Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.011 | 1 | 1 |
Onchocerca volvulus | Deterin homolog | 0.011 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4987 | 0.4987 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4987 | 0.4987 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.011 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.011 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4987 | 0.3291 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4987 | 0.4987 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.011 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4987 | 0.4987 |
Onchocerca volvulus | 0.011 | 1 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4987 | 0.3291 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4987 | 0.4987 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.011 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4987 | 0.4987 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4987 | 0.3291 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.011 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2528 | 0.2528 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.011 | 1 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.011 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4987 | 0.4987 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4987 | 0.4987 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2528 | 0.2528 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4987 | 0.4987 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.011 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4987 | 0.4987 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.6109 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.