Detailed information for compound 1487256

Basic information

Technical information
  • TDR Targets ID: 1487256
  • Name: [2-(4-nitrophenyl)-2-oxoethyl] 2-(2-fluorophe noxy)acetate
  • MW: 333.268 | Formula: C16H12FNO6
  • H donors: 0 H acceptors: 4 LogP: 3.15 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COc1ccccc1F)OCC(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C16H12FNO6/c17-13-3-1-2-4-15(13)23-10-16(20)24-9-14(19)11-5-7-12(8-6-11)18(21)22/h1-8H,9-10H2
  • InChiKey: AEAQZZIQJZCEOK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(4-nitrophenyl)-2-oxo-ethyl] 2-(2-fluorophenoxy)acetate
  • 2-(2-fluorophenoxy)acetic acid [2-(4-nitrophenyl)-2-oxoethyl] ester
  • 2-(2-fluorophenoxy)acetic acid [2-keto-2-(4-nitrophenyl)ethyl] ester
  • [2-(4-nitrophenyl)-2-oxo-ethyl] 2-(2-fluorophenoxy)ethanoate
  • T0509-6535
  • Oprea1_774458
  • ZINC03245777

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium knowlesi glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii Glucose-6-phosphate dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis 6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma congolense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Treponema pallidum glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K00036 glucose-6-phosphate 1-dehydrogenase [EC1.1.1.49], putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania infantum glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0113 0.7549 1
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0113 0.7549 1
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0086 0.5556 0.736
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0402 0.0485
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0086 0.5556 0.736
Loa Loa (eye worm) hypothetical protein 0.0012 0.0143 0.0143
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0036 0.1887 0.25
Schistosoma mansoni cercarial elastase (S01 family) 0.0036 0.1887 0.25
Schistosoma mansoni cercarial elastase (S01 family) 0.0036 0.1887 0.25
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.8286 1
Brugia malayi glucose-6-phosphate dehydrogenase 0.0113 0.7549 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0036 0.1887 0.25
Schistosoma mansoni cercarial elastase (S01 family) 0.0036 0.1887 0.25
Brugia malayi Trypsin-like protease protein 5 0.0036 0.1887 0.25
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0688 0.0669
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0036 0.1887 0.25
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0086 0.5556 0.736
Loa Loa (eye worm) hypothetical protein 0.0036 0.1887 0.1887
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0086 0.5556 0.736
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0086 0.5556 0.6705
Schistosoma mansoni cercarial elastase (S01 family) 0.0036 0.1887 0.25
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0402 0.0532
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0086 0.5556 0.736
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0123 0.8286 1
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0113 0.7549 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0086 0.5556 0.736
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0113 0.7549 1
Plasmodium falciparum eukaryotic initiation factor 4A 0.0086 0.5556 0.6647
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0143 0.0189
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0086 0.5556 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0143 0.0172
Loa Loa (eye worm) hypothetical protein 0.0036 0.1887 0.1887
Schistosoma mansoni cercarial elastase (S01 family) 0.0036 0.1887 0.25
Loa Loa (eye worm) trypsin family protein 0.0036 0.1887 0.1887
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0036 0.1928 0.2555
Loa Loa (eye worm) hypothetical protein 0.0036 0.1887 0.1887
Echinococcus granulosus Mastin 0.0036 0.1887 0.25
Echinococcus granulosus bloom syndrome protein 0.0029 0.1395 0.1849
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0113 0.7549 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.1887 0.25
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.1395 0.1849
Brugia malayi Trypsin family protein 0.0036 0.1887 0.25
Schistosoma mansoni DNA helicase recq5 0.0012 0.0143 0.0189
Echinococcus granulosus transmembrane protease serine 3 0.0036 0.1887 0.25
Echinococcus granulosus eukaryotic initiation factor 4A 0.0086 0.5556 0.736
Schistosoma mansoni hypothetical protein 0.0036 0.1887 0.25
Schistosoma mansoni cercarial elastase (S01 family) 0.0036 0.1887 0.25
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0113 0.7549 1
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0086 0.5556 0.6705
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.7549 1
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0402 0.0723
Loa Loa (eye worm) hypothetical protein 0.0086 0.5556 0.5556
Brugia malayi hypothetical protein 0.0036 0.1887 0.25
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0123 0.8286 1
Echinococcus multilocularis Mastin 0.0036 0.1887 0.25
Brugia malayi eukaryotic initiation factor 4A 0.0086 0.5556 0.736
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0086 0.5556 0.6705
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0036 0.1887 0.25
Echinococcus multilocularis enteropeptidase 0.0036 0.1887 0.25
Schistosoma mansoni hypothetical protein 0.0036 0.1887 0.25
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0036 0.1887 0.25
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0123 0.8286 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0036 0.1887 0.25
Brugia malayi Trypsin family protein 0.0036 0.1887 0.25
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0113 0.7549 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0123 0.8286 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1887 0.1887
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0086 0.5556 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0143 0.0189
Brugia malayi Trypsin family protein 0.0036 0.1887 0.25
Schistosoma mansoni cercarial elastase (S01 family) 0.0036 0.1887 0.25
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0143 0.0189
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0086 0.5556 0.736
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0402 0.0532
Echinococcus granulosus enteropeptidase 0.0036 0.1887 0.25
Loa Loa (eye worm) hypothetical protein 0.0036 0.1887 0.1887
Treponema pallidum ATP-dependent RNA helicase 0.0086 0.5556 0.736
Echinococcus multilocularis glycoprotein Antigen 5 0.0036 0.1887 0.25
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0086 0.5556 0.6647
Schistosoma mansoni cercarial elastase (S01 family) 0.0036 0.1887 0.25
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.1136 0.122
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0143 0.0189
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0123 0.8286 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0036 0.1887 0.25
Plasmodium vivax RNA helicase-1, putative 0.0086 0.5556 0.6398
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.1395 0.1684
Leishmania major eukaryotic initiation factor 4a, putative 0.0086 0.5556 0.736
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0086 0.5556 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0947 0.1254
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0143 0.0143
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.001 0 0.5
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0402 0.0532
Brugia malayi Trypsin family protein 0.0036 0.1887 0.25
Loa Loa (eye worm) hypothetical protein 0.0036 0.1887 0.1887
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0143 0.00000000049246
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0143 0.0189
Echinococcus granulosus glycoprotein Antigen 5 0.0036 0.1887 0.25
Leishmania major eukaryotic initiation factor 4a, putative 0.0086 0.5556 0.736
Schistosoma mansoni cercarial elastase (S01 family) 0.0036 0.1887 0.25
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0143 0.0189
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0113 0.7549 0.7549
Loa Loa (eye worm) hypothetical protein 0.0036 0.1887 0.1887
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0036 0.1887 0.25
Echinococcus multilocularis transmembrane protease serine 3 0.0036 0.1887 0.25
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0074 0.4674 0.6192
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0036 0.1887 0.25
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0086 0.5556 0.6705
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.1395 0.1684
Loa Loa (eye worm) RecQ helicase 0.0029 0.1395 0.1395
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0074 0.4674 0.5564
Schistosoma mansoni cercarial elastase (S01 family) 0.0036 0.1887 0.25
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0036 0.1887 0.25
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0036 0.1887 0.25
Echinococcus multilocularis bloom syndrome protein 0.0029 0.1395 0.1849
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0036 0.1887 0.25
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0036 0.1887 0.25
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0086 0.5556 0.736
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0036 0.1887 0.25
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.7549 1
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0037 0.2008 0.266
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.8286 1
Schistosoma mansoni DNA helicase recq1 0.0012 0.0143 0.0189

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 12.4 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) = 44.6 uM PUBCHEM_BIOASSAY: Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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