Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0319 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0319 | 0.5 | 0.5 | |
Brugia malayi | Blistered cuticle protein 3 | 0.0319 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0319 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0319 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0319 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0319 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0319 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0319 | 0.5 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0319 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0319 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0319 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0319 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0319 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0319 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 6.33 uM | Cytotoxicity against human HT-29 cells after 4 hrs by MTT assay | ChEMBL. | 21194953 |
GI50 (functional) | = 14.06 uM | Cytotoxicity against human DU145 cells after 4 hrs by MTT assay | ChEMBL. | 21194953 |
IC50 (binding) | Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cells | ChEMBL. | 21194953 | |
Inhibition (functional) | = 49 % | Cytotoxicity against human DU145 cells at 10 uM after 4 hrs by MTT assay | ChEMBL. | 21194953 |
Inhibition (functional) | = 78 % | Cytotoxicity against human HT-29 cells at 10 uM after 4 hrs by MTT assay | ChEMBL. | 21194953 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.