Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gliotactin | 0.0102 | 0.0479 | 0.0479 |
Onchocerca volvulus | 0.0102 | 0.0479 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0479 | 0.0479 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.0479 | 0.0479 |
Brugia malayi | hypothetical protein | 0.0102 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | carboxylesterase | 0.0102 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2439 | 0.2439 |
Onchocerca volvulus | 0.0102 | 0.0479 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | carboxylesterase | 0.0102 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0479 | 0.0479 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0102 | 0.0479 | 0.0479 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0102 | 0.0479 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0102 | 0.0479 | 0.0479 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0479 | 0.0479 |
Onchocerca volvulus | 0.0102 | 0.0479 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2439 | 0.2439 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0479 | 0.0479 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0102 | 0.0479 | 0.0479 |
Echinococcus multilocularis | neuroligin | 0.0102 | 0.0479 | 0.0479 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0102 | 0.0479 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0479 | 0.0479 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0102 | 0.0479 | 0.0479 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0102 | 0.0479 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | carboxylesterase | 0.0602 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0102 | 0.0479 | 0.0479 |
Echinococcus multilocularis | acetylcholinesterase | 0.0602 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0602 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0602 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0602 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0479 | 0.0479 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0102 | 0.0479 | 0.0479 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0102 | 0.0479 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0102 | 0.0479 | 0.0479 |
Echinococcus granulosus | carboxylesterase 5A | 0.0602 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0102 | 0.0479 | 0.0479 |
Onchocerca volvulus | 0.0102 | 0.0479 | 0.5 | |
Echinococcus granulosus | neuroligin | 0.0102 | 0.0479 | 0.0479 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0102 | 0.0479 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0602 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0102 | 0.0479 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0602 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0602 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.2439 | 0.2439 |
Onchocerca volvulus | 0.0102 | 0.0479 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0602 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.2439 | 0.2439 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0102 | 0.0479 | 0.0479 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1095 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.1995 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.