TDR Targets

Basic information

Technical information

TDR Targets ID: 1486457
Name: 2-phenyl-4-(trifluoromethyl)pyrimidine-5-carb oxylic acid
MW: 268.191 | Formula: C12H7F3N2O2
H donors: 1 H acceptors: 4 LogP: 2.31 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)c1cnc(nc1C(F)(F)F)c1ccccc1
InChi: 1S/C12H7F3N2O2/c13-12(14,15)9-8(11(18)19)6-16-10(17-9)7-4-2-1-3-5-7/h1-6H,(H,18,19)
InChiKey: ANRSNMBBSUTAEN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-phenyl-4-(trifluoromethyl)-5-pyrimidinecarboxylic acid
SMR000338456
5W-1087
MLS000736206

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	glutaminase	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0905	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0677	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0677	0.0677
Brugia malayi	Muscleblind-like protein	0.0317	0.3409	0.3409
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0074	0.0677	0.0448
Echinococcus granulosus	muscleblind protein	0.0317	0.3409	0.3409
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0626	0.6874	0.6874
Trichomonas vaginalis	aldo-keto reductase, putative	0.0905	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0905	1	1
Entamoeba histolytica	aldose reductase, putative	0.0905	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0262	0.279	0.279
Trichomonas vaginalis	aldo/keto reductase, putative	0.0905	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0128	0.1282	0.1282
Plasmodium falciparum	aldehyde reductase, putative	0.0262	0.279	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0677	0.0677
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0074	0.0677	0.0677
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Toxoplasma gondii	aldose reductase, putative	0.0905	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0074	0.0677	0.0677
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0041	0.0041
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0035	0.024	0.024
Brugia malayi	nuclear hormone receptor	0.0074	0.0677	0.0677
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0262	0.279	0.279
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0074	0.0677	0.0677
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.0366	0.0366
Schistosoma mansoni	thyroid hormone receptor	0.0074	0.0677	0.0677
Plasmodium falciparum	histone acetyltransferase GCN5	0.0042	0.0323	0.1158
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0677	0.0677
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.0366	0.1312
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0039	0.0287	0.0287
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0074	0.0677	0.0677
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0074	0.0677	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3409	0.3409
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0035	0.024	0.024
Giardia lamblia	Aldose reductase	0.0905	1	1
Leishmania major	prostaglandin f synthase, putative	0.0905	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0074	0.0677	0.0677
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0074	0.0677	0.0677
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0074	0.0677	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0287	0.0287
Echinococcus granulosus	aldo keto reductase	0.0905	1	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0708	0.0708
Trichomonas vaginalis	aldo-keto reductase, putative	0.0905	1	1
Echinococcus multilocularis	aldo keto reductase	0.0905	1	1
Brugia malayi	hypothetical protein	0.0039	0.0287	0.0287
Brugia malayi	nuclear hormone receptor family member odr-7	0.0035	0.024	0.024
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0041	0.0041
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0074	0.0677	0.0677
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.0366	0.0366
Trichomonas vaginalis	aldo-keto reductase, putative	0.0262	0.279	0.279
Schistosoma mansoni	nuclear receptor nhr-48	0.0035	0.024	0.024
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0074	0.0677	0.0677
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0128	0.1282	0.1282
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0074	0.0677	0.0677
Brugia malayi	conserved hypotetical protein	0.0035	0.024	0.024
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0708	0.0708
Echinococcus granulosus	hypothetical protein	0.0905	1	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0041	0.0041
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0905	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0905	1	1
Loa Loa (eye worm)	glutaminase 2	0.033	0.3552	0.3552
Brugia malayi	Nuclear hormone receptor-like 1	0.0074	0.0677	0.0677
Brugia malayi	Nuclear hormone receptor E75	0.0035	0.024	0.024
Schistosoma mansoni	nuclear receptor	0.0035	0.024	0.024
Trypanosoma brucei	aldo-keto reductase, putative	0.0905	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0074	0.0677	0.0677
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0905	1	1
Loa Loa (eye worm)	oxidoreductase	0.0905	1	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0074	0.0677	0.0677
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0074	0.0677	0.0677
Echinococcus multilocularis	aldo keto reductase	0.0905	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0128	0.1282	0.1282
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0074	0.0677	0.0677
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0074	0.0677	0.0677
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0262	0.279	0.279
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0708	0.0708
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.0366	0.0366
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0287	0.0287
Brugia malayi	TAR-binding protein	0.0076	0.0708	0.0708
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0035	0.024	0.024
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0074	0.0677	0.0677
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0039	0.0287	0.0287
Schistosoma mansoni	potassium channel beta	0.0262	0.279	0.279
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0035	0.024	0.024
Brugia malayi	NADH-dependent xylose reductase	0.0262	0.279	0.279
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0905	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0128	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0263	0.0263
Trichomonas vaginalis	aldo-keto reductase, putative	0.0905	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0905	1	1
Loa Loa (eye worm)	oxidoreductase	0.0905	1	1
Echinococcus granulosus	GPCR family 2	0.0017	0.0041	0.0041
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0905	1	1
Onchocerca volvulus	Bile acid receptor homolog	0.0074	0.0677	0.0448
Loa Loa (eye worm)	acetyltransferase	0.0157	0.1606	0.1606
Schistosoma mansoni	thyroid hormone receptor	0.0074	0.0677	0.0677
Mycobacterium ulcerans	glutaminase	0.033	0.3552	0.1057
Loa Loa (eye worm)	glutaminase	0.033	0.3552	0.3552
Toxoplasma gondii	aldo-keto reductase	0.0262	0.279	0.279
Onchocerca volvulus		0.0905	1	1
Echinococcus multilocularis	muscleblind protein 1	0.0317	0.3409	0.3409
Brugia malayi	ecdysteroid receptor	0.0074	0.0677	0.0677
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0454	0.0454
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0035	0.024	0.024
Trichomonas vaginalis	glutaminase, putative	0.033	0.3552	0.3552
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0074	0.0677	0.0677
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0041	0.0041
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0074	0.0677	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3409	0.3409
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0905	1	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0035	0.024	0.024
Schistosoma mansoni	nuclear hormone receptor	0.0035	0.024	0.024
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0035	0.024	0.024
Trichomonas vaginalis	aldo-keto reductase, putative	0.0905	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0074	0.0677	0.0677
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0905	1	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0385	0.0385
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0035	0.024	0.024
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0035	0.024	0.024
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0905	1	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0035	0.024	0.024
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0905	1	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0905	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0287	0.0287
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0262	0.279	0.279
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0905	1	1
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0708	0.0708
Brugia malayi	nuclear receptor NHR-88	0.0035	0.024	0.024
Echinococcus multilocularis	aldo keto reductase	0.0905	1	1
Onchocerca volvulus		0.0905	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0074	0.0677	0.0677
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0262	0.279	0.279
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0905	1	1
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0262	0.279	0.279
Loa Loa (eye worm)	DR-78	0.0035	0.024	0.024
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0074	0.0677	0.0677
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0041	0.0041
Leishmania major	aldo-keto reductase-like protein	0.0905	1	1
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0262	0.279	0.279
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0128	0.1282	0.1282
Onchocerca volvulus		0.0262	0.279	0.2613
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0905	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0905	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0905	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0074	0.0677	0.0677
Onchocerca volvulus		0.0074	0.0677	0.0448
Echinococcus granulosus	nuclear receptor nhr 48	0.0035	0.024	0.024
Mycobacterium ulcerans	oxidoreductase	0.0905	1	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0039	0.0287	0.0287
Brugia malayi	nuclear receptor RXR	0.0035	0.024	0.024
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0454	0.0454
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0074	0.0677	0.0677
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0074	0.0677	0.0677
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0035	0.024	0.024
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0385	0.0385
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0905	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0035	0.024	0.024
Brugia malayi	glutaminase DH11.1	0.033	0.3552	0.3552
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0385	0.0385
Trichomonas vaginalis	aldo/keto reductase, putative	0.0905	1	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0041	0.0041
Onchocerca volvulus		0.0905	1	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0263	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Trichomonas vaginalis	aldo-keto reductase, putative	0.0905	1	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0708	0.0708
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0905	1	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0074	0.0677	0.0677
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0035	0.024	0.024
Trypanosoma cruzi	aldo-keto reductase	0.0905	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0708	0.0708
Schistosoma mansoni	glutaminase	0.033	0.3552	0.3552
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0074	0.0677	0.0677
Schistosoma mansoni	nuclear hormone receptor	0.0074	0.0677	0.0677
Loa Loa (eye worm)	oxidoreductase	0.0905	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.0074	0.0677	0.0677
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0074	0.0677	0.0677
Brugia malayi	nuclear hormone receptor	0.0035	0.024	0.024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0385	0.0385
Brugia malayi	orphan nuclear receptor NR2E1	0.0035	0.024	0.024
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0708	0.0708
Brugia malayi	Nuclear hormone receptor-like 1	0.0039	0.0287	0.0287
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0074	0.0677	0.0677
Trichomonas vaginalis	aldo/keto reductase, putative	0.0905	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0074	0.0677	0.0677
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0905	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0905	1	1
Brugia malayi	RNA binding protein	0.0076	0.0708	0.0708
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0074	0.0677	0.0677
Echinococcus granulosus	aldo keto reductase	0.0905	1	1
Schistosoma mansoni	aldo-keto reductase	0.0905	1	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0039	0.0287	0.0287
Brugia malayi	hypothetical protein	0.0035	0.024	0.024
Schistosoma mansoni	zinc finger protein	0.0035	0.024	0.024
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0905	1	1
Brugia malayi	Nuclear hormone receptor E75	0.0035	0.024	0.024
Loa Loa (eye worm)	oxidoreductase	0.0905	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0074	0.0677	0.0677
Brugia malayi	hypothetical protein	0.0035	0.024	0.024
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0262	0.279	0.279
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0905	1	1
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0262	0.279	0.279
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0074	0.0677	0.0677
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0905	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0708	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0677	0.0677
Brugia malayi	Nuclear hormone receptor-like 1	0.0039	0.0287	0.0287
Onchocerca volvulus		0.0905	1	1
Brugia malayi	nuclear receptor NHR-67	0.0035	0.024	0.024
Echinococcus granulosus	voltage gated potassium channel subunit	0.0262	0.279	0.279
Trichomonas vaginalis	aldo-keto reductase, putative	0.0905	1	1
Echinococcus granulosus	aldo keto reductase	0.0905	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Brugia malayi	nuclear receptor NHR-88	0.0074	0.0677	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0677	0.0677
Brugia malayi	nuclear receptor RXR	0.0039	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Trichomonas vaginalis	aldo-keto reductase, putative	0.0905	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0454	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0454	0.0454
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0905	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0128	0.1282	0.1282
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0128	0.1282	0.1282
Trichomonas vaginalis	aldo-keto reductase, putative	0.0905	1	1
Trypanosoma brucei	prostaglandin f synthase	0.0905	1	1
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0262	0.279	0.279
Echinococcus multilocularis	ecdysone induced protein 78C	0.0074	0.0677	0.0677
Schistosoma mansoni	nuclear receptor	0.0035	0.024	0.024
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0905	1	1
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0708	0.0708
Mycobacterium tuberculosis	Probable oxidoreductase	0.0905	1	1
Onchocerca volvulus		0.0905	1	1
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0262	0.279	1
Schistosoma mansoni	coup transcription factor	0.0074	0.0677	0.0677
Schistosoma mansoni	hypothetical protein	0.0017	0.0041	0.0041
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0074	0.0677	0.0677
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0074	0.0677	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0677	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0905	1	1
Echinococcus multilocularis	muscleblind protein	0.0317	0.3409	0.3409
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0074	0.0677	0.0677
Schistosoma mansoni	hypothetical protein	0.0017	0.0041	0.0041
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0157	0.1606	0.1606
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0677	0.0677
Onchocerca volvulus	Protein ultraspiracle homolog	0.0074	0.0677	0.0448
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0905	1	1
Echinococcus multilocularis	aldo keto reductase	0.0905	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0074	0.0677	0.0677
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0035	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0287	0.0287
Plasmodium vivax	aldehyde reductase, putative	0.0262	0.279	1
Schistosoma mansoni	aldo-keto reductase	0.0905	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0385	0.0385
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0074	0.0677	0.0677
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0074	0.0677	0.0677
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0708	0.0708
Loa Loa (eye worm)	oxidoreductase	0.0905	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0035	0.024	0.024
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0041	0.0041
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0074	0.0677	0.0677
Giardia lamblia	Histone acetyltransferase GCN5	0.0042	0.0323	0.0323
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0385	0.0385
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0074	0.0677	0.0677
Loa Loa (eye worm)	steroid hormone receptor	0.0074	0.0677	0.0677
Brugia malayi	photoreceptor-specific nuclear receptor	0.0074	0.0677	0.0677
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0035	0.024	0.024
Echinococcus granulosus	FTZ F1 alpha	0.0074	0.0677	0.0677
Entamoeba histolytica	acetyltransferase, GNAT family	0.0042	0.0323	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0041	0.0041
Brugia malayi	steroid hormone receptor	0.0074	0.0677	0.0677
Brugia malayi	tailless protein	0.0035	0.024	0.024
Trichomonas vaginalis	aldo-keto reductase, putative	0.0262	0.279	0.279
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0074	0.0677	0.0677
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0905	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0074	0.0677	0.0677
Brugia malayi	hypothetical protein	0.0039	0.0287	0.0287
Trypanosoma cruzi	aldo/keto reductase, putative	0.0262	0.279	0.279
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0263	0.0263
Schistosoma mansoni	hypothetical protein	0.0017	0.0041	0.0041
Echinococcus multilocularis	nuclear receptor nhr 48	0.0035	0.024	0.024
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0152	0.1557	0.1557
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0157	0.1606	0.1606
Giardia lamblia	Aldose reductase	0.0905	1	1
Echinococcus granulosus	aldehyde reductase	0.0643	0.706	0.706
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0905	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0262	0.279	0.279
Entamoeba histolytica	aldose reductase, putative	0.0905	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0385	0.0385
Trypanosoma brucei	aldo/keto reductase, putative	0.0262	0.279	0.279
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0905	1	1
Loa Loa (eye worm)	hypothetical protein	0.0905	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0035	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Brugia malayi	acetyltransferase, GNAT family protein	0.0157	0.1606	0.1606
Entamoeba histolytica	aldose reductase, putative	0.0905	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0905	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0905	1	1
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.0626	0.6874	0.6874
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0708	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0287	0.0287
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0074	0.0677	0.0677
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0039	0.0287	0.0287
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0041	0.0041
Plasmodium falciparum	aldo-keto reductase, putative	0.0262	0.279	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0905	1	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0035	0.024	0.024
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0262	0.279	0.279
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0041	0.0041
Brugia malayi	Steroid receptor seven-up type 2	0.0074	0.0677	0.0677
Echinococcus multilocularis	aldehyde reductase	0.0643	0.706	0.706
Schistosoma mansoni	pol-related	0.0905	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Mycobacterium leprae	Conserved hypothetical protein	0.0643	0.706	0.5922
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0035	0.024	0.024
Brugia malayi	ecdysone receptor	0.0035	0.024	0.024

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0828 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	0.3162 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.122 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.5849 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1725106

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1486457