Detailed information for compound 148501

Basic information

Technical information
  • TDR Targets ID: 148501
  • Name: (3S)-5-(2,6-dichlorobenzoyl)oxy-3-[[(2S)-4-me thyl-2-[[2-(naphthalen-1-ylamino)-2-oxoacetyl ]amino]pentanoyl]amino]-4-oxopentanoic acid
  • MW: 630.473 | Formula: C30H29Cl2N3O8
  • H donors: 4 H acceptors: 7 LogP: 5.25 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](C(=O)N[C@H](C(=O)COC(=O)c1c(Cl)cccc1Cl)CC(=O)O)NC(=O)C(=O)Nc1cccc2c1cccc2)C
  • InChi: 1S/C30H29Cl2N3O8/c1-16(2)13-23(35-29(41)28(40)33-21-12-5-8-17-7-3-4-9-18(17)21)27(39)34-22(14-25(37)38)24(36)15-43-30(42)26-19(31)10-6-11-20(26)32/h3-12,16,22-23H,13-15H2,1-2H3,(H,33,40)(H,34,39)(H,35,41)(H,37,38)/t22-,23-/m0/s1
  • InChiKey: IYOWEQNCAXMHGH-GOTSBHOMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S)-5-(2,6-dichlorobenzoyl)oxy-3-[[(2S)-4-methyl-2-[[2-(1-naphthylamino)-2-oxo-acetyl]amino]pentanoyl]amino]-4-oxo-pentanoic acid
  • (3S)-5-[(2,6-dichlorophenyl)-oxomethoxy]-3-[[(2S)-4-methyl-2-[[2-(1-naphthalenylamino)-1,2-dioxoethyl]amino]-1-oxopentyl]amino]-4-oxopentanoic acid
  • (3S)-5-(2,6-dichlorophenyl)carbonyloxy-3-[[(2S)-4-methyl-2-[[2-(naphthalen-1-ylamino)-2-oxo-ethanoyl]amino]pentanoyl]amino]-4-oxo-pentanoic acid
  • (3S)-5-(2,6-dichlorobenzoyl)oxy-4-keto-3-[[(2S)-2-[[2-keto-2-(1-naphthylamino)acetyl]amino]-4-methyl-pentanoyl]amino]valeric acid
  • (3S)-5-[(2,6-dichlorophenyl)-oxomethoxy]-3-[[(2S)-4-methyl-2-[[2-(1-naphthylamino)-1,2-dioxoethyl]amino]-1-oxopentyl]amino]-4-oxopentanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.0213 0.0213
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0224 0.0213 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0001 0.0001
Plasmodium falciparum plasmepsin IV 0.0038 0.0022 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.1942 0.1979 0.3231
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0026 0.0566
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0091 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0026 0.0033
Onchocerca volvulus 0.0148 0.0135 0.1805
Schistosoma mansoni hypothetical protein 0.0071 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Echinococcus granulosus MAM 0.0071 0.0055 0.0055
Echinococcus granulosus cubilin 0.0025 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Leishmania major UDP-galactopyranose mutase 0.0139 0.0126 0.1726
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0105 0.0091 0.0114
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0026 0.0566
Mycobacterium ulcerans oxidoreductase 0.0139 0.0126 0.2929
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0073 0.0057 0.131
Brugia malayi serpin 0.0023 0.0006 0.0006
Toxoplasma gondii type I fatty acid synthase, putative 0.008 0.0065 0.1476
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0025 0.0009 0.0009
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0063 0.0047 0.0047
Onchocerca volvulus 0.0023 0.0006 0.0079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0051 0.0034 0.0756
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0049 0.0033 0.0601
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0075 0.006 0.1377
Schistosoma mansoni cell polarity protein 0.0023 0.0006 0.0006
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0049 0.0033 0.0714
Toxoplasma gondii subtilisin SUB6 0.0429 0.0424 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Brugia malayi serpin 0.0023 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0071 0.0055 0.0055
Trichomonas vaginalis hypothetical protein 0.0043 0.0026 0.0029
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.002 0.0003 0.0003
Plasmodium vivax subtilisin-like protease 2, putative 0.0429 0.0424 0.9928
Loa Loa (eye worm) serpin 0.0023 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0139 0.0126 0.2908
Toxoplasma gondii subtilisin SUB8 0.0429 0.0424 1
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.002 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.1942 0.1979 0.3231
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0429 0.0424 0.0424
Entamoeba histolytica hypothetical protein 0.0098 0.0083 0.1161
Schistosoma mansoni hypothetical protein 0.0043 0.0026 0.0026
Plasmodium vivax cysteine repeat modular protein 1, putative 0.003 0.0014 0.0258
Schistosoma mansoni hypothetical protein 0.0025 0.0009 0.0009
Brugia malayi amine oxidase, flavin-containing family protein 0.0198 0.0186 0.0186
Brugia malayi Nematode astacin protease protein 30 0.0025 0.0009 0.0009
Echinococcus multilocularis chromatin regulatory protein sir2 0.0715 0.0717 0.0896
Trichomonas vaginalis hypothetical protein 0.1942 0.1979 0.3231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0045 0.0029 0.0036
Echinococcus granulosus disks large 3 0.0023 0.0006 0.0006
Mycobacterium ulcerans NAD-dependent deacetylase 0.0105 0.0091 0.2097
Plasmodium falciparum plasmepsin I 0.0038 0.0022 0.0457
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.002 0.0003 0.0003
Echinococcus multilocularis Estrogen regulated protein EP45 0.0023 0.0006 0.0007
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0606 0.0606 0.0606
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Echinococcus multilocularis integrin alpha 3 0.0115 0.0101 0.0126
Giardia lamblia Furin precursor putative serine protease 0.1942 0.1979 0.5387
Schistosoma mansoni hypothetical protein 0.0025 0.0009 0.0009
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0429 0.0424 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Brugia malayi protein kinase C II. 0.0092 0.0078 0.0078
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0092 0.0078 0.0078
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0108 0.0094 0.0094
Toxoplasma gondii subtilisin SUB11 0.0429 0.0424 1
Plasmodium falciparum plasmepsin II 0.0038 0.0022 0.0457
Mycobacterium leprae Probable polyketide synthase Pks1 0.008 0.0065 0.1372
Mycobacterium ulcerans polyketide synthase Pks9 0.0049 0.0033 0.0714
Loa Loa (eye worm) hypothetical protein 0.0043 0.0026 0.0026
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0715 0.0717 0.0896
Toxoplasma gondii aspartyl protease 0.0038 0.0022 0.0461
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0075 0.006 0.1369
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0091 0.0091
Loa Loa (eye worm) Carm1-pending protein 0.0035 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0083 0.0068 0.0068
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0025 0.0009 0.0009
Echinococcus multilocularis disks large 3 0.0023 0.0006 0.0008
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.006 0.0044 0.0986
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Plasmodium vivax NAD-dependent deacetylase, putative 0.0105 0.0091 0.2082
Onchocerca volvulus 0.0038 0.0022 0.0294
Loa Loa (eye worm) hypothetical protein 0.0043 0.0026 0.0026
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0026 0.0562
Schistosoma mansoni integrin alpha-ps 0.0067 0.0052 0.0052
Giardia lamblia Sirtuin type 2 0.0105 0.0091 0.0232
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0025 0.0009 0.0009
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.0026 0.0029
Toxoplasma gondii histone lysine-specific demethylase 0.0139 0.0126 0.2929
Plasmodium falciparum plasmepsin VIII, putative 0.0038 0.0022 0.0457
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0139 0.0126 0.2929
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0043 0.0026 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0057 0.0057
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0105 0.0091 0.1268
Echinococcus granulosus c-Jun N-terminal kinases 0.0224 0.0213 0.0213
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0454 0.045 0.6256
Loa Loa (eye worm) serpin protein 6 0.0023 0.0006 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Schistosoma mansoni memapsin-2 (A01 family) 0.0038 0.0022 0.0022
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0105 0.0091 0.2082
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2371 0.2421 0.3955
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0135
Toxoplasma gondii histone deacetylase SIR2 0.0105 0.0091 0.2097
Echinococcus granulosus discoidin domain receptor 0.0043 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0429 0.0424 0.5892
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0043 0.0026 0.0578
Leishmania major silent information regulator 2, putative 0.0715 0.0717 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0715 0.0717 1
Onchocerca volvulus 0.0429 0.0424 0.5664
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0135
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0429 0.0424 0.0424
Onchocerca volvulus Putative cubilin 0.0034 0.0018 0.0234
Mycobacterium ulcerans polyketide synthase 0.0075 0.006 0.1358
Toxoplasma gondii aspartyl protease ASP3 0.0038 0.0022 0.0461
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1432 0.1455 0.1455
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0029 0.0029
Brugia malayi BmSERPIN 0.0023 0.0006 0.0006
Plasmodium falciparum plasmepsin IX 0.0038 0.0022 0.0457
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0105 0.0091 0.1236
Echinococcus granulosus serine protease inhibitor 0.0023 0.0006 0.0006
Mycobacterium ulcerans Sir2-like regulatory protein 0.0105 0.0091 0.2097
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0125 0.0112 0.0111
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0686 0.0688 0.086
Echinococcus granulosus protein arginine methyltransferase 0.0063 0.0047 0.0047
Onchocerca volvulus 0.0023 0.0006 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0429 0.0424 1
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0025 0.0009 0.0009
Brugia malayi CUB domain containing protein 0.0025 0.0009 0.0009
Echinococcus granulosus neuroendocrine convertase 2 0.6155 0.6313 0.6313
Mycobacterium tuberculosis Probable thioesterase TesA 0.0065 0.0049 0.1119
Brugia malayi Protein kinase domain containing protein 0.0071 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Plasmodium vivax LCCL domain-containing protein 0.0043 0.0026 0.0562
Brugia malayi Probable ATP-dependent helicase DHX35 0.0032 0.0016 0.0016
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0026 0.0026
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0035 0.0019 0.0024
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0124 0.011 0.011
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0063 0.0047 0.1046
Echinococcus granulosus disintegrin and metalloproteinase 0.0019 0.0002 0.0002
Mycobacterium ulcerans polyketide synthase 0.008 0.0065 0.1476
Entamoeba histolytica hypothetical protein 0.0058 0.0042 0.0589
Brugia malayi hypothetical protein 0.0025 0.0009 0.0009
Brugia malayi ADAMTS-like protease 0.0026 0.0009 0.0009
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0105 0.0091 0.1236
Plasmodium falciparum subtilisin-like protease 2 0.0429 0.0424 0.9928
Brugia malayi serpin 0.0023 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0025 0.0025
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0025 0.0009 0.0009
Echinococcus multilocularis Furin 1 0.2371 0.2421 0.3025
Brugia malayi serpin (BmSERPIN) 0.0023 0.0006 0.0006
Giardia lamblia Transcriptional regulator, Sir2 family 0.0105 0.0091 0.0232
Echinococcus multilocularis membrane bound transcription factor site 1 0.0429 0.0424 0.0529
Brugia malayi CUB domain containing protein 0.0025 0.0009 0.0009
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0038 0.0022 0.0022
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0139 0.0126 0.2929
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Brugia malayi Kelch motif family protein 0.0025 0.0009 0.0009
Mycobacterium ulcerans monoamine oxidase 0.0139 0.0126 0.2929
Brugia malayi Carm1-pending protein 0.0035 0.0019 0.0019
Loa Loa (eye worm) CUB domain-containing protein 0.0025 0.0009 0.0009
Echinococcus granulosus serine:threonine protein kinase N2 0.0076 0.006 0.006
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0056 0.004 0.09
Onchocerca volvulus 0.0023 0.0006 0.0079
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0105 0.0091 0.0091
Echinococcus multilocularis integrin alpha ps 0.0067 0.0052 0.0065
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0429 0.0424 1
Echinococcus multilocularis 0.0139 0.0126 0.0157
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0001 0.0001
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0025 0.0009 0.0009
Plasmodium falciparum cysteine repeat modular protein 1 0.003 0.0014 0.0258
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.008 0.0065 0.1372
Echinococcus granulosus integrin alpha ps 0.0067 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.1942 0.1979 0.3231
Loa Loa (eye worm) DEAH box polypeptide 35 0.0032 0.0016 0.0016
Toxoplasma gondii subtilisin SUB9 0.0429 0.0424 1
Schistosoma mansoni dock 0.0043 0.0026 0.0026
Brugia malayi ADAM-TS Spacer 1 family protein 0.0026 0.0009 0.0009
Loa Loa (eye worm) acyl carrier protein 0.0036 0.0019 0.0019
Toxoplasma gondii kringle domain-containing protein 0.003 0.0014 0.026
Brugia malayi hypothetical protein 0.0038 0.0022 0.0022
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0038 0.0022 0.0022
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0075 0.006 0.1253
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0063 0.0047 0.0063
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0124 0.011 0.0137
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0429 0.0424 0.0529
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0715 0.0717 1
Leishmania major sir2-family protein-like protein 0.0105 0.0091 0.1236
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1942 0.1979 0.3231
Brugia malayi NAD-dependent deacetylase SIRT1 0.0105 0.0091 0.0091
Mycobacterium tuberculosis Polyketide synthase Pks12 0.008 0.0065 0.1487
Echinococcus granulosus integrin alpha 3 0.0115 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.1942 0.1979 0.1979
Loa Loa (eye worm) hypothetical protein 0.9741 1 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0139 0.0126 0.2929
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0091 0.0091
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0024 0.0008 0.0133
Giardia lamblia Hypothetical protein 0.0715 0.0717 0.1942
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0022 0.0022
Leishmania major subtilisin-like serine peptidase 0.0429 0.0424 0.5892
Echinococcus granulosus methyltransferase protein 5 0.0035 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0715 0.0717 0.0717
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0026 0.0566
Echinococcus multilocularis MAM 0.0071 0.0055 0.0069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5956 0.6108 1
Schistosoma mansoni SWI/SNF complex-related 0.0058 0.0042 0.0042
Onchocerca volvulus 0.0038 0.0022 0.0294
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0139 0.0126 0.0126
Toxoplasma gondii subtilisin SUB5 0.0429 0.0424 1
Onchocerca volvulus 0.0071 0.0055 0.0737
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0038 0.0022 0.0028
Toxoplasma gondii PA14 domain-containing protein 0.0043 0.0026 0.0566
Loa Loa (eye worm) hypothetical protein 0.0038 0.0022 0.0022
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0038 0.0022 0.0022
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0038 0.0022 0.0022
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0098 0.0083 0.1129
Echinococcus granulosus lysine specific histone demethylase 1A 0.0686 0.0688 0.0688
Mycobacterium ulcerans dehydrogenase 0.0139 0.0126 0.2929
Echinococcus multilocularis protoporphyrinogen oxidase 0.0139 0.0126 0.0157
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0006 0.0006
Echinococcus multilocularis Estrogen regulated protein EP45 0.0023 0.0006 0.0007
Brugia malayi CUB domain containing protein 0.0025 0.0009 0.0009
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0075 0.006 0.1369
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0014 0.0153
Loa Loa (eye worm) serpin 0.0023 0.0006 0.0006
Mycobacterium ulcerans thioesterase 0.0065 0.0049 0.1107
Brugia malayi proprotein convertase 2 0.6155 0.6313 0.6313
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Echinococcus granulosus integrin alpha ps 0.0032 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0429 0.0424 0.0681
Onchocerca volvulus 0.003 0.0014 0.0181
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0114 0.0099 0.2308
Loa Loa (eye worm) hypothetical protein 0.0032 0.0016 0.0016
Echinococcus multilocularis disintegrin and metalloproteinase 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Brugia malayi Will die slowly protein 0.0148 0.0135 0.0135
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0098 0.0083 0.1161
Brugia malayi CUB domain containing protein 0.0025 0.0009 0.0009
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0018 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Schistosoma mansoni amine oxidase 0.0139 0.0126 0.0126
Brugia malayi transcriptional regulator, Sir2 family protein 0.0715 0.0717 0.0717
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0715 0.0717 0.1162
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0006 0.0006
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.006 0.0044 0.0986
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0007 0.0007
Trypanosoma cruzi subtilisin peptidase 0.0429 0.0424 0.5892
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0022 0.0022
Entamoeba histolytica PH domain containing protein kinase, putative 0.0076 0.006 0.084
Toxoplasma gondii subtilisin SUB1 0.0429 0.0424 1
Schistosoma mansoni dihydroceramide desaturase 0.0019 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0035 0.0019 0.0385
Schistosoma mansoni btb and poz domain-containing protein 0.0043 0.0026 0.0026
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0715 0.0717 1
Brugia malayi Stress-activated protein kinase jnk-1 0.0224 0.0213 0.0213
Onchocerca volvulus 0.0025 0.0009 0.0114
Schistosoma mansoni serpin 0.0023 0.0006 0.0006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Trichomonas vaginalis WD repeat domain, putative 0.0148 0.0135 0.0207
Leishmania major hypothetical protein, conserved 0.003 0.0014 0.0153
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0035 0.0019 0.0019
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0108 0.0094 0.0094
Plasmodium vivax aspartyl protease, putative 0.0038 0.0022 0.0457
Brugia malayi aspartic protease BmAsp-1, identical 0.0038 0.0022 0.0022
Plasmodium falciparum plasmepsin X 0.0038 0.0022 0.0457
Echinococcus multilocularis Tolloid protein 1 0.0025 0.0009 0.0011
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0043 0.0026 0.0033
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0105 0.0091 0.0091
Plasmodium falciparum subtilisin-like protease 1 0.0429 0.0424 0.9928
Brugia malayi Pepsin A precursor 0.0038 0.0022 0.0022
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0686 0.0688 0.0688
Plasmodium falciparum protoporphyrinogen oxidase 0.0139 0.0126 0.2908
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0026 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2371 0.2421 0.3955
Loa Loa (eye worm) hypothetical protein 0.0038 0.0022 0.0022
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0063 0.0047 0.1054
Echinococcus granulosus protein will die slowly 0.0148 0.0135 0.0135
Brugia malayi Subtilase family protein 0.0429 0.0424 0.0424
Brugia malayi CUB domain containing protein 0.0025 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Onchocerca volvulus 0.0136 0.0122 0.1629
Loa Loa (eye worm) hypothetical protein 0.0071 0.0055 0.0055
Brugia malayi transcriptional regulator, Sir2 family protein 0.0105 0.0091 0.0091
Trypanosoma brucei SIR2-like protein 4, putative 0.0105 0.0091 0.1236
Echinococcus multilocularis serine protease inhibitor 0.0023 0.0006 0.0007
Brugia malayi Protein kinase domain containing protein 0.003 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Toxoplasma gondii aspartyl protease ASP1 0.0038 0.0022 0.0461
Trypanosoma cruzi UDP-galactopyranose mutase 0.0139 0.0126 0.1726
Loa Loa (eye worm) WD40 repeat protein 0.0148 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0429 0.0424 0.0424
Entamoeba histolytica serine protease inhibitor, putative 0.0023 0.0006 0.0082
Loa Loa (eye worm) reprolysin 0.0045 0.0029 0.0029
Schistosoma mansoni septate junction protein 0.0051 0.0035 0.0035
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.002 0.0003 0.0003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0073 0.0057 0.0057
Brugia malayi hypothetical protein 0.0023 0.0006 0.0006
Echinococcus granulosus CUB 0.0025 0.0009 0.0009
Echinococcus granulosus lysine specific histone demethylase 1A 0.0139 0.0126 0.0126
Plasmodium vivax hypothetical protein, conserved 0.0139 0.0126 0.2908
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0026 0.0033
Echinococcus multilocularis adam 0.0059 0.0043 0.0053
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0058 0.0042 0.0053
Loa Loa (eye worm) proprotein convertase 2 0.2371 0.2421 0.2421
Leishmania major arginine N-methyltransferase, type I 0.0035 0.0019 0.0227
Loa Loa (eye worm) hypothetical protein 0.0038 0.0022 0.0022
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0045 0.0029 0.0029
Plasmodium vivax subtilisin-like protease 1 0.0429 0.0424 0.9928
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0139 0.0126 0.2908
Trichomonas vaginalis conserved hypothetical protein 0.0429 0.0424 0.0681
Echinococcus multilocularis integrin alpha ps 0.0032 0.0016 0.002
Schistosoma mansoni growth factor receptor-bound protein 0.0125 0.0112 0.0111
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.026 0.025 0.025
Schistosoma mansoni hypothetical protein 0.0025 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0744 0.0748 0.0748
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0025 0.0009 0.0011
Schistosoma mansoni hypothetical protein 0.003 0.0014 0.0014
Echinococcus granulosus growth factor receptor bound protein 2 0.0125 0.0112 0.0111
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0043 0.0026 0.0033
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0024 0.0007 0.012
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0035 0.0019 0.0227
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Loa Loa (eye worm) hypothetical protein 0.0105 0.0091 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0139 0.0126 0.2908
Loa Loa (eye worm) DPY-31 protein 0.0025 0.0009 0.0009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0022 0.0022
Echinococcus granulosus membrane bound transcription factor site 1 0.0429 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0135
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0105 0.0091 0.2107
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0065 0.0049 0.0999
Plasmodium vivax aspartyl protease, putative 0.0038 0.0022 0.0457
Brugia malayi Protein arginine N-methyltransferase 0.0035 0.0019 0.0019
Brugia malayi astacin protease protein 30 0.0025 0.0009 0.0009
Brugia malayi hypothetical protein 0.0098 0.0083 0.0083
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Schistosoma mansoni amine oxidase 0.0139 0.0126 0.0126
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0075 0.006 0.1377
Echinococcus granulosus Estrogen regulated protein EP45 0.0023 0.0006 0.0006
Echinococcus granulosus plasminogen activator inhibitor 2 0.0023 0.0006 0.0006
Brugia malayi serpin precursor 0.0023 0.0006 0.0006
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0135
Schistosoma mansoni discoidin domain receptor 0.0043 0.0026 0.0026
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0071 0.0055 0.0055
Brugia malayi serpin 0.0023 0.0006 0.0006
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0031 0.0015 0.0304
Toxoplasma gondii subtilisin SUB2 0.0429 0.0424 1
Trichomonas vaginalis conserved hypothetical protein 0.1942 0.1979 0.3231
Plasmodium falciparum plasmepsin VI 0.0038 0.0022 0.0457
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.008 0.0065 0.1487
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0429 0.0424 0.0424
Mycobacterium ulcerans polyketide synthase Pks13 0.0114 0.0099 0.2298
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0044 0.0028 0.0616
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Schistosoma mansoni discoidin domain receptor 0.0043 0.0026 0.0026
Echinococcus granulosus adam 0.0059 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0025 0.0009 0.0009
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0105 0.0091 0.2082
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0026 0.0562
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0454 0.045 0.6256
Echinococcus multilocularis 0.7799 0.8003 1
Echinococcus granulosus adam 17 protease 0.0019 0.0002 0.0002
Brugia malayi Eukaryotic aspartyl protease family protein 0.0038 0.0022 0.0022
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0035 0.0019 0.0024
Echinococcus granulosus protein arginine N methyltransferase 7 0.0035 0.0019 0.0019
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0022 0.0005 0.0005
Brugia malayi Kringle domain containing protein 0.003 0.0014 0.0014
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0035 0.0019 0.0227
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5956 0.6108 0.7632
Echinococcus granulosus serine protease inhibitor 0.0023 0.0006 0.0006
Plasmodium falciparum subtilisin-like protease 3 0.0429 0.0424 0.9928
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0025 0.0009 0.0009
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0026 0.0026
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0198 0.0186 0.0186
Echinococcus granulosus chromatin regulatory protein sir2 0.0715 0.0717 0.0717
Mycobacterium leprae Possible secreted protease 0.0429 0.0424 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0715 0.0717 0.0717
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0429 0.0424 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0035 0.0019 0.0017
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0075 0.006 0.1369
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Leishmania major arginine N-methyltransferase-like protein 0.0063 0.0047 0.0621
Loa Loa (eye worm) hypothetical protein 0.0058 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0019
Onchocerca volvulus 0.0172 0.016 0.2133
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0035 0.0019 0.0227
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5956 0.6108 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0053 0.0052
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0105 0.0091 0.0114
Echinococcus multilocularis epidermal growth factor receptor 0.0639 0.064 0.08
Mycobacterium ulcerans thioesterase TesA 0.0065 0.0049 0.1107
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.008 0.0065 0.1476
Brugia malayi Furin-like cysteine rich region family protein 0.0639 0.064 0.064
Plasmodium falciparum plasmepsin V 0.0432 0.0427 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2371 0.2421 0.3955
Plasmodium vivax plasmepsin V, putative 0.0432 0.0427 1
Trichomonas vaginalis conserved hypothetical protein 0.1942 0.1979 0.3231
Echinococcus granulosus protein arginine N methyltransferase 8 0.0063 0.0047 0.0047
Trypanosoma cruzi UDP-galactopyranose mutase 0.0139 0.0126 0.1726
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0075 0.006 0.1253
Schistosoma mansoni site-1 peptidase (S08 family) 0.0429 0.0424 0.0424
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.008 0.0065 0.1487
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Brugia malayi transcriptional regulator, Sir2 family protein 0.0105 0.0091 0.0091
Onchocerca volvulus 0.0043 0.0026 0.0354
Schistosoma mansoni hypothetical protein 0.0148 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0429 0.0424 1
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0429 0.0424 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.008 0.0065 0.1372
Mycobacterium tuberculosis Possible oxidoreductase 0.0139 0.0126 0.2938
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0013 0.0013
Plasmodium vivax hypothetical protein, conserved 0.0139 0.0126 0.2908
Toxoplasma gondii aspartyl protease ASP5 0.0394 0.0387 0.9134
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.0099 0.0099
Onchocerca volvulus 0.0023 0.0006 0.0079
Loa Loa (eye worm) hypothetical protein 0.0113 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0032 0.0016 0.0016
Plasmodium vivax subtilisin-like serine protease, putative 0.0429 0.0424 0.9928
Mycobacterium ulcerans Type I modular polyketide synthase 0.0075 0.006 0.1358
Loa Loa (eye worm) serpin 0.0023 0.0006 0.0006
Echinococcus granulosus Protein kinase C brain isozyme 0.0018 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Mycobacterium ulcerans Type I modular polyketide synthase 0.0075 0.006 0.1358
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0002
Brugia malayi Integrin alpha pat-2 precursor 0.015 0.0137 0.0137
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0454 0.045 0.6256
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Echinococcus multilocularis CUB 0.0025 0.0009 0.0011
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0135
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0024 0.0007 0.0122
Brugia malayi hypothetical protein 0.0023 0.0006 0.0006
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.002 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.3785 0.3875 0.3875
Schistosoma mansoni hypothetical protein 0.0032 0.0016 0.0016
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0022 0.0457
Loa Loa (eye worm) hypothetical protein 0.0139 0.0126 0.0126
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0035 0.0019 0.0227
Loa Loa (eye worm) transcriptional regulator 0.0105 0.0091 0.0091
Schistosoma mansoni serpin 0.0023 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0098 0.0083 0.0083
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2371 0.2421 0.3955
Loa Loa (eye worm) hypothetical protein 0.0686 0.0688 0.0688
Echinococcus multilocularis discoidin domain receptor 0.0043 0.0026 0.0033
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0035 0.0019 0.0017
Trypanosoma brucei subtilisin peptidase 0.0429 0.0424 0.5892
Brugia malayi BmSERPIN, truncated 0.0023 0.0006 0.0006
Brugia malayi Nematode astacin protease protein 30 0.0025 0.0009 0.0009
Schistosoma mansoni integrin alpha-ps 0.0035 0.0019 0.0019
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0059 0.0043 0.0043
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0715 0.0717 0.1162
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0025 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.1942 0.1979 0.3231
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0135
Echinococcus multilocularis cubilin 0.0025 0.0009 0.0011
Onchocerca volvulus 0.0043 0.0026 0.0354
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0019 0.0002 0.0002
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0038 0.0022 0.0461
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0006 0.0006
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0025 0.0009 0.0009
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0429 0.0424 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.0104 0.0104
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0139 0.0126 0.0126
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0022 0.0022
Onchocerca volvulus 0.0071 0.0055 0.0737
Brugia malayi hypothetical protein 0.0139 0.0126 0.0126
Loa Loa (eye worm) integrin alpha pat-2 0.0231 0.022 0.022
Giardia lamblia hypothetical protein 0.0058 0.0042 0.0099
Toxoplasma gondii subtilisin SUB4 0.0429 0.0424 1
Plasmodium vivax LCCL domain-containing protein 0.0043 0.0026 0.0562
Plasmodium falciparum plasmepsin III 0.0038 0.0022 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.0429 0.0424 0.0681
Loa Loa (eye worm) aspartyl protease 6 0.0038 0.0022 0.0022
Loa Loa (eye worm) endoprotease bli-4 0.9741 1 1
Schistosoma mansoni protein kinase 0.0124 0.011 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0025 0.0009 0.0009
Brugia malayi celfurPC protein 0.7799 0.8003 0.8003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0022 0.0457
Brugia malayi serpin (BmSERPIN) 0.0023 0.0006 0.0006
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0026 0.0026
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1942 0.1979 0.3231
Loa Loa (eye worm) serpin 0.0023 0.0006 0.0006
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0043 0.0026 0.0029
Brugia malayi Lectin C-type domain containing protein 0.0025 0.0009 0.0009
Loa Loa (eye worm) TK/ALK protein kinase 0.0071 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0063 0.0047 0.0059
Schistosoma mansoni chromatin regulatory protein sir2 0.0715 0.0717 0.0717
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0078 0.0078
Toxoplasma gondii subtilisin SUB10 0.0429 0.0424 1
Plasmodium vivax aspartyl protease, putative 0.0038 0.0022 0.0457
Schistosoma mansoni chromatin regulatory protein sir2 0.0715 0.0717 0.0717
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0063 0.0047 0.0063
Toxoplasma gondii SWIRM domain-containing protein 0.0058 0.0042 0.0941
Echinococcus multilocularis protein will die slowly 0.0148 0.0135 0.0169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2371 0.2421 0.3955
Echinococcus multilocularis serine protease inhibitor 0.0023 0.0006 0.0007
Echinococcus granulosus Tolloid protein 1 0.0025 0.0009 0.0009
Schistosoma mansoni site-1 peptidase (S08 family) 0.0429 0.0424 0.0424
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2371 0.2421 0.3955
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Loa Loa (eye worm) hypothetical protein 0.0686 0.0688 0.0688
Echinococcus multilocularis integrin alpha ps 0.0067 0.0052 0.0065
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0063 0.0047 0.0063
Loa Loa (eye worm) CUB domain-containing protein 0.0025 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Loa Loa (eye worm) fatty acid synthase 0.0077 0.0062 0.0062
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0035 0.0019 0.0263
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0043 0.0026 0.0452
Echinococcus granulosus tissue type plasminogen activator 0.003 0.0014 0.0014
Toxoplasma gondii bicoid-interacting protein BIN3 0.0035 0.0019 0.0385
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0014
Loa Loa (eye worm) TK/ROR protein kinase 0.003 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0035 0.0019 0.0019
Brugia malayi serpin 0.0023 0.0006 0.0006
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0139 0.0126 0.2843
Onchocerca volvulus 0.0025 0.0009 0.0114
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0098 0.0083 0.1129
Schistosoma mansoni protein kinase 0.0124 0.011 0.011
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0035 0.0019 0.0227
Loa Loa (eye worm) hypothetical protein 0.0034 0.0018 0.0018
Entamoeba histolytica SWIRM domain protein 0.0058 0.0042 0.0589
Toxoplasma gondii type I fatty acid synthase, putative 0.0055 0.004 0.0876
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0071 0.0055 0.0055
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0063 0.0047 0.0047
Brugia malayi serpin 0.0023 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0042 0.0055
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0091 0.2082
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0105 0.0091 0.1236
Toxoplasma gondii subtilisin SUB12 0.0429 0.0424 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Toxoplasma gondii subtilisin SUB7 0.0429 0.0424 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0022 0.0022
Loa Loa (eye worm) guanylate kinase 0.0024 0.0007 0.0007
Schistosoma mansoni growth factor receptor-bound protein 0.0125 0.0112 0.0111
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0022 0.0022
Onchocerca volvulus 0.0073 0.0057 0.0766
Brugia malayi Reprolysin 0.0026 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.1942 0.1979 0.3231
Trichomonas vaginalis conserved hypothetical protein 0.1942 0.1979 0.3231
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.0026 0.0029
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0006 0.0006
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0058 0.0042 0.0042
Brugia malayi Disintegrin family protein 0.0019 0.0002 0.0002
Brugia malayi hypothetical protein 0.0059 0.0043 0.0043
Onchocerca volvulus 0.0025 0.0009 0.0114
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0035 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0029 0.0029
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0715 0.0717 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0091 0.0091
Toxoplasma gondii histone deacetylase SIR2-like 0.0105 0.0091 0.2097
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0022 0.0022
Echinococcus granulosus epidermal growth factor receptor 0.0639 0.064 0.064
Mycobacterium ulcerans polyketide synthase MbtD 0.0024 0.0007 0.0107
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.9741 1 1
Loa Loa (eye worm) transcriptional regulator 0.0715 0.0717 0.0717
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.006 0.0044 0.0877
Echinococcus granulosus Estrogen regulated protein EP45 0.0023 0.0006 0.0006
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.0023 0.0006 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Brugia malayi Protein kinase domain containing protein 0.0043 0.0026 0.0026
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0035 0.0019 0.0227
Echinococcus multilocularis serine:threonine protein kinase N2 0.0085 0.007 0.0087
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5956 0.6108 0.6108
Mycobacterium leprae Polyketide synthase Pks13 0.0114 0.0099 0.2205
Onchocerca volvulus Fatty acid synthase homolog 0.014 0.0127 0.1696
Schistosoma mansoni protein kinase 0.0124 0.011 0.011
Echinococcus multilocularis protein arginine methyltransferase 0.0063 0.0047 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2371 0.2421 0.2421
Plasmodium vivax plasmepsin IV, putative 0.0038 0.0022 0.0457
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0105 0.0091 0.1236
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0039 0.0023 0.0484
Schistosoma mansoni protein arginine n-methyltransferase 0.0035 0.0019 0.0019
Schistosoma mansoni furin-1 (S08 family) 0.4214 0.4316 0.4316
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0105 0.0091 0.1268
Brugia malayi SWIRM domain containing protein 0.0744 0.0748 0.0748
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Brugia malayi Guanylate kinase family protein 0.003 0.0014 0.0014
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0075 0.006 0.006
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0025 0.0009 0.0009
Echinococcus multilocularis protein kinase c epsilon type 0.0092 0.0078 0.0097
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0061 0.0045 0.1023
Brugia malayi hypothetical protein 0.0071 0.0055 0.0055
Brugia malayi hypothetical protein 0.0038 0.0022 0.0022
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0063 0.0047 0.1046
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0105 0.0091 0.0091
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0224 0.0213 0.0266
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0145 0.0132 0.0131
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0035 0.0019 0.0385
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0429 0.0424 0.0424
Schistosoma mansoni tyrosine kinase 0.0639 0.064 0.064
Trichomonas vaginalis conserved hypothetical protein 0.1942 0.1979 0.3231
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0105 0.0091 0.0232
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.002 0.0003 0.5
Chlamydia trachomatis protoporphyrinogen oxidase 0.0139 0.0126 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0715 0.0717 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.008 0.0065 0.1476
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0429 0.0424 1
Brugia malayi neuroendocrine convertase 1 precursor 0.6155 0.6313 0.6313
Giardia lamblia High cysteine membrane protein Group 2 0.3585 0.367 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Echinococcus granulosus serine protease inhibitor 0.0023 0.0006 0.0006
Loa Loa (eye worm) subtilase 0.0429 0.0424 0.0424
Brugia malayi aspartic protease BmAsp-2, identical 0.0038 0.0022 0.0022
Schistosoma mansoni integrin alpha 0.015 0.0137 0.0137
Onchocerca volvulus 0.0025 0.0009 0.0114
Brugia malayi Angiotensin-converting enzyme family protein 0.0606 0.0606 0.0606
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0022 0.0022
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0098 0.0083 0.1129
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0139 0.0126 0.2908
Loa Loa (eye worm) sirtuin 4 0.0105 0.0091 0.0091
Echinococcus granulosus protein kinase c epsilon type 0.0092 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0128 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.1942 0.1979 0.3231
Brugia malayi Serpin protein 6 0.0023 0.0006 0.0006
Echinococcus granulosus cubilin 0.0025 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Loa Loa (eye worm) hypothetical protein 0.0071 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0429 0.0424 0.0681
Brugia malayi SWIRM domain containing protein 0.0058 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0429 0.0424 0.0681
Trichomonas vaginalis conserved hypothetical protein 0.1942 0.1979 0.3231
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0139 0.0126 0.2929
Toxoplasma gondii protease inhibitor PI1 0.0023 0.0006 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0026 0.0029
Loa Loa (eye worm) TK/EGFR protein kinase 0.0639 0.064 0.064
Plasmodium falciparum plasmepsin VII 0.0038 0.0022 0.0457
Brugia malayi angiogenesis inhibito 0.0026 0.0009 0.0009
Echinococcus granulosus furin 0.9741 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0029 0.0029
Mycobacterium ulcerans fatty acid synthase Fas 0.0024 0.0008 0.012
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0013 0.0013
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0063 0.0047 0.0047
Onchocerca volvulus 0.0744 0.0748 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0022 0.0022
Echinococcus granulosus Furin 1 0.2371 0.2421 0.2421
Schistosoma mansoni hypothetical protein 0.0025 0.0009 0.0009
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0429 0.0424 0.0681
Entamoeba histolytica hypothetical protein, conserved 0.0105 0.0091 0.1268
Mycobacterium ulcerans Type I modular polyketide synthase 0.0075 0.006 0.1358
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0042 0.0055
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0114 0.0099 0.2308
Entamoeba histolytica SWIRM domain protein 0.0058 0.0042 0.0589
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0429 0.0424 1
Echinococcus multilocularis cubilin 0.0025 0.0009 0.0011
Echinococcus multilocularis growth factor receptor bound protein 2 0.0125 0.0112 0.0139
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0429 0.0424 0.0424
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0006 0.0006
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0038 0.0022 0.0461
Mycobacterium tuberculosis Conserved hypothetical protein 0.0139 0.0126 0.2938
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0022 0.0022
Loa Loa (eye worm) transcriptional regulator 0.0105 0.0091 0.0091
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0135
Echinococcus multilocularis tissue type plasminogen activator 0.003 0.0014 0.0017
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0105 0.0091 0.0114
Brugia malayi Sex muscle abnormal protein 5 0.0125 0.0112 0.0111
Echinococcus multilocularis neuroendocrine convertase 2 0.6155 0.6313 0.7888
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0035 0.0019 0.0019
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0075 0.006 0.1358
Onchocerca volvulus 0.0023 0.0006 0.0079
Onchocerca volvulus 0.0023 0.0006 0.0079
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1942 0.1979 0.3231

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.5 uM Inhibitory activity evaluated against rat Con A embryonic cortical neurons in cellular assay ChEMBL. 15109679
IC50 (functional) = 1.3 uM Inhibitory activity evaluated against human jurkat cell line in cellular assay ChEMBL. 15109679
IC50 (functional) = 1.3 uM Inhibitory activity evaluated against human jurkat cell line in cellular assay ChEMBL. 15109679
k3/Ki (binding) = 112166 M-1 s-1 Binding affinity towards human caspase 8 ChEMBL. 15109679
k3/Ki (binding) = 112166 M-1 s-1 Binding affinity towards human caspase 8 ChEMBL. 15109679
k3/Ki (binding) = 282834 M-1 s-1 Binding affinity towards human caspase 3 ChEMBL. 15109679
k3/Ki (binding) = 282834 M-1 s-1 Binding affinity towards human caspase 3 ChEMBL. 15109679

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15109679

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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