381
Brugia malayi Proteasome subunit alpha type 7-1 0.0079 0.0509 0.0475
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0079 0.0509 0.0509
Trypanosoma cruzi DNA polymerase eta, putative 0.0088 0.0583 0.1608
Loa Loa (eye worm) hypothetical protein 0.0033 0.0111 0.0111
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0079 0.0509 0.0585
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0079 0.0509 0.1381
Toxoplasma gondii peptidase, T1 family protein 0.0079 0.0509 0.1381
Loa Loa (eye worm) proteasome subunit beta type 1 0.0313 0.2526 0.2526
Loa Loa (eye worm) hypothetical protein 0.0181 0.1386 0.1386
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) RNA binding protein 0.0466 0.3844 0.3844
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0079 0.0509 0.0515
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0027 0.0062 0.0071
Echinococcus multilocularis ubiquitin specific protease 41 0.0027 0.0062 0.0048
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0194 0.1499 0.1548
Echinococcus multilocularis dna polymerase eta 0.0088 0.0583 0.0592
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0027 0.0062 0.0071
Loa Loa (eye worm) Smad1 0.006 0.0342 0.0342
Giardia lamblia 20S proteasome alpha subunit 5 0.0079 0.0509 0.1381
Echinococcus granulosus Smad4 0.006 0.0342 0.034
Brugia malayi hypothetical protein 0.0088 0.0584 0.055
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0079 0.0509 0.5
Onchocerca volvulus 0.0044 0.0204 0.1105
Echinococcus granulosus geminin 0.1029 0.8705 0.9068
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0194 0.1499 0.4437
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0027 0.0062 0.0048
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 23 0.0027 0.0062 0.0048
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0079 0.0509 0.0515
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0108 0.0757 0.0757
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0079 0.0509 0.1381
Giardia lamblia Proteasome subunit beta type 1 0.0313 0.2526 0.7607
Leishmania major proteasome alpha 2 subunit, putative 0.0079 0.0509 0.1381
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0194 0.1499 0.4437
Echinococcus granulosus smad 0.006 0.0342 0.034
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0129 0.0117
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0079 0.0509 0.1381
Echinococcus granulosus subfamily T1A non peptidase ue 0.0079 0.0509 0.0515
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0079 0.0509 0.1381
Brugia malayi Bromodomain containing protein 0.0073 0.0457 0.0422
Loa Loa (eye worm) hypothetical protein 0.0053 0.0283 0.0283
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0044 0.0204 0.0204
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0313 0.2526 0.7607
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0129 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0079 0.0509 0.0515
Brugia malayi 20S proteasome alpha5 subunit 0.0079 0.0509 0.0475
Brugia malayi Uncoordinated protein 44 0.0108 0.0757 0.0723
Echinococcus multilocularis proteasome subunit alpha type 6 0.0079 0.0509 0.0515
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1018 0.8607 0.8966
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.1439 0.1485
Loa Loa (eye worm) latrophilin receptor protein 2 0.0373 0.3046 0.3046
Leishmania major proteasome beta 2 subunit, putative 0.0079 0.0509 0.1381
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0079 0.0509 0.0585
Brugia malayi Proteasome A-type and B-type family protein 0.0079 0.0509 0.0475
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0079 0.0509 0.1381
Giardia lamblia 20S proteasome alpha subunit 7 0.0079 0.0509 0.1381
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0227 0.0261
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.1018 0.8607 0.8607
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0079 0.0509 0.0585
Loa Loa (eye worm) MH2 domain-containing protein 0.0876 0.7385 0.7385
Trypanosoma brucei unspecified product 0.0041 0.018 0.0363
Brugia malayi G-protein alpha subunit 0.0044 0.0204 0.0168
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0313 0.2526 0.7607
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 24 0.0027 0.0062 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Giardia lamblia 20S proteasome alpha subunit 1 0.0079 0.0509 0.1381
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 36 0.0027 0.0062 0.0048
Brugia malayi MH2 domain containing protein 0.0876 0.7385 0.7376
Onchocerca volvulus 0.0044 0.0204 0.1105
Schistosoma mansoni Smad4 0.0027 0.0057 0.0065
Echinococcus granulosus proteasome subunit alpha type 6 0.0079 0.0509 0.0515
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0079 0.0509 0.0515
Brugia malayi Latrophilin receptor protein 2 0.0373 0.3046 0.302
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0027 0.0062 0.0071
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0227 0.0221
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0027 0.0062 0.0026
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0079 0.0509 0.1381
Echinococcus granulosus Proteasome subunit alpha type 7 0.0079 0.0509 0.0515
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0027 0.0062 0.0071
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0027 0.0062 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0027 0.0062 0.0062
Onchocerca volvulus 0.0046 0.0227 0.1283
Brugia malayi MH1 domain containing protein 0.0033 0.0111 0.0076
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0057 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1018 0.8607 0.9888
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0079 0.0509 0.1381
Schistosoma mansoni netrin receptor unc5 0.0108 0.0757 0.0869
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0079 0.0509 0.1381
Brugia malayi N-terminal motif family protein 0.0181 0.1386 0.1355
Brugia malayi Bromodomain containing protein 0.0037 0.0148 0.0113
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0403 0.3301 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0027 0.0062 0.0048
Loa Loa (eye worm) hypothetical protein 0.0806 0.6781 0.6781
Echinococcus granulosus TGF beta signal transducer SmadC 0.006 0.0342 0.034
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0338 0.0338
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0027 0.0062 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0044 0.0204 0.0196
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0044 0.0204 0.0168
Brugia malayi hypothetical protein 0.0027 0.0062 0.0026
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0044 0.0204 0.0437
Echinococcus granulosus tar DNA binding protein 0.0466 0.3844 0.3995
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0108 0.0757 0.0757
Leishmania major proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0079 0.0509 0.0515
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0079 0.0509 0.1381
Echinococcus multilocularis tar DNA binding protein 0.0466 0.3844 0.3995
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0027 0.0062 0.0048
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0338 0.0853
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0313 0.2526 0.7607
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0403 0.3301 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0079 0.0509 0.0577
Leishmania major hypothetical protein, conserved 0.0136 0.1 0.2896
Echinococcus multilocularis geminin 0.1029 0.8705 0.9068
Brugia malayi proteasome subunit beta type 3 0.0079 0.0509 0.0475
Trypanosoma cruzi PAB1-binding protein , putative 0.0136 0.1 0.2896
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Brugia malayi Death domain containing protein 0.0108 0.0757 0.0723
Loa Loa (eye worm) hypothetical protein 0.0044 0.0204 0.0204
Echinococcus granulosus proteasome subunit beta t family 0.0079 0.0509 0.0515
Brugia malayi Proteasome A-type and B-type family protein 0.0079 0.0509 0.0475
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 0.0027 0.0062 0.0048
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0338 0.0337
Entamoeba histolytica G protein alpha subunit, putative 0.0044 0.0204 0.0437
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0338 0.0304
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0079 0.0509 0.0515
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0194 0.1499 0.1722
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1018 0.8607 0.9888
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0845 0.712 0.7414
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 16 0.0027 0.0062 0.0048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0373 0.3046 0.302
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0079 0.0509 0.1381
Echinococcus granulosus mothers against decapentaplegic 6 0.0027 0.0057 0.0043
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0044 0.0204 0.0437
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0079 0.0509 0.0585
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Schistosoma mansoni hypothetical protein 0.0061 0.0353 0.0405
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0027 0.0062 0.0048
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.018 0.0363
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0403 0.3301 0.3301
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0079 0.0509 0.1381
Brugia malayi Proteasome A-type and B-type family protein 0.0403 0.3301 0.3277
Echinococcus multilocularis netrin receptor unc 5 0.0108 0.0757 0.0773
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0027 0.0062 0.0048
Schistosoma mansoni Smad4 0.0027 0.0057 0.0065
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0079 0.0509 0.0509
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0044 0.0204 0.0234
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0044 0.0204 0.0168
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0079 0.0509 0.0585
Loa Loa (eye worm) hypothetical protein 0.0037 0.0149 0.0149
Brugia malayi Proteasome subunit alpha type 1 0.0079 0.0509 0.0475
Leishmania major proteasome alpha 1 subunit, putative 0.0079 0.0509 0.1381
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0079 0.0509 0.1381
Schistosoma mansoni TGF-beta signal transducer Smad2 0.006 0.0342 0.0392
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0044 0.0204 0.0196
Schistosoma mansoni peptidase 0.0027 0.0062 0.0071
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0044 0.0204 0.0204
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0079 0.0509 0.0509
Plasmodium vivax ataxin-2 like protein, putative 0.0136 0.1 0.2896
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0079 0.0509 0.1381
Schistosoma mansoni tar DNA-binding protein 0.0466 0.3844 0.4416
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0044 0.0204 0.0196
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0044 0.0204 0.0168
Trypanosoma brucei proteasome alpha 7 subunit 0.0079 0.0509 0.1381
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0079 0.0509 0.1381
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0079 0.0509 0.1381
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0204 0.0437
Loa Loa (eye worm) hypothetical protein 0.1179 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0227 0.0227
Toxoplasma gondii heat shock protein hslv, putative 0.0079 0.0509 0.1381
Brugia malayi Proteasome A-type and B-type family protein 0.0079 0.0509 0.0475
Schistosoma mansoni tar DNA-binding protein 0.0466 0.3844 0.4416
Entamoeba histolytica hypothetical protein 0.0037 0.0146 0.0259
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0027 0.0062 0.0071
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0194 0.1499 0.4437
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0044 0.0204 0.0234
Plasmodium falciparum proteasome subunit beta type-4 0.0079 0.0509 0.1381
Plasmodium falciparum proteasome subunit beta type-5 0.0403 0.3301 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 24 0.0027 0.0062 0.0048
Giardia lamblia Proteasome subunit beta type 2 0.0194 0.1499 0.4437
Trypanosoma cruzi 20S proteasome subunit 0.0194 0.1499 0.4437
Onchocerca volvulus Notchless protein homolog 0.0079 0.0509 0.3403
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.1386 1
Onchocerca volvulus 0.0027 0.0062 0.004
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0027 0.0062 0.0048
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0079 0.0509 0.1381
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0328 0.0326
Brugia malayi Protein kinase domain containing protein 0.0108 0.0757 0.0723
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Schistosoma mansoni hypothetical protein 0.0037 0.0146 0.0168
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0227 0.0261
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0027 0.0062 0.0062
Loa Loa (eye worm) MH2 domain-containing protein 0.006 0.0342 0.0342
Trypanosoma brucei proteasome beta 6 subunit 0.0313 0.2526 0.7607
Leishmania major proteasome beta 5 subunit, putative 0.0403 0.3301 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.023 0.0518
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0079 0.0509 0.0509
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0027 0.0062 0.0071
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 12 0.0027 0.0062 0.0048
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0044 0.0204 0.0168
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0044 0.0204 0.0234
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0044 0.0204 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0079 0.0509 0.1381
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0027 0.0062 0.0071
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 14 0.0027 0.0062 0.0048
Plasmodium vivax proteasome subunit beta type-5, putative 0.0403 0.3301 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0421 0.0421
Loa Loa (eye worm) proteasome subunit beta type 3 0.0079 0.0509 0.0509
Leishmania major DNA polymerase eta, putative 0.0047 0.023 0.0518
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0044 0.0204 0.0196
Loa Loa (eye worm) hypothetical protein 0.0042 0.0185 0.0185
Trypanosoma cruzi PAB1-binding protein , putative 0.0136 0.1 0.2896
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0146 0.0136
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0044 0.0204 0.0196
Trypanosoma brucei unspecified product 0.0059 0.0338 0.0853
Leishmania major proteasome beta 3 subunit, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis expressed protein 0.0027 0.0062 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0079 0.0509 0.1381
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 14 0.0027 0.0062 0.0048
Brugia malayi MH2 domain containing protein 0.006 0.0342 0.0307
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0044 0.0204 0.0196
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0079 0.0509 0.1381
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0079 0.0509 0.1381
Trypanosoma brucei DNA polymerase eta, putative 0.0088 0.0583 0.1608
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0079 0.0509 0.1381
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0079 0.0509 0.1381
Brugia malayi TAR-binding protein 0.0466 0.3844 0.3822
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 47 0.0027 0.0062 0.0048
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0044 0.0204 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Echinococcus granulosus Ankyrin 0.0108 0.0761 0.0777
Loa Loa (eye worm) MH1 domain-containing protein 0.006 0.0342 0.0342
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0044 0.0204 0.0204
Schistosoma mansoni smad1 5 8 and 0.006 0.0342 0.0392
Echinococcus multilocularis ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase 0.0027 0.0062 0.0048
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0027 0.0062 0.0048
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0079 0.0509 0.0509
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0044 0.0204 0.0234
Schistosoma mansoni hypothetical protein 0.0373 0.3046 0.3499
Echinococcus multilocularis Ubiquitin carboxyl terminal hydrolase 48 0.0027 0.0062 0.0048
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0079 0.0509 0.1381
Schistosoma mansoni GTP-binding protein alpha subunit 0.0044 0.0204 0.0234
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Schistosoma mansoni hypothetical protein 0.0027 0.0062 0.0071
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 12 0.0027 0.0062 0.0048
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 47 0.0027 0.0062 0.0048
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0079 0.0509 0.1381
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 36 0.0027 0.0062 0.0048
Echinococcus multilocularis proteasome (prosome, macropain) 0.0403 0.3301 0.3428
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0079 0.0509 0.1381
Brugia malayi proteasome subunit alpha type 1 0.0079 0.0509 0.0475
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0027 0.0062 0.0071
Loa Loa (eye worm) TAR-binding protein 0.0466 0.3844 0.3844
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0079 0.0509 0.1381
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0079 0.0509 0.1381
Brugia malayi latrophilin 2 splice variant baaae 0.0806 0.6781 0.6769
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0227 0.1283
Toxoplasma gondii proteasome subunit alpha1, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) G protein alpha subunit 3 0.0044 0.0204 0.0204
Onchocerca volvulus Netrin receptor homolog 0.0108 0.0757 0.5263
Brugia malayi mbt repeat family protein 0.0046 0.0227 0.0192
Schistosoma mansoni Smad4 0.006 0.0342 0.0392
Trypanosoma brucei proteasome beta 7 subunit 0.0079 0.0509 0.1381
Plasmodium vivax proteasome subunit beta type-2, putative 0.0194 0.1499 0.4437
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0079 0.0509 0.0509
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0079 0.0509 0.1381
Toxoplasma gondii LsmAD domain-containing protein 0.0136 0.1 0.2896
Toxoplasma gondii proteasome beta subunit 0.0079 0.0509 0.1381
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0283 0.0248

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) NA 0 uM Effective concentration against 50% survival of HIV -1 infected cells relative to uninfected untreated control (in vitro anti HIV-1 activity); NA =' Not active' ChEMBL. 8709096
IC50 (binding) = 600 uM Compound was tested for Inhibition of HIV-1 RT activity. ChEMBL. 8709096
IC50 (binding) = 600 uM Compound was tested for Inhibition of HIV-1 RT activity. ChEMBL. 8709096

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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