Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | jun proto-oncogene | Starlite/ChEMBL | No references |
Saccharomyces cerevisiae | Sir2p | Starlite/ChEMBL | References |
Homo sapiens | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Starlite/ChEMBL | No references |
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 0.2192 | 0.2192 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0678 | 0.0678 |
Brugia malayi | thymidylate synthase | 0.0195 | 0.4629 | 0.4238 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.2172 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 0.4629 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0678 | 0.0678 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0101 | 0.2172 | 0.2172 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0087 | 0.1826 | 1 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0087 | 0.1826 | 0.1826 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4629 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.2172 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4629 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1826 | 0.1826 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4629 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0.1962 | 0.394 |
Brugia malayi | hypothetical protein | 0.0093 | 0.1962 | 0.1378 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 0.2192 | 0.2192 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2172 | 0.2172 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0678 | 0.0678 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0089 | 0.1866 | 0.1866 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0087 | 0.1826 | 1 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0101 | 0.2172 | 0.2172 |
Brugia malayi | bZIP transcription factor family protein | 0.0101 | 0.2192 | 0.1625 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.2172 | 1 |
Echinococcus granulosus | jun protein | 0.0101 | 0.2192 | 0.2192 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4629 | 0.4629 |
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.0101 | 0.2172 | 1 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0087 | 0.1826 | 0.1231 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.212 | 0.212 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4629 | 0.5 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0087 | 0.1826 | 0.1826 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0089 | 0.1866 | 0.1866 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0093 | 0.1962 | 0.0487 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 1 | 1 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.04 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 0.4629 | 0.4629 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 0.4629 | 0.4629 |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 0.4629 | 0.4629 |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.1696 | 0.1696 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.04 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.008 | 0.1623 | 0.1014 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1826 | 0.1826 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0087 | 0.1826 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.4629 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0101 | 0.2172 | 0.2172 |
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 0.4629 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4629 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.2172 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 0.4629 | 1 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.04 | 1 | 1 |
Brugia malayi | NAD-dependent deacetylase SIRT1 | 0.0101 | 0.2172 | 0.1603 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0087 | 0.1826 | 0.1231 |
Onchocerca volvulus | 0.0195 | 0.4629 | 1 | |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0087 | 0.1826 | 0.1826 |
Echinococcus multilocularis | jun protein | 0.0101 | 0.2192 | 0.2192 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.1696 | 0.1696 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0678 | 0.0678 |
Onchocerca volvulus | 0.0087 | 0.1826 | 0.0673 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.8 uM | In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysates | ChEMBL. | 15115404 |
IC50 (binding) | = 8.8 uM | In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysates | ChEMBL. | 15115404 |
Inhibition (binding) | Inhibition of Escherichia coli thymidylate synthase A at 60 uM | ChEMBL. | 23273520 | |
Inhibition (binding) | = 0.94 uM | In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysates at 75 uM | ChEMBL. | 15115404 |
Inhibition (binding) | = 0.94 uM | In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysates at 75 uM | ChEMBL. | 15115404 |
Ki (binding) | = 2 uM | Inhibition of human thymidylate synthase A | ChEMBL. | 23273520 |
Ki (binding) | > 294 uM | Inhibition of Escherichia coli thymidylate synthase A | ChEMBL. | 23273520 |
MGC (binding) | >= 150 uM | Sirtuin 2 inhibitory activity and was reported as minimum growth-stimulating concentration in S. cerevisiae | ChEMBL. | 15115404 |
MGC (binding) | >= 150 uM | Sirtuin 2 inhibitory activity and was reported as minimum growth-stimulating concentration in S. cerevisiae | ChEMBL. | 15115404 |
Potency (functional) | 2.4559 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.861 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.929 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.