Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0219 | 0.9877 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.011 | 0.2099 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.2099 | 0.0714 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0221 | 0.997 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0109 | 0.2022 | 0.0623 |
Onchocerca volvulus | 0.0102 | 0.1501 | 0.715 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0221 | 0.997 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0221 | 0.997 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.2099 | 0.0714 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0172 | 0.6487 | 0.5597 |
Brugia malayi | Dihydrofolate reductase | 0.0219 | 0.9877 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.7951 | 0.77 |
Brugia malayi | Kringle domain containing protein | 0.011 | 0.2099 | 0.0714 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0219 | 0.9877 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0219 | 0.9877 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.011 | 0.2099 | 0.0096 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0175 | 0.6737 | 0.5909 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0172 | 0.6487 | 0.5953 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0109 | 0.2022 | 0.0623 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.011 | 0.2099 | 0.0714 |
Echinococcus granulosus | dihydrofolate reductase | 0.0219 | 0.9877 | 0.9846 |
Brugia malayi | dihydrofolate reductase family protein | 0.0219 | 0.9877 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0221 | 1 | 1 |
Onchocerca volvulus | 0.011 | 0.2099 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.011 | 0.2099 | 0.0714 |
Echinococcus granulosus | ankyrin repeat protein | 0.0172 | 0.6487 | 0.5597 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0221 | 0.997 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0221 | 0.997 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0219 | 0.9877 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0219 | 0.9877 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0175 | 0.6737 | 0.5909 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0221 | 0.997 | 1 |
Brugia malayi | thymidylate synthase | 0.0109 | 0.2022 | 0.0623 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0219 | 0.9877 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0219 | 0.9877 | 0.9846 |
Onchocerca volvulus | 0.0109 | 0.2022 | 0.9634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.