Detailed information for compound 148472

Basic information

Technical information
  • TDR Targets ID: 148472
  • Name: 1-chloro-6-ethyl-6-phenylpyrrolo[2,1-d][1,5]b enzothiazepin-7-one
  • MW: 353.865 | Formula: C20H16ClNOS
  • H donors: 0 H acceptors: 1 LogP: 5.79 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1(Sc2cccc(c2n2c(C1=O)ccc2)Cl)c1ccccc1
  • InChi: 1S/C20H16ClNOS/c1-2-20(14-8-4-3-5-9-14)19(23)16-11-7-13-22(16)18-15(21)10-6-12-17(18)24-20/h3-13H,2H2,1H3
  • InChiKey: OKAFEYOTXFKGMK-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-chloro-6-ethyl-6-phenyl-pyrrolo[2,1-d][1,5]benzothiazepin-7-one
  • 1-chloro-6-ethyl-6-phenyl-7-pyrrolo[2,1-d][1,5]benzothiazepinone
  • AIDS051862
  • (+/-)-1-chloro-6-ethyl-6-phenylpyrrolo[2,1-d][1,5]benzothiazepin-7(6H)-one
  • AIDS-051862

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0044 0.0204 0.0196
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0194 0.1499 0.4437
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Brugia malayi Uncoordinated protein 44 0.0108 0.0757 0.0723
Toxoplasma gondii proteasome subunit 0.0079 0.0509 0.1381
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0079 0.0509 0.1381
Echinococcus granulosus Proteasome subunit alpha type 7 0.0079 0.0509 0.0515
Brugia malayi G-protein alpha subunit 0.0044 0.0204 0.0168
Leishmania major proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0027 0.0062 0.0048
Leishmania major proteasome beta-1 subunit, putative 0.0079 0.0509 0.1381
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0403 0.3301 1
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0044 0.0204 0.0168
Brugia malayi MH1 domain containing protein 0.0033 0.0111 0.0076
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0227 0.1283
Schistosoma mansoni Smad4 0.006 0.0342 0.0392
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0027 0.0062 0.0071
Loa Loa (eye worm) nuclear factor I 0.0033 0.0111 0.0111
Echinococcus multilocularis ubiquitin specific protease 41 0.0027 0.0062 0.0048
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 14 0.0027 0.0062 0.0048
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0283 0.0278
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0403 0.3301 1
Schistosoma mansoni calpain-7 (C02 family) 0.0027 0.0062 0.0071
Echinococcus multilocularis netrin receptor unc 5 0.0108 0.0757 0.0773
Leishmania major proteasome alpha 2 subunit, putative 0.0079 0.0509 0.1381
Brugia malayi Latrophilin receptor protein 2 0.0373 0.3046 0.302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1018 0.8607 0.9888
Echinococcus multilocularis proteasome subunit alpha type 2 0.0079 0.0509 0.0515
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0283 0.0248
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Entamoeba histolytica hypothetical protein 0.0037 0.0146 0.0259
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0079 0.0509 0.1381
Echinococcus granulosus GPCR family 2 0.0373 0.3046 0.3162
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.023 0.0518
Trypanosoma cruzi 20S proteasome subunit 0.0194 0.1499 0.4437
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0338 0.0304
Schistosoma mansoni hypothetical protein 0.0108 0.0757 0.0869
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0194 0.1499 0.4437
Brugia malayi proteasome subunit beta type 2 0.0194 0.1499 0.1468
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0313 0.2526 0.2619
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 0.0027 0.0062 0.0048
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0079 0.0509 0.0515
Onchocerca volvulus Notchless protein homolog 0.0079 0.0509 0.3403
Leishmania major DNA polymerase eta, putative 0.0047 0.023 0.0518
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 47 0.0027 0.0062 0.0048
Brugia malayi Proteasome subunit alpha type 1 0.0079 0.0509 0.0475
Leishmania major proteasome beta 7 subunit, putative 0.0079 0.0509 0.1381
Schistosoma mansoni hypothetical protein 0.0037 0.0146 0.0168
Onchocerca volvulus 0.0044 0.0204 0.1105
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Brugia malayi Proteasome A-type and B-type family protein 0.0079 0.0509 0.0475
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Brugia malayi Proteasome subunit alpha type 7-1 0.0079 0.0509 0.0475
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0108 0.0761 0.0874
Brugia malayi Protein kinase domain containing protein 0.0108 0.0757 0.0723
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0283 0.0278
Loa Loa (eye worm) hypothetical protein 0.0033 0.0111 0.0111
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 16 0.0027 0.0062 0.0048
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0079 0.0509 0.1381
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0079 0.0509 0.1381
Leishmania major proteasome beta 2 subunit, putative 0.0194 0.1499 0.4437
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 12 0.0027 0.0062 0.0048
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0079 0.0509 0.1381
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0079 0.0509 0.1381
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0079 0.0509 0.1381
Schistosoma mansoni GTP-binding protein alpha subunit 0.0044 0.0204 0.0234
Leishmania major DNA polymerase eta, putative 0.0088 0.0583 0.1608
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0044 0.0204 0.0196
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0108 0.0757 0.0773
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0338 0.0853
Echinococcus granulosus 5'partial|Ubiquitin carboxyl terminal hydrolase 48 0.0027 0.0062 0.0048
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0079 0.0509 0.0515
Brugia malayi Proteasome A-type and B-type family protein 0.0079 0.0509 0.0475
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Schistosoma mansoni DNA polymerase eta 0.0088 0.0583 0.067
Echinococcus granulosus proteasome subunit alpha type 6 0.0079 0.0509 0.0515
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0194 0.1499 0.4437
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0079 0.0509 0.1381
Plasmodium vivax proteasome subunit beta type-5, putative 0.0403 0.3301 1
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0044 0.0204 0.0437
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0079 0.0509 0.1381
Plasmodium vivax proteasome subunit beta type-6, putative 0.0079 0.0509 0.1381
Echinococcus granulosus proteasome subunit beta t family 0.0079 0.0509 0.0515
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0044 0.0204 0.0196
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0027 0.0062 0.0071
Loa Loa (eye worm) hypothetical protein 0.0044 0.0204 0.0204
Echinococcus multilocularis nuclear factor of activated T cells 5 0.1133 0.9598 1
Echinococcus granulosus Smad4 0.006 0.0342 0.034
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0403 0.3301 1
Brugia malayi N-terminal motif family protein 0.0181 0.1386 0.1355
Loa Loa (eye worm) hypothetical protein 0.1179 1 1
Echinococcus granulosus proteasome subunit beta type 7 0.0079 0.0509 0.0515
Brugia malayi hypothetical protein 0.0088 0.0584 0.055
Giardia lamblia Proteasome subunit beta type 3 0.0079 0.0509 0.1381
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0044 0.0204 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0079 0.0509 0.0585
Schistosoma mansoni smad 0.006 0.0342 0.0392
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 20 0.0027 0.0062 0.0048
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0027 0.0062 0.0071
Echinococcus granulosus mothers against decapentaplegic 6 0.0027 0.0057 0.0043
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0027 0.0062 0.0048
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0027 0.0062 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0373 0.3046 0.3162
Echinococcus granulosus Ankyrin 0.0108 0.0761 0.0777
Brugia malayi Bromodomain containing protein 0.0037 0.0148 0.0113
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 20 0.0027 0.0062 0.0048
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0403 0.3301 0.3792
Brugia malayi Proteasome A-type and B-type family protein 0.0079 0.0509 0.0475
Schistosoma mansoni hypothetical protein 0.0027 0.0062 0.0071
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0044 0.0204 0.0234
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0338 0.0853
Brugia malayi proteasome subunit beta type 1 0.0313 0.2526 0.2499
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0044 0.0204 0.0168
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0027 0.0062 0.0071
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0338 0.0853
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0194 0.1499 0.1548
Plasmodium falciparum proteasome subunit beta type-4 0.0079 0.0509 0.1381
Echinococcus multilocularis GPCR, family 2 0.0373 0.3046 0.3162
Trypanosoma brucei proteasome beta 6 subunit 0.0313 0.2526 0.7607
Brugia malayi proteasome subunit alpha type 3 0.0079 0.0509 0.0475
Schistosoma mansoni GTP-binding protein alpha subunit 0.0044 0.0204 0.0234
Brugia malayi proteasome subunit alpha type 4 0.0079 0.0509 0.0475
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Loa Loa (eye worm) RNA binding protein 0.0466 0.3844 0.3844
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0079 0.0509 0.1381
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0079 0.0509 0.0585
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0227 0.0261
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0338 0.0337
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0079 0.0509 0.0585
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0079 0.0509 0.0585
Trypanosoma cruzi PAB1-binding protein , putative 0.0136 0.1 0.2896
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0079 0.0509 0.0585
Loa Loa (eye worm) hypothetical protein 0.0108 0.0761 0.0761
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 36 0.0027 0.0062 0.0048
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0079 0.0509 0.1381
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1018 0.8607 0.8966
Leishmania major proteasome alpha 3 subunit, putative 0.0079 0.0509 0.1381
Toxoplasma gondii heat shock protein hslv, putative 0.0079 0.0509 0.1381
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0194 0.1499 0.4437
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0108 0.0757 0.0773
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 12 0.0027 0.0062 0.0048
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Giardia lamblia 20S proteasome alpha subunit 1 0.0079 0.0509 0.1381
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0079 0.0509 0.1381
Schistosoma mansoni hypothetical protein 0.1029 0.8705 1
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0079 0.0509 0.1381
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.018 0.0363
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1018 0.8607 0.8966
Loa Loa (eye worm) hypothetical protein 0.0044 0.0204 0.0204
Brugia malayi Death domain containing protein 0.0108 0.0757 0.0723
Brugia malayi proteasome subunit beta type 3 0.0079 0.0509 0.0475
Onchocerca volvulus Netrin receptor homolog 0.0108 0.0757 0.5263
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Schistosoma mansoni calpain-7 (C02 family) 0.0027 0.0062 0.0071
Brugia malayi MH2 domain containing protein 0.006 0.0342 0.0307
Brugia malayi latrophilin 2 splice variant baaae 0.0806 0.6781 0.6769
Brugia malayi MH1 domain containing protein 0.006 0.0342 0.0307
Giardia lamblia 20S proteasome alpha subunit 4 0.0079 0.0509 0.1381
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0283 0.0278
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Echinococcus multilocularis proteasome subunit beta type 7 0.0079 0.0509 0.0515
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0079 0.0509 0.1381
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0466 0.3844 0.4416
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0079 0.0509 0.0509
Echinococcus multilocularis Smad4 0.006 0.0342 0.034
Schistosoma mansoni smad1 5 8 and 0.006 0.0342 0.0392
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0079 0.0509 0.1381
Schistosoma mansoni hypothetical protein 0.0373 0.3046 0.3499
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0079 0.0509 0.0585
Trypanosoma brucei proteasome beta 7 subunit 0.0079 0.0509 0.1381
Trypanosoma brucei unspecified product 0.0059 0.0338 0.0853
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0194 0.1499 0.4437
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0338 0.0853
Loa Loa (eye worm) hypothetical protein 0.0181 0.1386 0.1386
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0079 0.0509 0.1381
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 47 0.0027 0.0062 0.0048
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0079 0.0509 0.1381
Leishmania major DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0044 0.0204 0.0196
Schistosoma mansoni smad1 5 8 and 0.006 0.0342 0.0392
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0227 0.0261
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0079 0.0509 0.1381
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0027 0.0062 0.0071
Schistosoma mansoni ankyrin 23/unc44 0.0108 0.0757 0.0869
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0027 0.0062 0.0071
Brugia malayi proteasome subunit alpha type 1 0.0079 0.0509 0.0475
Brugia malayi MH2 domain containing protein 0.0876 0.7385 0.7376
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0079 0.0509 0.1381
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Leishmania major proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Echinococcus granulosus Proteasome subunit alpha beta 0.0079 0.0509 0.0515
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.1386 1
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0044 0.0204 0.0168
Loa Loa (eye worm) hypothetical protein 0.0156 0.1169 0.1169
Loa Loa (eye worm) hypothetical protein 0.0088 0.0583 0.0583
Loa Loa (eye worm) MBCTL1 0.0053 0.0283 0.0283
Toxoplasma gondii LsmAD domain-containing protein 0.0136 0.1 0.2896
Plasmodium falciparum ataxin-2 like protein, putative 0.0136 0.1 0.2896
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0027 0.0062 0.0048
Echinococcus granulosus dna polymerase kappa 0.0059 0.0338 0.0337
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0146 0.0136
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0079 0.0509 0.0585
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0079 0.0509 0.0515
Loa Loa (eye worm) hypothetical protein 0.0044 0.0204 0.0204
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0044 0.0204 0.0168
Echinococcus granulosus proteasome prosome macropain 0.0403 0.3301 0.3428
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0079 0.0509 0.1381
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0313 0.2526 0.7607
Brugia malayi RNA binding protein 0.0466 0.3844 0.3822
Giardia lamblia 20S proteasome alpha subunit 2 0.0079 0.0509 0.1381
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0079 0.0509 0.1381
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0079 0.0509 0.1381
Echinococcus granulosus TGF beta signal transducer SmadC 0.006 0.0342 0.034
Schistosoma mansoni peptidase 0.0027 0.0062 0.0071
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0027 0.0062 0.0048
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0044 0.0204 0.0168
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0079 0.0509 0.1381
Echinococcus granulosus ubiquitin specific peptidase 30 (C19 family) 0.0027 0.0062 0.0048
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0079 0.0509 0.1381
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0079 0.0509 0.1381
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0044 0.0204 0.0168
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0079 0.0509 0.1381
Schistosoma mansoni hypothetical protein 0.0061 0.0353 0.0405
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0283 0.0278
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0027 0.0062 0.0071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0373 0.3046 0.3162
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.023 0.0518
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0027 0.0062 0.0071
Trypanosoma brucei PAB1-binding protein , putative 0.0136 0.1 0.2896
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0079 0.0509 0.1381
Plasmodium vivax proteasome subunit beta type-2, putative 0.0194 0.1499 0.4437
Plasmodium vivax proteasome subunit beta type-4, putative 0.0079 0.0509 0.1381
Onchocerca volvulus 0.0027 0.0062 0.004
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0079 0.0509 0.1381
Echinococcus multilocularis TGF beta signal transducer SmadC 0.006 0.0342 0.034
Trypanosoma brucei DNA polymerase eta, putative 0.0088 0.0583 0.1608
Onchocerca volvulus 0.0156 0.1169 0.8363
Brugia malayi MH2 domain containing protein 0.0027 0.0057 0.0021
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0194 0.1499 0.1722
Giardia lamblia Proteasome subunit beta type 2 0.0194 0.1499 0.4437
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0227 0.0221
Brugia malayi Calcitonin receptor-like protein seb-1 0.1179 1 1
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0313 0.2526 0.7607
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0044 0.0204 0.0168
Loa Loa (eye worm) TAR-binding protein 0.0466 0.3844 0.3844
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0079 0.0509 0.0585
Plasmodium vivax proteasome subunit beta type-3, putative 0.0079 0.0509 0.1381
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0136 0.1 0.1
Brugia malayi mbt repeat family protein 0.0046 0.0227 0.0192
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0044 0.0204 0.0234
Echinococcus multilocularis proteasome subunit beta type 6 0.0079 0.0509 0.0515
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 24 0.0027 0.0062 0.0048
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0079 0.0509 0.1381
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0044 0.0204 0.0234
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Echinococcus granulosus death domain containing protein 0.0108 0.0757 0.0773
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.004 0.0169 0.0169
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0313 0.2526 0.2619
Loa Loa (eye worm) MH2 domain-containing protein 0.006 0.0342 0.0342
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0403 0.3301 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0373 0.3046 0.3162
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0079 0.0509 0.1381
Leishmania major proteasome beta 5 subunit, putative 0.0403 0.3301 1
Mycobacterium ulcerans proteasome PrcA 0.0079 0.0509 0.0577
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0044 0.0204 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0466 0.3844 0.4416
Loa Loa (eye worm) hypothetical protein 0.0044 0.0204 0.0204
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0079 0.0509 0.0585
Giardia lamblia 20S proteasome alpha subunit 3 0.0079 0.0509 0.1381
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0079 0.0509 0.1381
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0027 0.0062 0.0071
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0016 0.0018
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0194 0.1499 0.4437
Brugia malayi MH1 domain containing protein 0.0033 0.0111 0.0076
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 16 0.0027 0.0062 0.0048
Echinococcus multilocularis Ubiquitin carboxyl terminal hydrolase 48 0.0027 0.0062 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0079 0.0509 0.1381
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0079 0.0509 0.1381
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0338 0.0853
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Echinococcus granulosus Ubiquitin carboxyl terminal hydrolase 48 0.0027 0.0062 0.0048
Onchocerca volvulus 0.0027 0.0062 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis dna polymerase eta 0.0088 0.0583 0.0592
Loa Loa (eye worm) PAS-3 protein 0.0079 0.0509 0.0509
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0338 0.0389
Giardia lamblia 20S proteasome alpha subunit 6 0.0079 0.0509 0.1381
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0079 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0057 0.0057
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0313 0.2526 0.7607
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0079 0.0509 0.1381
Brugia malayi MH2 domain containing protein 0.006 0.0342 0.0307
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0027 0.0062 0.0071
Loa Loa (eye worm) proteasome subunit beta type 3 0.0079 0.0509 0.0509
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0079 0.0509 0.1381
Schistosoma mansoni netrin receptor unc5 0.0108 0.0757 0.0869
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 23 0.0027 0.0062 0.0048
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0079 0.0509 0.0585
Entamoeba histolytica hypothetical protein 0.0037 0.0146 0.0259
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0338 0.0337
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0079 0.0509 0.1381
Leishmania major proteasome beta 3 subunit, putative 0.0079 0.0509 0.1381
Schistosoma mansoni tar DNA-binding protein 0.0466 0.3844 0.4416
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0027 0.0062 0.0048
Brugia malayi MH1 domain containing protein 0.006 0.0342 0.0307
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0108 0.0757 0.0757
Leishmania major hypothetical protein, conserved 0.0136 0.1 0.2896
Echinococcus granulosus smad 0.006 0.0342 0.034
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Plasmodium falciparum ataxin-2 like protein, putative 0.0136 0.1 0.2896
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0338 0.0853
Schistosoma mansoni hypothetical protein 0.0373 0.3046 0.3499
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 36 0.0027 0.0062 0.0048
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0338 0.0338
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0338 0.0389
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0079 0.0509 0.1381
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0079 0.0509 0.0585
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Trypanosoma cruzi DNA polymerase eta, putative 0.0088 0.0583 0.1608
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0227 0.0261
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0027 0.0062 0.0048
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0313 0.2526 0.7607
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0403 0.3301 1
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0079 0.0509 0.1381
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0079 0.0509 0.1381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1018 0.8607 0.8966
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0079 0.0509 0.1381
Brugia malayi TAR-binding protein 0.0466 0.3844 0.3822
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0079 0.0509 0.1381
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0079 0.0509 0.1381
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0027 0.0062 0.0071
Loa Loa (eye worm) hypothetical protein 0.0108 0.0757 0.0757
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0146 0.0136
Brugia malayi Proteasome A-type and B-type family protein 0.0403 0.3301 0.3277
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0079 0.0509 0.5
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0403 0.3301 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0338 0.0337
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0061 0.0353 0.0352
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0129 0.0117
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0313 0.2526 0.7607
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0079 0.0509 0.0585
Schistosoma mansoni tar DNA-binding protein 0.0466 0.3844 0.4416
Giardia lamblia 20S proteasome alpha subunit 5 0.0079 0.0509 0.1381
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0373 0.3046 0.3162
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0027 0.0062 0.0048
Echinococcus multilocularis proteasome (prosome, macropain) 0.0403 0.3301 0.3428
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0044 0.0204 0.0234
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0079 0.0509 0.0515
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0079 0.0509 0.0515
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0194 0.1499 0.4437
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0044 0.0204 0.0204
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0027 0.0062 0.0071
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0227 0.0227
Leishmania major proteasome beta 2 subunit, putative 0.0079 0.0509 0.1381
Echinococcus granulosus ubiquitin specific protease 41 0.0027 0.0062 0.0048
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0079 0.0509 0.1381
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0204 0.0437
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0079 0.0509 0.0509
Echinococcus multilocularis expressed protein 0.0044 0.0204 0.0196
Echinococcus multilocularis smad 0.006 0.0342 0.034
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0044 0.0204 0.0196
Brugia malayi 20S proteasome alpha5 subunit 0.0079 0.0509 0.0475
Schistosoma mansoni Smad4 0.0027 0.0057 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.018 0.0363
Schistosoma mansoni tar DNA-binding protein 0.0466 0.3844 0.4416
Brugia malayi hypothetical protein 0.0037 0.0146 0.0111
Brugia malayi proteasome subunit alpha type 6 0.0079 0.0509 0.0475
Schistosoma mansoni TGF-beta signal transducer Smad2 0.006 0.0342 0.0392
Schistosoma mansoni bromodomain containing protein 0.0062 0.0358 0.0412
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0079 0.0509 0.1381
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0044 0.0204 0.0234
Onchocerca volvulus 0.0027 0.0062 0.004
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0027 0.0062 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Schistosoma mansoni hypothetical protein 0.0373 0.3046 0.3499
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0044 0.0204 0.0234
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0027 0.0062 0.0048
Loa Loa (eye worm) hypothetical protein 0.0046 0.0227 0.0227
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 14 0.0027 0.0062 0.0048
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0079 0.0509 0.0515
Echinococcus granulosus subfamily T1A non peptidase ue 0.0079 0.0509 0.0515
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) proteasome subunit beta type 2 0.0194 0.1499 0.1499
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0044 0.0204 0.0196
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0079 0.0509 0.0509
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0079 0.0509 0.0509
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0227 0.0221
Echinococcus multilocularis tar DNA binding protein 0.0466 0.3844 0.3995
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0079 0.0509 0.1381
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0027 0.0062 0.0071
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0027 0.0062 0.0071
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0044 0.0204 0.0196
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0283 0.0325
Toxoplasma gondii proteasome subunit beta type, putative 0.0403 0.3301 1
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0079 0.0509 0.1381
Leishmania major proteasome alpha 1 subunit, putative 0.0079 0.0509 0.1381
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0328 0.0326
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0079 0.0509 0.0585
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0079 0.0509 0.1381
Schistosoma mansoni smad 0.0027 0.0057 0.0065
Brugia malayi hypothetical protein 0.0027 0.0062 0.0026
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0079 0.0509 0.1381
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1179 1 1
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) hypothetical protein 0.0053 0.0283 0.0283
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0044 0.0204 0.0196
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0079 0.0509 0.0509
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0044 0.0204 0.0234
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0227 0.0221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0027 0.0062 0.0062
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0027 0.0062 0.0071
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0079 0.0509 0.1381
Entamoeba histolytica G protein alpha subunit, putative 0.0044 0.0204 0.0437
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0146 0.0168
Brugia malayi proteasome subunit alpha type 2 0.0079 0.0509 0.0475
Toxoplasma gondii proteasome subunit alpha type, putative 0.0079 0.0509 0.1381
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0061 0.0353 0.0352
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0079 0.0509 0.1381
Echinococcus granulosus netrin receptor unc 5 0.0108 0.0757 0.0773
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0129 0.0117
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0027 0.0062 0.0071
Echinococcus multilocularis ubiquitin specific peptidase 42 (C19 family) 0.0027 0.0062 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Brugia malayi hypothetical protein 0.0136 0.1 0.0968
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0079 0.0509 0.1381
Giardia lamblia Proteasome subunit beta type 1 0.0313 0.2526 0.7607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1018 0.8607 0.8966
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Plasmodium falciparum proteasome subunit beta type-5 0.0403 0.3301 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0136 0.1 0.2896
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0027 0.0062 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Echinococcus multilocularis mothers against decapentaplegic 2 0.0027 0.0057 0.0043
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0027 0.0062 0.0048
Loa Loa (eye worm) transcription factor SMAD2 0.0876 0.7385 0.7385
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0079 0.0509 0.1381
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0079 0.0509 0.0509
Schistosoma mansoni Smad4 0.0027 0.0057 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0027 0.0062 0.0048
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0027 0.0062 0.0026
Loa Loa (eye worm) hypothetical protein 0.0373 0.3046 0.3046
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0403 0.3301 1
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0044 0.0204 0.0437
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0079 0.0509 0.0515
Toxoplasma gondii peptidase, T1 family protein 0.0079 0.0509 0.1381
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0313 0.2526 0.7607
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0079 0.0509 0.1381
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0079 0.0509 0.1381
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0079 0.0509 0.1381
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.018 0.0363
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0079 0.0509 0.0509
Schistosoma mansoni hypothetical protein 0.0373 0.3046 0.3499
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0079 0.0509 0.1381
Giardia lamblia 20S proteasome alpha subunit 7 0.0079 0.0509 0.1381
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0044 0.0204 0.0234
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0044 0.0204 0.0168
Trypanosoma brucei proteasome alpha 7 subunit 0.0079 0.0509 0.1381
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0027 0.0062 0.0048
Toxoplasma gondii proteasome beta subunit 0.0079 0.0509 0.1381
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0466 0.3844 0.3844
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0313 0.2526 0.2902
Loa Loa (eye worm) hypothetical protein 0.0806 0.6781 0.6781
Loa Loa (eye worm) G protein alpha subunit 3 0.0044 0.0204 0.0204
Brugia malayi hypothetical protein 0.0044 0.0204 0.0168
Loa Loa (eye worm) hypothetical protein 0.0042 0.0185 0.0185
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0079 0.0509 0.1381
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1018 0.8607 0.9888
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0227 0.0221
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0079 0.0509 0.1381
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0079 0.0509 0.1381
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0044 0.0204 0.0437
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0373 0.3046 0.302
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0057 0.0057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0108 0.0757 0.0723
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0079 0.0509 0.0515
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0079 0.0509 0.1381
Brugia malayi mothers against decapentaplegic homolog 3 0.0027 0.0057 0.0021
Onchocerca volvulus 0.0046 0.0227 0.1283
Brugia malayi Smad1 0.006 0.0342 0.0307
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0079 0.0509 0.1381
Trypanosoma brucei unspecified product 0.0041 0.018 0.0363
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0194 0.1499 0.1722
Brugia malayi hypothetical protein 0.0156 0.1169 0.1137
Onchocerca volvulus 0.0044 0.0204 0.1105
Echinococcus multilocularis mothers against decapentaplegic 6 0.0027 0.0057 0.0043
Toxoplasma gondii proteasome subunit alpha1, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0044 0.0204 0.0204
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0194 0.1499 0.1548
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1018 0.8607 0.9888
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0079 0.0509 0.0515
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0027 0.0062 0.0048
Echinococcus multilocularis mothers against decapentaplegic 5 0.006 0.0342 0.034
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0027 0.0062 0.0071
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0079 0.0509 0.1381
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0338 0.0853
Plasmodium vivax proteasome subunit beta type-1, putative 0.0313 0.2526 0.7607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.1018 0.8607 0.8602
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0845 0.712 0.7414
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0027 0.0062 0.0048
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0027 0.0062 0.0071
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0079 0.0509 0.1381
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0027 0.0062 0.0048
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0079 0.0509 0.1381
Echinococcus granulosus tar DNA binding protein 0.0466 0.3844 0.3995
Echinococcus granulosus dna polymerase eta 0.0088 0.0583 0.0592
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0044 0.0204 0.0234
Echinococcus granulosus nuclear factor of activated T cells 5 0.1133 0.9598 1
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0027 0.0062 0.0071
Loa Loa (eye worm) hypothetical protein 0.0037 0.0149 0.0149
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0044 0.0204 0.0196
Mycobacterium ulcerans proteasome PrcB 0.0403 0.3301 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0204 0.0204
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0044 0.0204 0.0204
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0204 0.0437
Plasmodium vivax proteasome subunit beta type-7, putative 0.0079 0.0509 0.1381
Loa Loa (eye worm) MH1 domain-containing protein 0.006 0.0342 0.0342
Schistosoma mansoni hypothetical protein 0.1029 0.8705 1
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0079 0.0509 0.1381
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0204 0.0437
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0044 0.0204 0.0234
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0027 0.0062 0.0062
Brugia malayi mbt repeat family protein 0.0046 0.0227 0.0192
Brugia malayi ImpB/MucB/SamB family protein 0.0088 0.0583 0.0549
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase 0.0027 0.0062 0.0048
Loa Loa (eye worm) Smad1 0.006 0.0342 0.0342
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0027 0.0062 0.0048
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0079 0.0509 0.0577
Echinococcus multilocularis Ankyrin 0.0108 0.0761 0.0777
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.1018 0.8607 0.8607
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0328 0.0326
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0044 0.0204 0.0437
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.1439 0.1485
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0079 0.0509 0.0585
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0079 0.0509 0.1381
Entamoeba histolytica hypothetical protein 0.0037 0.0146 0.0259
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0027 0.0062 0.0071
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0079 0.0509 0.1381
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0079 0.0509 0.0515
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0057 0.0057
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0062 0.0062
Brugia malayi Bromodomain containing protein 0.0073 0.0457 0.0422
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Echinococcus granulosus mothers against decapentaplegic 5 0.006 0.0342 0.034
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Echinococcus multilocularis expressed protein 0.0027 0.0062 0.0048
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 24 0.0027 0.0062 0.0048
Loa Loa (eye worm) proteasome subunit beta type 1 0.0313 0.2526 0.2526
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0027 0.0062 0.0071
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0044 0.0204 0.0196
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0027 0.0062 0.0048
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0079 0.0509 0.1381
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0403 0.3301 0.3301
Brugia malayi RNA recognition motif domain containing protein 0.0466 0.3844 0.3822
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0079 0.0509 0.1381
Giardia lamblia DINP protein human, muc B family 0.0059 0.0338 0.0853
Trypanosoma brucei unspecified product 0.0041 0.018 0.0363
Schistosoma mansoni hypothetical protein 0.0286 0.2296 0.2637
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Echinococcus multilocularis geminin 0.1029 0.8705 0.9068
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0044 0.0204 0.0168
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0079 0.0509 0.0515
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0079 0.0509 0.1381
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0079 0.0509 0.0515
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 0.0027 0.0062 0.0048
Plasmodium vivax ataxin-2 like protein, putative 0.0136 0.1 0.2896
Echinococcus multilocularis proteasome subunit alpha type 6 0.0079 0.0509 0.0515
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0079 0.0509 0.0509
Echinococcus granulosus proteasome subunit beta type 6 0.0079 0.0509 0.0515
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0338 0.0853
Echinococcus granulosus ubiquitin specific peptidase c family 0.0027 0.0062 0.0048
Loa Loa (eye worm) MH2 domain-containing protein 0.0876 0.7385 0.7385
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Echinococcus granulosus proteasome subunit alpha type 2 0.0079 0.0509 0.0515
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0204 0.0437
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.1439 0.1485
Echinococcus granulosus geminin 0.1029 0.8705 0.9068
Onchocerca volvulus 0.0044 0.0204 0.1105
Echinococcus granulosus mothers against decapentaplegic 2 0.0027 0.0057 0.0043
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0027 0.0062 0.0048
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0062 0.0026
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0313 0.2526 0.7607
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0079 0.0509 0.0585
Leishmania major proteasome alpha 1 subunit, putative 0.0079 0.0509 0.1381
Entamoeba histolytica hypothetical protein 0.0037 0.0146 0.0259
Schistosoma mansoni hypothetical protein 0.0806 0.6781 0.779
Echinococcus granulosus expressed protein 0.0044 0.0204 0.0196
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0403 0.3301 1
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0079 0.0509 0.1381
Loa Loa (eye worm) latrophilin receptor protein 2 0.0373 0.3046 0.3046
Schistosoma mansoni smad1 5 8 and 0.006 0.0342 0.0392
Brugia malayi ubiquitin specific protease 14 0.0027 0.0062 0.0026
Loa Loa (eye worm) hypothetical protein 0.0069 0.0421 0.0421

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) NA 0 uM Effective concentration against 50% survival of HIV -1 infected cells relative to uninfected untreated control (in vitro anti HIV-1 activity); NA =' Not active' ChEMBL. 8709096
IC50 (binding) = 600 uM Compound was tested for Inhibition of HIV-1 RT activity. ChEMBL. 8709096
IC50 (binding) = 600 uM Compound was tested for Inhibition of HIV-1 RT activity. ChEMBL. 8709096

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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