Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.3256 | 1 |
Brugia malayi | hypothetical protein | 0.0073 | 0.3256 | 0.3256 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1589 | 0.1589 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.3256 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3256 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3256 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0126 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.3256 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1589 | 0.1589 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1589 | 0.1589 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1589 | 0.1589 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3256 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0126 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.3256 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3256 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 30.1313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.