Detailed information for compound 1486462

Basic information

Technical information
  • TDR Targets ID: 1486462
  • Name: 4-chloro-N-(2-oxothiolan-3-yl)benzamide
  • MW: 255.721 | Formula: C11H10ClNO2S
  • H donors: 1 H acceptors: 2 LogP: 2.45 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)Cl)NC1CCSC1=O
  • InChi: 1S/C11H10ClNO2S/c12-8-3-1-7(2-4-8)10(14)13-9-5-6-16-11(9)15/h1-4,9H,5-6H2,(H,13,14)
  • InChiKey: FEYWQJPSSZZVEF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-chloro-N-(2-oxotetrahydrothiophen-3-yl)benzamide
  • 4-chloro-N-(2-oxo-3-tetrahydrothiophenyl)benzamide
  • 4-chloro-N-(2-ketotetrahydrothiophen-3-yl)benzamide
  • AG-690/12892394
  • Oprea1_247704
  • 4-Chloro-N-(2-oxo-tetrahydro-thiophen-3-yl)-benzamide
  • BAS 00500802
  • MLS000106234
  • SMR000103203
  • Oprea1_863127
  • ST5232538

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0071 0.7219 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0071 0.7219 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.4951 0.4951
Schistosoma mansoni ap endonuclease 0.0023 0.0302 0.0379
Mycobacterium ulcerans oxidoreductase 0.0071 0.7219 1
Loa Loa (eye worm) oxidoreductase 0.0071 0.7219 0.7794
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0071 0.7219 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0071 0.7219 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0302 0.0411
Brugia malayi PHD-finger family protein 0.003 0.1356 0.1356
Schistosoma mansoni aldo-keto reductase 0.0071 0.7219 0.9049
Trichomonas vaginalis aldo-keto reductase, putative 0.0071 0.7219 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0071 0.7219 0.9809
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0071 0.7219 0.9809
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0071 0.7219 0.9809
Brugia malayi Bromodomain containing protein 0.0046 0.3666 0.3666
Entamoeba histolytica aldose reductase, putative 0.0071 0.7219 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0302 0.0419
Trichomonas vaginalis aldo-keto reductase, putative 0.0071 0.7219 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0071 0.7219 0.9809
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0302 0.0419
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0617 0.0667
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.4951 0.6206
Echinococcus multilocularis aldo keto reductase 0.0071 0.7219 0.9809
Echinococcus multilocularis zinc finger protein 0.0024 0.0435 0.0591
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.4951 0.6206
Echinococcus multilocularis aldo keto reductase 0.0071 0.7219 0.9809
Onchocerca volvulus 0.0071 0.7219 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0302 0.0411
Trichomonas vaginalis aldo-keto reductase, putative 0.0071 0.7219 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.4951 0.6727
Onchocerca volvulus 0.0071 0.7219 1
Echinococcus granulosus zinc finger protein 0.0024 0.0435 0.0591
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0071 0.7219 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.4951 0.6727
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0071 0.7219 0.7219
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0071 0.7219 0.9809
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.3258 0.4426
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0071 0.7219 1
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0302 0.0302
Loa Loa (eye worm) oxidoreductase 0.0071 0.7219 0.7794
Onchocerca volvulus 0.0071 0.7219 1
Leishmania major aldo-keto reductase-like protein 0.0071 0.7219 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0302 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0302 0.0419
Echinococcus multilocularis aldehyde reductase 0.0051 0.4275 0.5809
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0071 0.7219 0.9809
Trypanosoma brucei aldo-keto reductase, putative 0.0071 0.7219 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.3678 0.3972
Trichomonas vaginalis aldo-keto reductase, putative 0.0071 0.7219 1
Onchocerca volvulus 0.0071 0.7219 1
Schistosoma mansoni pol-related 0.0071 0.7219 0.9049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0302 0.0419
Loa Loa (eye worm) hypothetical protein 0.0049 0.4087 0.4413
Trichomonas vaginalis aldo-keto reductase, putative 0.0071 0.7219 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0071 0.7219 0.9809
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0071 0.7219 0.7219
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0071 0.7219 0.9809
Loa Loa (eye worm) oxidoreductase 0.0071 0.7219 0.7794
Trichomonas vaginalis aldo-keto reductase, putative 0.0071 0.7219 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.736 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0071 0.7219 0.9809
Leishmania major prostaglandin f synthase, putative 0.0071 0.7219 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0071 0.7219 0.9809
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0071 0.7219 1
Schistosoma mansoni ap endonuclease 0.0023 0.0302 0.0379
Trichomonas vaginalis aldo-keto reductase, putative 0.0071 0.7219 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0071 0.7219 0.9809
Toxoplasma gondii aldose reductase, putative 0.0071 0.7219 1
Giardia lamblia Aldose reductase 0.0071 0.7219 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0071 0.7219 0.9809
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.4951 0.6727
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0947 0.1187
Schistosoma mansoni bromodomain containing protein 0.0076 0.7978 1
Trypanosoma cruzi aldo-keto reductase 0.0071 0.7219 1
Echinococcus granulosus aldehyde reductase 0.0051 0.4275 0.5809
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.3258 0.4426
Giardia lamblia Aldose reductase 0.0071 0.7219 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0071 0.7219 0.9809
Trichomonas vaginalis aldo-keto reductase, putative 0.0071 0.7219 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0071 0.7219 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0947 0.1287
Trichomonas vaginalis aldo/keto reductase, putative 0.0071 0.7219 1
Onchocerca volvulus 0.0071 0.7219 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0071 0.7219 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0071 0.7219 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0302 0.0419
Trichomonas vaginalis aldo/keto reductase, putative 0.0071 0.7219 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0071 0.7219 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0071 0.7219 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.4951 0.5345
Entamoeba histolytica aldose reductase, putative 0.0071 0.7219 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0947 0.1287
Echinococcus granulosus aldo keto reductase 0.0071 0.7219 0.9809
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0302 0.5
Loa Loa (eye worm) hypothetical protein 0.0085 0.9262 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0302 0.0419
Mycobacterium leprae Conserved hypothetical protein 0.0051 0.4275 0.5922
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.4951 0.6727
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0071 0.7219 0.9809
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0302 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.736 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0302 1
Echinococcus granulosus hypothetical protein 0.0071 0.7219 0.9809
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0071 0.7219 0.9809
Trypanosoma brucei prostaglandin f synthase 0.0071 0.7219 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.4417 0.4769
Loa Loa (eye worm) oxidoreductase 0.0071 0.7219 0.7794
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0302 0.0419
Echinococcus granulosus aldo keto reductase 0.0071 0.7219 0.9809
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0302 0.0419
Toxoplasma gondii exonuclease III APE 0.0023 0.0302 0.0419
Loa Loa (eye worm) oxidoreductase 0.0071 0.7219 0.7794
Echinococcus multilocularis aldo keto reductase 0.0071 0.7219 0.9809
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0071 0.7219 0.9809
Trichomonas vaginalis aldo-keto reductase, putative 0.0071 0.7219 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.7219 0.7794
Echinococcus multilocularis aldo keto reductase 0.0071 0.7219 0.9809
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0302 0.0326
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0071 0.7219 0.9809
Schistosoma mansoni zinc finger protein 0.0024 0.0435 0.0545
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0071 0.7219 0.7219
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.4951 0.6206
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0071 0.7219 0.7219
Echinococcus granulosus aldo keto reductase 0.0071 0.7219 0.9809
Trichomonas vaginalis aldo-keto reductase, putative 0.0071 0.7219 1
Entamoeba histolytica aldose reductase, putative 0.0071 0.7219 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0071 0.7219 0.9809
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0071 0.7219 0.9809
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0105 0.0114
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0071 0.7219 0.9809
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0302 0.0419
Schistosoma mansoni aldo-keto reductase 0.0071 0.7219 0.9049
Schistosoma mansoni hypothetical protein 0.0025 0.0617 0.0774

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.