Detailed information for compound 1486728

Basic information

Technical information
  • TDR Targets ID: 1486728
  • Name: S-[(3,5-dioxo-2H-1,2,4-triazin-6-yl)] benzene carbothioate
  • MW: 249.246 | Formula: C10H7N3O3S
  • H donors: 2 H acceptors: 6 LogP: 1.44 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nnc(c(n1)O)SC(=O)c1ccccc1
  • InChi: 1S/C10H7N3O3S/c14-7-8(12-13-10(16)11-7)17-9(15)6-4-2-1-3-5-6/h1-5H,(H2,11,13,14,16)
  • InChiKey: NADNGNYULOPOGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzenecarbothioic acid S-[(3,5-dioxo-2H-1,2,4-triazin-6-yl)] ester
  • thiobenzoic acid S-[(3,5-diketo-2H-1,2,4-triazin-6-yl)] ester
  • 24168-34-1
  • ZINC04159249
  • NSC118349
  • 1,2,4-Triazine-3,5(2H,4H)-dione, 6-benzoylthio-
  • S-(3,5-Dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl) benzenecarbothioate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Theileria parva glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei gambiense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K00036 glucose-6-phosphate 1-dehydrogenase [EC1.1.1.49], putative Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii Glucose-6-phosphate dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis 6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.065 0.1557
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.1622
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2894 0.6464
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0074 0.2459 0.5491
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Echinococcus multilocularis Chromo domain 0.0014 0.00000000020295 0.00000000048596
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0113 0.4065 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.1186 0.2183
Echinococcus granulosus peregrin 0.0035 0.0882 0.2111
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0113 0.4065 0.7479
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0481 0.1075
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.1521 0.3686
Onchocerca volvulus Alhambra homolog 0.0035 0.0882 0.2137
Brugia malayi CHD4 protein 0.0014 0.00000000020295 0.00000000048596
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.065 0.1453
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.00000000020295 0.00000000049196
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.1186 0.2841
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.065 0.0584
Schistosoma mansoni hypothetical protein 0.0014 0.00000000020295 0.00000000049196
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0882 0.1969
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0123 0.4478 1
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.00000000020295 0.00000000048596
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.4125 0.4084
Schistosoma mansoni chromobox protein 0.0084 0.2894 0.7015
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0123 0.4478 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.5435 1
Schistosoma mansoni jumonji domain containing protein 0.0092 0.3202 0.7761
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0882 0.1969
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0882 0.1969
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0882 0.2111
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.1186 0.2876
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0113 0.4065 0.9854
Echinococcus granulosus jumonji domain containing protein 0.0049 0.1449 0.3469
Plasmodium falciparum phd finger protein, putative 0.0035 0.0882 0.1969
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.4065 0.4023
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1521 0.3396
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0113 0.4065 0.9734
Schistosoma mansoni kinase 0.0058 0.1818 0.4407
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.1373 0.3329
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.1186 0.2841
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0123 0.4478 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.4125 0.9878
Plasmodium vivax hypothetical protein, conserved 0.0014 0.00000000020295 0.00000000045326
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0036 0.0924 0.0859
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.065 0.0584
Brugia malayi jmjC domain containing protein 0.0115 0.4176 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Echinococcus granulosus chromobox protein 1 0.0084 0.2894 0.693
Schistosoma mansoni chromobox protein 0.0084 0.2894 0.7015
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0071 0.0158
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4125 0.9213
Trypanosoma brucei polo-like protein kinase 0.0114 0.4125 0.4084
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4125 0.9213
Schistosoma mansoni hypothetical protein 0.0035 0.0882 0.2137
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0039 0.104 1
Echinococcus granulosus chromobox protein 1 0.0084 0.2894 0.693
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.00000000020295 0.00000000037338
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.1449 0.3469
Loa Loa (eye worm) hypothetical protein 0.0014 0.00000000020295 0.00000000037338
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0807 0.1802
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4125 0.9213
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Trypanosoma brucei hypothetical protein, conserved 0.0257 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.2424 0.4459
Echinococcus multilocularis chromobox protein 1 0.0084 0.2894 0.693
Brugia malayi PHD-finger family protein 0.0035 0.0882 0.2111
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.00000000020295 0.00000000048596
Echinococcus multilocularis chromobox protein 1 0.0084 0.2894 0.693
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.4125 1
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.4478 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.023 0.0514
Trypanosoma cruzi hypothetical protein, conserved 0.0257 1 1
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.00000000020295 0.00000000048596
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4125 0.9213
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0113 0.4065 0.4023
Brugia malayi Heterochromatin protein 1 0.0084 0.2894 0.693
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0626 0.1499
Entamoeba histolytica hypothetical protein 0.0014 0.00000000020295 0.00000000049196
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0071 0.0171
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0626 0.1499
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Echinococcus granulosus bloom syndrome protein 0.0029 0.0626 0.1499
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4125 0.9213
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000020295 0.00000000049196
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.4065 0.4023
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.4125 0.759
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000020295 0.00000000049196
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1521 0.3396
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1756 0.3922
Brugia malayi chromobox protein homolog 3 0.0047 0.1373 0.3289
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0626 0.1398
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.024 0.0536
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.00000000020295 0.00000000048596
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0375 0.0909
Brugia malayi glucose-6-phosphate dehydrogenase 0.0113 0.4065 0.9734
Loa Loa (eye worm) hypothetical protein 0.0047 0.1373 0.2527
Brugia malayi Bromodomain containing protein 0.0035 0.0882 0.2111
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0807 0.1802
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.4125 1
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.065 0.1557
Echinococcus multilocularis peregrin 0.0035 0.0882 0.2111
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0074 0.2459 0.5295
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1373 0.3067
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1373 0.3067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Trypanosoma cruzi hypothetical protein, conserved 0.0257 1 1
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0113 0.4065 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4125 0.9213
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0014 0.00000000020295 0.00000000045326
Loa Loa (eye worm) hypothetical protein 0.006 0.1916 0.3525
Loa Loa (eye worm) hypothetical protein 0.0037 0.0954 0.1756
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1756 0.3922
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0037 0.0968 0.0904
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.4125 0.4084
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.00000000020295 0.00000000049196
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.00000000020295 0.00000000048596
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.00000000020295 0.00000000045326
Echinococcus granulosus Chromo domain 0.0014 0.00000000020295 0.00000000048596
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0123 0.4478 1
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0113 0.4065 0.5
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.4125 0.9878
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.4176 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.4125 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.00000000020295 0.00000000048596
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0113 0.4065 0.9734
Loa Loa (eye worm) RecQ helicase 0.0029 0.0626 0.1152
Onchocerca volvulus 0.0037 0.0954 0.2313
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Giardia lamblia Kinase, PLK 0.0114 0.4125 0.902
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0882 0.2137
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0882 0.2111
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0626 0.1398
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000020295 0.00000000045326
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.4176 1
Brugia malayi jmjC domain containing protein 0.0043 0.1186 0.2841
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.4478 1
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0882 0.1622
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000020295 0.00000000049196
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2894 0.6464
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.2894 0.5325
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4125 0.9213
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.4125 0.9878
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.065 0.0584
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.1186 0.2876
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.4125 0.4084
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0123 0.4478 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.33 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) = 22.8 uM PUBCHEM_BIOASSAY: Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) = 23.3 uM PUBCHEM_BIOASSAY: Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) 224.23 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.3233 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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