Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.3523 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.3523 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0367 | 0.0367 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.1234 | 0.1234 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.3523 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.1234 | 0.1234 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.3523 | 1 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0166 | 0.0367 | 0.0367 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0243 | 0.0588 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.3523 | 1 | 1 |
Onchocerca volvulus | 0.0468 | 0.1234 | 1 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3523 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0468 | 0.1234 | 0.1234 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | lozenge | 0.0059 | 0.0059 | 0.0059 |
Echinococcus multilocularis | Protein lozenge | 0.0059 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.3523 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3523 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3523 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3523 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.3523 | 1 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.3523 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3523 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3523 | 1 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0367 | 0.0367 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.3523 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.3523 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.3523 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.3523 | 1 | 1 |
Loa Loa (eye worm) | runx1 | 0.0059 | 0.0059 | 0.0059 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.3523 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0166 | 0.0367 | 0.0367 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3523 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.