Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0051 | 0.4522 | 0.3801 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0051 | 0.4522 | 0.5626 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0051 | 0.4522 | 0.5918 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7437 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0051 | 0.4522 | 0.5918 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.8037 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4581 | 0.4769 |
Loa Loa (eye worm) | glutamate receptor | 0.0027 | 0.1163 | 0.0967 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.4522 | 0.4703 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0717 | 0.0592 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7437 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4261 | 0.4413 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0294 | 0.0366 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0294 | 0.0366 |
Loa Loa (eye worm) | glutamate receptor | 0.0041 | 0.3155 | 0.3183 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3864 | 0.3972 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0894 | 0.1112 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3456 | 0.4427 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3456 | 0.4427 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9283 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0027 | 0.1163 | 0.0967 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0894 | 0.0667 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0717 | 0.0592 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0294 | 0.0366 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.1214 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1163 | 0.0967 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.161 | 0.0506 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0027 | 0.1163 | 0.0967 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0041 | 0.3155 | 0.3925 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.1214 | 0.151 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0717 | 0.0891 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0397 | 0.0114 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3853 | 0.3044 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0294 | 0.0366 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.1214 | 0.1287 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.