Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.054 | 0.445 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.115 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.115 | 1 | 1 |
Brugia malayi | CHE-14 protein | 0.0474 | 0.385 | 0.3844 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.115 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0474 | 0.385 | 0.3697 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.054 | 0.445 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 0.385 | 0.3844 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0474 | 0.385 | 0.3844 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.115 | 1 | 0.5 |
Schistosoma mansoni | patched 1 | 0.0474 | 0.385 | 0.385 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0474 | 0.385 | 0.3697 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0474 | 0.385 | 0.3697 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.115 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.054 | 0.445 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.115 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.115 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0474 | 0.385 | 0.385 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0474 | 0.385 | 0.3697 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.115 | 1 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0474 | 0.385 | 0.3697 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.054 | 0.445 | 1 |
Echinococcus multilocularis | protein patched | 0.0474 | 0.385 | 0.3697 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0474 | 0.385 | 0.3697 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.115 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.