Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.0218 | 0.994 | 1 |
Brugia malayi | thymidylate synthase | 0.0109 | 0.4865 | 0.4228 |
Echinococcus granulosus | dihydrofolate reductase | 0.0218 | 0.994 | 0.9948 |
Echinococcus granulosus | ankyrin repeat protein | 0.0155 | 0.7038 | 0.7044 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0218 | 0.994 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0218 | 0.994 | 0.9948 |
Echinococcus multilocularis | thymidylate synthase | 0.0109 | 0.4865 | 0.4869 |
Echinococcus multilocularis | kinesin family 1 | 0.0219 | 0.9991 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0218 | 0.994 | 0.5 |
Onchocerca volvulus | 0.0109 | 0.4865 | 0.5 | |
Echinococcus granulosus | kinesin family 1 | 0.0219 | 0.9991 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0202 | 0.9203 | 0.9162 |
Entamoeba histolytica | kinesin, putative | 0.0028 | 0.1148 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0219 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0219 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0218 | 0.994 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0219 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0218 | 0.994 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0219 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0109 | 0.4865 | 0.4869 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0109 | 0.4865 | 0.4228 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0218 | 0.994 | 1 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0155 | 0.7038 | 0.7044 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.2224 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0159 | 0.7185 | 0.7191 |
Loa Loa (eye worm) | thymidylate synthase | 0.0109 | 0.4865 | 0.4228 |
Brugia malayi | hypothetical protein | 0.0052 | 0.2224 | 0.1224 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0159 | 0.7185 | 0.7191 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0202 | 0.9203 | 0.9162 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.9203 | 0.9162 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0155 | 0.7038 | 0.6699 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0218 | 0.994 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0218 | 0.994 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0219 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.8671 | 0.8557 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0109 | 0.4865 | 0.3423 |
Giardia lamblia | Kinesin-5 | 0.0028 | 0.1148 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.