Detailed information for compound 1489035

Basic information

Technical information
  • TDR Targets ID: 1489035
  • Name: 6-fluoro-2-phenyl-1,2-benzothiazol-3-one
  • MW: 245.272 | Formula: C13H8FNOS
  • H donors: 0 H acceptors: 1 LogP: 3.11 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)sn(c2=O)c1ccccc1
  • InChi: 1S/C13H8FNOS/c14-9-6-7-11-12(8-9)17-15(13(11)16)10-4-2-1-3-5-10/h1-8H
  • InChiKey: DSSXORGEYXPNQS-UHFFFAOYSA-N  


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Synonyms

  • ZINC01430591
  • ST4114558
  • A3737/0158367

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mannose phosphate isomerase Starlite/ChEMBL References
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Starlite/ChEMBL No references
Homo sapiens phosphatase, orphan 1 Starlite/ChEMBL References
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Trypanosoma brucei hexokinase Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Homo sapiens glucose-6-phosphate dehydrogenase Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus mannose 6 phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium yoelii Glucose-6-phosphate dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium berghei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium yoelii Phosphomannose isomerase type I, putative Get druggable targets OG5_127555 All targets in OG5_127555
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis phosphomannose isomerase type I family protein Get druggable targets OG5_127555 All targets in OG5_127555
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Neospora caninum hypothetical protein Get druggable targets OG5_127555 All targets in OG5_127555
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum ko:K00036 glucose-6-phosphate 1-dehydrogenase [EC1.1.1.49], putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium yoelii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium knowlesi glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Toxoplasma gondii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania braziliensis phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium knowlesi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 2 Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Plasmodium vivax hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans mannose-6-phosphate isomerase capable of functionally substituting for S. cerevisiae PMI40 (YER003C) Get druggable targets OG5_127555 All targets in OG5_127555
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trichomonas vaginalis mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica hexokinase 1 Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium vivax mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis 6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania donovani phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Theileria parva glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans mannose-6-phosphate isomerase capable of functionally substituting for S. cerevisiae PMI40 (YER003C) Get druggable targets OG5_127555 All targets in OG5_127555
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma congolense hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO Get druggable targets OG5_127555 All targets in OG5_127555
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei gambiense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi mannose-6-phosphate isomerase, class I family protein Get druggable targets OG5_127555 All targets in OG5_127555
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi mannose-6-phosphate isomerase, class I family protein Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania infantum phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania mexicana phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Neospora caninum cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126743 All targets in OG5_126743
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma congolense phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii phosphomannose isomerase type I protein Get druggable targets OG5_127555 All targets in OG5_127555
Cryptosporidium hominis hexokinase i Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Treponema pallidum hexokinase (hxk) Get druggable targets OG5_126743 All targets in OG5_126743
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K00844 hexokinase [EC2.7.1.1], putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium knowlesi mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium parvum mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Entamoeba histolytica phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania mexicana glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania braziliensis glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) hexokinase type II Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium falciparum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma mansoni mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Brugia malayi glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Trypanosoma brucei gambiense phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis mannose 6 phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium berghei mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Brugia malayi Hexokinase family protein Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Treponema pallidum glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma japonicum ko:K01809 mannose-6-phosphate isomerase [EC5.3.1.8], putative Get druggable targets OG5_127555 All targets in OG5_127555
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase glucose-6-phosphate dehydrogenase 545 aa 495 aa 39.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative phosphatase, orphan 1 292 aa 281 aa 28.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0117 0.2899 0.2899
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0117 0.2899 0.1203
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1533 0.1223
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0823 0.0823
Echinococcus granulosus hexokinase 0.0096 0.219 0.1973
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0085 0.1801 0.0955
Entamoeba histolytica phosphomannose isomerase, putative 0.0117 0.2899 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0989 0.0989
Loa Loa (eye worm) hypothetical protein 0.0041 0.0353 0.0353
Loa Loa (eye worm) hexokinase 0.006 0.0994 0.0994
Trichomonas vaginalis glutaminase, putative 0.033 1 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1533 0.1533
Leishmania major hexokinase, putative 0.0096 0.219 0.1546
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2787 0.2835
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0263 0.7751 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2787 0.9473
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0117 0.2899 0.2228
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0823 0.0823
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0823 0.0487
Loa Loa (eye worm) RNA binding protein 0.0076 0.1533 0.1533
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3792 0.3792
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0117 0.2899 0.2899
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1533 0.1223
Echinococcus multilocularis hexokinase 0.0096 0.219 0.1973
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1533 0.1223
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0263 0.7751 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0989 0.0989
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2787 0.2453
Echinococcus granulosus hexokinase 0.0096 0.219 0.1973
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0091 0.2022 1
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0273 0.8086 1
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0064 0.1104 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0353 0.0353
Brugia malayi MH2 domain containing protein 0.0144 0.3792 0.3792
Brugia malayi Hexokinase family protein 0.006 0.0994 0.0994
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2787 1
Trypanosoma brucei polo-like protein kinase 0.0114 0.2787 0.2453
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2787 0.2835
Loa Loa (eye worm) hexokinase 0.0096 0.219 0.219
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1533 0.1533
Trypanosoma cruzi hexokinase, putative 0.0096 0.219 0.1546
Trypanosoma brucei hexokinase, putative 0.0096 0.219 0.1546
Echinococcus multilocularis hexokinase 0.0096 0.219 0.1973
Echinococcus multilocularis hexokinase type 2 0.0096 0.219 0.1973
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0117 0.2899 0.2997
Entamoeba histolytica hexokinase 2 0.0096 0.219 0.6664
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1533 0.1223
Brugia malayi RNA binding protein 0.0076 0.1533 0.1533
Trypanosoma cruzi phosphomannose isomerase, putative 0.0117 0.2899 0.2624
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2787 0.2453
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.7556 0.9703
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0989 0.0989
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0273 0.8086 1
Mycobacterium ulcerans glutaminase 0.033 1 1
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0117 0.2899 0.2899
Trypanosoma cruzi phosphomannose isomerase, putative 0.0117 0.2899 0.2624
Echinococcus granulosus hexokinase 0.0096 0.219 0.1973
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0263 0.7751 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0823 0.0487
Trypanosoma cruzi hexokinase, putative 0.0096 0.219 0.1546
Schistosoma mansoni mannose-6-phosphate isomerase 0.0117 0.2899 0.264
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1533 0.1533
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0263 0.7751 0.6833
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0263 0.7751 1
Echinococcus granulosus mannose 6 phosphate isomerase 0.0117 0.2899 0.2997
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2787 0.2523
Loa Loa (eye worm) hexokinase 0.0096 0.219 0.219
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1533 0.1223
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0087 0.1886 0.1083
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2787 0.2105
Onchocerca volvulus 0.0096 0.219 0.6671
Onchocerca volvulus 0.0096 0.219 0.6671
Echinococcus multilocularis hexokinase 0.0096 0.219 0.1973
Schistosoma mansoni glutaminase 0.033 1 1
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0273 0.8086 0.7905
Leishmania major phosphomannose isomerase 0.0117 0.2899 0.2624
Loa Loa (eye worm) glutaminase 2 0.033 1 1
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0263 0.7751 1
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0117 0.2899 0.1203
Toxoplasma gondii phosphomannose isomerase type I protein 0.0117 0.2899 0.1203
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0273 0.8086 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.1169 0.1169
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.7556 0.9703
Brugia malayi Hexokinase family protein 0.0096 0.219 0.219
Leishmania major hypothetical protein, conserved 0.0257 0.7556 0.9703
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2787 0.2787
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2787 0.2105
Trypanosoma brucei hexokinase 0.0096 0.219 0.1546
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2787 0.2453
Schistosoma mansoni hexokinase 0.0096 0.219 0.1905
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0172 0.4708 0.4271
Schistosoma mansoni kinase 0.0058 0.0914 0.0582
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0117 0.2899 0.2899
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0823 0.0487
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1533 0.1024
Trypanosoma brucei phosphomannose isomerase 0.0117 0.2899 0.2624
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0989 0.0989
Echinococcus granulosus hexokinase type 2 0.0096 0.219 0.1973
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2787 0.2105
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0263 0.7751 1
Brugia malayi TAR-binding protein 0.0076 0.1533 0.1533
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0263 0.7751 0.7669
Brugia malayi hexokinase 0.0096 0.219 0.219
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3792 0.3792
Entamoeba histolytica hexokinase 1 0.0096 0.219 0.6664
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0263 0.7751 0.7751
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2787 0.2105
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.7556 0.9703
Echinococcus granulosus tar DNA binding protein 0.0076 0.1533 0.1024
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0263 0.7751 0.5
Onchocerca volvulus 0.0096 0.219 0.6671
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0273 0.8086 1
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0172 0.4708 0.2548
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0273 0.8086 0.7905
Brugia malayi glucose-6-phosphate dehydrogenase 0.0263 0.7751 0.7751
Loa Loa (eye worm) glutaminase 0.033 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2787 0.2105
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2787 0.2105
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0273 0.8086 0.7905
Leishmania major hexokinase, putative 0.0096 0.219 0.1546
Loa Loa (eye worm) hexokinase type II 0.0096 0.219 0.219
Trypanosoma brucei hexokinase 0.0096 0.219 0.1546
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2787 0.2787
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2787 0.2105

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 103.794 uM PUBCHEM_BIOASSAY: Absorbance-based biochemical high throughput dose response assay for activators of Methionine sulfoxide reductase A (MsrA). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 0.79 uM Inhibition of PHOSPHO1 phosphoethanolamine activity (unknown origin) assessed as amount of inorganic phosphate release after 30 mins ChEMBL. 25124115
IC50 (binding) = 1.3 uM Inhibition of phosphomannose isomerase (unknown origin) ChEMBL. 25124115
IC50 (functional) = 1.98 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) = 2.31 uM PUBCHEM_BIOASSAY: Confirmation assay for inhibitors of Trypanosoma brucei hexokinase 1-Analogue-first series. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1430, AID1632, AID2516, AID2560, AID2579, AID2600, AID449725, AID492951] ChEMBL. No reference
IC50 (functional) = 11.8 uM PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) = 14.5 uM PUBCHEM_BIOASSAY: Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) = 15.4 uM PUBCHEM_BIOASSAY: Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) 23.408 uM PubChem BioAssay. Counterscreen for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and receptor-interacting serine-threonine kinase 2 (RIPK2): Fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 36.43 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 50 uM Inhibition of PMM2 (unknown origin) ChEMBL. 25124115
Potency (functional) 3.3587 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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