Detailed information for compound 1487735

Basic information

Technical information
  • TDR Targets ID: 1487735
  • Name: 2-(ethyl-(phenylmethyl)amino)-N-(furan-2-ylme thylcarbamoyl)acetamide
  • MW: 315.367 | Formula: C17H21N3O3
  • H donors: 2 H acceptors: 2 LogP: 2.23 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(Cc1ccccc1)CC(=O)NC(=O)NCc1ccco1
  • InChi: 1S/C17H21N3O3/c1-2-20(12-14-7-4-3-5-8-14)13-16(21)19-17(22)18-11-15-9-6-10-23-15/h3-10H,2,11-13H2,1H3,(H2,18,19,21,22)
  • InChiKey: PHGKWWZCPNJOKO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(ethyl-(phenylmethyl)amino)-N-(2-furylmethylcarbamoyl)acetamide
  • 2-(ethyl-(phenylmethyl)amino)-N-[(2-furylmethylamino)-oxomethyl]acetamide
  • 2-(benzyl-ethyl-amino)-N-(2-furylmethylcarbamoyl)acetamide
  • 2-(ethyl-(phenylmethyl)amino)-N-(furan-2-ylmethylcarbamoyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.009 0.0139
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0036 0.0036
Brugia malayi cytosol aminopeptidase 0.0022 0.0043 0.0067
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0281 0.3787
Brugia malayi PXA domain containing protein 0.0021 0.0036 0.0056
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0194 0.0717
Plasmodium vivax subtilisin-like serine protease, putative 0.0036 0.0153 0.2006
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0033 0.0066
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0036 0.0036
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0198 0.1421 0.1421
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0194 0.0194
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0036 0.0036
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0036 0.0036
Echinococcus granulosus membrane bound transcription factor site 1 0.0036 0.0153 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0389 0.5036
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.1141 0.2943
Brugia malayi celfurPC protein 0.0678 0.5162 0.8027
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0043 0.0489
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0043 0.0489
Echinococcus multilocularis cysteine protease 0.0017 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.1141 0.2943
Toxoplasma gondii subtilisin SUB7 0.0036 0.0153 0.1194
Toxoplasma gondii subtilisin SUB1 0.0036 0.0153 0.1194
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0194 0.2198
Echinococcus multilocularis dnaJ subfamily B 0.1298 1 1
Trichomonas vaginalis hypothetical protein 0.0163 0.1141 0.2943
Echinococcus multilocularis membrane bound transcription factor site 1 0.0036 0.0153 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0153 0.0376
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0194 0.2198
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0194 0.0194
Schistosoma mansoni cpg binding protein 0.0091 0.0583 0.0583
Echinococcus granulosus dna polymerase kappa 0.0041 0.0194 0.0194
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0008 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0153 0.0376
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0049 0.0049
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0008 0.0012
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0092 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0194 0.2198
Toxoplasma gondii subtilisin SUB6 0.0036 0.0153 0.1194
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0036 0.0036
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0276 0.0429
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0056
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0049 0.0049
Echinococcus multilocularis Furin 1 0.0198 0.1421 0.1421
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0194 0.2198
Schistosoma mansoni leucine aminopeptidase 0.0022 0.0043 0.0043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0276 0.0429
Onchocerca volvulus 0.0091 0.0583 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Plasmodium vivax subtilisin-like protease 2, putative 0.0036 0.0153 0.2006
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0344 0.4658
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0153 0.0376
Echinococcus multilocularis 0.0678 0.5162 0.5162
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0511 0.3858 0.3858
Leishmania major cathepsin L-like protease 0.0066 0.0389 0.5279
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0389 0.5279
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0194 0.0483
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0008 0.0008
Brugia malayi Cathepsin L-like precursor 0.0017 0.0008 0.0012
Brugia malayi Cathepsin L-like precursor 0.0017 0.0008 0.0012
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0281 0.3467
Schistosoma mansoni furin-1 (S08 family) 0.0366 0.2725 0.2725
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.1141 0.2943
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0036 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0244 0.0379
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0036 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0153 0.0376
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0036 0.0036
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0036 0.0056
Schistosoma mansoni hypothetical protein 0.0035 0.0148 0.0148
Toxoplasma gondii subtilisin SUB4 0.0036 0.0153 0.1194
Giardia lamblia Furin precursor putative serine protease 0.0163 0.1141 0.4476
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Loa Loa (eye worm) hypothetical protein 0.0052 0.0281 0.0437
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0148 0.023
Trypanosoma brucei unspecified product 0.0028 0.0094 0.0743
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0194 0.0717
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Echinococcus granulosus cathepsin l1 0.0017 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0033 0.0066
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0389 0.5279
Leishmania major DNA polymerase kappa, putative 0.0041 0.0194 0.2579
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0036 0.0153 0.2006
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0094 0.0743
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0036 0.0073
Brugia malayi hypothetical protein 0.0034 0.0136 0.0212
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0049 0.0049
Toxoplasma gondii subtilisin SUB2 0.0036 0.0153 0.1194
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.011 0.0729 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0008 0.0012
Onchocerca volvulus 0.0036 0.0153 0.2515
Loa Loa (eye worm) hypothetical protein 0.033 0.2444 0.3802
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0194 0.2198
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.011 0.0729 1
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0163 0.1141 0.2943
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0094 0.0743
Echinococcus granulosus cpg binding protein 0.0096 0.0624 0.0624
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0276 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.1141 0.2943
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0056 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0194 0.2198
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0511 0.3858 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0033 0.0066
Loa Loa (eye worm) hypothetical protein 0.0036 0.0153 0.0237
Loa Loa (eye worm) hypothetical protein 0.0155 0.1086 0.1688
Echinococcus multilocularis muscleblind protein 1 0.0155 0.1086 0.1086
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0043 0.0489
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0008 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0281 0.3787
Echinococcus multilocularis expressed protein 0.0409 0.3061 0.3061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0244 0.0244
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0033 0.0066
Mycobacterium ulcerans leucyl aminopeptidase 0.011 0.0729 1
Leishmania major DNA polymerase eta, putative 0.0041 0.0194 0.2579
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0036 0.0036
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0036 0.0056
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0281 0.3787
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0244 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0194 0.2198
Schistosoma mansoni hypothetical protein 0.1298 1 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0008 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.1141 0.2943
Leishmania major subtilisin-like serine peptidase 0.0036 0.0153 0.2006
Loa Loa (eye worm) subtilase 0.0036 0.0153 0.0237
Echinococcus multilocularis cpg binding protein 0.0096 0.0624 0.0624
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.011 0.0729 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0056
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0036 0.0056
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0056 0.0056
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0511 0.3858 0.3858
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0036 0.0153 0.0153
Brugia malayi hypothetical protein 0.0021 0.0036 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0036 0.0036
Schistosoma mansoni site-1 peptidase (S08 family) 0.0036 0.0153 0.0153
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0036 0.0036
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0036 0.0153 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0389 0.5036
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0033 0.0066
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0036 0.0056
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.084 0.643 0.643
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.1141 0.2943
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0036 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0198 0.1421 0.3671
Echinococcus granulosus neuroendocrine convertase 2 0.0528 0.3993 0.3993
Toxoplasma gondii subtilisin SUB9 0.0036 0.0153 0.1194
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.011 0.0729 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0194 1
Leishmania major hypothetical protein, conserved 0.0052 0.0281 0.3787
Leishmania major cathepsin L-like protease 0.0066 0.0389 0.5279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0194 0.2579
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0389 0.5036
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0036 0.0036
Echinococcus multilocularis leucine aminopeptidase protein 0.011 0.0729 0.0729
Toxoplasma gondii subtilisin SUB12 0.0036 0.0153 0.1194
Brugia malayi Cathepsin L-like precursor 0.0017 0.0008 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0389 0.5036
Leishmania major cathepsin L-like protease 0.0066 0.0389 0.5279
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0036 0.0036
Plasmodium vivax subtilisin-like protease 1 0.0036 0.0153 0.2006
Toxoplasma gondii subtilisin SUB10 0.0036 0.0153 0.1194
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0036 0.0073
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0036 0.0153 0.1595
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0389 0.5279
Loa Loa (eye worm) ctsf protein 0.0017 0.0008 0.0012
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0056
Plasmodium falciparum M17 leucyl aminopeptidase 0.011 0.0729 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0193 0.1381 0.1381
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0033 0.0066
Plasmodium falciparum subtilisin-like protease 2 0.0036 0.0153 0.2006
Loa Loa (eye worm) endoprotease bli-4 0.084 0.643 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0036 0.0036
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0036 0.0056
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0033 0.0066
Trypanosoma brucei subtilisin peptidase 0.0036 0.0153 0.1595
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.1141 0.2943
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.1141 0.2943
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0036 0.0036
Loa Loa (eye worm) cysteine protease 0.0017 0.0008 0.0012
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0052 0.0276 0.0429
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0036 0.0056
Giardia lamblia High cysteine membrane protein Group 2 0.0312 0.2309 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0278 0.3747
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0036 0.0153 0.2006
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.011 0.0729 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0194 0.2198
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Loa Loa (eye worm) proprotein convertase 2 0.0198 0.1421 0.221
Toxoplasma gondii subtilisin SUB11 0.0036 0.0153 0.1194
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.011 0.0729 1
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0036 0.0036
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0008 0.0008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0049 0.0049
Brugia malayi hypothetical protein 0.0052 0.0281 0.0437
Echinococcus granulosus expressed protein 0.0409 0.3061 0.3061
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0036 0.0036
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.1141 0.2943
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0033 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0033 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0036 0.0073
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0022 0.0043 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0033 0.0066
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0194 0.0717
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0033 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0036 0.0036
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0036 0.0056
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0036 0.0153 0.0153
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0036 0.0036
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.084 0.643 1
Echinococcus granulosus furin 0.084 0.643 0.643
Plasmodium falciparum subtilisin-like protease 3 0.0036 0.0153 0.2006
Brugia malayi proprotein convertase 2 0.0528 0.3993 0.621
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0036 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0194 0.2198
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0036 0.0056
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0194 0.0717
Trichomonas vaginalis helicase, putative 0.0021 0.0033 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0244 0.0244
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0008 0.0008
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.011 0.0729 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0056
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0194 0.0302
Toxoplasma gondii histone lysine methyltransferase SET1 0.0173 0.122 1
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0194 0.0302
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0198 0.1421 0.3671
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0022 0.0043 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.1141 0.2943
Brugia malayi Cathepsin L-like precursor 0.0017 0.0008 0.0012
Echinococcus granulosus muscleblind protein 0.0155 0.1086 0.1086
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0194 0.0302
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0043 0.0043
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0163 0.1141 0.2943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0389 0.5036
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0194 0.2198
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0036 0.0153 0.2006
Echinococcus multilocularis dna polymerase eta 0.0041 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0012
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0022 0.0043 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0036 0.0153 0.0153
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0008 0.0008
Echinococcus granulosus leucine aminopeptidase protein 0.011 0.0729 0.0729
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0033 0.0066
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0194 0.2579
Brugia malayi Subtilase family protein 0.0036 0.0153 0.0237
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0023 0.0056 0.0056
Trypanosoma cruzi subtilisin peptidase 0.0036 0.0153 0.2006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0511 0.3858 1
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0194 0.2198
Brugia malayi CXXC zinc finger family protein 0.0091 0.0583 0.0907
Chlamydia trachomatis cytosol aminopeptidase 0.011 0.0729 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0194 0.2579
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0194 0.0483
Trypanosoma brucei unspecified product 0.0028 0.0094 0.0743
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0043 0.0043
Echinococcus granulosus Furin 1 0.0198 0.1421 0.1421
Toxoplasma gondii leucyl aminopeptidase LAP 0.011 0.0729 0.5955
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0056
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0036 0.0036
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0198 0.1421 0.3671
Plasmodium falciparum subtilisin-like protease 1 0.0036 0.0153 0.2006
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0008 0.0008
Toxoplasma gondii subtilisin SUB5 0.0036 0.0153 0.1194
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0036 0.0036
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0036 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0194 0.2579
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0153 0.0376
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0281 0.3787
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0043 0.0489
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0194 0.2198
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0094 0.0743
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0033 0.0066
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0025 0.0067 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0389 0.5036
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0194 0.2198
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0036 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0244 0.0244
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0036 0.0036
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0043 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0389 0.5036
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0194 0.2198
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0198 0.1421 0.3671
Entamoeba histolytica hypothetical protein 0.0021 0.0036 0.1517
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0244 0.0244
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0036 0.0153 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.1141 0.2943
Schistosoma mansoni cpg binding protein 0.0096 0.0624 0.0624
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0281 0.2255
Schistosoma mansoni cpg binding protein 0.0096 0.0624 0.0624
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0036 0.0073
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0583 0.0907
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0163 0.1141 0.1141
Loa Loa (eye worm) hypothetical protein 0.0155 0.1086 0.1688
Echinococcus multilocularis neuroendocrine convertase 2 0.0528 0.3993 0.3993
Schistosoma mansoni DNA polymerase eta 0.0041 0.0194 0.0194
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0022 0.0043 0.0043
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0022 0.0043 0.0067
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0036 0.0153 0.0153
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0092 0.0092
Trypanosoma brucei unspecified product 0.0041 0.0194 0.2198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0389 0.5036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0056
Brugia malayi Muscleblind-like protein 0.0155 0.1086 0.1688
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0244 0.0379
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0049 0.0049
Entamoeba histolytica hypothetical protein 0.0021 0.0036 0.1517
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0008 0.0012
Entamoeba histolytica hypothetical protein 0.0021 0.0036 0.1517
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0244 0.0244
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0036 0.0036
Brugia malayi PXA domain containing protein 0.0021 0.0036 0.0056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0148 0.023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0389 0.5036
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0036 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0389 0.5036
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0163 0.1141 0.2943
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0194 0.0194
Echinococcus multilocularis muscleblind protein 0.0155 0.1086 0.1086
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.011 0.0729 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0281 0.3787
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0033 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0033 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0194 0.2579
Brugia malayi hypothetical protein 0.0021 0.0036 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0198 0.1421 0.3671
Loa Loa (eye worm) fibroinase 0.0017 0.0008 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0033 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0389 0.5279
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0036 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0194 0.2579
Echinococcus granulosus dna polymerase eta 0.0041 0.0194 0.0194
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0043 0.0489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0244 0.0244
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0022 0.0043 0.0067
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0036 0.0153 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0033 0.0066
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0036 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0389 0.5036
Brugia malayi endoprotease bli-4 precursor 0.084 0.643 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0198 0.1421 0.3671
Echinococcus multilocularis cysteine protease 0.0017 0.0008 0.0008
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0194 0.0194
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0194 0.0194
Schistosoma mansoni site-1 peptidase (S08 family) 0.0036 0.0153 0.0153
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0036 0.0036
Brugia malayi neuroendocrine convertase 1 precursor 0.0528 0.3993 0.621
Loa Loa (eye worm) hypothetical protein 0.0041 0.0194 0.0302
Toxoplasma gondii subtilisin SUB8 0.0036 0.0153 0.1194
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0036 0.0036
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0092 0.0092

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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