Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0102 | 0.0951 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0102 | 0.0951 | 0.1552 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0951 | 0.1552 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0951 | 0.1552 |
Loa Loa (eye worm) | carboxylesterase | 0.0604 | 0.6126 | 1 |
Schistosoma mansoni | gliotactin | 0.0102 | 0.0951 | 0.1552 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1386 | 0.2262 |
Loa Loa (eye worm) | hypothetical protein | 0.0604 | 0.6126 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0951 | 0.1552 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0102 | 0.0951 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0102 | 0.0951 | 0.1552 |
Loa Loa (eye worm) | carboxylesterase | 0.0102 | 0.0951 | 0.1552 |
Echinococcus granulosus | carboxylesterase 5A | 0.0604 | 0.6126 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0604 | 0.6126 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.0951 | 0.1552 |
Brugia malayi | Carboxylesterase family protein | 0.0604 | 0.6126 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0951 | 0.1552 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0951 | 0.1552 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0102 | 0.0951 | 0.1552 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0604 | 0.6126 | 0.6126 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0951 | 0.1552 |
Brugia malayi | hypothetical protein | 0.0102 | 0.0951 | 0.1552 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0102 | 0.0951 | 0.0951 |
Onchocerca volvulus | 0.0102 | 0.0951 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0951 | 0.1552 |
Onchocerca volvulus | 0.0102 | 0.0951 | 0.5 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0102 | 0.0951 | 0.1552 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0102 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0951 | 0.1552 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0604 | 0.6126 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0951 | 0.1552 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0102 | 0.0951 | 0.0951 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1386 | 0.2262 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0102 | 0.0951 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0951 | 0.1552 |
Onchocerca volvulus | 0.0102 | 0.0951 | 0.5 | |
Onchocerca volvulus | 0.0102 | 0.0951 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.0951 | 0.1552 |
Schistosoma mansoni | acetylcholinesterase | 0.0102 | 0.0951 | 0.1552 |
Onchocerca volvulus | 0.0102 | 0.0951 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0604 | 0.6126 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0951 | 0.1552 |
Brugia malayi | Carboxylesterase family protein | 0.0604 | 0.6126 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0102 | 0.0951 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0102 | 0.0951 | 0.0951 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0102 | 0.0951 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0604 | 0.6126 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1386 | 0.2262 |
Echinococcus multilocularis | acetylcholinesterase | 0.0604 | 0.6126 | 0.6126 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.0951 | 0.1552 |
Echinococcus multilocularis | acetylcholinesterase | 0.0604 | 0.6126 | 0.6126 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0604 | 0.6126 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0102 | 0.0951 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0102 | 0.0951 | 0.1552 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0102 | 0.0951 | 0.1552 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0102 | 0.0951 | 0.1552 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 16.3535 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.