Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0243 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0243 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6882 | 0.6963 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0241 | 0.9883 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0243 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0241 | 0.9883 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0241 | 0.9883 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0243 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.6882 | 0.6963 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6882 | 0.6963 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0241 | 0.9883 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0241 | 0.9883 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0241 | 0.9883 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.6882 | 0.6963 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0241 | 0.9883 | 1 |
Onchocerca volvulus | 0.012 | 0 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.0241 | 0.9883 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0241 | 0.9883 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0243 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0241 | 0.9883 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.5821 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.