Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0238 | 0.157 | 0.157 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0238 | 0.157 | 0.157 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1411 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0202 | 0.1309 | 0.1309 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0238 | 0.157 | 0.157 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1411 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0202 | 0.1309 | 0.1309 |
Brugia malayi | hypothetical protein | 0.0238 | 0.157 | 0.157 |
Echinococcus multilocularis | neuroligin | 0.0238 | 0.157 | 0.157 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0238 | 0.157 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1411 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0238 | 0.157 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0238 | 0.157 | 0.157 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.157 | 0.157 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0238 | 0.157 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0238 | 0.157 | 0.157 |
Loa Loa (eye worm) | carboxylesterase | 0.1411 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1411 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0238 | 0.157 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0238 | 0.157 | 0.157 |
Onchocerca volvulus | 0.0238 | 0.157 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0238 | 0.157 | 0.157 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0238 | 0.157 | 0.157 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0238 | 0.157 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0238 | 0.157 | 0.157 |
Brugia malayi | Carboxylesterase family protein | 0.0238 | 0.157 | 0.157 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.157 | 0.157 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.157 | 0.157 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0238 | 0.157 | 0.157 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.157 | 0.157 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0238 | 0.157 | 0.157 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0238 | 0.157 | 1 |
Echinococcus granulosus | neuroligin | 0.0238 | 0.157 | 0.157 |
Onchocerca volvulus | 0.0238 | 0.157 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0238 | 0.157 | 0.157 |
Brugia malayi | Carboxylesterase family protein | 0.0238 | 0.157 | 0.157 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1411 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1411 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1411 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1411 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1411 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.157 | 0.157 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.1309 | 0.1309 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1411 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0238 | 0.157 | 0.157 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.157 | 0.157 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0 | 0.5 |
Onchocerca volvulus | 0.0238 | 0.157 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0238 | 0.157 | 0.157 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0238 | 0.157 | 0.157 |
Brugia malayi | Carboxylesterase family protein | 0.0238 | 0.157 | 0.157 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0238 | 0.157 | 0.157 |
Onchocerca volvulus | 0.0238 | 0.157 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1411 | 1 | 1 |
Onchocerca volvulus | 0.0238 | 0.157 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.157 | 0.157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.