Detailed information for compound 1488699

Basic information

Technical information
  • TDR Targets ID: 1488699
  • Name: N-(2,5-dimethylphenyl)-1-(thiophene-2-carbony l)piperidine-4-carboxamide
  • MW: 342.455 | Formula: C19H22N2O2S
  • H donors: 1 H acceptors: 2 LogP: 3.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)NC(=O)C1CCN(CC1)C(=O)c1cccs1)C
  • InChi: 1S/C19H22N2O2S/c1-13-5-6-14(2)16(12-13)20-18(22)15-7-9-21(10-8-15)19(23)17-4-3-11-24-17/h3-6,11-12,15H,7-10H2,1-2H3,(H,20,22)
  • InChiKey: FHZZHGLSDGDEDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-dimethylphenyl)-1-[oxo-(2-thienyl)methyl]-4-piperidinecarboxamide
  • N-(2,5-dimethylphenyl)-1-(thiophene-2-carbonyl)isonipecotamide
  • N-(2,5-dimethylphenyl)-1-thiophen-2-ylcarbonyl-piperidine-4-carboxamide
  • BAS 04840398
  • ZINC00269539

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1851 0.8804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0227 0.1078
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.3592 0.5709
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0478 0.076
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.1033 0.1641
Schistosoma mansoni hypothetical protein 0.0049 0.031 0.0493
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.1033 0.1641
Loa Loa (eye worm) hypothetical protein 0.0051 0.0331 0.0525
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0227 0.036
Onchocerca volvulus 0.0167 0.1851 0.3921
Onchocerca volvulus 0.0167 0.1851 0.3921
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0039 0.0184
Toxoplasma gondii cathepsin CPL 0.0167 0.1851 0.8804
Trypanosoma cruzi major cysteine proteinase, putative 0.0043 0.0227 0.036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0885 0.421
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.1192 0.6442
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0227 0.1078
Plasmodium falciparum cysteine proteinase falcipain 3 0.0167 0.1851 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0478 0.076
Trypanosoma cruzi cysteine peptidase, putative 0.0093 0.0885 0.1407
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0043 0.0227 0.1078
Onchocerca volvulus Cathepsin L homolog 0.0167 0.1851 0.3921
Echinococcus multilocularis glycoprotein Antigen 5 0.0105 0.1033 0.1033
Plasmodium vivax vivapain-2 0.0167 0.1851 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0086 0.0785 0.1248
Loa Loa (eye worm) fibroinase 0.0167 0.1851 0.2942
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0015
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0187 0.2102 0.3342
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0227 0.1078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.2683 0.2683
Schistosoma mansoni hypothetical protein 0.0166 0.183 0.2908
Leishmania major cathepsin L-like protease 0.0167 0.1851 0.8804
Onchocerca volvulus 0.0105 0.1033 0.2187
Brugia malayi Trypsin family protein 0.0388 0.4721 0.7504
Plasmodium falciparum serine repeat antigen 9 0.0043 0.0227 0.1224
Entamoeba histolytica cysteine proteinase, putative 0.0093 0.0885 0.4782
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0015
Toxoplasma gondii cathepsin CPC2 0.0043 0.0227 0.1078
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0039 0.0184
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0167 0.1851 0.8804
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0043 0.0227 0.036
Loa Loa (eye worm) hypothetical protein 0.0051 0.033 0.0524
Loa Loa (eye worm) trypsin family protein 0.0105 0.1033 0.1641
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.0936 0.1487
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0043 0.0227 0.1224
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0167 0.1851 0.1851
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0009 0.0015
Leishmania major cathepsin L-like protease 0.0167 0.1851 0.8804
Trypanosoma cruzi metacaspase, putative 0.0026 0.0009 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0167 0.1851 0.8804
Onchocerca volvulus Cathepsin L homolog 0.0167 0.1851 0.3921
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0167 0.1851 0.8804
Loa Loa (eye worm) TK/ROR protein kinase 0.0132 0.1396 0.2219
Giardia lamblia Cathepsin B precursor 0.0187 0.2102 1
Giardia lamblia Encystation-specific protease 0.0043 0.0227 0.1078
Loa Loa (eye worm) DOMON domain-containing protein 0.0049 0.031 0.0493
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0009 0.0045
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0254 0.0404
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0009 0.0045
Echinococcus granulosus Protein patched homolog 1 0.0041 0.021 0.0333
Trypanosoma brucei metacaspase MCA2 0.0026 0.0009 0.0045
Onchocerca volvulus 0.0167 0.1851 0.3921
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0157 0.1717 0.9276
Brugia malayi Protein kinase domain containing protein 0.0132 0.1396 0.2219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0167 0.1851 0.8804
Trypanosoma cruzi metacaspase, putative 0.0026 0.0009 0.0015
Schistosoma mansoni cathepsin F (C01 family) 0.0117 0.1192 0.1895
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1192 0.5672
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0157 0.1717 0.2729
Echinococcus granulosus geminin 0.0166 0.183 0.2908
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.021 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0093 0.0885 0.421
Echinococcus multilocularis cathepsin b 0.0509 0.6292 0.6292
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.1033 0.1641
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0117 0.1192 0.1895
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0187 0.2102 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0009 0.0045
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.021 0.0333
Echinococcus granulosus cathepsin l1 0.0167 0.1851 0.2942
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0009 0.0045
Echinococcus granulosus sentrin specific protease 7 0.0157 0.1717 0.2729
Schistosoma mansoni cathepsin C 0.0043 0.0227 0.036
Brugia malayi cathepsin F-like cysteine proteinase 0.0043 0.0227 0.036
Plasmodium falciparum serine repeat antigen 8 0.0043 0.0227 0.1224
Toxoplasma gondii kringle domain-containing protein 0.0132 0.1396 0.6639
Echinococcus multilocularis cysteine protease 0.0167 0.1851 0.1851
Brugia malayi RNA, U transporter 1 0.008 0.0716 0.1138
Trypanosoma brucei Metacaspase-4 0.0026 0.0009 0.0045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0167 0.1851 0.2942
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0086 0.0785 0.1248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0254 0.0404
Plasmodium falciparum serine repeat antigen 5 0.0043 0.0227 0.1224
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0227 0.036
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.1033 0.1641
Echinococcus granulosus caspase 8 0.0026 0.0009 0.0015
Echinococcus multilocularis enteropeptidase 0.0105 0.1033 0.1033
Brugia malayi Importin beta-1 subunit 0.0028 0.0039 0.0061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0227 0.036
Trypanosoma cruzi cysteine proteinase, putative 0.0093 0.0885 0.1407
Brugia malayi Trypsin-like protease protein 5 0.0105 0.1033 0.1641
Brugia malayi Trypsin family protein 0.0105 0.1033 0.1641
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0043 0.0227 0.1078
Loa Loa (eye worm) hypothetical protein 0.0036 0.0135 0.0215
Echinococcus granulosus cathepsin l1 0.0117 0.1192 0.1895
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0105 0.1033 0.1641
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0043 0.0227 0.1224
Schistosoma mansoni caspase-3 (C14 family) 0.0097 0.0936 0.1487
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.1851 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0286 0.0454
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.1851 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0227 0.036
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0132 0.1396 0.7541
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1464 0.2326
Entamoeba histolytica cysteine proteinase, putative 0.0093 0.0885 0.4782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0227 0.1078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1851 0.8804
Treponema pallidum ATP-dependent RNA helicase 0.0086 0.0785 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0043 0.0227 0.1078
Plasmodium falciparum eukaryotic initiation factor 4A 0.0086 0.0785 0.424
Plasmodium vivax vivapain-3 0.0093 0.0885 0.4782
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.1033 0.1641
Onchocerca volvulus 0.0047 0.0286 0.0605
Schistosoma mansoni patched 1 0.0041 0.021 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0043 0.0227 0.1078
Trypanosoma brucei metacaspase 0.0026 0.0009 0.0045
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0009 0.0045
Echinococcus multilocularis nmda type glutamate receptor 0.0028 0.003 0.003
Brugia malayi TAR-binding protein 0.0062 0.0478 0.076
Brugia malayi hypothetical protein 0.0231 0.2683 0.4265
Brugia malayi eukaryotic initiation factor 4A 0.0086 0.0785 0.1248
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0086 0.0785 0.3733
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0043 0.0227 0.1224
Echinococcus granulosus nmda type glutamate receptor 0.0028 0.003 0.0048
Brugia malayi Kringle domain containing protein 0.0132 0.1396 0.2219
Schistosoma mansoni cathepsin B (C01 family) 0.0043 0.0227 0.036
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0086 0.0785 0.3733
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0478 0.076
Plasmodium falciparum cysteine repeat modular protein 1 0.0132 0.1396 0.7541
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0093 0.0885 0.1407
Echinococcus granulosus cathepsin L cysteine proteinase 0.0167 0.1851 0.2942
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0009 0.0015
Echinococcus multilocularis caspase 2 0.0026 0.0009 0.0009
Brugia malayi Cathepsin L-like precursor 0.0167 0.1851 0.2942
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0105 0.1033 0.1033
Plasmodium vivax unspecified product 0.0093 0.0885 0.4782
Echinococcus multilocularis expressed conserved protein 0.009 0.0849 0.0849
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0086 0.0785 0.1248
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.1033 0.1641
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.1033 0.1641
Schistosoma mansoni cathepsin s 0.0051 0.033 0.0524
Plasmodium falciparum importin beta, putative 0.0028 0.0039 0.0209
Giardia lamblia Hypothetical protein 0.0043 0.0227 0.1078
Brugia malayi Papain family cysteine protease containing protein 0.0167 0.1851 0.2942
Loa Loa (eye worm) hypothetical protein 0.0049 0.031 0.0493
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.021 0.0333
Trypanosoma cruzi cysteine protease, putative 0.0093 0.0885 0.1407
Loa Loa (eye worm) hypothetical protein 0.0105 0.1033 0.1641
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Plasmodium falciparum serine repeat antigen 3 0.0043 0.0227 0.1224
Brugia malayi cathepsin L-like cysteine proteinase 0.0043 0.0227 0.036
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0009 0.0045
Giardia lamblia Hypothetical protein 0.0043 0.0227 0.1078
Brugia malayi Probable ATP-dependent helicase DHX35 0.0036 0.0135 0.0215
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0401 0.4891 0.7773
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.1033 0.1641
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0093 0.0885 0.1407
Echinococcus granulosus Mastin 0.0105 0.1033 0.1641
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0478 0.076
Loa Loa (eye worm) hypothetical protein 0.0105 0.1033 0.1641
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0254 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Trypanosoma cruzi metacaspase, putative 0.0026 0.0009 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1851 0.8804
Echinococcus multilocularis cathepsin L cysteine protease 0.0167 0.1851 0.1851
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0043 0.0227 0.1078
Echinococcus multilocularis caspase 8 0.0026 0.0009 0.0009
Brugia malayi Muscle positioning protein 4 0.0054 0.0379 0.0603
Entamoeba histolytica cysteine proteinase, putative 0.0093 0.0885 0.4782
Onchocerca volvulus 0.0049 0.031 0.0657
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0043 0.0227 0.036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1851 0.8804
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0227 0.036
Echinococcus granulosus expressed conserved protein 0.0132 0.1388 0.2207
Echinococcus granulosus importin subunit beta 1 0.0028 0.0039 0.0061
Loa Loa (eye worm) hypothetical protein 0.0086 0.0785 0.1248
Trypanosoma cruzi cysteine peptidase, putative 0.0167 0.1851 0.2942
Giardia lamblia Cathepsin B precursor 0.0043 0.0227 0.1078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0227 0.1078
Onchocerca volvulus 0.0167 0.1851 0.3921
Entamoeba histolytica hypothetical protein 0.0043 0.0227 0.1224
Brugia malayi Cathepsin L-like precursor 0.0167 0.1851 0.2942
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1851 0.8804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1192 0.5672
Loa Loa (eye worm) hypothetical protein 0.0105 0.1033 0.1641
Brugia malayi cathepsin B-like cysteine proteinase 0.0509 0.6292 1
Leishmania major cathepsin L-like protease 0.0167 0.1851 0.8804
Brugia malayi Trypsin family protein 0.0105 0.1033 0.1641
Trypanosoma brucei metacaspase MCA3 0.0026 0.0009 0.0045
Leishmania major cathepsin L-like protease 0.0167 0.1851 0.8804
Giardia lamblia Cathepsin L precursor 0.0043 0.0227 0.1078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1851 0.8804
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0051 0.033 0.0524
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1464 0.1464
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0009 0.0045
Echinococcus granulosus cysteine protease 0.0093 0.0885 0.1407
Brugia malayi fibroinase precursor 0.0043 0.0227 0.036
Echinococcus granulosus cathepsin b 0.0509 0.6292 1
Giardia lamblia Cathepsin L precursor 0.0043 0.0227 0.1078
Leishmania major cathepsin L-like protease 0.0167 0.1851 0.8804
Trypanosoma cruzi cysteine peptidase, putative 0.0167 0.1851 0.2942
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0086 0.0785 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Onchocerca volvulus 0.0167 0.1851 0.3921
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0478 0.076
Giardia lamblia Cathepsin L precursor 0.0043 0.0227 0.1078
Echinococcus granulosus cathepsin b 0.0509 0.6292 1
Schistosoma mansoni hypothetical protein 0.004 0.019 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0009 0.0045
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Brugia malayi Cathepsin L-like precursor 0.0051 0.033 0.0524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Brugia malayi cathepsin Z-like cysteine proteinase 0.0043 0.0227 0.036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Loa Loa (eye worm) hypothetical protein 0.0051 0.033 0.0524
Plasmodium falciparum serine repeat antigen 6 0.0043 0.0227 0.1224
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0043 0.0227 0.1224
Echinococcus multilocularis cathepsin L 0.0093 0.0885 0.0885
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0043 0.0227 0.036
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0043 0.0227 0.1224
Plasmodium vivax unspecified product 0.0051 0.033 0.1782
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0167 0.1851 0.8804
Plasmodium falciparum serine repeat antigen 1 0.0043 0.0227 0.1224
Leishmania major cathepsin L-like protease 0.0167 0.1851 0.8804
Plasmodium vivax serine-repeat antigen (SERA) 0.0043 0.0227 0.1224
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0105 0.1033 0.1641
Onchocerca volvulus 0.0167 0.1851 0.3921
Schistosoma mansoni cathepsin F (C01 family) 0.0167 0.1851 0.2942
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0009 0.0045
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0109 0.1086 0.1726
Giardia lamblia Cathepsin B precursor 0.0043 0.0227 0.1078
Loa Loa (eye worm) hypothetical protein 0.0043 0.0227 0.036
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0509 0.6292 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0227 0.036
Entamoeba histolytica cysteine protease, putative 0.0043 0.0227 0.1224
Brugia malayi cathepsin L-like precursor 0.0117 0.1192 0.1895
Schistosoma mansoni hypothetical protein 0.0105 0.1033 0.1641
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0167 0.1851 0.1851
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0009 0.0051
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0009 0.0045
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.1033 0.1641
Brugia malayi Cathepsin L-like precursor 0.0117 0.1192 0.1895
Echinococcus granulosus snurportin 1 0.0301 0.3592 0.5709
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0105 0.1033 0.1033
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0254 0.0404
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.033 0.0524
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0167 0.1851 0.8804
Schistosoma mansoni cathepsin F (C01 family) 0.0167 0.1851 0.2942
Echinococcus granulosus cathepsin L 0.0093 0.0885 0.1407
Leishmania major metacaspase, putative 0.0026 0.0009 0.0045
Echinococcus granulosus eukaryotic initiation factor 4A 0.0086 0.0785 0.1248
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.1033 0.1641
Trypanosoma cruzi major cysteine proteinase, putative 0.0043 0.0227 0.036
Echinococcus granulosus caspase 3 0.0071 0.0598 0.095
Loa Loa (eye worm) hypothetical protein 0.0132 0.1396 0.2219
Brugia malayi SEA domain containing protein 0.0049 0.031 0.0493
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0227 0.1078
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0043 0.0227 0.1224
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.033 0.0524
Schistosoma mansoni survival motor neuron protein 0.0047 0.0286 0.0454
Trypanosoma brucei cysteine peptidase C (CPC) 0.0187 0.2102 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0009 0.0045
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0043 0.0227 0.1224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0022 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0254 0.0404
Loa Loa (eye worm) hypothetical protein 0.0054 0.0379 0.0603
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0043 0.0227 0.1224
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Loa Loa (eye worm) hypothetical protein 0.0117 0.1192 0.1895
Giardia lamblia Cysteine protease 0.0043 0.0227 0.1078
Loa Loa (eye worm) hypothetical protein 0.0167 0.1851 0.2942
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.1033 0.1641
Loa Loa (eye worm) RNA binding protein 0.0062 0.0478 0.076
Trypanosoma cruzi cysteine peptidase, putative 0.0167 0.1851 0.2942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Toxoplasma gondii preprocathepsin c precursor, putative 0.0043 0.0227 0.1078
Brugia malayi cathepsin Z-like cysteine proteinase 0.0043 0.0227 0.036
Onchocerca volvulus 0.0388 0.4721 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0043 0.0227 0.036
Toxoplasma gondii cathepsin CPC1 0.0043 0.0227 0.1078
Trypanosoma cruzi hypothetical protein, conserved 0.0132 0.1396 0.2219
Onchocerca volvulus 0.0049 0.031 0.0657
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0254 0.0254
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0043 0.0227 0.036
Echinococcus multilocularis tissue type plasminogen activator 0.0132 0.1396 0.1396
Loa Loa (eye worm) hypothetical protein 0.0231 0.2683 0.4265
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0025 0 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1851 0.8804
Loa Loa (eye worm) hypothetical protein 0.0509 0.6292 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0167 0.1851 0.2942
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0086 0.0785 0.0785
Giardia lamblia Cysteine protease 0.0043 0.0227 0.1078
Brugia malayi Cathepsin L-like precursor 0.0167 0.1851 0.2942
Giardia lamblia Cathepsin B precursor 0.0043 0.0227 0.1078
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Giardia lamblia Cathepsin L-like protease 0.0043 0.0227 0.1078
Trypanosoma cruzi cysteine peptidase, putative 0.0167 0.1851 0.2942
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0093 0.0885 0.1407
Onchocerca volvulus Cathepsin F homolog 0.0167 0.1851 0.3921
Plasmodium vivax metacaspase 1, putative 0.0026 0.0009 0.0051
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.033 0.0524
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0509 0.6292 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1851 0.8804
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0086 0.0785 0.0785
Entamoeba histolytica cysteine protease, putative 0.0043 0.0227 0.1224
Giardia lamblia Cathepsin L precursor 0.0043 0.0227 0.1078
Brugia malayi Cell death protein 3 precursor 0.0026 0.0009 0.0015
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.1033 0.1641
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0925 0.1471
Echinococcus multilocularis cysteine protease 0.0167 0.1851 0.1851
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0105 0.1033 0.1641
Schistosoma mansoni importin beta-1 0.0028 0.0039 0.0061
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0925 0.1471
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0227 0.036
Schistosoma mansoni hypothetical protein 0.0166 0.183 0.2908
Plasmodium falciparum metacaspase-like protein 0.0026 0.0009 0.0051
Onchocerca volvulus 0.0132 0.1396 0.2956
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0043 0.0227 0.1224
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0097 0.0936 0.0936
Trypanosoma cruzi metacaspase, putative 0.0026 0.0009 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1851 0.8804
Plasmodium vivax importin-beta 2, putative 0.0028 0.0039 0.0209
Echinococcus granulosus transmembrane protease serine 3 0.0105 0.1033 0.1641
Entamoeba histolytica cysteine protease, putative 0.0043 0.0227 0.1224
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0043 0.0227 0.1078
Trypanosoma cruzi cysteine proteinase, putative 0.0093 0.0885 0.1407
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0509 0.6292 1
Plasmodium vivax RNA helicase-1, putative 0.0086 0.0785 0.424
Entamoeba histolytica cysteine proteinase, putative 0.0093 0.0885 0.4782
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0043 0.0227 0.1224
Echinococcus multilocularis cathepsin b 0.0509 0.6292 0.6292
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0086 0.0785 0.3733
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Giardia lamblia Cathepsin L precursor 0.0043 0.0227 0.1078
Echinococcus multilocularis caspase 3 0.0071 0.0598 0.0598
Loa Loa (eye worm) hypothetical protein 0.0043 0.0227 0.036
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0009 0.0015
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Loa Loa (eye worm) cysteine protease 0.0167 0.1851 0.2942
Echinococcus granulosus glycoprotein Antigen 5 0.0105 0.1033 0.1641
Echinococcus multilocularis transmembrane protease serine 3 0.0105 0.1033 0.1033
Echinococcus granulosus caspase 2 0.0026 0.0009 0.0015
Schistosoma mansoni hypothetical protein 0.0105 0.1033 0.1641
Schistosoma mansoni cathepsin S (C01 family) 0.0043 0.0227 0.036
Brugia malayi Cathepsin L-like precursor 0.0167 0.1851 0.2942
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0009 0.0045
Echinococcus multilocularis protein patched 0.0041 0.021 0.021
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0167 0.1851 1
Onchocerca volvulus 0.0117 0.1192 0.2526
Mycobacterium ulcerans hypothetical protein 0.0105 0.1033 0.5
Brugia malayi Cathepsin L-like precursor 0.0117 0.1192 0.1895
Brugia malayi Cathepsin L-like precursor 0.0167 0.1851 0.2942
Leishmania major cathepsin L-like protease 0.0167 0.1851 0.8804
Schistosoma mansoni hypothetical protein 0.0301 0.3592 0.5709
Giardia lamblia Cathepsin B precursor 0.0043 0.0227 0.1078
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0509 0.6292 1
Schistosoma mansoni hypothetical protein 0.0132 0.1396 0.2219
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0227 0.036
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0227 0.036
Giardia lamblia Cathepsin B precursor 0.0043 0.0227 0.1078
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0093 0.0885 0.1407
Schistosoma mansoni hypothetical protein 0.004 0.019 0.0302
Echinococcus granulosus cathepsin L cysteine protease 0.0093 0.0885 0.1407
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.1033 0.1641
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0227 0.1078
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0086 0.0785 0.3733
Onchocerca volvulus 0.0043 0.0227 0.048
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0086 0.0785 0.1663
Schistosoma mansoni hypothetical protein 0.004 0.019 0.0302
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.1033 0.1641
Schistosoma mansoni hypothetical protein 0.004 0.019 0.0302
Giardia lamblia Cathepsin B precursor 0.0187 0.2102 1
Giardia lamblia Cathepsin L-like protease 0.0043 0.0227 0.1078
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0478 0.076
Loa Loa (eye worm) DEAH box polypeptide 35 0.0036 0.0135 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0009 0.0045
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0039 0.0061
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0043 0.0227 0.036
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0043 0.0227 0.1224
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0167 0.1851 1
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0025 0 0.5
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0043 0.0227 0.1078
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0039 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0254 0.0404
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0028 0.003 0.003
Echinococcus granulosus enteropeptidase 0.0105 0.1033 0.1641
Echinococcus multilocularis expressed conserved protein 0.0132 0.1388 0.1388
Toxoplasma gondii cathepsin B 0.0187 0.2102 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0227 0.1078
Plasmodium vivax serine-repeat antigen (SERA) 0.0043 0.0227 0.1224
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0043 0.0227 0.1078
Loa Loa (eye worm) hypothetical protein 0.0043 0.0227 0.036
Brugia malayi cathepsin L precursor 0.0043 0.0227 0.036
Echinococcus multilocularis cathepsin L cysteine protease 0.0167 0.1851 0.1851
Plasmodium falciparum serine repeat antigen 7 0.0043 0.0227 0.1224
Onchocerca volvulus 0.0049 0.031 0.0657
Brugia malayi Papain family cysteine protease containing protein 0.0093 0.0885 0.1407
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0105 0.1033 0.1641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0167 0.1851 0.8804
Onchocerca volvulus 0.0105 0.1033 0.2187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0227 0.1078
Echinococcus multilocularis snurportin 1 0.0301 0.3592 0.3592
Schistosoma mansoni hypothetical protein 0.0047 0.0286 0.0454
Entamoeba histolytica cysteine protease, putative 0.0043 0.0227 0.1224
Giardia lamblia Cysteine protease 0.0043 0.0227 0.1078
Plasmodium falciparum serine repeat antigen 4 0.0043 0.0227 0.1224
Loa Loa (eye worm) hypothetical protein 0.0105 0.1033 0.1641
Giardia lamblia Cysteine protease 0.0043 0.0227 0.1078
Loa Loa (eye worm) hypothetical protein 0.0388 0.4721 0.7504
Echinococcus multilocularis geminin 0.0166 0.183 0.183
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0925 0.0925
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0043 0.0227 0.1224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0227 0.1078
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0043 0.0227 0.036
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0945 0.1502
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1851 0.8804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Plasmodium vivax vivapain-2 0.0167 0.1851 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0009 0.0045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0509 0.6292 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0086 0.0785 0.3733
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0925 0.4999
Loa Loa (eye worm) cathepsin B 0.0187 0.2102 0.3342
Plasmodium vivax unspecified product 0.0043 0.0227 0.1224
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.021 0.0996
Echinococcus multilocularis sentrin specific protease 7 0.0157 0.1717 0.1717
Giardia lamblia Cathepsin B precursor 0.0187 0.2102 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0187 0.2102 0.3342
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0043 0.0227 0.1078
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0043 0.0227 0.1078
Echinococcus multilocularis caspase 0.0097 0.0936 0.0936
Echinococcus granulosus caspase 0.0097 0.0936 0.1487
Leishmania major hypothetical protein, conserved 0.0132 0.1396 0.6639
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0043 0.0227 0.1224
Plasmodium falciparum metacaspase 1 0.0026 0.0009 0.0051
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Entamoeba histolytica cysteine protease, putative 0.0043 0.0227 0.1224
Echinococcus granulosus cathepsin L 0.0043 0.0227 0.036
Leishmania major eukaryotic initiation factor 4a, putative 0.0086 0.0785 0.3733
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0254 0.0254
Brugia malayi hypothetical protein 0.0105 0.1033 0.1641
Loa Loa (eye worm) hypothetical protein 0.0117 0.1192 0.1895
Echinococcus granulosus tar DNA binding protein 0.0062 0.0478 0.076
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0009 0.0045
Echinococcus multilocularis Mastin 0.0105 0.1033 0.1033
Entamoeba histolytica cysteine proteinase 2 0.0093 0.0885 0.4782
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0885 0.421
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.2683 0.4265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0086 0.0785 0.1248
Entamoeba histolytica cysteine protease, putative 0.0167 0.1851 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0093 0.0885 0.4782
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0009 0.0045
Brugia malayi Cathepsin L-like cysteine proteinase 0.0117 0.1192 0.1895
Loa Loa (eye worm) hypothetical protein 0.0105 0.1033 0.1641
Onchocerca volvulus 0.0054 0.0379 0.0803
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0478 0.0478
Onchocerca volvulus 0.0283 0.336 0.7116
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0167 0.1851 0.8804
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0478 0.076
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0086 0.0785 0.424
Onchocerca volvulus 0.0049 0.031 0.0657
Entamoeba histolytica cysteine protease, putative 0.0043 0.0227 0.1224
Onchocerca volvulus 0.0105 0.1033 0.2187
Echinococcus multilocularis protein dispatched 1 0.0047 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0117 0.1192 0.1895
Leishmania major cathepsin L-like protease 0.0167 0.1851 0.8804
Echinococcus granulosus cathepsin l cysteine peptidase 0.0167 0.1851 0.2942
Leishmania major eukaryotic initiation factor 4a, putative 0.0086 0.0785 0.3733
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0043 0.0227 0.1078
Leishmania major cysteine peptidase A (CPA) 0.0167 0.1851 0.8804
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0388 0.4721 0.7504
Brugia malayi Cathepsin L-like precursor 0.0167 0.1851 0.2942
Brugia malayi Trypsin family protein 0.0105 0.1033 0.1641
Onchocerca volvulus 0.0105 0.1033 0.2187
Plasmodium vivax vivapain-1 0.0093 0.0885 0.4782
Loa Loa (eye worm) ctsf protein 0.0167 0.1851 0.2942
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1851 0.8804
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0478 0.076
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0043 0.0227 0.1224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0086 0.0785 0.1248
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0009 0.0045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0043 0.0227 0.036
Echinococcus granulosus tissue type plasminogen activator 0.0132 0.1396 0.2219
Plasmodium falciparum cysteine proteinase falcipain 1 0.0093 0.0885 0.4782
Loa Loa (eye worm) hypothetical protein 0.0051 0.033 0.0524
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0167 0.1851 0.8804
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0043 0.0227 0.1224
Loa Loa (eye worm) hypothetical protein 0.0388 0.4721 0.7504
Echinococcus multilocularis cathepsin L 0.0043 0.0227 0.0227
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0009 0.0015
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0039 0.0184
Brugia malayi RNA binding protein 0.0062 0.0478 0.076
Onchocerca volvulus Cathepsin L homolog 0.0043 0.0227 0.048
Brugia malayi CHE-14 protein 0.0041 0.021 0.0333
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Plasmodium falciparum serine repeat antigen 2 0.0043 0.0227 0.1224
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.1033 0.1641
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0227 0.1078
Loa Loa (eye worm) hypothetical protein 0.0096 0.0925 0.1471
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0227 0.036
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.033 0.0524
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0009 0.0045
Brugia malayi Papain family cysteine protease containing protein 0.0093 0.0885 0.1407
Trypanosoma cruzi cruzipain precursor, putative 0.0167 0.1851 0.2942
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0043 0.0227 0.1078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0254 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1851 0.8804
Loa Loa (eye worm) hypothetical protein 0.0041 0.021 0.0333
Echinococcus granulosus expressed conserved protein 0.009 0.0849 0.135
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0009 0.0045
Giardia lamblia Cathepsin L precursor 0.0043 0.0227 0.1078
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Onchocerca volvulus 0.0167 0.1851 0.3921
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0187 0.2102 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0086 0.0785 0.3733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0093 0.0885 0.421
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0167 0.1851 0.8804
Loa Loa (eye worm) hypothetical protein 0.0043 0.0227 0.036
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0097 0.0936 0.1487
Entamoeba histolytica cysteine protease, putative 0.0093 0.0885 0.4782
Onchocerca volvulus 0.0105 0.1033 0.2187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0167 0.1851 0.8804

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: SAR analysis for the identification of translation initiation inhibitors (eIF4H). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2012, AID2014, AID2028] ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: SAR analysis for the identification of translation initiation inhibitors (PABP). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2012, AID2014, AID2030] ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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