Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0157 | 0.2129 | 0.8172 |
Echinococcus granulosus | adenosine deaminase | 0.0179 | 0.2605 | 0.2605 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0058 | 0.007 | 0.033 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0157 | 0.2129 | 0.2129 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0179 | 0.2605 | 0.2605 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0157 | 0.2129 | 1 |
Plasmodium falciparum | AMP deaminase, putative | 0.0058 | 0.007 | 0.027 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0157 | 0.2129 | 0.2129 |
Schistosoma mansoni | adenosine deaminase-related | 0.0179 | 0.2605 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0179 | 0.2605 | 1 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0179 | 0.2605 | 0.2605 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.2605 | 0.2945 |
Echinococcus multilocularis | aminopeptidase N | 0.0532 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.138 | 0.1561 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0157 | 0.2129 | 0.2129 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0102 | 0.0975 | 0.4578 |
Echinococcus granulosus | AMP deaminase 2 | 0.0058 | 0.007 | 0.007 |
Entamoeba histolytica | aminopeptidase, putative | 0.0157 | 0.2129 | 0.8122 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0058 | 0.007 | 0.033 |
Mycobacterium ulcerans | adenosine deaminase | 0.0179 | 0.2605 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0157 | 0.2129 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0179 | 0.2605 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0058 | 0.007 | 0.033 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0179 | 0.2605 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.0058 | 0.007 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.007 | 0.0079 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0157 | 0.2129 | 0.8172 |
Echinococcus multilocularis | adenosine deaminase | 0.0179 | 0.2605 | 0.2605 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0157 | 0.2129 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0058 | 0.007 | 0.027 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0179 | 0.2605 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0058 | 0.007 | 0.033 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0179 | 0.2605 | 1 |
Onchocerca volvulus | 0.0058 | 0.007 | 0.007 | |
Brugia malayi | adenosine monophosphate deaminase | 0.0058 | 0.007 | 0.007 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0157 | 0.2129 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0157 | 0.2129 | 0.2129 |
Schistosoma mansoni | AMP deaminase | 0.0058 | 0.007 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0975 | 0.1102 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0058 | 0.007 | 0.033 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0157 | 0.2129 | 0.2129 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.6717 | 0.7593 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.138 | 0.1561 |
Onchocerca volvulus | 0.0532 | 1 | 1 | |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0179 | 0.2605 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0058 | 0.007 | 0.033 |
Loa Loa (eye worm) | aminopeptidase N | 0.0157 | 0.2129 | 0.2407 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0058 | 0.007 | 0.007 |
Trypanosoma brucei | AMP deaminase, putative | 0.0058 | 0.007 | 0.033 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0157 | 0.2129 | 0.2129 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0157 | 0.2129 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.138 | 0.1561 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0157 | 0.2129 | 0.2129 |
Onchocerca volvulus | 0.0157 | 0.2129 | 0.2129 | |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0179 | 0.2605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.234 | 0.2645 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0157 | 0.2129 | 0.8172 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0058 | 0.007 | 0.033 |
Trypanosoma brucei | AMP deaminase, putative | 0.0058 | 0.007 | 0.033 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0058 | 0.007 | 0.027 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0157 | 0.2129 | 0.2129 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0157 | 0.2129 | 0.8172 |
Leishmania major | AMP deaminase, putative | 0.0058 | 0.007 | 0.027 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0058 | 0.007 | 0.033 |
Echinococcus granulosus | aminopeptidase N | 0.0532 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0179 | 0.2605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2531 | 0.2862 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.0058 | 0.007 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.234 | 0.2645 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0157 | 0.2129 | 0.8172 |
Brugia malayi | hypothetical protein | 0.0157 | 0.2129 | 0.2129 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.043 | 0.7871 | 0.8898 |
Leishmania major | adenine aminohydrolase | 0.0179 | 0.2605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0975 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.8846 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0157 | 0.2129 | 0.2129 |
Treponema pallidum | adenosine deaminase | 0.0179 | 0.2605 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0157 | 0.2129 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0157 | 0.2129 | 0.2129 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0157 | 0.2129 | 0.2129 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0179 | 0.2605 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0058 | 0.007 | 0.007 |
Schistosoma mansoni | adenosine deaminase | 0.0179 | 0.2605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.234 | 0.2645 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0157 | 0.2129 | 0.8172 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0058 | 0.007 | 0.027 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0058 | 0.007 | 0.033 |
Onchocerca volvulus | 0.0167 | 0.234 | 0.234 | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0102 | 0.0975 | 0.0975 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0058 | 0.007 | 0.033 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0102 | 0.0975 | 0.3741 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.138 | 0.1561 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0157 | 0.2129 | 0.8172 |
Toxoplasma gondii | AMP deaminase | 0.0058 | 0.007 | 0.027 |
Plasmodium falciparum | adenosine deaminase | 0.0179 | 0.2605 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0058 | 0.007 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.2611 | 0.2951 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 uM | Inhibition of partially purified recombinant human calcium sensitive protein kinase C alpha | ChEMBL. | 12036372 |
IC50 (binding) | > 50 uM | Inhibition of partially purified recombinant human calcium sensitive protein kinase C beta 2 | ChEMBL. | 12036372 |
IC50 (binding) | > 50 uM | Inhibition of partially purified recombinant human calcium sensitive protein kinase C alpha | ChEMBL. | 12036372 |
IC50 (binding) | > 50 uM | Inhibition of partially purified recombinant human calcium sensitive protein kinase C beta 2 | ChEMBL. | 12036372 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.